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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FGF8 | 2253 | fibroblast growth factor 8 (androgen-induced) | 10 | AIGF |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25473897 | 2015 | Cell line : - Source : Sichuan Provincial People�s Hospital (Chengdu, China). Sample Type : CRC Tumor No. of Sample : 98 Stage : TNM Stage I-IV | Immunohistochemistry,Real time RT-PCR,Immunoblottinh,Cell migration and invasion assays | Up-regulation | - | Level of FGF8 was elevated in the great majority of CRC cases and high FGF8 expression was significantly correlated with lymph nodes metastasis and worse overall survival. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Endogenous ligands |
| Description | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008] |
| Chromosome | 10 |
| Location | 10q25-q26 |
| Start | 103529887 |
| End | 103540126 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 10240 |
| OMIM ID | 600483 |
| HGNC ID | HGNC:3686 |
| Unigene ID | Hs.57710 |
| Ensembl ID | ENSG00000107831 |
| PharmGKB ID | PA28125 |
mRNA Information
| mRNA ID | NM_001206389.1 |
|---|---|
| Exon | join(1..74,4594..4630,5491..5638,8801..8907,9751..10240) | mRNA Sequence | Download Select all |
| Length | 856 |
Protein Information
| Protein ID | NP_001193318.1 |
|---|---|
| Protein Name | fibroblast growth factor 8 (androgen-induced) |
| Molecular Wt. (Da) | 16123 |
| Protein Sequence | Download Select all |
| Length | 140 |
| Uniprot ID | P28827 |
| Ensembl Protein ID | ENSP00000331418 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2261 | FGFR3 | 624 | NP_000133.1 | in vivo | 10574949 |
| 2264 | FGFR4 | 625 | NP_002002.3 | in vivo | 10736564 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MAPK signaling pathway | hsa04010 |
| Melanoma | hsa05218 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Regulation of actin cytoskeleton | hsa04810 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00058 | 72-196 | FGF |
| cl00060 | 72-196 | FGF superfamily |
| pfam00167 | 70-193 | FGF |
| smart00442 | 69-195 | FGF |
| TIGR03103 | 26-125 | trio_acet_GNAT |
Ontology Information
| HPRD ID | 2784 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Receptor signaling protein tyrosine phosphatase activity (GO:0004728) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.