Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ALDOA | 226 | Aldolase A, fructose-bisphosphate  | 16 | ALDA; GSD12  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989    | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and Normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis | Up-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Aug 2011]   |
| Chromosome | 16 |
| Location | 16p11.2 |
| Start | 30053090   |
| End | 30070420   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 17331   |
| OMIM ID | 103850    |
| HGNC ID | HGNC:414    |
| Unigene ID | Hs.513490     |
| Ensembl ID | ENSG00000149925    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_000034.3 |
|---|---|
| Exon | join(1..128,375..410,1695..1838,2083..2238,10640..11159, 11335..11416,14145..14277,14361..14572,15557..15611, 15729..15889,16217..16300,16410..16584,16741..16940, 17028..17331)   | mRNA Sequence |    Download   Select all |
| Length | 2408   |
CDS Information
| Location | join(13809..13949,14145..14277,14361..14572,15557..15611, 15729..15889,16217..16300,16410..16584,16741..16940, 17028..17123) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS58450.1 |    
Protein Information
| Protein ID | NP_000025.1 |
|---|---|
| Protein Name | Aldolase A, fructose-bisphosphate |
| Molecular Wt. (Da) | 39289 |
| Protein Sequence |    Download   Select all |
| Length | 364   |
| Uniprot ID | O43707 |    
| Ensembl Protein ID | ENSP00000252699   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 204;- |
| Y | Phosphorylation | 204;- |
| Y | Phosphorylation | 204;- |
| S | Phosphorylation | 36;- |
| S | Phosphorylation | 36;- |
| S | Phosphorylation | 36;- |
| T | Phosphorylation | 37;- |
| T | Phosphorylation | 37;- |
| T | Phosphorylation | 37;- |
| Y | Phosphorylation | 3;- |
| Y | Phosphorylation | 3;- |
| Y | Phosphorylation | 3;- |
| Y | Phosphorylation | 5;- |
| Y | Phosphorylation | 5;- |
| Y | Phosphorylation | 5;- |
| Y | Phosphorylation | 223;- |
| Y | Phosphorylation | 223;- |
| Y | Phosphorylation | 223;- |
| S | Phosphorylation | 46;- |
| S | Phosphorylation | 46;- |
| S | Phosphorylation | 46;- |
| S | Phosphorylation | 46;- |
| S | Phosphorylation | 46;- |
| S | Phosphorylation | 39 |
| S | Phosphorylation | 39 |
| S | Phosphorylation | 39 |
| T | Phosphorylation | 9 |
| T | Phosphorylation | 9 |
| T | Phosphorylation | 9 |
| S | Phosphorylation | 354 |
| S | Phosphorylation | 354 |
| S | Phosphorylation | 354 |
| S | Phosphorylation | 356 |
| S | Phosphorylation | 356 |
| S | Phosphorylation | 356 |
| T | Phosphorylation | 235 |
| T | Phosphorylation | 241 |
| T | Phosphorylation | 235 |
| T | Phosphorylation | 241 |
| T | Phosphorylation | 235 |
| T | Phosphorylation | 241 |
| K | Acetylation | 42 |
| K | Acetylation | 42 |
| K | Acetylation | 42 |
| K | Acetylation | 330 |
| K | Acetylation | 330 |
| K | Acetylation | 330 |
| K | Acetylation | 108 |
| K | Acetylation | 108 |
| K | Acetylation | 108 |
| K | Acetylation | 230 |
| K | Acetylation | 230 |
| K | Acetylation | 230 |
| S | Phosphorylation | 17 |
| S | Phosphorylation | 17 |
| S | Phosphorylation | 17 |
| T | Phosphorylation | 65 |
| T | Phosphorylation | 65 |
| T | Phosphorylation | 65 |
Enzyme Information
| EC | 4.1.2.13 |    
|---|---|
| Name | fructose-bisphosphate aldolase aldolase fructose-1,6-bisphosphate triosephosphate-lyase fructose diphosphate aldolase diphosphofructose aldolase fructose 1,6-diphosphate aldolase ketose 1-phosphate aldolase phosphofructoaldolase zymohexase fructoaldolase fructose 1-phosphate aldolase fructose 1-monophosphate aldolase 1,6-Diphosphofructose aldolase SMALDO D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase |
| Class | Lyases; Carbon-carbon lyases; Aldehyde-lyases |
| Sysname | D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)   |
| Substrate | D-fructose 1,6-bisphosphate   |
| Product | glycerone phosphate [CPD:C00111]; D-glyceraldehyde 3-phosphate   |
| Reaction (IUBMB) | ![]() |
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Biosynthesis of amino acids |    hsa01230 |    
| Carbon metabolism |    hsa01200 |    
| Fructose and mannose metabolism |    hsa00051 |    
| Glycolysis / Gluconeogenesis |    hsa00010 |    
| HIF-1 signaling pathway |    hsa04066 |    
| Metabolic pathways |    hsa01100 |    
| Pentose phosphate pathway |    hsa00030 |    
Structure Information
| PDB ID | 1ZY7 |
|---|---|
| Resolution | 1.7 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B   |
| Molecule | RNA-specific adenosine deaminase B1, isoform DRADA2a   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00948 | 13-343  | FBP_aldolase_I_a |
| cl21457 | 13-343  | TIM_phosphate_binding superfamily |
| pfam00274 | 15-364  | Glycolytic |
| cd00344 | 13-340  | FBP_aldolase_I |
| PTZ00019 | 10-364  | PTZ00019 |
| PLN02455 | 13-364  | PLN02455 |
| PLN02425 | 5-364  | PLN02425 |
| COG3588 | 15-344  | Fba1 |
| PLN02227 | 15-364  | PLN02227 |
| cd00949 | 27-191  | FBP_aldolase_I_bact |
| PRK05377 | 24-191  | PRK05377 |
Ontology Information
| HPRD ID | 5222 |    
|---|---|
| Molecular Class | Enzyme: Lyase |
| Molecular Function | Structural constituent of cytoskeleton (GO:0005200) |
| Biological Process | Cell growth and/or maintenance (GO:0008151)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    

