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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ALDOA 226 Aldolase A, fructose-bisphosphate  16ALDA; GSD12 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tumor and Normal tissue

No. of Sample : -

Stage : -

Biochemical isolation to nano-LC-MS/MS analysisUp-regulation-This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue.


Gene Details



Chromosome: 16; NC_000016.9 (30064411..30081741)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Aug 2011]  
Chromosome 16
Location 16p11.2
Start 30053090  
End 30070420  
Strand +  
Gene Sequence

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Length 17331  
OMIM ID 103850   
HGNC ID HGNC:414   
Unigene ID Hs.513490    
Ensembl ID ENSG00000149925   
PharmGKB ID -   

mRNA Information


mRNA ID NM_000034.3
Exon join(1..128,375..410,1695..1838,2083..2238,10640..11159, 11335..11416,14145..14277,14361..14572,15557..15611, 15729..15889,16217..16300,16410..16584,16741..16940, 17028..17331)  
mRNA Sequence

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Length 2408  



CDS Information


   
Location join(13809..13949,14145..14277,14361..14572,15557..15611, 15729..15889,16217..16300,16410..16584,16741..16940, 17028..17123)
CDS Sequence

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CCDS ID CCDS58450.1



Protein Information


      
Protein IDNP_000025.1
Protein NameAldolase A, fructose-bisphosphate
Molecular Wt. (Da)39289
Protein Sequence

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Length 364  
Uniprot IDO43707
Ensembl Protein ID ENSP00000252699  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation204;-
YPhosphorylation204;-
YPhosphorylation204;-
SPhosphorylation36;-
SPhosphorylation36;-
SPhosphorylation36;-
TPhosphorylation37;-
TPhosphorylation37;-
TPhosphorylation37;-
YPhosphorylation3;-
YPhosphorylation3;-
YPhosphorylation3;-
YPhosphorylation5;-
YPhosphorylation5;-
YPhosphorylation5;-
YPhosphorylation223;-
YPhosphorylation223;-
YPhosphorylation223;-
SPhosphorylation46;-
SPhosphorylation46;-
SPhosphorylation46;-
SPhosphorylation46;-
SPhosphorylation46;-
SPhosphorylation39
SPhosphorylation39
SPhosphorylation39
TPhosphorylation9
TPhosphorylation9
TPhosphorylation9
SPhosphorylation354
SPhosphorylation354
SPhosphorylation354
SPhosphorylation356
SPhosphorylation356
SPhosphorylation356
TPhosphorylation235
TPhosphorylation241
TPhosphorylation235
TPhosphorylation241
TPhosphorylation235
TPhosphorylation241
KAcetylation42
KAcetylation42
KAcetylation42
KAcetylation330
KAcetylation330
KAcetylation330
KAcetylation108
KAcetylation108
KAcetylation108
KAcetylation230
KAcetylation230
KAcetylation230
SPhosphorylation17
SPhosphorylation17
SPhosphorylation17
TPhosphorylation65
TPhosphorylation65
TPhosphorylation65

Enzyme Information


   
EC4.1.2.13
Namefructose-bisphosphate aldolase
aldolase
fructose-1,6-bisphosphate triosephosphate-lyase
fructose diphosphate aldolase
diphosphofructose aldolase
fructose 1,6-diphosphate aldolase
ketose 1-phosphate aldolase
phosphofructoaldolase
zymohexase
fructoaldolase
fructose 1-phosphate aldolase
fructose 1-monophosphate aldolase
1,6-Diphosphofructose aldolase
SMALDO
D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase
ClassLyases; Carbon-carbon lyases; Aldehyde-lyases
SysnameD-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)  
SubstrateD-fructose 1,6-bisphosphate  
Productglycerone phosphate [CPD:C00111]; D-glyceraldehyde 3-phosphate  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                                          
Pathway Name Pathway ID
Biosynthesis of amino acids hsa01230
Carbon metabolism hsa01200
Fructose and mannose metabolism hsa00051
Glycolysis / Gluconeogenesis hsa00010
HIF-1 signaling pathway hsa04066
Metabolic pathways hsa01100
Pentose phosphate pathway hsa00030


Structure Information


PDB ID1ZY7
Resolution1.7
MethodX-RAY DIFFRACTION
Chains A,B  
Molecule RNA-specific adenosine deaminase B1, isoform DRADA2a  
Model View



Domain Information




ID Location Description
cd0094813-343  FBP_aldolase_I_a
cl2145713-343  TIM_phosphate_binding superfamily
pfam0027415-364  Glycolytic
cd0034413-340  FBP_aldolase_I
PTZ0001910-364  PTZ00019
PLN0245513-364  PLN02455
PLN024255-364  PLN02425
COG358815-344  Fba1
PLN0222715-364  PLN02227
cd0094927-191  FBP_aldolase_I_bact
PRK0537724-191  PRK05377


Ontology Information


   
HPRD ID5222
Molecular ClassEnzyme: Lyase
Molecular FunctionStructural constituent of cytoskeleton (GO:0005200)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO