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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
FEN1 2237 flap structure-specific endonuclease 1  11FEN-1, MF1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22072618   2012Cell line : -

Source : -

Sample Type : Population based case-control study

No. of Sample : Cohorts of 1850 gastrointestinal cancer (hepatocellular carcinoma, esophageal cancer, gastric cancer and colorectal cancer) patients and 2222 healthy controls

Stage : -

Polymorphism genotyping,Real-time analysis of FEN1 mRNAPolymorhpism-FEN1 as an important gene in human gastrointestinal oncogenesis and genetic polymorphisms in FEN1 confer susceptibility to gastrointestinal cancers.FEN1 -69GG genotypes were significantly correlated to increased risk for developing gastrointestinal cancer compared with the -69AA genotype.


Gene Details



NC_000011.9 (61560109..61564716)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]  
Chromosome 11
Location 11q12
Start 61560109  
End 61564716  
Strand +  
Gene Sequence

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Length 4608  
OMIM ID 600393   
HGNC ID HGNC:3650   
Unigene ID Hs.409065   
Ensembl ID ENSG00000168496   
PharmGKB ID PA28090   

mRNA Information


mRNA ID NM_004111.5
Exon join(1..392,2705..4608)  
mRNA Sequence

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Length 2308  



CDS Information


   
Location414..1556
CDS Sequence

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CCDS ID CCDS8010.1



Protein Information


      
Protein IDNP_004102.1
Protein Nameflap structure-specific endonuclease 1
Molecular Wt. (Da)42462
Protein Sequence

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Length 380  
Uniprot IDQ05397
Ensembl Protein ID ENSP00000341189  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KAcetylation354
KAcetylation375
KAcetylation377
KAcetylation380
SPhosphorylation187
KAcetylation80
KAcetylation267
TPhosphorylation195
SPhosphorylation197
TPhosphorylation364
SPhosphorylation335

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                          
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
328APEX1136NP_542380.1in vitro;in vivo11601988   
396ARHGDIA3565NP_004300.1yeast 2-hybrid16169070   
1017CDK2310NP_001789.2in vitro;in vivo12853968   
1937EEF1G11745NP_001395.1yeast 2-hybrid16169070   
3178HNRNPA11242NP_112420.1in vitro;in vivo;yeast 2-hybrid14690413   
5111PCNA1456NP_002583.1in vitro;in vivo;yeast 2-hybrid930   591   614   770   731   000   000   000   000   000   000   000   000   000   000   000   000   


Pathway Information


                  
Pathway Name Pathway ID
Base excision repair hsa03410
DNA replication hsa03030
Non-homologous end-joining hsa03450


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd098675-344  PIN_FEN1
cl148125-344  PIN_SF superfamily
cd09907221-290  H3TH_FEN1-Euk
cl22433221-290  H3TH_StructSpec-5'-nucleases superfamily
cd001286-218  PIN_FEN1_EXO1-like
cd0985330-208  PIN_StructSpec-5'-nucleases
cd098681-216  PIN_XPG
pfam007522-106  XPG_N
cl026282-106  XPG_N superfamily
smart004851-106  XPGN
pfam00867147-233  XPG_I
cl22865147-233  XPG_I superfamily
cd0985628-219  PIN_FEN1-like
cd09901221-290  H3TH_FEN1-like
smart00484146-218  XPGI
cd0986928-212  PIN_GEN1
cd09897221-285  H3TH_FEN1-XPG-like
cd098701-203  PIN_YEN1
cd098571-191  PIN_EXO1
cd0985232-188  PIN_SF
cd00080221-279  H3TH_StructSpec-5'-nucleases
cd09903221-290  H3TH_FEN1-Arc
cd09908221-276  H3TH_EXO1
cd09900221-262  H3TH_XPG-like
pfam01367218-308  5_3_exonuc
smart00279220-253  HhH2
cd09898221-264  H3TH_53EXO
cd09904221-250  H3TH_XPG
cd09902221-235  H3TH_MKT1
cd09905220-263  H3TH_GEN1
PTZ002171-373  PTZ00217
TIGR036741-344  fen_arch
PRK0398055-344  PRK03980
COG025818-345  Exo
TIGR00600133-378  rad2
TIGR006001-104  rad2
smart00475142-264  53EXOc
PRK05755212-309  PRK05755
TIGR00593142-359  pola
PRK09482212-281  PRK09482
PRK1497633-264  PRK14976


Ontology Information


   
HPRD ID1199
Molecular ClassDeoxyribonuclease
Molecular FunctionCytokine activity (GO:0005125)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO