Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| UNC5B | 219699 | unc-5 homolog B (C. elegans) | 10 | UNC5H2, p53RDL1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21922135 | 2012 | Cell line : - Source : Tokyo Medical and Dental University Hospital (Tokyo, Japan) Sample Type : CRC tumor and normal tissue No. of Sample : 100 Stage : - | Microarray, real time RT-PCR, methylation-specific PCR assay | Down-regulation | - | UNC5B is a potential biomarker for the selection of patients with high risk of postoperative recurrence and worse prognosis in CRC. The mRNA expression analysis using tissue samples revealed that UNC5B mRNA was down-expressed in about 20% of CRC patients, and the patients with low-UNC5B-expression tumors showed a significantly higher recurrence rate after curative surgery. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Immunoglobulin superfamily / I-set domain containing |
| Description | This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. |
| Chromosome | 10 |
| Location | 10q22.2 |
| Start | 71212535 |
| End | 71302879 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 90345 |
| OMIM ID | 607870 |
| HGNC ID | HGNC:12568 |
| Unigene ID | Hs.522997 |
| Ensembl ID | ENSG00000107731 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_170744.4 |
|---|---|
| Exon | join(1..530,67287..67511,72186..72329,72792..72895, 74155..74335,75064..75231,76034..76198,76424..76456, 78381..78575,78898..79287,79933..80020,80871..81039, 81166..81399,83277..83426,84044..84208,85375..85556, 86578..90344) | mRNA Sequence | Download Select all |
| Length | 6874 |
CDS Information
| Location | join(452..530,67287..67511,72186..72329,72792..72895, 74155..74335,75064..75231,76034..76198,76424..76456, 78381..78575,78898..79287,79933..80020,80871..81039, 81166..81399,83277..83426,84044..84208,85375..85556, 86578..86743) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS7309.1 |
Protein Information
| Protein ID | NP_001231818.1 |
|---|---|
| Protein Name | unc-5 homolog B (C. elegans) |
| Molecular Wt. (Da) | 99712 |
| Protein Sequence | Download Select all |
| Length | 934 |
| Uniprot ID | Q14767 |
| Ensembl Protein ID | ENSP00000261978 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 733 |
| Y | Phosphorylation | 737 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Axon guidance | hsa04360 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08802 | 858-941 | Death_UNC5B |
| cl14633 | 858-941 | DD superfamily |
| pfam00791 | 541-643 | ZU5 |
| cl02517 | 541-643 | ZU5 superfamily |
| smart00218 | 541-644 | ZU5 |
| cd08781 | 858-939 | Death_UNC5-like |
| cd08799 | 858-940 | Death_UNC5C |
| cd08801 | 858-942 | Death_UNC5D |
| cd08800 | 858-937 | Death_UNC5A |
| smart00209 | 249-300 | TSP1 |
| cl15278 | 249-300 | TSP_1 superfamily |
| cd05724 | 157-243 | Ig2_Robo |
| cl11960 | 157-243 | Ig superfamily |
| smart00005 | 859-942 | DEATH |
| smart00209 | 305-353 | TSP1 |
| cl15278 | 305-353 | TSP_1 superfamily |
| pfam00531 | 864-934 | Death |
| cd08312 | 863-931 | Death_MyD88 |
| cd00096 | 170-238 | Ig |
| cd08310 | 862-934 | Death_NFkB-like |
| pfam00090 | 250-296 | TSP_1 |
| cd05736 | 172-242 | Ig2_Follistatin_like |
| pfam13895 | 168-243 | Ig_2 |
| cd04967 | 155-240 | Ig1_Contactin |
| cd04969 | 169-243 | Ig5_Contactin_like |
| cd05848 | 155-241 | Ig1_Contactin-5 |
| cd05849 | 155-241 | Ig1_Contactin-1 |
| cd05729 | 162-229 | Ig2_FGFR_like |
| cd08797 | 862-939 | Death_NFkB1_p105 |
| cd08798 | 864-934 | Death_NFkB2_p100 |
| cd05725 | 170-243 | Ig3_Robo |
| pfam13927 | 169-229 | Ig_3 |
| cd05748 | 179-245 | Ig_Titin_like |
| cd05723 | 169-242 | Ig4_Neogenin |
| cd08782 | 862-932 | Death_DAPK1 |
| cd04979 | 170-245 | Ig_Semaphorin_C |
| cd05730 | 166-229 | Ig3_NCAM-1_like |
| cd05738 | 179-243 | Ig2_RPTP_IIa_LAR_like |
| cd05727 | 170-231 | Ig2_Contactin-2-like |
| cd05845 | 165-233 | Ig2_L1-CAM_like |
| cd04976 | 179-243 | Ig2_VEGFR |
| PTZ00087 | 305-348 | PTZ00087 |
| cd07693 | 172-243 | Ig1_Robo |
| cd05750 | 172-241 | Ig_Pro_neuregulin |
| pfam00090 | 306-353 | TSP_1 |
| cd01670 | 862-936 | Death |
| cd05864 | 179-243 | Ig2_VEGFR-2 |
| cd04978 | 172-229 | Ig4_L1-NrCAM_like |
| cd04972 | 178-245 | Ig_TrkABC_d4 |
| pfam07679 | 155-243 | I-set |
| smart00410 | 159-243 | IG_like |
| smart00409 | 159-243 | IG |
| smart00408 | 170-229 | IGc2 |
Ontology Information
| HPRD ID | 2988 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Transmembrane receptor activity (GO:0004888) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.