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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
USP33 23032 ubiquitin specific peptidase 33  1KIAA1097, VDU1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25242263   2015Cell line : -

Source : -

Sample Type : CRCtumor andadjacent normal tissues

No. of Sample : -

Stage : -

real time RT-PCRDown-regulation-Potential value of USP33 as an independent prognostic marker of CRC.


Gene Details



NC_000001.10 (78161672..78225564, complement)

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Gene Type protein coding
Gene Family Ubiquitin-specific peptidases
Description This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]  
Chromosome 1
Location 1p31
Start 78161672  
End 78225564  
Strand -  
Gene Sequence

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Length 63893  
OMIM ID 615146   
HGNC ID HGNC:20059   
Unigene ID Hs.480597   
Ensembl ID ENSG00000077254   
PharmGKB ID PA134955343   

mRNA Information


mRNA ID ?NM_015017.4
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS678.1



Protein Information


      
Protein IDNP_055832.3
Protein Nameubiquitin specific peptidase 33
Molecular Wt. (Da)0
Protein Sequence

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Length 942  
Uniprot IDQ9UI26
Ensembl Protein ID ENSP00000316651  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation439
SPhosphorylation408
SPhosphorylation439

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1734DIO29027NP_001007024.1in vitro;in vivo;yeast 2-hybrid12865408   
7428VHL1905NP_000542.1in vitro;in vivo;yeast 2-hybrid11739384   
54606DDX5612154NP_061955.1yeast 2-hybrid16169070   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd02674473-713  Peptidase_C19R
cl02553473-713  Peptidase_C19 superfamily
cd02257461-713  Peptidase_C19
cd02660186-712  Peptidase_C19D
cd02661185-712  Peptidase_C19E
cd02659475-716  peptidase_C19C
cd02667472-713  Peptidase_C19K
cd02663475-712  Peptidase_C19G
smart00695840-924  DUSP
cl12116840-924  DUSP superfamily
cd02668465-696  Peptidase_C19L
cd02662479-712  Peptidase_C19F
cd02664473-713  Peptidase_C19H
cd02671472-713  Peptidase_C19O
pfam06337846-918  DUSP
pfam0214861-121  zf-UBP
cl0995761-121  zf-UBP superfamily
cd02657609-713  Peptidase_C19A
cd02658464-713  Peptidase_C19B
smart00695734-803  DUSP
cl12116734-803  DUSP superfamily
cd02669609-713  Peptidase_C19M
cd02657186-288  Peptidase_C19A
cl02553186-288  Peptidase_C19 superfamily
pfam06337740-810  DUSP
cd02666657-712  Peptidase_C19J
cd02673590-712  Peptidase_C19Q
smart0029060-112  ZnF_UBP
cd02665609-712  Peptidase_C19I
cd02672590-712  Peptidase_C19P
cd02670552-713  Peptidase_C19N
cd02666185-215  Peptidase_C19J
pfam00443184-712  UCH
COG5560180-716  UBP12
COG5533186-716  COG5533
COG5077568-702  COG5077
COG520739-285  UBP14
pfam13423565-694  UCH_1
pfam10243284-517  MIP-T3


Ontology Information


   
HPRD ID9785
Molecular ClassUbiquitin proteasome system protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO