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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 9072001 | 1997 | Cell line : - Source : Histopathology Department of Hammmersmith Hospital, London. Sample Type : CRC Tumor No. of Sample : 41 colorectal tumours (24 adenomas, 17 adenocarcinomas) Stage : - | Immunohistochemistry | Down-regulation | - | FGF-2 expression was reduced in 16 (66 per cent), 8 (47 per cent), and 40 (80 per cent) adenomas and colorectal and gastric samples, respectively. |
| 19082464 | 2009 | Cell line : - Source : - Sample Type : CRC Tumor No. of Sample : 202 Stage : - | real time RT-PCR | Up-regulation | - | Overexpression of the FGFR-1 gene may thus be a useful predictor of liver metastasis in patients with colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008] |
| Chromosome | 4 |
| Location | 4q26 |
| Start | 123747568 |
| End | 123819390 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 71823 |
| OMIM ID | 134920 |
| HGNC ID | HGNC:3676 |
| Unigene ID | Hs.284244 |
| Ensembl ID | ENSG00000138685 |
| PharmGKB ID | PA28115 |
mRNA Information
| mRNA ID | NM_002006.4 |
|---|---|
| Exon | join(1..645,49614..49717,65504..71528) | mRNA Sequence | Download Select all |
| Length | 6774 |
Protein Information
| Protein ID | NP_001997.5 |
|---|---|
| Protein Name | fibroblast growth factor 2 (basic) |
| Molecular Wt. (Da) | 30639 |
| Protein Sequence | Download Select all |
| Length | 288 |
| Uniprot ID | Q06124 |
| Ensembl Protein ID | ENSP00000340944 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| R | Methylation | 108 |
| R | Methylation | 110 |
| R | Methylation | 112 |
| R | Methylation | 86 |
| R | Methylation | 84 |
| R | Methylation | 82 |
| R | Methylation | 96 |
| R | Methylation | 98 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 960 | CD44 | 115 | NP_000601.3 | in vivo | 7532176 |
| 1457 | CSNK2A1 | 277 | NP_001886.1 | in vitro | 12145206 |
| 1459 | CSNK2A2 | 279 | NP_001887.1 | in vitro;in vivo | 7735329 |
| 2261 | FGFR3 | 624 | NP_000133.1 | in vivo | 10574949 |
| 6197 | RPS6KA3 | 2092 | NP_004577.1 | in vitro | 15879597 |
| 6382 | SDC1 | 1718 | NP_002988.3 | in vitro | 16982797 |
| 6383 | SDC2 | 803 | NP_002989.2 | in vitro | 16982797 |
| 8829 | NRP1 | 3642 | NP_003864.4 | in vitro | 15695515 |
| 9672 | SDC3 | 1719 | NP_055469.3 | in vitro | 169 827 978 344 959 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MAPK signaling pathway | hsa04010 |
| Melanoma | hsa05218 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Proteoglycans in cancer | hsa05205 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Regulation of actin cytoskeleton | hsa04810 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00058 | 163-285 | FGF |
| cl00060 | 163-285 | FGF superfamily |
| smart00442 | 160-284 | FGF |
| pfam00167 | 162-282 | FGF |
Ontology Information
| HPRD ID | 1478 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Receptor signaling protein tyrosine phosphatase activity (GO:0004728) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P09038 | DB00364 | Sucralfate | SmallMoleculeDrug |
| P09038 | DB00686 | Pentosan Polysulfate | SmallMoleculeDrug |
| P09038 | DB00877 | Sirolimus | SmallMoleculeDrug |