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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
FGFR4 2264 fibroblast growth factor receptor 4  5JTK2, CD334 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23943801   2013Cell line : RKO, HCT116, LoVo, SW480.

Source : ATCC, Department of Hepatobiliary Pancreatic Surgery, West China Hospital, Sichuan University. The School of Biomedical Sciences, Chengdu Medical College.Department of Oncology, Sichuan Provincial People's Hospital, Chengdu, People's Republic of China.

Sample Type : CRC tumor and normal tissue

No. of Sample : 5

Stage : -

Immunoblotting, immunocytofluorescence analysisUp-regulation-Study shows a pivotal role of FGFR4 in tumor-stroma interactions during colorectal cancer metastasis, and suggests novel therapeutic opportunities for the treatment of colorectal cancer.

24410190   2014Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 316

Stage : -

Multivariate analysis ,ImmunohistochemistryUp-regulation- FGFR4 is a potential prognostic and therapeutic marker for colorectal cancer.

24503538   2014Cell line : HCT116, LS174T, RKO

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Western blotting analysis,Annexin V,propidium iodide analysis,Caspase-activation assays,Cell viability assays,ImmunohistochemistryUp-regulation-FGFR4 is highly expressed at the RNA and protein levels in colon cancer tumour tissue compared with normal colonic mucosa and other tumours.


Gene Details



NC_000005.9 (176513906..176525143)

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Gene Type protein coding
Gene Family CD molecules, "Immunoglobulin superfamily / I-set domain containing"
Description The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]  
Chromosome 5
Location 5q35.2
Start 176513906  
End 176525143  
Strand +  
Gene Sequence

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Length 11238  
OMIM ID 134935   
HGNC ID HGNC:3691   
Unigene ID Hs.165950   
Ensembl ID ENSG00000160867   
PharmGKB ID PA28130   

mRNA Information


mRNA ID NM_213647.2
Exon join(1..206,2679..2822,3519..3782,3874..3954,4067..4233, 4814..4937,5450..5640,5775..5913,6267..6460,6535..6680, 6783..6904,8459..8569,8662..8852,9186..9308,9416..9486, 9733..9870,10421..10526,10656..11271)  
mRNA Sequence

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Length 3159  



CDS Information


   
Location260..2668
CDS Sequence

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CCDS ID CCDS4410.1



Protein Information


      
Protein IDNP_998812.1
Protein Namefibroblast growth factor receptor 4
Molecular Wt. (Da)0
Protein Sequence

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Length 802  
Uniprot IDP32322
Ensembl Protein ID ENSP00000328858  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation754
YPhosphorylation714
YPhosphorylation754
SPhosphorylation573
SPhosphorylation533
SPhosphorylation573

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                 
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1000CDH2226NP_001783.2in vitro9168198   
2043EPHA43719NP_004429.1in vivo16365308   
2246FGF1567NP_000791.1in vitro;in vivo1   073   656   410   336   500   
2247FGF2622NP_001997.5in vitro8530375   
2248FGF31289NP_005238.1in vitro8663044   
2249FGF41294NP_001998.1in vitro8663044   
2250FGF51307NP_004455.2in vitro8663044   
2251FGF6623NP_066276.2in vivo1385111   
2252FGF71022NP_002000.1in vivo7680645   
2254FGF92951NP_002001.1in vitro8663044   
5335PLCG11398NP_002651.2in vitro7518429   
6772STAT12777NP_009330.1in vitro;in vivo765   766   011   294   897   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   
6774STAT326NP_644805.1in vitro;in vivo11   940   572   112   948   900   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   
8817FGF184766NP_387498.1in vitro10751172   
8822FGF174765NP_003858.1in vitro10751172   


Pathway Information


                                          
Pathway Name Pathway ID
Endocytosis hsa04144
MAPK signaling pathway hsa04010
PI3K-Akt signaling pathway hsa04151
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014
Regulation of actin cytoskeleton hsa04810
Signaling pathways regulating pluripotency of stem cells hsa04550


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd05858264-351  Ig3_FGFR-2
cl11960264-351  Ig superfamily
cd05099454-767  PTKc_FGFR4
cl21453454-767  PKc_like superfamily
cd05053454-748  PTKc_FGFR
cd05100454-785  PTKc_FGFR3
cd05101444-753  PTKc_FGFR2
cd05098453-753  PTKc_FGFR1
cd00192471-744  PTKc
cd05054460-743  PTKc_VEGFR
cd05055454-747  PTKc_PDGFR
cd05103460-749  PTKc_VEGFR2
cd05045466-747  PTKc_RET
cd05102460-747  PTKc_VEGFR3
cd05104454-747  PTKc_Kit
cd14207460-743  PTKc_VEGFR1
cd05106454-747  PTKc_CSF-1R
cd05032460-744  PTKc_InsR_like
cd05107452-747  PTKc_PDGFR_beta
cd05105452-747  PTKc_PDGFR_alpha
cd05039460-743  PTKc_Csk_like
cd05034471-744  PTKc_Src_like
cd05148460-744  PTKc_Srm_Brk
cd05048461-739  PTKc_Ror
cd05036461-745  PTKc_ALK_LTK
cd05044473-743  PTKc_c-ros
cd05050461-745  PTKc_Musk
cd05068460-739  PTKc_Frk_like
cd05047473-747  PTKc_Tie
cd05052460-744  PTKc_Abl
cd05051461-739  PTKc_DDR
cd05089473-770  PTKc_Tie1
cd05061460-743  PTKc_InsR
cd05056460-747  PTKc_FAK
cd05049461-745  PTKc_Trk
cd05035467-747  PTKc_TAM
cd05041473-744  PTKc_Fes_like
cd13999473-743  STKc_MAP3K-like
cd05038462-747  PTKc_Jak_rpt2
cd05083460-745  PTKc_Chk
cd05060471-743  PTKc_Syk_like
cd05088473-747  PTKc_Tie2
cd05059467-743  PTKc_Tec_like
cd05082460-746  PTKc_Csk
cd14204464-747  PTKc_Mer
cd05092464-739  PTKc_TrkA
cd05062460-743  PTKc_IGF-1R
cd05033471-747  PTKc_EphR
cd05072460-754  PTKc_Lyn
cd05057459-747  PTKc_EGFR_like
cd05040471-743  PTKc_Ack_like
cd05074463-747  PTKc_Tyro3
cd05043464-743  PTK_Ryk
cd05075466-747  PTKc_Axl
cd05084470-743  PTKc_Fes
cd05046462-745  PTK_CCK4
cd05085470-743  PTKc_Fer
cd05091473-739  PTKc_Ror2
cd05090461-739  PTKc_Ror1
cd05067460-749  PTKc_Lck_Blk
cd05058473-749  PTKc_Met_Ron
cd05095461-743  PTKc_DDR2
cd05093464-756  PTKc_TrkB
cd05073460-744  PTKc_Hck
cd05094464-743  PTKc_TrkC
cd14203471-744  PTKc_Src_Fyn_like
cd05097461-743  PTKc_DDR_like
cd05096461-739  PTKc_DDR1
cd05113463-740  PTKc_Btk_Bmx
cd05115464-736  PTKc_Zap-70
cd05116471-736  PTKc_Syk
cd05108461-746  PTKc_EGFR
cd05069460-754  PTKc_Yes
cd05071460-754  PTKc_Src
cd00180473-741  PKc
cd05112465-743  PTKc_Itk
cd05063471-747  PTKc_EphR_A2
cd05114467-747  PTKc_Tec_Rlk
cd05109471-746  PTKc_HER2
cd05079471-747  PTKc_Jak1_rpt2
cd05070460-754  PTKc_Fyn
cd05080473-746  PTKc_Tyk2_rpt2
cd05066466-747  PTKc_EphR_A
cd05065473-747  PTKc_EphR_B
cd14205462-746  PTKc_Jak2_rpt2
cd05081473-743  PTKc_Jak3_rpt2
cd05110471-746  PTKc_HER4
cd05111462-739  PTK_HER3
cd05857157-241  Ig2_FGFR
cl11960157-241  Ig superfamily
cd14061473-746  STKc_MLK
cd05064473-747  PTKc_EphR_A10
cd04974264-351  Ig3_FGFR
cd14059499-744  STKc_MAP3K12_13
cd05729157-241  Ig2_FGFR_like
cd14206473-739  PTKc_Aatyk3
cd06606466-741  STKc_MAPKKK
cd14060474-744  STKc_MLTK
cd14146473-746  STKc_MLK4
cd14065473-743  PKc_LIMK_like
cd14145467-746  STKc_MLK1
cd13978473-736  STKc_RIP
cd14058473-743  STKc_TAK1
cd14148473-746  STKc_MLK2
cd05042471-739  PTKc_Aatyk
cd14147467-744  STKc_MLK3
cd14014469-745  STKc_PknB_like
cd05087471-739  PTKc_Aatyk1
cd14154473-748  STKc_LIMK
cd14066473-745  STKc_IRAK
cd14155502-747  PKc_TESK
cd06627469-739  STKc_Cdc7_like
cd05122469-739  PKc_STE
cd14003468-739  STKc_AMPK-like
cd06632470-741  STKc_MEKK1_plant
cd14007469-741  STKc_Aurora
cd14002465-689  STKc_STK36
cd14027515-741  STKc_RIP1
cd14000473-743  STKc_LRRK
cd14062473-744  STKc_Raf
cd14151460-746  STKc_B-Raf
cd14221473-748  STKc_LIMK1
cd14099470-741  STKc_PLK
cd14009473-736  STKc_ATG1_ULK_like
cd13979465-735  STKc_Mos
cd06623467-741  PKc_MAPKK_plant_like
cd08215473-739  STKc_Nek
cd14222473-748  STKc_LIMK2
cd07833468-739  STKc_CDKL
cd13968473-632  PKc_like
cd06611473-741  STKc_SLK_like
cd07829473-692  STKc_CDK_like
cd13992499-738  PK_GC
cd06614471-741  STKc_PAK
cd14063467-745  PK_KSR
cd05118468-741  STKc_CMGC
cd14008473-739  STKc_LKB1_CaMKK
cd06644456-741  STKc_STK10
cd05086473-735  PTKc_Aatyk2
cd08530471-739  STKc_CNK2-like
cd07830468-739  STKc_MAK_like
cd06612473-741  STKc_MST1_2
cd05117468-705  STKc_CAMK
cd14156496-746  PKc_LIMK_like_unk
cd06643460-741  STKc_SLK
cd05037467-743  PTK_Jak_rpt1
cd06629466-741  STKc_Bck1_like
cd06628470-740  STKc_Byr2_like
cd14068473-744  STKc_LRRK2
cd08217473-741  STKc_Nek2
cd14150471-746  STKc_A-Raf
cd14119473-739  STKc_LKB1
cd06610472-741  STKc_OSR1_SPAK
cd08529469-739  STKc_FA2-like
cd14149460-744  STKc_C-Raf
cd08225471-741  STKc_Nek5
cd14064473-744  PKc_TNNI3K
cd14080469-679  STKc_TSSK-like
cd06917473-739  STKc_NAK1_like
cd14158464-746  STKc_IRAK4
cd06631470-739  STKc_YSK4
cd06609473-739  STKc_MST3_like
cd06613471-739  STKc_MAP4K3_like
cd08224469-735  STKc_Nek6_7
cd14026473-752  STKc_RIP2
cd14069468-740  STKc_Chk1
cd14042500-739  PK_GC-A_B
cd06608463-741  STKc_myosinIII_N_like
cd06625469-739  STKc_MEKK3_like
cd14121473-738  STKc_ULK3
cd14045499-746  PK_GC_unk
cd05619465-711  STKc_nPKC_theta
cd14161473-739  STKc_NUAK2
cd08228471-734  STKc_Nek6
cd14664473-746  STK_BAK1_like
cd06640473-741  STKc_MST4
cd14056471-746  STKc_TGFbR_I
cd06642473-741  STKc_STK25
cd06638463-741  STKc_myosinIIIA_N
cd14043529-739  PK_GC-2D
cd06605473-741  PKc_MAPKK
cd14081469-738  STKc_BRSK1_2
cd06641473-741  STKc_MST3
cd07840473-692  STKc_CDK9_like
cd06620463-758  PKc_Byr1_like
cd14116469-741  STKc_Aurora-A
cd14052466-760  PTKc_Wee1_fungi
cd08223468-740  STKc_Nek4
cd07841466-738  STKc_CDK7
cd08229471-734  STKc_Nek7
cd14073466-735  STKc_NUAK
cd08218471-741  STKc_Nek1
cd14162469-707  STKc_TSSK4-like
cd06639446-741  STKc_myosinIIIB_N
cd05581470-735  STKc_PDK1
cd14187464-740  STKc_PLK1
cd07851459-692  STKc_p38
cd07846468-741  STKc_CDKL2_3
cd14663469-741  STKc_SnRK3
cd07857471-689  STKc_MPK1
cd14012506-739  PK_eIF2AK_GCN2_rpt1
cd05570471-699  STKc_PKC
cd05077467-740  PTK_Jak1_rpt1
cd06624465-741  STKc_ASK
cd13982471-738  STKc_IRE1
cd14202460-698  STKc_ULK1
cd07832468-703  STKc_CCRK
cd13993466-679  STKc_Pat1_like
cd14025473-739  STKc_RIP4_like
cd14164469-739  STKc_TSSK6-like
cd07834471-684  STKc_MAPK
cd07831468-741  STKc_MOK
cd13998474-735  STKc_TGFbR-like
cd13996473-743  STKc_EIF2AK
cd06622473-741  PKc_PBS2_like
cd14067473-741  STKc_LRRK1
cd05616473-733  STKc_cPKC_beta
cd14165468-741  STKc_TSSK1_2-like
cd08219471-735  STKc_Nek3
cd13994473-684  STKc_HAL4_like
cd05592471-699  STKc_nPKC_theta_like
cd05620471-715  STKc_nPKC_delta
cd13997473-740  PKc_Wee1_like
cd14053499-684  STKc_ACVR2
cd14072469-741  STKc_MARK
cd05582471-733  STKc_RSK_N
cd14152469-746  STKc_KSR1
cd14071498-739  STKc_SIK
cd07860473-703  STKc_CDK2_3
cd14075500-741  STKc_NIM1
cd14044502-746  PK_GC-C
cd07877459-703  STKc_p38alpha
cd14120473-690  STKc_ULK1_2-like
cd05589473-699  STKc_PKN
cd14084464-697  STKc_Chk2
cd05123473-733  STKc_AGC
cd05580469-689  STKc_PKA_like
cd13975584-746  PKc_Dusty
cd05856157-241  Ig2_FGFRL1-like
cd07878459-692  STKc_p38beta
cd06617465-741  PKc_MKK3_6
cd06648463-741  STKc_PAK_II
cd08221473-741  STKc_Nek9
cd07862473-683  STKc_CDK6
cd13985471-747  STKc_GAK_like
cd07856471-704  STKc_Sty1_Hog1
cd07845473-692  STKc_CDK10
cd06630470-739  STKc_MEKK1
cd06637473-741  STKc_TNIK
cd14097470-705  STKc_STK33
cd14078473-741  STKc_MELK
cd14142473-747  STKc_ACVR1_ALK1
cd07863473-683  STKc_CDK4
cd07838473-685  STKc_CDK4_6_like
cd05587473-700  STKc_cPKC
cd06626470-741  STKc_MEKK4
cd08222595-735  STKc_Nek11
cd14001578-746  PKc_TOPK
cd13983473-690  STKc_WNK
cd14079468-739  STKc_AMPK_alpha
cd14004471-741  STKc_PASK
cd14054473-743  STKc_BMPR2_AMHR2
cd14048473-741  STKc_EIF2AK3_PERK
cd06636473-741  STKc_MAP4K4_6_N
cd14208467-744  PTK_Jak3_rpt1
cd08528473-740  STKc_Nek10
cd14057496-746  PK_ILK
cd14070468-738  STKc_HUNK
cd14189470-741  STKc_PLK3
cd14143473-735  STKc_TGFbR1_ACVR1b_ACVR1c
cd07848473-701  STKc_CDKL5
cd14098473-705  STKc_Rad53_Cds1
cd14201460-690  STKc_ULK2
cd07880459-684  STKc_p38gamma
cd14175501-741  STKc_RSK1_C
cd07866464-684  STKc_BUR1
cd07836500-692  STKc_Pho85
cd14077468-741  STKc_Kin1_2
cd14131471-739  PKc_Mps1
cd14186473-741  STKc_PLK4
cd06653469-684  STKc_MEKK3_like_u1
cd07835473-703  STKc_CDK1_CdkB_like
cd14188520-741  STKc_PLK2
cd14050473-739  PKc_Myt1
cd14159473-684  STKc_IRAK1
cd05615473-733  STKc_cPKC_alpha
cd14117461-741  STKc_Aurora-B_like
cd06655463-741  STKc_PAK2
cd07854593-763  STKc_MAPK4_6
cd06646463-740  STKc_MAP4K5
cd07839473-697  STKc_CDK5
cd05078467-744  PTK_Jak2_rpt1
cd05584471-733  STKc_p70S6K
cd07873473-702  STKc_PCTAIRE1
cd14194469-692  STKc_DAPK1
cd14010593-698  STKc_ULK4
cd13987473-684  STKc_SBK1
cd06652469-684  STKc_MEKK2
cd14135472-684  STKc_PRP4
cd06619587-741  PKc_MKK5
cd06645463-741  STKc_MAP4K3
cd07865473-684  STKc_CDK9
cd06621465-698  PKc_Pek1_like
cd08220493-739  STKc_Nek8
cd14153466-746  PK_KSR2
cd07847469-741  STKc_CDKL1_4
cd07842474-685  STKc_CDK8_like
cd06616460-741  PKc_MKK4
cd07879459-684  STKc_p38delta
cd14006473-692  STKc_MLCK-like
cd14047472-743  STKc_EIF2AK2_PKR
cd06647473-690  STKc_PAK_I
cd14118520-741  STKc_CAMKK
cd14074469-740  STKc_SNRK
cd07853594-729  STKc_NLK
cd05595471-733  STKc_PKB_beta
cd07852593-743  STKc_MAPK15-like
cd14185469-741  STKc_DCKL3
cd14199520-690  STKc_CaMKK2
cd07871594-702  STKc_PCTAIRE3
cd06654463-741  STKc_PAK1
cd14055473-682  STKc_TGFbR2_like
cd13989473-704  STKc_IKK
cd14144471-735  STKc_BMPR1
cd05579592-741  STKc_MAST_like
cd06635471-741  STKc_TAO1
cd14106467-699  STKc_DRAK
cd00096168-233  Ig
cd14178501-705  STKc_RSK3_C
cd06633473-682  STKc_TAO3
cd14137466-735  STKc_GSK3
cd14133473-692  PKc_DYRK_like
cd07855520-682  STKc_ERK5
cd14011594-740  PK_SCY1_like
cd14036466-743  STKc_GAK
cd06656463-741  STKc_PAK3
cd07872594-702  STKc_PCTAIRE2
cd06607595-677  STKc_TAO
cd05578596-733  STKc_Yank1
cd14049582-742  STKc_EIF2AK1_HRI
cd13995529-743  STKc_MAP3K8
cd14198471-699  STKc_DRAK2
cd05725168-233  Ig3_Robo
cd14177501-741  STKc_RSK4_C
cd14176501-741  STKc_RSK2_C
cd14209471-733  STKc_PKA
cd05591471-704  STKc_nPKC_epsilon
cd14167473-711  STKc_CaMKI_alpha
cd07858594-692  STKc_TEY_MAPK
cd14076468-680  STKc_Kin4
cd14166464-706  STKc_CaMKI_gamma
cd06634471-741  STKc_TAO2
cd07861473-684  STKc_CDK1_euk
cd14091501-741  STKc_RSK_C
cd14169473-711  STKc_CaMKI_beta
cd08226500-715  PK_STRAD_beta
cd07850471-692  STKc_JNK
cd14046471-681  STKc_EIF2AK4_GCN2_rpt2
cd07864473-684  STKc_CDK12
cd14087473-690  STKc_PSKH1
cd05590473-699  STKc_nPKC_eta
cd14038473-709  STKc_IKK_beta
cd05572473-692  STKc_cGK
cd06618578-741  PKc_MKK7
cd06615587-739  PKc_MEK
cd14039473-681  STKc_IKK_alpha
cd05630593-705  STKc_GRK6
cd14037464-739  STKc_NAK_like
cd14210473-704  PKc_DYRK
cd14095469-706  STKc_DCKL
cd14220471-746  STKc_BMPR1a
cd06651470-740  STKc_MEKK3
cd14105469-700  STKc_DAPK
cd05611471-699  STKc_Rim15_like
cd07843594-684  STKc_CDC2L1
cd07849594-692  STKc_ERK1_2_like
cd05612519-689  STKc_PRKX_like
cd06659463-741  STKc_PAK6
cd05728165-241  Ig4_Contactin-2-like
cd07844594-698  STKc_PCTAIRE_like
cd14200520-690  STKc_CaMKK1
cd14083464-679  STKc_CaMKI
cd05076530-743  PTK_Tyk2_rpt1
cd14110499-735  STKc_obscurin_rpt2
cd14020479-684  STKc_KIS
cd07874471-682  STKc_JNK3
cd14103473-692  STKc_MLCK
cd14093501-689  STKc_PhKG
cd14196469-700  STKc_DAPK2
cd14111589-690  STKc_SPEG_rpt2
cd14163469-680  STKc_TSSK3-like
cd14190473-692  STKc_MLCK2
cd07875471-692  STKc_JNK1
cd06657596-741  STKc_PAK4
cd14086465-741  STKc_CaMKII
cd14094515-741  STKc_CASK
cd05609582-700  STKc_MAST
cd06650533-747  PKc_MEK1
cd14005469-741  STKc_PIM
cd07869473-727  STKc_PFTAIRE1
cd07859594-692  STKc_TDY_MAPK
cd06658463-741  STKc_PAK5
cd06649533-721  PKc_MEK2
cd14195469-700  STKc_DAPK3
cd14229473-692  STKc_HIPK3
cd05593471-702  STKc_PKB_gamma
cd14141476-730  STKc_ACVR2a
cd07870594-693  STKc_PFTAIRE2
cd00096267-347  Ig
cd05577593-690  STKc_GRK
cd13986510-747  STKc_16
cd14197470-699  STKc_DRAK1
cd07837473-706  STKc_CdkB_plant
cd07876471-682  STKc_JNK2
cd05571602-733  STKc_PKB
cd05598609-689  STKc_LATS
cd05608586-687  STKc_GRK1
cd14179471-690  STKc_MSK1_C
cd05632593-692  STKc_GRK5
cd14136593-684  STKc_SRPK
cd14160473-744  PK_IRAK3
cd05747150-231  Ig5_Titin_like
cd05631593-690  STKc_GRK4
cd07693162-235  Ig1_Robo
cd14096473-689  STKc_RCK1-like
cd14192473-692  STKc_MLCK3
cd14033520-741  STKc_WNK4
cd08216468-677  PK_STRAD
cd14219471-746  STKc_BMPR1b
cd14193473-692  STKc_MLCK4
cd05605593-690  STKc_GRK4_like
cd14174473-692  STKc_Mnk1
cd05594595-733  STKc_PKB_alpha
cd14031520-740  STKc_WNK3
cd05603471-724  STKc_SGK2
cd14183465-692  STKc_DCKL1
cd14173520-692  STKc_Mnk2
cd14085469-690  STKc_CaMKIV
cd14214473-684  PKc_CLK3
cd14168473-711  STKc_CaMKI_delta
cd14113473-697  STKc_Trio_C
cd14140500-684  STKc_ACVR2b
cd14018595-735  STKc_PINK1
cd14184465-690  STKc_DCKL2
cd14082500-680  STKc_PKD
cd14109517-705  PK_Unc-89_rpt1
cd05573608-690  STKc_ROCK_NDR_like
cd14180470-692  STKc_MSK2_C
cd05724165-231  Ig2_Robo
cd13977546-739  STKc_PDIK1L
cd14102579-741  STKc_PIM3
cd14090470-692  STKc_Mnk
cd05586600-705  STKc_Sck1_like
cd05723168-234  Ig4_Neogenin
cd14665529-739  STKc_SnRK2-3
cd14101469-740  STKc_PIM2
cd05602471-683  STKc_SGK1
cd05763169-242  Ig_1
cd05731172-237  Ig3_L1-CAM_like
cd05600609-711  STKc_Sid2p_like
cd05894162-231  Ig_C5_MyBP-C
pfam13895162-238  Ig_2
cd05614469-690  STKc_MSK2_N
cd14181520-689  STKc_PhKG2
cd14019473-684  STKc_Cdc7
cd14227473-692  STKc_HIPK2
cd14092520-680  STKc_MSK_C
pfam13927164-228  Ig_3
pfam00047165-226  ig
cd05604471-689  STKc_SGK3
cd05599609-681  STKc_NDR_like
cd05765165-241  Ig_3
cd05750171-231  Ig_Pro_neuregulin
cd04968249-350  Ig3_Contactin_like
cd04978165-242  Ig4_L1-NrCAM_like
cd05607595-690  STKc_GRK7
cd05726165-249  Ig4_Robo
cd05617499-704  STKc_aPKC_zeta
cd13990466-682  STKc_TLK
cd07867578-684  STKc_CDC2L6
cd14030588-691  STKc_WNK1
cd14112463-697  STKc_Unc-89_rpt2
pfam13895248-350  Ig_2
cd05728256-350  Ig4_Contactin-2-like
cd04968165-231  Ig3_Contactin_like
cd05725267-350  Ig3_Robo
cd04978264-351  Ig4_L1-NrCAM_like
pfam13927248-337  Ig_3
cd05763268-351  Ig_1
pfam00047264-333  ig
cd05731279-340  Ig3_L1-CAM_like
cd05856263-340  Ig2_FGFRL1-like
pfam07714467-743  Pkinase_Tyr
smart00408165-231  IGc2
smart00410256-350  IG_like
smart0040850-107  IGc2
smart00221467-743  STYKc
smart00219467-743  TyrKc
smart00220469-741  S_TKc
pfam00069467-741  Pkinase
COG0515469-719  SPS1
PTZ00024469-692  PTZ00024
smart00409162-241  IG
smart00410162-241  IG_like
pfam07679150-232  I-set
smart00409256-350  IG
PTZ00426471-690  PTZ00426
PHA02988500-743  PHA02988
PLN00009473-703  PLN00009
PTZ00267488-741  PTZ00267
PTZ00283548-740  PTZ00283
PLN00034501-741  PLN00034
pfam07679256-350  I-set
PHA03209471-682  PHA03209
PTZ00263467-690  PTZ00263
PTZ00036469-691  PTZ00036
TIGR03903500-684  TOMM_kin_cyc
PRK13184473-690  pknD
smart00408264-340  IGc2
smart0041043-117  IG_like
smart0040943-117  IG
pfam0767936-106  I-set


Ontology Information


   
HPRD ID1538
Molecular ClassReceptor tyrosine kinase
Molecular FunctionGTPase activity (GO:0003924)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P22455DB00039PaliferminBiotechDrug
P22455DB08901PonatinibSmallMoleculeDrug
P22455DB09078LenvatinibSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO