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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21355292 | 2011 | Cell line : SW480, SW480/CPT Source : - Sample Type : - No. of Sample : - Stage : - | Microarray, RT-PCR | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Glutathione S-transferases / Soluble |
| Description | The glutathione S-transferases (GST; EC 2.5.1.18) catalyze the conjugation of reduced glutathiones and a variety of electrophiles, including many known carcinogens and mutagens. The cytosolic GSTs belong to a large superfamily, with members located on different chromosomes. For additional information on GSTs, see GSTA1 (MIM 138359).[supplied by OMIM, Sep 2008] |
| Chromosome | 6 |
| Location | 6p12.2 |
| Start | 52696540 |
| End | 52710893 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 14354 |
| OMIM ID | 607605 |
| HGNC ID | HGNC:19662 |
| Unigene ID | Hs.646984 |
| Ensembl ID | ENSG00000182793 |
| PharmGKB ID | PA134962856 |
Protein Information
| Protein ID | NP_714543.1 |
|---|---|
| Protein Name | glutathione S-transferase alpha 5 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 222 |
| Uniprot ID | A1A5B4 |
| Ensembl Protein ID | ENSP00000332788 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 37 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemical carcinogenesis | hsa05204 |
| Drug metabolism - cytochrome P450 | hsa00982 |
| Glutathione metabolism | hsa00480 |
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03208 | 86-220 | GST_C_Alpha |
| cl02776 | 86-220 | GST_C_family superfamily |
| cd03077 | Apr-82 | GST_N_Alpha |
| cl00388 | Apr-82 | Thioredoxin_like superfamily |
| cd03039 | May-76 | GST_N_Sigma_like |
| cd03192 | 88-188 | GST_C_Sigma_like |
| pfam00043 | 99-192 | GST_C |
| pfam02798 | May-77 | GST_N |
| cd03210 | 87-207 | GST_C_Pi |
| cd00570 | May-76 | GST_N_family |
| cd03076 | Apr-78 | GST_N_Pi |
| cd03075 | May-79 | GST_N_Mu |
| cd03209 | 87-204 | GST_C_Mu |
| cd10293 | 130-196 | GST_C_Ure2p |
| cd03191 | 118-196 | GST_C_Zeta |
| cd00299 | 89-188 | GST_C_family |
| cd03046 | May-79 | GST_N_GTT1_like |
| cd03181 | 125-198 | GST_C_EF1Bgamma_like |
| cd03053 | 52-78 | GST_N_Phi |
| cd03188 | 114-198 | GST_C_Beta |
| cd03056 | Jun-76 | GST_N_4 |
| PTZ00057 | 1-198 | PTZ00057 |
| COG0625 | 5-197 | GstA |
| PLN02473 | 40-199 | PLN02473 |
| TIGR01262 | 53-195 | maiA |
| PLN02395 | 52-199 | PLN02395 |
Ontology Information
| HPRD ID | 18214 |
|---|---|
| Molecular Class | Enzyme: Glutathione transferase |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Apoptosis (GO:0006915) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q7RTV2 | DB00143 | Glutathione | SmallMoleculeDrug |