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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
WDFY3 23001 WD repeat and FYVE domain containing 3  4KIAA0993, ALFY, ZFYVE25 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23045723   2012Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 17 CRC and 59 healthy colorectal tissues and 25 CRC specimens and 32 healthy colorectal tissues

Stage : -

MicroarrayDown-regulation-In CRC, found down-regulation of SHOC2 (P < 0.00003) and LRRC28 (P < 0.01) and up-regulation of LRSAM1 (P < 0.000001), while up-regulation of MFHAS1 (P = 0.0005) and down-regulation of WDFY3 (P = 0.026) were found only in the Exon1.0 ST data-set.


Gene Details



NC_000004.11 (85590690..85887544, complement)

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Gene Type protein coding
Gene Family Zinc fingers, FYVE domain containing, "WD repeat domain containing"
Description This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]  
Chromosome 4
Location 4q21.3
Start 85590690  
End 85887544  
Strand -  
Gene Sequence

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Length 296855  
OMIM ID -   
HGNC ID HGNC:20751   
Unigene ID Hs.480116   
Ensembl ID ENSG00000163625   
PharmGKB ID PA134903706   

mRNA Information


mRNA ID ?NM_014991.4
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS3609.1



Protein Information


      
Protein IDNP_055806.2
Protein NameWD repeat and FYVE domain containing 3
Molecular Wt. (Da)0
Protein Sequence

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Length 3526  
Uniprot IDQ9UJU2
Ensembl Protein ID ENSP00000265165  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation1016;-
TPhosphorylation1020;-
SPhosphorylation1015;-
YPhosphorylation813
SPhosphorylation815
SPhosphorylation817
TPhosphorylation818
YPhosphorylation822
SPhosphorylation2490
SPhosphorylation2492
SPhosphorylation2277
SPhosphorylation3339
SPhosphorylation94
SPhosphorylation779

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd060712695-2976  Beach
cl105112695-2976  Beach superfamily
cd157193449-3513  FYVE_WDFY3
cl228513449-3513  PHD_SF superfamily
cd012012534-2657  PH_BEACH
cl171712534-2657  PH-like superfamily
smart010262695-2976  Beach
pfam021382695-2976  Beach
pfam013633449-3515  FYVE
smart000643448-3515  FYVE
cd002003084-3246  WD40
cl025673084-3246  WD40 superfamily
cd002003084-3247  WD40
cd002003047-3245  WD40
cd157203457-3513  FYVE_Hrs
cd002003080-3247  WD40
cd157313451-3510  FYVE_LST2
cd157303451-3510  FYVE_EEA1
cd157603450-3510  FYVE_scVPS27p_like
cd000653459-3510  FYVE_like_SF
cd157283457-3510  FYVE_ANFY1
cd157273451-3510  FYVE_ZF21
cd157213451-3510  FYVE_RUFY1_like
cd157333451-3510  FYVE_MTMR4
cd002003119-3247  WD40
cd157353457-3510  FYVE_spVPS27p_like
cd157293451-3510  FYVE_endofin
cd157583451-3519  FYVE_RUFY1
cd157163451-3517  FYVE_RBNS5
cd157543451-3513  FYVE_PKHF1
cd157253450-3510  FYVE_PIKfyve_Fab1
cd157173451-3510  FYVE_PKHF
cd157323451-3510  FYVE_MTMR3
pfam148442608-2654  PH_BEACH
cd157243451-3510  FYVE_ZFY26
cd157343451-3510  FYVE_ZFYV1
cd157433451-3510  FYVE_FGD6
cd157393451-3516  FYVE_RABE_unchar
cd157593451-3510  FYVE_RUFY2
cd157423460-3514  FYVE_FGD5
cd157363460-3510  FYVE_scVPS27p_Vac1p_like
cd157183455-3510  FYVE_WDFY1_like
cd157403453-3510  FYVE_FGD3
cd157373451-3509  FYVE2_Vac1p_like
cd157413451-3510  FYVE_FGD1_2_4
cd157553451-3510  FYVE_PKHF2
cd157233459-3513  FYVE_protrudin
cd157613449-3512  FYVE1_Vac1p_like
cd157263451-3510  FYVE_FYCO1
cd157563458-3516  FYVE_WDFY1
cd157493459-3510  FYVE_ZFY19
cd157383450-3510  FYVE_MTMR_unchar
cd157453460-3510  FYVE_RUFY4
cd157443459-3510  FYVE_RUFY3
cd157573458-3510  FYVE_WDFY2
pfam133851191-1250  Laminin_G_3
cl228611191-1250  LamG superfamily
cd157503459-3509  FYVE_CARP
pfam004003118-3155  WD40
smart003203116-3155  WD40
cd157693460-3510  FYVE_CARP1
cd157703459-3507  FYVE_CARP2
COG23193044-3247  WD40
COG23193055-3252  WD40
COG23193084-3247  WD40
COG23192931-3244  WD40
COG23193120-3262  WD40
COG23192996-3205  WD40
PTZ003033451-3510  PTZ00303


Ontology Information


   
HPRD ID10003
Molecular ClassUnclassified
Molecular FunctionTransporter activity (GO:0005215)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO