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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| MAPRE1 | 22919 | microtubule-associated protein, RP/EB family, member 1 | 20 | EB1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26342024 | 2015 | Cell line : - Source : - Sample Type : Plasma samples No. of Sample : 60 adenomas, 30 early CRC, 30 advanced CRC, and 60 healthy controls Stage : TNM Stage I-IV | High-density antibody arrays, ELISA | Up-regulation | - | MAPRE1 can contribute to the detection of early-stage CRC and adenomas together with other biomarkers.Plasma MAPRE1 levels were significantly elevated in both patients with adenomas and patients with CRC compared with controls . |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008] |
| Chromosome | 20 |
| Location | 20q11.1-q1 |
| Start | 31407699 |
| End | 31438211 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 30513 |
| OMIM ID | 603108 |
| HGNC ID | HGNC:6890 |
| Unigene ID | Hs.472437 |
| Ensembl ID | ENSG00000101367 |
| PharmGKB ID | PA30634 |
Protein Information
| Protein ID | NP_036457.1 |
|---|---|
| Protein Name | microtubule-associated protein, RP/EB family, member 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 268 |
| Uniprot ID | Q9BY76 |
| Ensembl Protein ID | ENSP00000301455 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 124;- |
| Y | Phosphorylation | 124;- |
| S | Phosphorylation | 155 |
| T | Phosphorylation | 166 |
| Y | Phosphorylation | 6 |
| K | Acetylation | 220 |
| K | Acetylation | 66 |
| S | Phosphorylation | 165 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 324 | APC | 1439 | NP_000029.2 | in vitro;in vivo;yeast 2-hybrid | 11 470 413 123 887 600 000 000 |
| 7013 | TERF1 | 2975 | NP_059523.2 | in vitro;in vivo;yeast 2-hybrid | 1 194 315 011 701 120 |
| 30849 | PIK3R4 | 4010 | NP_055417.1 | in vitro | 1 238 876 212 686 590 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00307 | 17-115 | CH |
| cl00030 | 17-115 | CH superfamily |
| pfam03271 | 209-248 | EB1 |
| cl03974 | 209-248 | EB1 superfamily |
| smart00033 | 18-100 | CH |
| cd14718 | 192-222 | bZIP_Maf_large |
| cl21462 | 192-222 | bZIP superfamily |
| COG5217 | 16-257 | BIM1 |
Ontology Information
| HPRD ID | 12725 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.