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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11598623 | 2001 | Cell line : COLO 205, DLD 1, HCT 15, SW 480, WiDr Source : Center for Digestive Diseases, Second Affiliated Hospital of Nippon Medical School. Sample Type : CRC Tumor No. of Sample : 10 Stage : - | Immunohistochemistry, in situ hybridization, real time RT-PCR,Western blotting | Up-regulation | - | FGF-10 and its receptor, FGFR2 iiib expression in colorectal adenocarcinoma cells and FGF-10 may contribute to the growth of cells of this type. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008] |
| Chromosome | 5 |
| Location | 5p13-p12 |
| Start | 44305004 |
| End | 44389808 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 84805 |
| OMIM ID | 602115 |
| HGNC ID | HGNC:3666 |
| Unigene ID | Hs.664499 |
| Ensembl ID | ENSG00000070193 |
| PharmGKB ID | PA28106 |
mRNA Information
| mRNA ID | XM_005248264.2 |
|---|---|
| Exon | join(1..633,725..1423,79251..79354,84589..86240) | mRNA Sequence | Download Select all |
| Length | 3088 |
Protein Information
| Protein ID | XP_005248321.1 |
|---|---|
| Protein Name | fibroblast growth factor 10 |
| Molecular Wt. (Da) | 23305 |
| Protein Sequence | Download Select all |
| Length | 208 |
| Uniprot ID | Q15256 |
| Ensembl Protein ID | ENSP00000283228 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2263 | FGFR2 | 1492 | NP_075261.1 | in vitro;in vivo | 9582367 |
| 5443 | POMC | 1462 | NP_000930.1 | in vitro | 12591959 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MAPK signaling pathway | hsa04010 |
| Melanoma | hsa05218 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Regulation of actin cytoskeleton | hsa04810 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00058 | 80-204 | FGF |
| cl00060 | 80-204 | FGF superfamily |
| smart00442 | 76-204 | FGF |
| pfam00167 | 78-202 | FGF |
Ontology Information
| HPRD ID | 3344 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Receptor signaling protein tyrosine phosphatase activity (GO:0004728) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.