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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RASA3 22821 RAS p21 protein activator 3  13GAP1IP4BP, GAPIII 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23416983   2014Cell line : -

Source : -

Sample Type : CRC tumor and normal tissues

No. of Sample : 29 human and 10 canine sporadic CRCs

Stage : -

-Down-regulation-This study uncovered four new potential cell polarity and colorectal tumor suppressor genes (RASA3, NUPL1, DENND5A and AVL9).


Gene Details



NC_000013.10 (114747194..114898095, complement)

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Gene Type protein coding
Gene Family Pleckstrin homology (PH) domain containing
Description The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane. [provided by RefSeq, Jul 2008]  
Chromosome 13
Location 13q34
Start 114747194  
End 114898095  
Strand -  
Gene Sequence

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Length 150902  
OMIM ID 605182   
HGNC ID HGNC:20331   
Unigene ID Hs.593075   
Ensembl ID ENSG00000185989   
PharmGKB ID PA134905447   

mRNA Information


mRNA ID ?NM_007368.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS32016.1



Protein Information


      
Protein IDNP_031394.2
Protein NameRAS p21 protein activator 3
Molecular Wt. (Da)0
Protein Sequence

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Length 834  
Uniprot IDQ9Y458
Ensembl Protein ID ENSP00000362390  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation809

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2242FES1814NP_001996.1in vitro7691175   
3055HCK796NP_002101.2in vitro;in vivo7782336   
5906RAP1A1545NP_002875.1in vivo2158984   
10399GNB2L11503NP_006089.1in vivo11350068   


Pathway Information


      
Pathway Name Pathway ID
Ras signaling pathway hsa04014


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd05134297-565  RasGAP_RASA3
cl02569297-565  RasGAP superfamily
cd13371562-686  PH_GAP1_mammal-like
cl17171562-686  PH-like superfamily
cd0840113-133  C2A_RasA2_RasA3
cl1460313-133  C2 superfamily
cd04010146-288  C2B_RasA3
cl14603146-288  C2 superfamily
cd05128298-564  RasGAP_GAP1_like
cd05394297-564  RasGAP_RASA2
cd05135297-559  RasGAP_RASAL
cd13370562-694  PH_GAP1m_mammal-like
cd04519300-563  RasGAP
cd05136288-564  RasGAP_DAB2IP
pfam00616351-524  RasGAP
cd01244579-683  PH_GAP1-like
cd08675147-283  C2B_RasGAP
cd0838313-133  C2A_RasGAP
cd05137286-563  RasGAP_CLA2_BUD2
cd05395297-539  RasGAP_RASA4
cd05392324-573  RasGAP_Neurofibromin_like
cd01238579-713  PH_Btk
cd05391300-575  RasGAP_p120GAP
cd05130357-566  RasGAP_Neurofibromin
cd0405413-133  C2A_Rasal1_RasA4
cd13369569-694  PH_RASAL1
cd0003014-114  C2
cd05132351-561  RasGAP_GAPA
smart00239146-262  C2
smart0023913-111  C2
smart00233577-677  PH
pfam0016814-95  C2
cd00030150-265  C2
cd10573575-672  PH_DAPP1
smart00107679-714  BTK
cl02465679-714  BTK superfamily
pfam00168150-247  C2
cd13298577-677  PH1_PH_fungal
pfam00169577-676  PH
cd00821579-672  PH
pfam00779684-714  BTK
cd13271575-669  PH2_TAPP1_2
cd13372574-679  PH_CAPRI
cd04030145-266  C2C_KIAA1228
cd13296579-675  PH2_MyoX
cd13255572-685  PH_TAAP2-like
cd08387162-267  C2A_Synaptotagmin-8
cd08381156-265  C2B_PI3K_class_II
cd08390146-202  C2A_Synaptotagmin-15-17
cd08373151-258  C2A_Ferlin
cd08521151-265  C2A_SLP
cd04035145-253  C2A_Rabphilin_Doc2
cd04009161-206  C2B_Munc13-like
cd0838715-115  C2A_Synaptotagmin-8
cd04025160-287  C2B_RasA1_RasA4
cd13380577-670  PH_Skap1
cd04040151-260  C2D_Tricalbin-like
cd08378150-274  C2B_MCTP_PRT_plant
cd0401413-129  C2_PKC_epsilon
cd04026125-265  C2_PKC_alpha_gamma
cd05127359-520  RasGAP_IQGAP_like
cd13282579-681  PH1_PLEKHH1_PLEKHH2
cd08393124-266  C2A_SLP-1_2
cd08676181-265  C2A_Munc13-like
cd04044147-260  C2A_Tricalbin-like
cd04033162-289  C2_NEDD4_NEDD4L
cd08388145-200  C2A_Synaptotagmin-4-11
cd08391159-271  C2A_C2C_Synaptotagmin_like
cd0404014-129  C2D_Tricalbin-like
cd04022146-268  C2A_MCTP_PRT_plant
cd08385147-216  C2A_Synaptotagmin-1-5-6-9-10
cd08389145-267  C2A_Synaptotagmin-14_16
cd08402146-203  C2B_Synaptotagmin-1
cd00275146-255  C2_PLC_like
cd04011150-205  C2B_Ferlin
cd13215577-675  PH-GRAM1_AGT26
cd13274578-677  PH_DGK_type2
cd08405151-224  C2B_Synaptotagmin-7
cd08384151-265  C2B_Rabphilin_Doc2
cd08404145-224  C2B_Synaptotagmin-4
cd04052160-271  C2B_Tricalbin-like
cd04050155-205  C2B_Synaptotagmin-like
cd0837518-147  C2_Intersectin
cd00276146-248  C2B_Synaptotagmin
cd08386144-201  C2A_Synaptotagmin-7
cd13250579-669  PH_ACAP
cd13277578-677  PH_Bem3
cd084009-114  C2_Ras_p21A1
cd0839020-102  C2A_Synaptotagmin-15-17
cd04027146-287  C2B_Munc13
cd0868814-97  C2_KIAA0528-like
cd12207404-520  RasGAP_IQGAP3
cd13273577-669  PH_SWAP-70
cd04021165-255  C2_E3_ubiquitin_ligase
cd08685130-265  C2_RGS-like
cd13302576-676  PH2_Pleckstrin_2
cd0839114-131  C2A_C2C_Synaptotagmin_like
cd04046161-292  C2_Calpain
cd01252577-659  PH_GRP1-like
cd13297566-675  PH3_MyoX-like
cd0838818-97  C2A_Synaptotagmin-4-11
cd08383150-289  C2A_RasGAP
cd04031165-250  C2A_RIM1alpha
cd04029153-266  C2A_SLP-4_5
cd0404316-130  C2_Munc13_fungal
cd04009Dec-97  C2B_Munc13-like
cd08688147-263  C2_KIAA0528-like
cd0027620-97  C2B_Synaptotagmin
cd01218578-674  PH_Phafin2-like
cd0405237-129  C2B_Tricalbin-like
cd0402614-114  C2_PKC_alpha_gamma
cd0403835-110  C2_ArfGAP
cd0839349-115  C2A_SLP-1_2
cd13301575-680  PH1_Pleckstrin_2
cd04045162-251  C2C_Tricalbin-like
cd04020151-251  C2B_SLP_1-2-3-4
cd0838512-111  C2A_Synaptotagmin-1-5-6-9-10
cd08678147-292  C2_C21orf25-like
cd13248577-672  PH_PEPP1_2_3
cd13381577-672  PH_Skap-hom_Skap2
cd08376152-267  C2B_MCTP_PRT
cd05129359-561  RasGAP_RAP6
cd13279591-670  PH_Cla4_Ste20
cd08392163-250  C2A_SLP-3
cd13253578-675  PH1_ARAP
cd0868214-114  C2_Rab11-FIP_classI
cd04049162-269  C2_putative_Elicitor-responsive_gene
cd13258579-676  PH_PLEKHJ1
cd0402113-108  C2_E3_ubiquitin_ligase
cd13276579-669  PH_AtPH1
cd0403714-101  C2E_Ferlin
cd0869013-142  C2_Freud-1
cd05131423-545  RasGAP_IQGAP2
cd01251578-677  PH2_ADAP
cd13266577-677  PH_Skap_family
cd0404114-102  C2A_fungal
cd13299590-661  PH2_PH_fungal
cd0404414-102  C2A_Tricalbin-like
cd13389578-682  PH1_FGD5_FGD6
cd083814-114  C2B_PI3K_class_II
cd0403335-134  C2_NEDD4_NEDD4L
cd04039165-223  C2_PSD
cd04024161-276  C2A_Synaptotagmin-like
cd04051150-266  C2_SRC2_like
cd01265593-672  PH_TBC1D2A
cd0404235-134  C2A_MCTP_PRT
cd05133406-545  RasGAP_IQGAP1
cd01235580-677  PH_Sbf1_hMTMR5
cd0401516-114  C2_plant_PLD
cd08406146-202  C2B_Synaptotagmin-12
cd13292595-674  PH_Osh1p_Osh2p_yeast
cd01264574-672  PH_MELT_VEPH1
cd04017161-201  C2D_Ferlin
cd08681165-204  C2_fungal_Inn1p-like
smart00323275-614  RasGAP
COG5038127-282  COG5038
COG5038128-287  COG5038
PLN0300835-112  PLN03008
COG503813-103  COG5038
COG503814-249  COG5038
COG5261477-562  IQG1


Ontology Information


   
HPRD ID658
Molecular ClassGTPase activating protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessRegulation of physiological process (GO:0050791)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO