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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FOXC2 | 2303 | forkhead box C2 (MFH-1, mesenchyme forkhead 1) | 16 | MFH-1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25381815 | 2015 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Microarray analysis,luciferase reporter assays and chromatin immunoprecipitation assays | Up-regulation | - | FOXC2 as a potential therapeutic target for preventing or reducing metastasis in CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Forkhead boxes |
| Description | This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008] |
| Chromosome | 16 |
| Location | 16q24.1 |
| Start | 86600857 |
| End | 86602539 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 1683 |
| OMIM ID | 602402 |
| HGNC ID | HGNC:3801 |
| Unigene ID | Hs.436448 |
| Ensembl ID | ENSG00000176692 |
| PharmGKB ID | PA28218 |
Protein Information
| Protein ID | NP_005242.1 |
|---|---|
| Protein Name | forkhead box C2 (MFH-1, mesenchyme forkhead 1) |
| Molecular Wt. (Da) | 53588 |
| Protein Sequence | Download Select all |
| Length | 501 |
| Uniprot ID | P04049 |
| Ensembl Protein ID | ENSP00000251849 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 232;- |
| S | Phosphorylation | 240;- |
| S | Phosphorylation | 36 |
| S | Phosphorylation | 215 |
| S | Phosphorylation | 219 |
| S | Phosphorylation | 235 |
| S | Phosphorylation | 281 |
| S | Phosphorylation | 288 |
| T | Phosphorylation | 230 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00059 | 72-149 | FH |
| cl00061 | 72-149 | FH superfamily |
| pfam00250 | 72-162 | Fork_head |
| smart00339 | 72-160 | FH |
| COG5025 | 68-158 | COG5025 |
| COG5025 | 72-157 | COG5025 |
Ontology Information
| HPRD ID | 1549 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | GTPase activity (GO:0003924) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.