Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DIS3 | 22894 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease | 13 | dis3p, RRP44, EXOSC11 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24478024 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 40 CRC and 47 Control Stage : - | real time RT-PCR | Up-regulation | - | DIS3 and LRCH1 revealed significant overexpression in carcinomas compared with adenomas. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - |
| Chromosome | 13 |
| Location | 13q21.32 |
| Start | 73329540 |
| End | 73356344 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 26805 |
| OMIM ID | 607533 |
| HGNC ID | HGNC:20604 |
| Unigene ID | Hs.744104 |
| Ensembl ID | ENSG00000083520 |
| PharmGKB ID | PA162383628 |
Protein Information
| Protein ID | NP_001121698.1 |
|---|---|
| Protein Name | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 958 |
| Uniprot ID | Q71UM5 |
| Ensembl Protein ID | ENSP00000331019 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 18 |
| K | Acetylation | 922 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7709 | ZBTB17 | 4968 | NP_003434.2 | yeast 2-hybrid | 15231747 |
| 23404 | EXOSC2 | 3758 | NP_055100.2 | in vivo | 11719186 |
| 54512 | EXOSC4 | 16221 | NP_061910.1 | in vivo | 11719186 |
| 56915 | EXOSC5 | 16222 | NP_064543.3 | in vivo | 11719186 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| RNA degradation | hsa03018 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd09862 | 9-197 | PIN_Rrp44 |
| cl14812 | 9-197 | PIN_SF superfamily |
| pfam00773 | 467-791 | RNB |
| cl19762 | 467-791 | RNB superfamily |
| smart00955 | 467-796 | RNB |
| pfam13638 | 68-195 | PIN_4 |
| smart00670 | 64-182 | PINc |
| cd09854 | 69-192 | PIN_VapC-Smg6_family |
| cd09880 | 65-200 | PIN_Smg5-Smg6-like |
| pfam09742 | 673-791 | Dymeclin |
| cl15483 | 673-791 | Dymeclin superfamily |
| COG0557 | 222-930 | VacB |
| TIGR02063 | 207-928 | RNase_R |
| TIGR00358 | 394-911 | 3_prime_RNase |
| PRK11642 | 414-789 | PRK11642 |
| PRK05054 | 432-824 | PRK05054 |
| TIGR02062 | 432-825 | RNase_B |
| COG4776 | 432-825 | Rnb |
| PRK14724 | 153-259 | PRK14724 |
Ontology Information
| HPRD ID | 6402 |
|---|---|
| Molecular Class | RNA binding protein |
| Molecular Function | Protein-hormone receptor activity (GO:0016500) |
| Biological Process | Fatty acid metabolism (GO:0006631) |
Drug Information
No matching records could be found.