Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FGFR3 | 2261 | fibroblast growth factor receptor 3 | 4 | CEK2, JTK4, CD333 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11325814 | 2001 | Cell line : - Source : Department of Surgery, Seoul National University Hospital (Seoul, Korea) Sample Type : - No. of Sample : - Stage : - | DNA Sequencing | Mutation | - | - |
| 21356388 | 2011 | Cell line : HCT 116,CCD 18Co Source : Departments of Medical Biosciences, Pathology, Integrative Medical Biology,Section for Histology and Cell Biology, and Surgical and Perioperative Sciences, Surgery, Ume� University, Ume�, Sweden.American Type Culture Collection, Manassas, VA. Sample Type : CRC Tumor and adjecentnormal tissue No. of Sample : 24 normal mucosa samples, 16 hyperplastic polyps, 30 tubular adenomas, 10 tubulovillous adenomas, 15 villous adenomas, and 61 adenocarcinomas. Stage : - | Immunohistochemistry,Immunofluorescence,Morphology,Migration,Cell Culture Invasion Assay,Proteome Profiler Array,Western Blotting. | Up-regulation | - | Fibroblast growth factor 1/fibroblast growth factor receptor 3 (FGF1/FGFR-3) signaling as mediators leading to the increased migration and invasion. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Immunoglobulin superfamily / I-set domain containing" |
| Description | This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009] |
| Chromosome | 4 |
| Location | 4p16.3 |
| Start | 1795039 |
| End | 1810599 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 15561 |
| OMIM ID | 134934 |
| HGNC ID | HGNC:3690 |
| Unigene ID | Hs.1420 |
| Ensembl ID | ENSG00000068078 |
| PharmGKB ID | PA28129 |
mRNA Information
| mRNA ID | XM_006713868.1 |
|---|---|
| Exon | join(1..167,535..745,5956..6225,6449..6514,8069..8238, 8322..8445,8537..8727,9616..9766,11032..11228, 11526..11671,12057..12178,12261..12371,12452..12642, 12753..12875,12959..13029,13248..13385,13531..13636, 13815..15574) | mRNA Sequence | Download Select all |
| Length | 4315 |
Protein Information
| Protein ID | XP_006713931.1 |
|---|---|
| Protein Name | fibroblast growth factor receptor 3 |
| Molecular Wt. (Da) | 88355 |
| Protein Sequence | Download Select all |
| Length | 811 |
| Uniprot ID | P23471 |
| Ensembl Protein ID | ENSP00000377047 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 577 |
| Y | Phosphorylation | 647 |
| Y | Phosphorylation | 648 |
| Y | Phosphorylation | 724 |
| Y | Phosphorylation | 760 |
| Y | Phosphorylation | 770 |
| Y | Phosphorylation | 465 |
| Y | Phosphorylation | 535 |
| Y | Phosphorylation | 536 |
| Y | Phosphorylation | 612 |
| Y | Phosphorylation | 648 |
| Y | Phosphorylation | 658 |
| S | Phosphorylation | 444 |
| S | Phosphorylation | 445 |
| S | Phosphorylation | 332 |
| S | Phosphorylation | 333 |
| T | Phosphorylation | 450 |
| T | Phosphorylation | 338 |
| S | Phosphorylation | 578 |
| S | Phosphorylation | 466 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 293 | SLC25A6 | 2461 | NP_001627.2 | yeast 2-hybrid | 16169070 |
| 2246 | FGF1 | 567 | NP_000791.1 | in vitro | 1 057 494 914 732 690 |
| 2248 | FGF3 | 1289 | NP_005238.1 | in vitro | 8663044 |
| 2249 | FGF4 | 1294 | NP_001998.1 | in vitro | 8663044 |
| 2250 | FGF5 | 1307 | NP_004455.2 | in vitro | 8663044 |
| 2252 | FGF7 | 1022 | NP_002000.1 | in vitro | 8663044 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vivo | 9045692 |
| 2975 | GTF3C1 | 7540 | NP_001511.2 | yeast 2-hybrid | 16169070 |
| 3050 | HBZ | 794 | NP_005323.1 | yeast 2-hybrid | 16169070 |
| 3191 | HNRNPL | 4360 | NP_001524.2 | yeast 2-hybrid | 16169070 |
| 3856 | KRT8 | 1015 | NP_002264.1 | yeast 2-hybrid | 16169070 |
| 4726 | NDUFS6 | 10356 | NP_004544.1 | yeast 2-hybrid | 16169070 |
| 6132 | RPL8 | 16044 | NP_000964.1 | yeast 2-hybrid | 16169070 |
| 6772 | STAT1 | 2777 | NP_009330.1 | in vitro;in vivo | 765 766 011 294 897 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 |
| 6774 | STAT3 | 26 | NP_644805.1 | in vitro;in vivo | 11 940 572 112 948 900 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 |
| 8074 | FGF23 | 5648 | NP_065689.1 | in vitro | 12032146 |
| 8817 | FGF18 | 4766 | NP_387498.1 | in vitro | 10751172 |
| 8822 | FGF17 | 4765 | NP_003858.1 | in vitro | 10751172 |
| 9887 | SMG7 | 10723 | AAH36381.1 | yeast 2-hybrid | 16169070 |
| 10571 | - | 10240 | NP_006771.1 | yeast 2-hybrid | 16169070 |
| 23649 | POLA2 | 10160 | NP_002680.2 | yeast 2-hybrid | 16169070 |
| 55698 | RADIL | 7663 | NP_060529.4 | yeast 2-hybrid | 16169070 |
| 55819 | RNF130 | 11504 | NP_060904.2 | yeast 2-hybrid | 16169070 |
| 57562 | KIAA1377 | 17212 | NP_065853.2 | yeast 2-hybrid | 16169070 |
| 79866 | C13orf34 | 13389 | NP_079084.2 | yeast 2-hybrid | 16169070 |
| 116985 | ARAP1 | 9440 | NP_001035207.1 | yeast 2-hybrid | 16169070 |
| 149483 | CCDC17 | 8155 | NP_689713.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Bladder cancer | hsa05219 |
| Central carbon metabolism in cancer | hsa05230 |
| Endocytosis | hsa04144 |
| MAPK signaling pathway | hsa04010 |
| MicroRNAs in cancer | hsa05206 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Regulation of actin cytoskeleton | hsa04810 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05858 | 268-357 | Ig3_FGFR-2 |
| cl11960 | 268-357 | Ig superfamily |
| cd05857 | 161-245 | Ig2_FGFR |
| cl11960 | 161-245 | Ig superfamily |
| cd00096 | 57-110 | Ig |
| cl11960 | 57-110 | Ig superfamily |
| cd05100 | 459-792 | PTKc_FGFR3 |
| cl21453 | 459-792 | PKc_like superfamily |
| cd05099 | 459-772 | PTKc_FGFR4 |
| cd05053 | 459-753 | PTKc_FGFR |
| cd05101 | 447-759 | PTKc_FGFR2 |
| cd05098 | 458-759 | PTKc_FGFR1 |
| cd00192 | 476-749 | PTKc |
| cd05054 | 464-748 | PTKc_VEGFR |
| cd05055 | 438-745 | PTKc_PDGFR |
| cd05103 | 464-752 | PTKc_VEGFR2 |
| cd05045 | 471-752 | PTKc_RET |
| cd14207 | 464-748 | PTKc_VEGFR1 |
| cd05102 | 464-752 | PTKc_VEGFR3 |
| cd05104 | 458-752 | PTKc_Kit |
| cd05106 | 438-752 | PTKc_CSF-1R |
| cd05107 | 445-753 | PTKc_PDGFR_beta |
| cd05032 | 465-750 | PTKc_InsR_like |
| cd05105 | 439-752 | PTKc_PDGFR_alpha |
| cd05039 | 465-751 | PTKc_Csk_like |
| cd05036 | 466-749 | PTKc_ALK_LTK |
| cd05044 | 478-748 | PTKc_c-ros |
| cd05047 | 478-752 | PTKc_Tie |
| cd05034 | 476-749 | PTKc_Src_like |
| cd05148 | 465-749 | PTKc_Srm_Brk |
| cd05089 | 478-776 | PTKc_Tie1 |
| cd05048 | 466-744 | PTKc_Ror |
| cd05050 | 466-750 | PTKc_Musk |
| cd05068 | 464-744 | PTKc_Frk_like |
| cd05061 | 465-748 | PTKc_InsR |
| cd05049 | 466-748 | PTKc_Trk |
| cd05088 | 478-776 | PTKc_Tie2 |
| cd05051 | 466-744 | PTKc_DDR |
| cd05060 | 476-750 | PTKc_Syk_like |
| cd05083 | 465-750 | PTKc_Chk |
| cd05056 | 465-752 | PTKc_FAK |
| cd05035 | 472-752 | PTKc_TAM |
| cd05052 | 465-749 | PTKc_Abl |
| cd05038 | 472-752 | PTKc_Jak_rpt2 |
| cd05082 | 465-751 | PTKc_Csk |
| cd05041 | 478-749 | PTKc_Fes_like |
| cd05046 | 467-748 | PTK_CCK4 |
| cd05058 | 478-752 | PTKc_Met_Ron |
| cd05059 | 472-748 | PTKc_Tec_like |
| cd05057 | 466-752 | PTKc_EGFR_like |
| cd13999 | 478-748 | STKc_MAP3K-like |
| cd05033 | 472-752 | PTKc_EphR |
| cd05062 | 465-748 | PTKc_IGF-1R |
| cd05092 | 467-744 | PTKc_TrkA |
| cd05043 | 468-748 | PTK_Ryk |
| cd14204 | 467-752 | PTKc_Mer |
| cd05075 | 471-752 | PTKc_Axl |
| cd05085 | 475-748 | PTKc_Fer |
| cd05074 | 471-752 | PTKc_Tyro3 |
| cd05040 | 476-748 | PTKc_Ack_like |
| cd05084 | 475-748 | PTKc_Fes |
| cd05072 | 465-757 | PTKc_Lyn |
| cd05093 | 467-744 | PTKc_TrkB |
| cd05095 | 466-744 | PTKc_DDR2 |
| cd05067 | 464-753 | PTKc_Lck_Blk |
| cd05090 | 466-744 | PTKc_Ror1 |
| cd05091 | 466-744 | PTKc_Ror2 |
| cd05109 | 467-751 | PTKc_HER2 |
| cd05097 | 466-744 | PTKc_DDR_like |
| cd05113 | 467-745 | PTKc_Btk_Bmx |
| cd05094 | 467-744 | PTKc_TrkC |
| cd05066 | 470-752 | PTKc_EphR_A |
| cd05096 | 466-744 | PTKc_DDR1 |
| cd04974 | 268-357 | Ig3_FGFR |
| cd00180 | 478-748 | PKc |
| cd05063 | 466-752 | PTKc_EphR_A2 |
| cd05112 | 472-748 | PTKc_Itk |
| cd05108 | 476-751 | PTKc_EGFR |
| cd05073 | 465-744 | PTKc_Hck |
| cd05114 | 470-752 | PTKc_Tec_Rlk |
| cd05111 | 467-751 | PTK_HER3 |
| cd05080 | 478-751 | PTKc_Tyk2_rpt2 |
| cd14203 | 476-744 | PTKc_Src_Fyn_like |
| cd05116 | 476-741 | PTKc_Syk |
| cd05069 | 461-773 | PTKc_Yes |
| cd14205 | 478-751 | PTKc_Jak2_rpt2 |
| cd05065 | 478-752 | PTKc_EphR_B |
| cd05110 | 467-766 | PTKc_HER4 |
| cd05079 | 476-752 | PTKc_Jak1_rpt2 |
| cd05081 | 478-749 | PTKc_Jak3_rpt2 |
| cd05115 | 478-741 | PTKc_Zap-70 |
| cd05070 | 465-773 | PTKc_Fyn |
| cd05071 | 465-773 | PTKc_Src |
| cd05064 | 466-752 | PTKc_EphR_A10 |
| cd05729 | 161-245 | Ig2_FGFR_like |
| cd14061 | 478-751 | STKc_MLK |
| cd14059 | 504-749 | STKc_MAP3K12_13 |
| cd14206 | 478-744 | PTKc_Aatyk3 |
| cd06606 | 471-747 | STKc_MAPKKK |
| cd14060 | 479-749 | STKc_MLTK |
| cd14058 | 478-745 | STKc_TAK1 |
| cd14145 | 466-748 | STKc_MLK1 |
| cd05042 | 476-753 | PTKc_Aatyk |
| cd05122 | 473-744 | PKc_STE |
| cd14148 | 478-751 | STKc_MLK2 |
| cd14146 | 478-748 | STKc_MLK4 |
| cd14147 | 472-749 | STKc_MLK3 |
| cd13978 | 478-750 | STKc_RIP |
| cd05087 | 476-744 | PTKc_Aatyk1 |
| cd14065 | 478-748 | PKc_LIMK_like |
| cd06627 | 471-744 | STKc_Cdc7_like |
| cd13968 | 478-637 | PKc_like |
| cd14066 | 478-750 | STKc_IRAK |
| cd14014 | 473-750 | STKc_PknB_like |
| cd06614 | 476-747 | STKc_PAK |
| cd14003 | 473-747 | STKc_AMPK-like |
| cd06632 | 471-746 | STKc_MEKK1_plant |
| cd14154 | 478-751 | STKc_LIMK |
| cd08530 | 471-744 | STKc_CNK2-like |
| cd14007 | 474-697 | STKc_Aurora |
| cd14099 | 475-747 | STKc_PLK |
| cd14002 | 479-694 | STKc_STK36 |
| cd07833 | 473-741 | STKc_CDKL |
| cd14000 | 478-748 | STKc_LRRK |
| cd14027 | 522-746 | STKc_RIP1 |
| cd08215 | 478-690 | STKc_Nek |
| cd14151 | 465-752 | STKc_B-Raf |
| cd14155 | 507-752 | PKc_TESK |
| cd05086 | 478-753 | PTKc_Aatyk2 |
| cd06611 | 478-747 | STKc_SLK_like |
| cd14221 | 478-752 | STKc_LIMK1 |
| cd13992 | 481-750 | PK_GC |
| cd06612 | 478-747 | STKc_MST1_2 |
| cd14158 | 475-748 | STKc_IRAK4 |
| cd14062 | 478-749 | STKc_Raf |
| cd06609 | 478-744 | STKc_MST3_like |
| cd08225 | 471-746 | STKc_Nek5 |
| cd06610 | 477-746 | STKc_OSR1_SPAK |
| cd06628 | 475-745 | STKc_Byr2_like |
| cd05117 | 473-710 | STKc_CAMK |
| cd05118 | 476-708 | STKc_CMGC |
| cd07829 | 478-705 | STKc_CDK_like |
| cd05037 | 472-748 | PTK_Jak_rpt1 |
| cd13979 | 471-753 | STKc_Mos |
| cd14008 | 478-744 | STKc_LKB1_CaMKK |
| cd08529 | 474-744 | STKc_FA2-like |
| cd06644 | 478-746 | STKc_STK10 |
| cd06613 | 476-747 | STKc_MAP4K3_like |
| cd06629 | 475-747 | STKc_Bck1_like |
| cd14222 | 478-754 | STKc_LIMK2 |
| cd06623 | 472-746 | PKc_MAPKK_plant_like |
| cd14080 | 473-684 | STKc_TSSK-like |
| cd07830 | 473-744 | STKc_MAK_like |
| cd06643 | 478-746 | STKc_SLK |
| cd14069 | 473-747 | STKc_Chk1 |
| cd14009 | 478-717 | STKc_ATG1_ULK_like |
| cd08217 | 478-747 | STKc_Nek2 |
| cd05570 | 476-704 | STKc_PKC |
| cd06608 | 471-746 | STKc_myosinIII_N_like |
| cd14156 | 507-749 | PKc_LIMK_like_unk |
| cd05619 | 474-716 | STKc_nPKC_theta |
| cd14150 | 476-751 | STKc_A-Raf |
| cd14042 | 505-744 | PK_GC-A_B |
| cd06624 | 478-747 | STKc_ASK |
| cd14063 | 472-750 | PK_KSR |
| cd08218 | 476-746 | STKc_Nek1 |
| cd14064 | 535-749 | PKc_TNNI3K |
| cd06625 | 474-744 | STKc_MEKK3_like |
| cd14162 | 473-712 | STKc_TSSK4-like |
| cd14149 | 465-749 | STKc_C-Raf |
| cd06640 | 478-746 | STKc_MST4 |
| cd08224 | 473-740 | STKc_Nek6_7 |
| cd06917 | 504-744 | STKc_NAK1_like |
| cd14072 | 474-747 | STKc_MARK |
| cd14664 | 478-751 | STK_BAK1_like |
| cd13996 | 478-748 | STKc_EIF2AK |
| cd14119 | 478-744 | STKc_LKB1 |
| cd14116 | 474-746 | STKc_Aurora-A |
| cd06641 | 478-746 | STKc_MST3 |
| cd05616 | 478-738 | STKc_cPKC_beta |
| cd05580 | 472-694 | STKc_PKA_like |
| cd08228 | 470-739 | STKc_Nek6 |
| cd14121 | 505-703 | STKc_ULK3 |
| cd06642 | 478-746 | STKc_STK25 |
| cd07840 | 478-697 | STKc_CDK9_like |
| cd05581 | 475-694 | STKc_PDK1 |
| cd14202 | 464-716 | STKc_ULK1 |
| cd13994 | 478-747 | STKc_HAL4_like |
| cd14188 | 471-746 | STKc_PLK2 |
| cd13993 | 471-745 | STKc_Pat1_like |
| cd08219 | 476-740 | STKc_Nek3 |
| cd07841 | 471-743 | STKc_CDK7 |
| cd14052 | 471-752 | PTKc_Wee1_fungi |
| cd14078 | 478-746 | STKc_MELK |
| cd14084 | 469-746 | STKc_Chk2 |
| cd07834 | 471-689 | STKc_MAPK |
| cd05123 | 478-710 | STKc_AGC |
| cd14045 | 504-751 | PK_GC_unk |
| cd05592 | 476-704 | STKc_nPKC_theta_like |
| cd14068 | 478-749 | STKc_LRRK2 |
| cd13975 | 474-753 | PKc_Dusty |
| cd14026 | 478-752 | STKc_RIP2 |
| cd14161 | 469-744 | STKc_NUAK2 |
| cd07832 | 474-697 | STKc_CCRK |
| cd05620 | 476-716 | STKc_nPKC_delta |
| cd13998 | 479-740 | STKc_TGFbR-like |
| cd14056 | 476-740 | STKc_TGFbR_I |
| cd14025 | 478-756 | STKc_RIP4_like |
| cd14073 | 471-740 | STKc_NUAK |
| cd06648 | 460-746 | STKc_PAK_II |
| cd06637 | 478-746 | STKc_TNIK |
| cd14189 | 475-746 | STKc_PLK3 |
| cd13997 | 478-745 | PKc_Wee1_like |
| cd06655 | 461-772 | STKc_PAK2 |
| cd14175 | 487-746 | STKc_RSK1_C |
| cd14043 | 534-744 | PK_GC-2D |
| cd14164 | 473-744 | STKc_TSSK6-like |
| cd05589 | 478-704 | STKc_PKN |
| cd14165 | 474-746 | STKc_TSSK1_2-like |
| cd05587 | 478-704 | STKc_cPKC |
| cd08223 | 473-747 | STKc_Nek4 |
| cd08221 | 478-746 | STKc_Nek9 |
| cd13987 | 478-689 | STKc_SBK1 |
| cd14048 | 478-746 | STKc_EIF2AK3_PERK |
| cd06631 | 505-744 | STKc_YSK4 |
| cd14079 | 473-710 | STKc_AMPK_alpha |
| cd06636 | 478-746 | STKc_MAP4K4_6_N |
| cd08528 | 478-690 | STKc_Nek10 |
| cd14208 | 472-749 | PTK_Jak3_rpt1 |
| cd07846 | 473-708 | STKc_CDKL2_3 |
| cd06605 | 537-746 | PKc_MAPKK |
| cd07848 | 478-708 | STKc_CDKL5 |
| cd14075 | 473-747 | STKc_NIM1 |
| cd07862 | 478-688 | STKc_CDK6 |
| cd06630 | 475-744 | STKc_MEKK1 |
| cd06647 | 462-695 | STKc_PAK_I |
| cd06654 | 461-772 | STKc_PAK1 |
| cd14050 | 478-744 | PKc_Myt1 |
| cd06620 | 472-745 | PKc_Byr1_like |
| cd07838 | 478-690 | STKc_CDK4_6_like |
| cd05856 | 161-245 | Ig2_FGFRL1-like |
| cd14071 | 476-744 | STKc_SIK |
| cd05615 | 478-738 | STKc_cPKC_alpha |
| cd14187 | 462-747 | STKc_PLK1 |
| cd14004 | 476-747 | STKc_PASK |
| cd14081 | 474-710 | STKc_BRSK1_2 |
| cd06638 | 460-746 | STKc_myosinIIIA_N |
| cd13985 | 476-748 | STKc_GAK_like |
| cd14152 | 471-751 | STKc_KSR1 |
| cd14098 | 478-718 | STKc_Rad53_Cds1 |
| cd06656 | 461-772 | STKc_PAK3 |
| cd14120 | 478-722 | STKc_ULK1_2-like |
| cd06622 | 478-746 | PKc_PBS2_like |
| cd05582 | 476-697 | STKc_RSK_N |
| cd07847 | 474-772 | STKc_CDKL1_4 |
| cd08229 | 468-739 | STKc_Nek7 |
| cd14012 | 517-744 | PK_eIF2AK_GCN2_rpt1 |
| cd07863 | 478-688 | STKc_CDK4 |
| cd14143 | 478-740 | STKc_TGFbR1_ACVR1b_ACVR1c |
| cd07851 | 465-697 | STKc_p38 |
| cd07877 | 465-697 | STKc_p38alpha |
| cd14044 | 507-753 | PK_GC-C |
| cd14103 | 478-697 | STKc_MLCK |
| cd07839 | 478-707 | STKc_CDK5 |
| cd08222 | 471-740 | STKc_Nek11 |
| cd14097 | 473-746 | STKc_STK33 |
| cd14037 | 469-744 | STKc_NAK_like |
| cd14053 | 504-689 | STKc_ACVR2 |
| cd14036 | 471-748 | STKc_GAK |
| cd14663 | 471-747 | STKc_SnRK3 |
| cd14144 | 476-740 | STKc_BMPR1 |
| cd14067 | 496-746 | STKc_LRRK1 |
| cd05584 | 476-697 | STKc_p70S6K |
| cd14055 | 478-740 | STKc_TGFbR2_like |
| cd14057 | 505-751 | PK_ILK |
| cd14054 | 523-702 | STKc_BMPR2_AMHR2 |
| cd07860 | 478-708 | STKc_CDK2_3 |
| cd05078 | 478-749 | PTK_Jak2_rpt1 |
| cd07857 | 471-708 | STKc_MPK1 |
| cd14117 | 474-695 | STKc_Aurora-B_like |
| cd13989 | 478-709 | STKc_IKK |
| cd14118 | 581-747 | STKc_CAMKK |
| cd05077 | 472-749 | PTK_Jak1_rpt1 |
| cd07878 | 465-697 | STKc_p38beta |
| cd06621 | 472-746 | PKc_Pek1_like |
| cd07873 | 478-707 | STKc_PCTAIRE1 |
| cd14077 | 474-746 | STKc_Kin1_2 |
| cd14039 | 478-686 | STKc_IKK_alpha |
| cd14167 | 478-716 | STKc_CaMKI_alpha |
| cd06659 | 478-746 | STKc_PAK6 |
| cd06639 | 457-746 | STKc_myosinIIIB_N |
| cd14178 | 500-745 | STKc_RSK3_C |
| cd07835 | 478-708 | STKc_CDK1_CdkB_like |
| cd14046 | 476-686 | STKc_EIF2AK4_GCN2_rpt2 |
| cd07866 | 474-689 | STKc_BUR1 |
| cd06658 | 460-747 | STKc_PAK5 |
| cd14177 | 506-746 | STKc_RSK4_C |
| cd06635 | 453-746 | STKc_TAO1 |
| cd13983 | 478-695 | STKc_WNK |
| cd14076 | 474-685 | STKc_Kin4 |
| cd06652 | 474-689 | STKc_MEKK2 |
| cd06645 | 478-746 | STKc_MAP4K3 |
| cd14199 | 525-695 | STKc_CaMKK2 |
| cd05578 | 479-697 | STKc_Yank1 |
| cd14186 | 478-695 | STKc_PLK4 |
| cd14176 | 506-746 | STKc_RSK2_C |
| cd07880 | 465-689 | STKc_p38gamma |
| cd06653 | 474-689 | STKc_MEKK3_like_u1 |
| cd14010 | 551-703 | STKc_ULK4 |
| cd06626 | 471-747 | STKc_MEKK4 |
| cd06646 | 478-745 | STKc_MAP4K5 |
| cd07842 | 479-690 | STKc_CDK8_like |
| cd07856 | 476-697 | STKc_Sty1_Hog1 |
| cd06633 | 478-687 | STKc_TAO3 |
| cd05591 | 476-704 | STKc_nPKC_epsilon |
| cd05572 | 478-697 | STKc_cGK |
| cd14047 | 477-688 | STKc_EIF2AK2_PKR |
| cd14070 | 474-747 | STKc_HUNK |
| cd07865 | 478-689 | STKc_CDK9 |
| cd07831 | 474-690 | STKc_MOK |
| cd07836 | 505-697 | STKc_Pho85 |
| cd14137 | 471-697 | STKc_GSK3 |
| cd07845 | 478-697 | STKc_CDK10 |
| cd08220 | 478-744 | STKc_Nek8 |
| cd05611 | 476-705 | STKc_Rim15_like |
| cd14209 | 476-738 | STKc_PKA |
| cd14006 | 478-697 | STKc_MLCK-like |
| cd07854 | 476-709 | STKc_MAPK4_6 |
| cd00096 | 172-242 | Ig |
| cd13995 | 476-746 | STKc_MAP3K8 |
| cd05612 | 476-694 | STKc_PRKX_like |
| cd14001 | 506-748 | PKc_TOPK |
| cd06651 | 475-689 | STKc_MEKK3 |
| cd14197 | 468-704 | STKc_DRAK1 |
| cd05579 | 597-704 | STKc_MAST_like |
| cd14095 | 473-711 | STKc_DCKL |
| cd14142 | 534-740 | STKc_ACVR1_ALK1 |
| cd13982 | 476-743 | STKc_IRE1 |
| cd14194 | 474-697 | STKc_DAPK1 |
| cd14192 | 478-697 | STKc_MLCK3 |
| cd14201 | 465-717 | STKc_ULK2 |
| cd07879 | 465-708 | STKc_p38delta |
| cd14159 | 478-689 | STKc_IRAK1 |
| cd07872 | 478-707 | STKc_PCTAIRE2 |
| cd06634 | 453-687 | STKc_TAO2 |
| cd14131 | 476-744 | PKc_Mps1 |
| cd07871 | 474-707 | STKc_PCTAIRE3 |
| cd05630 | 598-710 | STKc_GRK6 |
| cd14220 | 476-751 | STKc_BMPR1a |
| cd06617 | 478-746 | PKc_MKK3_6 |
| cd07874 | 476-687 | STKc_JNK3 |
| cd06607 | 478-682 | STKc_TAO |
| cd14200 | 519-695 | STKc_CaMKK1 |
| cd07853 | 599-687 | STKc_NLK |
| cd14185 | 474-711 | STKc_DCKL3 |
| cd05595 | 476-707 | STKc_PKB_beta |
| cd14198 | 476-704 | STKc_DRAK2 |
| cd14169 | 473-716 | STKc_CaMKI_beta |
| cd07850 | 476-697 | STKc_JNK |
| cd07864 | 478-689 | STKc_CDK12 |
| cd14106 | 475-704 | STKc_DRAK |
| cd07852 | 598-697 | STKc_MAPK15-like |
| cd14193 | 478-697 | STKc_MLCK4 |
| cd07875 | 476-697 | STKc_JNK1 |
| cd05590 | 478-705 | STKc_nPKC_eta |
| cd14094 | 521-746 | STKc_CASK |
| cd14111 | 593-695 | STKc_SPEG_rpt2 |
| cd14091 | 506-746 | STKc_RSK_C |
| cd14083 | 478-716 | STKc_CaMKI |
| cd14166 | 478-711 | STKc_CaMKI_gamma |
| cd14153 | 471-751 | PK_KSR2 |
| cd06657 | 460-746 | STKc_PAK4 |
| cd07861 | 478-689 | STKc_CDK1_euk |
| cd06619 | 505-758 | PKc_MKK5 |
| cd14038 | 478-695 | STKc_IKK_beta |
| cd07858 | 599-697 | STKc_TEY_MAPK |
| cd14210 | 478-697 | PKc_DYRK |
| cd07855 | 599-687 | STKc_ERK5 |
| cd07849 | 599-697 | STKc_ERK1_2_like |
| cd14190 | 478-697 | STKc_MLCK2 |
| cd14141 | 504-735 | STKc_ACVR2a |
| cd14087 | 478-758 | STKc_PSKH1 |
| cd05593 | 476-707 | STKc_PKB_gamma |
| cd14093 | 499-694 | STKc_PhKG |
| cd07843 | 580-709 | STKc_CDC2L1 |
| cd14011 | 599-745 | PK_SCY1_like |
| cd14135 | 477-689 | STKc_PRP4 |
| cd05577 | 598-695 | STKc_GRK |
| cd14168 | 478-716 | STKc_CaMKI_delta |
| cd05632 | 478-697 | STKc_GRK5 |
| cd14086 | 474-695 | STKc_CaMKII |
| cd14074 | 474-736 | STKc_SNRK |
| cd05728 | 171-245 | Ig4_Contactin-2-like |
| cd07876 | 476-687 | STKc_JNK2 |
| cd14219 | 471-740 | STKc_BMPR1b |
| cd14105 | 474-704 | STKc_DAPK |
| cd14183 | 471-697 | STKc_DCKL1 |
| cd06615 | 538-696 | PKc_MEK |
| cd00096 | 271-353 | Ig |
| cd14184 | 474-695 | STKc_DCKL2 |
| cd07844 | 599-707 | STKc_PCTAIRE_like |
| cd07870 | 476-706 | STKc_PFTAIRE2 |
| cd07859 | 599-697 | STKc_TDY_MAPK |
| cd08226 | 505-703 | PK_STRAD_beta |
| cd14195 | 474-702 | STKc_DAPK3 |
| cd05594 | 461-707 | STKc_PKB_alpha |
| cd05076 | 535-748 | PTK_Tyk2_rpt1 |
| cd05598 | 614-694 | STKc_LATS |
| cd05609 | 604-704 | STKc_MAST |
| cd14140 | 505-689 | STKc_ACVR2b |
| cd05602 | 476-688 | STKc_SGK1 |
| cd05617 | 478-709 | STKc_aPKC_zeta |
| cd08216 | 473-682 | PK_STRAD |
| cd05631 | 478-695 | STKc_GRK4 |
| cd14090 | 475-697 | STKc_Mnk |
| cd14019 | 478-689 | STKc_Cdc7 |
| cd14049 | 563-746 | STKc_EIF2AK1_HRI |
| cd07837 | 478-772 | STKc_CdkB_plant |
| cd13986 | 478-749 | STKc_16 |
| cd05608 | 586-692 | STKc_GRK1 |
| cd14109 | 522-710 | PK_Unc-89_rpt1 |
| cd14110 | 504-696 | STKc_obscurin_rpt2 |
| cd14665 | 471-744 | STKc_SnRK2-3 |
| cd06616 | 465-697 | PKc_MKK4 |
| cd06618 | 598-746 | PKc_MKK7 |
| cd14196 | 474-697 | STKc_DAPK2 |
| cd05618 | 474-695 | STKc_aPKC_iota |
| cd06650 | 538-703 | PKc_MEK1 |
| cd05571 | 476-738 | STKc_PKB |
| cd05605 | 598-695 | STKc_GRK4_like |
| cd05603 | 476-704 | STKc_SGK2 |
| cd05750 | 175-235 | Ig_Pro_neuregulin |
| cd05731 | 176-245 | Ig3_L1-CAM_like |
| cd05725 | 172-245 | Ig3_Robo |
| cd13977 | 551-750 | STKc_PDIK1L |
| cd06649 | 538-703 | PKc_MEK2 |
| cd14018 | 530-740 | STKc_PINK1 |
| cd14113 | 478-702 | STKc_Trio_C |
| pfam13927 | 170-232 | Ig_3 |
| cd05747 | 154-243 | Ig5_Titin_like |
| cd05604 | 476-694 | STKc_SGK3 |
| cd14031 | 478-745 | STKc_WNK3 |
| cd05586 | 605-710 | STKc_Sck1_like |
| cd14133 | 478-697 | PKc_DYRK_like |
| cd07693 | 164-238 | Ig1_Robo |
| cd14033 | 525-696 | STKc_WNK4 |
| cd14174 | 478-697 | STKc_Mnk1 |
| cd14191 | 478-697 | STKc_MLCK1 |
| cd05573 | 606-695 | STKc_ROCK_NDR_like |
| cd05613 | 474-695 | STKc_MSK1_N |
| cd14662 | 534-744 | STKc_SnRK2 |
| cd14136 | 598-689 | STKc_SRPK |
| cd14005 | 474-746 | STKc_PIM |
| cd14096 | 471-694 | STKc_RCK1-like |
| cd14114 | 478-697 | STKc_Twitchin_like |
| cd14173 | 478-697 | STKc_Mnk2 |
| cd14104 | 478-697 | STKc_Titin |
| cd07869 | 478-698 | STKc_PFTAIRE1 |
| cd14163 | 474-685 | STKc_TSSK3-like |
| cd14020 | 484-689 | STKc_KIS |
| cd14229 | 478-697 | STKc_HIPK3 |
| cd14179 | 476-710 | STKc_MSK1_C |
| cd14101 | 473-747 | STKc_PIM2 |
| cd14088 | 483-695 | STKc_CaMK_like |
| cd05737 | 159-245 | Ig_Myomesin_like_C |
| cd05607 | 478-695 | STKc_GRK7 |
| cd14132 | 473-688 | STKc_CK2_alpha |
| cd14181 | 499-694 | STKc_PhKG2 |
| cd14182 | 523-694 | STKc_PhKG1 |
| cd05610 | 472-699 | STKc_MASTL |
| cd13991 | 538-679 | STKc_NIK |
| cd04978 | 171-246 | Ig4_L1-NrCAM_like |
| cd14172 | 601-745 | STKc_MAPKAPK3 |
| cd14085 | 473-695 | STKc_CaMKIV |
| cd05625 | 476-717 | STKc_LATS1 |
| cd14112 | 471-702 | STKc_Unc-89_rpt2 |
| cd14032 | 478-745 | STKc_WNK2_like |
| cd05614 | 474-695 | STKc_MSK2_N |
| cd04969 | 176-245 | Ig5_Contactin_like |
| cd14102 | 473-746 | STKc_PIM3 |
| cd13990 | 525-687 | STKc_TLK |
| cd05763 | 173-246 | Ig_1 |
| cd05622 | 450-695 | STKc_ROCK1 |
| cd05725 | 271-356 | Ig3_Robo |
| cd05731 | 283-356 | Ig3_L1-CAM_like |
| cd04969 | 268-356 | Ig5_Contactin_like |
| cd05856 | 267-346 | Ig2_FGFRL1-like |
| pfam13927 | 252-343 | Ig_3 |
| cd05728 | 260-356 | Ig4_Contactin-2-like |
| pfam07714 | 472-748 | Pkinase_Tyr |
| smart00408 | 170-235 | IGc2 |
| smart00410 | 260-356 | IG_like |
| smart00221 | 472-748 | STYKc |
| smart00219 | 472-748 | TyrKc |
| smart00220 | 473-747 | S_TKc |
| pfam00069 | 472-747 | Pkinase |
| COG0515 | 473-729 | SPS1 |
| PHA02988 | 505-748 | PHA02988 |
| PTZ00024 | 474-697 | PTZ00024 |
| PTZ00426 | 476-695 | PTZ00426 |
| pfam07679 | 171-245 | I-set |
| smart00410 | 171-245 | IG_like |
| smart00409 | 171-245 | IG |
| PTZ00267 | 539-746 | PTZ00267 |
| smart00409 | 260-356 | IG |
| PTZ00263 | 457-695 | PTZ00263 |
| PLN00009 | 478-708 | PLN00009 |
| PTZ00283 | 553-745 | PTZ00283 |
| PTZ00036 | 414-772 | PTZ00036 |
| PHA03209 | 463-687 | PHA03209 |
| PRK13184 | 478-695 | pknD |
| pfam07679 | 260-356 | I-set |
| PLN00034 | 444-746 | PLN00034 |
| PHA03212 | 523-746 | PHA03212 |
| smart00408 | 268-346 | IGc2 |
| PTZ00266 | 476-743 | PTZ00266 |
| smart00408 | 53-110 | IGc2 |
| TIGR03903 | 505-738 | TOMM_kin_cyc |
| smart00409 | 54-125 | IG |
| smart00410 | 54-125 | IG_like |
Ontology Information
| HPRD ID | 3928 |
|---|---|
| Molecular Class | Receptor tyrosine kinase |
| Molecular Function | Defense/immunity protein activity (GO:0003793) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P22607 | DB00039 | Palifermin | BiotechDrug |
| P22607 | DB06589 | Pazopanib | SmallMoleculeDrug |
| P22607 | DB08901 | Ponatinib | SmallMoleculeDrug |
| P22607 | DB09078 | Lenvatinib | SmallMoleculeDrug |
| P22607 | DB09079 | Nintedanib | SmallMoleculeDrug |