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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24370550 | 2014 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 20 Stage : - | LOH, real-time RT-PCR, imunohistochemistry | Down-regulation | - | FHIT gene may be associated with the progression of these malignant tumors. |
| 23797051 | 2013 | Cell line : - Source : - Sample Type : Formalin-fixed paraffin-embedded tissue No. of Sample : 116 Stage : Duke Stage A,B,C,D | Array CGH Hybridization and Analysis,Microsatellite Stability Profiling,MLPA Assay and Analysis,Methylation Analysis | Hypermethylation | - | FHIT expression may be a valuable marker for CRC subtyping, and its diagnostic, prognostic, and therapeutic potential should be perused. |
| 18426086 | 2005 | Cell line : - Source : Croatian Tumor Bank Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : Duke Stage A,B,C | Sequence analysis, real time RT-PCR | Mutation | - | FHIT is frequently inactivated by exon skipping, intron retention, and activation of cryptic splice site within exon 6 in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009] |
| Chromosome | 3 |
| Location | 3p14.2 |
| Start | 59735036 |
| End | 61237133 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 1502098 |
| OMIM ID | 601153 |
| HGNC ID | HGNC:3701 |
| Unigene ID | Hs.655995 |
| Ensembl ID | ENSG00000189283 |
| PharmGKB ID | PA28140 |
mRNA Information
| mRNA ID | XM_011533481.1 |
|---|---|
| Exon | join(20..159,50795..50843,209361..209413,429449..429541, 543636..543707,714481..714600,1237308..1237453, 1240060..1240089,1329046..1329114,1499139..1499239, 1501881..1503873) | mRNA Sequence | Download Select all |
| Length | 2866 |
Protein Information
| Protein ID | XP_011531783.1 |
|---|---|
| Protein Name | fragile histidine triad |
| Molecular Wt. (Da) | 16727 |
| Protein Sequence | Download Select all |
| Length | 147 |
| Uniprot ID | O00194 |
| Ensembl Protein ID | ENSP00000262094 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 114 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2232 | FDXR | 60 | NP_004101.2 | in vitro | 19004824 |
| 3329 | HSPD1 | 318 | NP_002147.2 | in vitro | 19004824 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Non-small cell lung cancer | hsa05223 |
| Purine metabolism | hsa00230 |
| Small cell lung cancer | hsa05222 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01275 | 5-124 | FHIT |
| cl00228 | 5-124 | HIT_like superfamily |
| cd00468 | 16-101 | HIT_like |
| pfam01230 | 12-105 | HIT |
| COG0537 | 12-106 | Hit |
| cd01277 | 12-102 | HINT_subgroup |
| cd01276 | 12-100 | PKCI_related |
| pfam11969 | 12-100 | DcpS_C |
Ontology Information
| HPRD ID | 3627 |
|---|---|
| Molecular Class | Enzyme: Hydrolase |
| Molecular Function | GTPase activity (GO:0003924) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.