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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
FHL2 2274 four and a half LIM domains 2  2SLIM3, DRAL 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26320172   2015Cell line : -

Source : (Department of Pathology, Nanfang Hospital, First Affiliated Hospital of Southern Medical University, China).

Sample Type : CRC tumor and adjacent normal tissues

No. of Sample : 13

Stage : -

Chromatin immunoprecipitation assays, Gnen Knockdown assay,Cell migration and invasion assays,Western blotting, realtimeRT-PCR,dual luciferase assays,ImmunofluorescenceUp-regulation- KLF8-induced FHL2 activation as a novel and critical signaling mechanism underlying human breast/colorectal cancer invasion and metastasis.


Gene Details



NC_000002.11 (105977272..106055230, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]  
Chromosome 2
Location 2q12.2
Start 105977272  
End 106055230  
Strand -  
Gene Sequence

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Length 77959  
OMIM ID 602633   
HGNC ID HGNC:3703   
Unigene ID Hs.443687   
Ensembl ID ENSG00000115641   
PharmGKB ID PA164   

mRNA Information


mRNA ID XM_011510798.1
Exon join(248..375,42077..42127,52234..52413,65041..65215, 71035..71204,75303..75489,77340..77959)  
mRNA Sequence

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Length 1511  



CDS Information


   
Location 204..1043
CDS Sequence

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CCDS ID CCDS2070.1



Protein Information


      
Protein IDXP_011509100.1
Protein Namefour and a half LIM domains 2
Molecular Wt. (Da)32062
Protein Sequence

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Length 279  
Uniprot IDO60216
Ensembl Protein ID ENSP00000297338  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation238
SPhosphorylation238
SPhosphorylation238
SPhosphorylation238
TAcetylation2
TAcetylation2
TAcetylation112
TAcetylation2
TAcetylation2
TPhosphorylation171
TPhosphorylation171
TPhosphorylation171
TPhosphorylation171

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
203AK146NP_000467.1in vitro12432079   
367AR2437NP_000035.2in vitro;in vivo;yeast 2-hybrid10654935   
1158CKM426NP_001815.2in vitro12432079   
1499CTNNB1286NP_001895.1in vitro;in vivo12466281   
2033EP3004078NP_001420.2in vitro;in vivo15572674   
2273FHL12157NP_001440.2in vitro12432079   
2308FOXO1645NP_002006.2in vitro15692560   
3488IGFBP5901NP_000590.1in vitro;in vivo;yeast 2-hybrid11821401   
3679ITGA72761NP_001138468.1in vitro;yeast 2-hybrid10906324   
3688ITGB1628NP_391987.1in vitro;yeast 2-hybrid10906324   
3689ITGB22506NP_000202.2in vitro;yeast 2-hybrid10906324   
3694ITGB6947NP_000879.2in vitro;yeast 2-hybrid10906324   
4176MCM71154NP_005907.3in vitro;yeast 2-hybrid10649446   
5213PFKM1988NP_000280.1in vitro12432079   
5664PSEN22860NP_000438.2in vitro;in vivo;yeast 2-hybrid11001931   
6310ATXN13333NP_000323.2yeast 2-hybrid16713569   
6722SRF2788NP_003122.1in vitro;in vivo15610731   
7273TTN1787NP_596869.3in vitro;in vivo;yeast 2-hybrid12432079   
8792TNFRSF11A4609NP_003830.1in vivo16184196   
9372ZFYVE94782NP_004790.2yeast 2-hybrid15231748   
9421HAND13871NP_004812.1in vitro;in vivo15509787   


Pathway Information


      
Pathway Name Pathway ID
Osteoclast differentiation hsa04380


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd09433221-278  LIM4_FHL2
cl02475221-278  LIM superfamily
cd0942236-97  LIM1_FHL2
cl0247536-97  LIM superfamily
cd09426101-157  LIM2_FHL2
cl02475101-157  LIM superfamily
cd09431162-218  LIM3_Fhl2
cl02475162-218  LIM superfamily
cd09347221-276  LIM4_FHL
cd0934336-94  LIM1_FHL
cd09346162-213  LIM3_FHL
cd09345101-154  LIM2_FHL
cd0942798-155  LIM2_FHL3
cd09434221-275  LIM4_FHL3
cd09432221-275  LIM6_LIMPETin
cd0942136-93  LIM3_LIMPETin
cd09428101-154  LIM2_FHL5
cd09429162-213  LIM3_FHL1
cd09424101-156  LIM2_FHL1
cd09430162-213  LIM5_LIMPETin
cd09425101-154  LIM4_LIMPETin
cd0942336-94  LIM1_FHL3
cd09348218-279  LIM4_FHL1
cd0934440-92  LIM1_FHL1
cd0934740-92  LIM4_FHL
cd0943440-92  LIM4_FHL3
smart0013240-92  LIM
cd0943240-92  LIM6_LIMPETin
cd0934240-90  LIM3_Testin_like
cd09344101-153  LIM1_FHL1
cd0942297-158  LIM1_FHL2
cd0942040-90  LIM3_Prickle
cd09336162-213  LIM1_Paxillin_like
cd09343217-275  LIM1_FHL
cd08368162-213  LIM
cd08368101-154  LIM
pfam00412162-217  LIM
smart00132100-153  LIM
cd0934540-93  LIM2_FHL
cd09406162-211  LIM1_Leupaxin
smart00132220-275  LIM
cd0942940-93  LIM3_FHL1
cd09343159-214  LIM1_FHL
cd0836840-93  LIM
pfam00412101-158  LIM
cd09339162-213  LIM4_Paxillin_like
cd09422217-275  LIM1_FHL2
cd09345162-213  LIM2_FHL
cd0942197-155  LIM3_LIMPETin
cd09405162-209  LIM1_Paxillin
cd09344221-276  LIM1_FHL1
cd0934640-93  LIM3_FHL
cd0943340-92  LIM4_FHL2
smart00132162-212  LIM
cd0942540-93  LIM4_LIMPETin
cd09422162-217  LIM1_FHL2
cd09421159-213  LIM3_LIMPETin
cd0942440-93  LIM2_FHL1
cd09338162-209  LIM3_Paxillin_like
cd09348100-156  LIM4_FHL1
cd09336101-154  LIM1_Paxillin_like
cd09344162-212  LIM1_FHL1
pfam0041240-97  LIM
cd09424162-213  LIM2_FHL1
cd09429101-155  LIM3_FHL1
cd0942840-93  LIM2_FHL5
cd09411162-213  LIM4_Paxillin
cd0934837-95  LIM4_FHL1
cd09342101-152  LIM3_Testin_like
cd09346101-154  LIM3_FHL
cd09429221-277  LIM3_FHL1
cd09432162-212  LIM6_LIMPETin
cd09405101-150  LIM1_Paxillin
cd0942397-154  LIM1_FHL3
cd09348159-212  LIM4_FHL1
cd09421217-275  LIM3_LIMPETin
cd09341May-33  LIM2_Testin_like
cl02475May-33  LIM superfamily
cd0943140-98  LIM3_Fhl2
cd09417May-33  LIM2_LIMPETin_like
cd09430101-154  LIM5_LIMPETin
cd09427161-213  LIM2_FHL3
cd08368221-275  LIM
cd09353101-159  LIM2_Zyxin
cd0934040-89  LIM1_Testin_like
cd09341119-155  LIM2_Testin_like
cd0942740-93  LIM2_FHL3
cd09412162-213  LIM4_Leupaxin
cd09349162-213  LIM1_Zyxin
cd09363101-150  LIM3_Enigma_like
cd09350173-213  LIM1_TRIP6
cd09420101-150  LIM3_Prickle
cd0943054-93  LIM5_LIMPETin
cd0939340-92  LIM3_Lrg1p_like
cd09459221-272  LIM3_ENH
cd09458101-150  LIM3_Enigma
cd09337162-209  LIM2_Paxillin_like
cd09417162-213  LIM2_LIMPETin_like
cd09459101-150  LIM3_ENH
cd09362101-150  LIM2_Enigma_like
cd09434162-212  LIM4_FHL3
cd09331162-218  LIM1_PINCH
cd09396101-154  LIM_DA1
cd09346221-275  LIM3_FHL
cd09396162-213  LIM_DA1
cd09334162-209  LIM4_PINCH
cd09338101-150  LIM3_Paxillin_like
cd09428162-213  LIM2_FHL5
cd09341178-213  LIM2_Testin_like
cd0941940-90  LIM3_Testin
cd09418179-213  LIM2_Prickle
cd0934126-93  LIM2_Testin_like
cd09419162-209  LIM3_Testin
cd09362162-209  LIM2_Enigma_like
cd09331101-154  LIM1_PINCH
cd0941461-89  LIM1_LIMPETin
cd09840179-213  LIM2_CRP2
cd0932740-93  LIM1_abLIM
cd09457162-209  LIM2_ENH
cd09401101-154  LIM_TLP_like
cd09361221-275  LIM1_Enigma_like
cd09461101-150  LIM3_Enigma_like_1
cd09456162-209  LIM2_Enigma
cd09418116-155  LIM2_Prickle
cd09329162-213  LIM3_abLIM
cd09347101-153  LIM4_FHL
cd09482101-154  LIM2_CRP3


Ontology Information


   
HPRD ID1557
Molecular ClassAdapter molecule
Molecular FunctionDNA binding (GO:0003677); ATPase activity (GO:0016887)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO