Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FGF1 | 2246 | fibroblast growth factor 1 (acidic) | 5 | AFGF, ECGF, ECGFA, ECGFB, HBGF1, ECGF-beta, FGF-alpha, GLIO703 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 9072001 | 1997 | Cell line : - Source : Histopathology Department of Hammmersmith Hospital, London. Sample Type : CRC Tumor No. of Sample : 24 adenomas, 17 adenocarcinomas Stage : - | Immunohistochemistry | Up-regulation | - | FGF-1 was overexpressed in 42 per cent of colorectal adenomas,76 per cent of colorectal cancers. |
| 19082464 | 2009 | Cell line : - Source : - Sample Type : CRC Tumor No. of Sample : 202 Stage : - | real time RT-PCR | Up-regulation | - | Overexpression of the FGFR-1 gene may thus be a useful predictor of liver metastasis in patients with colorectal cancer. |
| 21356388 | 2011 | Cell line : HCT 116,CCD 18Co Source : Departments of Medical Biosciences, Pathology, Integrative Medical Biology,Section for Histology and Cell Biology, and Surgical and Perioperative Sciences, Surgery, Ume� University, Ume�, Sweden.American Type Culture Collection, Manassas, VA. Sample Type : CRC Tumor and adjecent normal tissue No. of Sample : 24 normal mucosa samples, 16 hyperplastic polyps, 30 tubular adenomas, 10 tubulovillous adenomas, 15 villous adenomas, and 61 adenocarcinomas? Stage : - | Immunohistochemistry,Immunofluorescence,Proteome Profiler Array,Western Blotting | Up-regulation | - | Activated fibroblasts increase their expression of FGF1, and by adding a fibroblast growth factor receptor inhibitor, as well as an FGF1-neutralizing antibody, reduced the migration of colon cancer cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009] |
| Chromosome | 5 |
| Location | 5q31.3-q33 |
| Start | 141971743 |
| End | 142077635 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 105893 |
| OMIM ID | 131220 |
| HGNC ID | HGNC:3665 |
| Unigene ID | Hs.483635 |
| Ensembl ID | ENSG00000113578 |
| PharmGKB ID | PA28105 |
mRNA Information
| mRNA ID | NM_001144935.1 |
|---|---|
| Exon | join(1..158,83910..84112,97266..97369,102587..105893) | mRNA Sequence | Download Select all |
| Length | 3781 |
Protein Information
| Protein ID | NP_001138407.1 |
|---|---|
| Protein Name | fibroblast growth factor 1 (acidic) |
| Molecular Wt. (Da) | 17329 |
| Protein Sequence | Download Select all |
| Length | 155 |
| Uniprot ID | P18031 |
| Ensembl Protein ID | ENSP00000360683 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1457 | CSNK2A1 | 277 | NP_001886.1 | in vitro | 12145206 |
| 1459 | CSNK2A2 | 279 | NP_001887.1 | in vitro;in vivo | 12145206 |
| 1460 | CSNK2B | 278 | NP_001311.3 | in vitro | 12145206 |
| 6187 | RPS2 | 4690 | NP_002943.2 | in vitro;yeast 2-hybrid | 16263090 |
| 8829 | NRP1 | 3642 | NP_003864.4 | in vitro | 15695515 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Hippo signaling pathway | hsa04390 |
| MAPK signaling pathway | hsa04010 |
| Melanoma | hsa05218 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Regulation of actin cytoskeleton | hsa04810 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00058 | 29-151 | FGF |
| cl00060 | 29-151 | FGF superfamily |
| smart00442 | 23-149 | FGF |
| pfam00167 | 25-148 | FGF |
| cd00257 | 29-110 | Fascin |
| cl22458 | 29-110 | RICIN superfamily |
Ontology Information
| HPRD ID | 1552 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Receptor signaling protein tyrosine phosphatase activity (GO:0004728) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P05230 | DB00686 | Pentosan Polysulfate | SmallMoleculeDrug |
| P05230 | DB01025 | Amlexanox | SmallMoleculeDrug |
| P05230 | DB06589 | Pazopanib | SmallMoleculeDrug |