CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
ATG4B	23192	autophagy related 4B, cysteine peptidase	2	Apg4B, KIAA0943, DKFZp586D1822, AUTL1

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24991826	2014	Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : -	-	Up-regulation	-	ATG4B is a potential biomarker and drug target for cancer therapy. ATG4B independently plays a role as a positive regulator on tumor proliferation and a negative regulator on autophagy in colorectal cancer cells. ATG4B expression was significantly increased in tumor cells of colorectal cancer patients compared with adjacent normal cells.

Gene Details

Chromosome 2 - NC_000002.12 (241637612..241673857)
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Gene Type	protein coding
Gene Family
Description	Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Chromosome	2
Location	2q37.3
Start	241637612
End	241673857
Strand	+
Gene Sequence	>gi\|568815596:241637612-241673857 Homo sapiens chromosome 2, GRCh38.p2 Primary Assembly GCGCCGGCACACCTATTGGCCCCCGCGGCGTCCCGTCGCCGCGTCGCGTTGCTGGCCCGTCGGAGCGACG CCGCTCGGGTCAGTCGGCGGCCGGACTGGGAAGATGGACGCAGGTGAGGAGTTGCCGGGGGTCGGTCTTT CCGCAGGAGGTGCTCGCCTTATCATTGGCCTCCCCTGCTCGGGTCGGGCTGCCGCGACTCGCCTCGGGGC ACGCCGGTGCGGGCCAGGCTGGGCCGGGGCGGCGGGCGCTGCGGGAGCGCGGGGCGGTGTTGGTGGGTGG TGGGCGGTGGGAGCGGGAGGGGGACGGCGGCGCACTGCGCCGCGGAACCCGCCGTCGGTTGCGCTGGAGC TTCTGCTTTTCCGGTCCCGTCCGGAGCGCTCCGGAGGTTGTGGCTGCACAGGCCCTTGCGCCAGGTCGGC CGTGGAGGGCGGCGGAGCCTGCCGGGCGGGGAGAGGCGCGGCGGCGAACGGGGCGGCCGCGGTCCGGGCC GGGGACGCGAGCGGCGGGCGAAAGCGTAGCCTTTCCGCAGCTGAGCGTGAAGGGATGGAAGCTCTTTAAC TTTTATGAAGTTATTGGTAGGTTGGAGGAGAGAAACGTGACGTGTTCATCACAGTATACGTATCTTTTTT GTTTTTGTCTTCAATTTAGTAACCAGTAGATTCTCCAAGCTGCTTTTCCGTGACGAGAAAGAGAAACAGT GAATTTGTATCATCGGGTCTTAGTTTCTTGGGGTCCTAAGAGAGAGAGAAAGAGAAGGAGTGTGTGTGTG TGTGTATAGGGAGTGTTGGTTTTTTTCCTATCCTTTCATGCTTCCGCTCCATTTTTGCTAGCAAGATTAT TTTAAGTCAGCGCCAAACCCATCGCTAGCCCAGTAGCCCTAGAAATATTTTTACACAGAAGTTTTAGCTC ATTCATTCTTTGTGGGAACTGATTTGCCTTTTACCAAGTATCCCCCATCTGTAAAGAAAGATTTTCATCT GGTTTAATTCTGTCATTCTGAATGGGATTGTTTTTACTTTTTATTTTTCTGGTAGCTACAACATAAATTT ATTAAGATCTGAGTTGGAAAACTGTAATGTGTATTGCCAATATCTATTAAAATGATTTGTAGCAGCTCAC CACTTAAATGTGGTAGGTGGCTGGAGGAAACAGGAGCCCTGACTCCCTAAGGAGCATGTTGACCAGGTGT ATATCTTGTGAAGTTTGTCTTTTAGAATAACCGTCATTCACGGTTGAACTATTTGCAGCTGTGTACTATT TGTTGTTTACTATTTTACAACTGTTGTATTATATCTTTTTAGGTGTTATTGTTTGTGATGCAGGATTTTT CTCAGCCACTCTGGCAGCCAGAGACCTCCGGCTGGCGAGGCCCCTGCCCAGGCCTTGCTTGGGTCCAGGC TCGCCGCAGGAGATACCCCATCTACTTGGTCCACCGGTGGGCACCTGGTTTGCACTATGGCACGGATACC ATGGCCACCATGACTGTATGCTCAGCCCCTGGCGGGAGTGGGTGTGTGGGTGAGTGAGTGCCGGGTCCCG CCAGCTGTTTCAAGCGCAGGCACCAGAGTGGGCTCTGCAGAGCTTACAGCTAGACATGTGGCAAGCAACT CCCACGGCGGACTCCAGCGTCCAGACAAAGGGACAGTGGATTCTGGTGTCCAGACAAGGGGAAGGTAGTG GCGCCCAAGCAGGGGTGCTTACAACCCTGAAGCCCAAGAGGGGGTGTTGCAGAGTGTCAGCAGCCCTGTT ACTCCCATTGCCCTGCTCCAGGCTATAGCTCTGGGGCTGGCTCCGTCCCCGCTGCTTCCCTTTGCTGCCT CCTGTCACGTGGGGTGTCACAGTGGGTGGCTGCCCTTTGCCGGCAGAGGGCCCAGGGCCACAGTGTTACA GCCTTCTTTGTACTTGCATTCATTGGGTCCCTAGTTCTTGTCCCACGTCCAAGAAGAATGAGACTACACT TAACACTGACAATCGAAGGGTGAGGAGGGTGGAGAATAGTTTTATTGAGTGATGAAACACCCCTCAGCAG AGAGGGGACTCAAGGGTGGTCTTCCACCCAAAGTCGGGTGGTCTCCCTTGGTGTGGCTGGGTCCAGGGCT TTTATAGGCTCAGAATGGGGAGTGTGTGCTGATTTGTCTGTGAGTATGCAAAAAAGGTTAAAACAAAGTC ACTACTCAAAGGTGGGCACAACAGTGTAATAAACCAATTAGAGAAAAGTAGGTATATGTAAAATAGGTGA AGGGTGGGGATTAATTAGAGGAAAGCGCACCAAACAGGAAGAGAGGTTCGCAATCCAGTCTGTGGATTTA TCCGAGACTCGTCGCTTGGCTTTCAGGCTTTAAACTGTGGCTTGAAGGTTGGGTTTCACTGGTGACCCAC CCCTCTCTGCCTAGGATTTGTCTGCCTCCTGCCTCTATCATTTCGATACCTTGAGGCTGGAGTATCATAT GAGAGACTTGGCTAAGGTCAAAAACACGGTTCAGTGTCGATCATATGACCTAAAATGTGAAAATCATCAT GTTCAAGTTGGGAGAACAGTTATGTTGTTACATGGCGATACTTTATTTTATCTTTTATTTTCCCTTGACA ACTGTGTTGACATGGTGATACTTTAATAGGACACTGGATGTTGCTGCATGTGGGATCAGAGTAGAAAAGG TGTTTGCATTTAAAGGTCTCTGTTTATGCTGATAAAAACGTATATGATGTTTGTAGGATATCATGGGGAA TTTTCCTTCTGACTTGATGCTGTATTTCCTTTCAGAGATGATTAATGATCTGCCCTCCTTTGATCTCTAG AGTTCTTGAAGATTCTGCCTTCCTTGACCATGTGTAATACAGTTTCTGTTCTGATAGTCATTAATTCAAT ACACTGTTTGTTACTGACTGTCAGATATGTGTTAGGCATTGTTCTAGACACTAGGACTAGAGAAGTAACA ACATAGATGAAAACCATTGCCCTGGGGTAGCTAACGTTCTAGACATGAGACCAGCATTAGCAGCGAAGTG CGTGGCTCCTGGGGGATGGTGATTTGGGCCAAGGATGAGGAGGATTGGAATTGTAGCCAGGATGGCCAGG AAGGGTCTCACTCTGAAGGTTTAAGTTTTGACGAAGACTTAAAGCAGTGTAGGAGGAAGGGCAGGTAGCA AGAGCCTGGTGTGGCTCAGGTGCAGCGGGTGGCGGTGGGAGAAGCAGGAGCTGAGGATAGAAAGGTGACT TAGGCTCAGTGTAGTGGGGCCTTGCCAGCTCATAGTGAGGACTCGGTGTTTATTCTGAACAGGATGGCAG CTCATAGTGAGGACTCAGTGTTTATTCTGAACAGGATGGCAGCCGTTTGGAAGGTTTCATTCTAGAGGAG GAGTCACATGATAGACTGTGTTCAACAGGCTTGCTCTGGCATCTCTTTTGAGAATGTACTGCAGAGGGGC AAGGGCAGAGGCAGCGAGACCAGCTAAGAGACTGTTGAACAAGCCAGCAAGGAGATGCCAGTGGATTAGC TCAGGGTGGGTAAGAGGTTGACTTCTGCATGTGTTTTGGAGGTTGAGACAATAGAATTTGTTTGTAGATT GGAAGTTGGGAGAGGGATGGGTAGAGAGGGAGGAGTTAAAGATGGCCCCATAGTGTATGGCCTGAGCTAA GCAACTCAGATGGAGGGGGGCGGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGT GGGCGGATCACAAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCGCTACTAAAAA TACAAAAAATTAGCCGGGCATAGTGGCGGGCGCCTGTGATCCCAGCTACGCAGGAGGCTGAGGCAGGAGA ATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGACTGCGCCACTGCACTCCAGCCTGGGCGAC AGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAAGAAACTCAGATGGGGAAGACTTGGGGAGGTCCTGT CTGGTGGGAAGCTTTCTGTTGCGAGTTTGGATTTATGTGTGTTGAATGTGAGGTGGATGTTAGACATCCT TGTAGAGCAGTGTCCAGTGGGCTTTTGGGTCTACAGGTTTGGAGCTAAAAGAATAAGCCTGGGCTGGAGA TAGACTGGAGGTCACATCAGATGAGGTCACCCAGGGTGTGAATGTGGGTGGGAAAGAAAAGAGGCCAAAG GCCTCTGCGGGTGTGGAGAGGTCCAGGAGGTGGCAGGCAGACCACAGTGTGGCTGTGTTCTCCACCAGTC CCTAGCACTGTCCCTAAAAGCATGCTCCCCATTCAGACGACTGGCAGGTGCCAGCACTTAAATAGCCACA CTGCCCATTCCTTGAGGACAGAGCTGGTGTCTTGTGCTTGCATTTCTAGTGCATCACTTGTGTCTGGCAT GTGGTTGGTAATAAAAAAAAAACAGAACTTGAATTAATAATAACCTACACATTCCCCTACTATCAAAGCT TTCAGTTTGTAGAGTTTAACATAAATCCAGTATGTTAGCATAACATGTAATGAATGCAGAGGCTGCTGGG GAGTGGTTTTTTTTTTTTTCTTGAGATGGAGTCTTGCTCTGTTTCCCAGGCTGGAGTGCGGTGGGCGCGA TCTAGGGGAGTGGGTTTTAATGTGCGCAATCTGCCCAGTGTGTGCACTGAAACAGTGTTTTCTAGCTTTC TGATGTAGCTAAATTTGGAGTTCCTTTCTCTCTTTCTCTGTTTTCATTCAGGACTGAACTACTAGCATTC TCATGTAAACTCTTGGAGATTTAAAAAAAAGTAGTAATCATATGCAAACTGTTATCTTAAACCTAAGAGC TTTCTAAAGGAAAAGAAGAACCTTTGTTGAATTTATAAAATATAAATCTTTTGGAAAATAACTTCTAAGT GTTTTAGGAAGGTTTCTTCGAAATGAAGTGGTTTACAGTAAGCTCTTAAATTTACTCGTTTTTTTTTGTA GTCCTCTCTGGTTGAATGAAGTGTAATTGGTACTAAATGGAGAGAAGTTGGTTAAATTCATTGAGTACAA TTCCCTACATTTCTGCCTGTCAGATTAGTAGTACTAAGTCACATGTTTTTTCTGATGGAATTACTATATT ATTAAAATGCCATCTGCCCTCTTCTGCTTGTGATCGCAGAAGTCCCAGGGAAGAGGGCGTGGAAAATCAA GTGTCTGGGATCCAGCCGACCAAATGGGAGAACTGCTTCTAAGGGGGACTCTTTCTTAAGGTGTACAGCA CCTCTCCGTCCTTTTTTTTTTTTTTTTTTTTTTTTTTAAGACGGAGTCTCACTGTCGCCCAGACTGGCTG GAGTGCAGTGGCTCTATCTCAGCTCACTGCAGCCTTCGCCTCCTGGGTTCAAGAGATTCTCCTGCCTCAG CCTCCCGAGTAGCTGGGATTACAGGTGTGCACCACCATGCCTGGCTAACTTTTTTATATTTTTAGTAGAG ATGGGGTTTCACCATGTTGGCCAGGCTGTTCTCGAACTTCTGACCTCAAGTGATCTGCCCGCCTCGGCCT CCCAAAGTGCTGGGATTACAGGTGAACCACCACACCCAACCTACTTCTTCATCTTGTTCCTCCTGCGTGT CATCTTTTTTTGAGGCAGGGTCTCACTTCATCGCTCAGACTGGAGTATGGTGTTGCGGCCTCAGCTCATT GCAGCCTTGACCTCCTGGGCTCAAGTGATCTTCTTGCCTCACATTCCTCAGTAGCTAAGACTACAGATGT CCACGCCTAGCTATTTTTTTTTTTTTTTTTTTTTTAAGAGAGACAGGGTCTCCCTGTATTGCCCAGGCTG GTCTCAAACTCCTGGGCTCAAGTGATCCTCCCATCTTGGCTTCTTAAAGTGCTGGGATTACAGGCATGAG CCACGGCACCTGGCCTTACATGTCATCTTATTTCAAATTAATATCATTACCTGGAAGTCTAGAGATGGGT CTATATATTTATTTATGTATATATGTACATATATATATAAACATATATATACGTATATATACACATAAAT ATATACACATATATGTATAAATATATATATACGTGTGTGTGTGTGTGTGTATGTATATATTTTCCCCCCC CCCCGTCGTCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAACGGGGTTTTGCCATGTTGGCC AGGCTGGTCTTGAACCCTTGACCTCAGGTGATCCACCCACCTTGGCCTCCTAAAGTGCTGGGATTACAGG TGTGAGCCACTGCACCCGGCGAGTGGATATTTTTTCCGAAGTTTGACTCCTTTTCTATCAGGAGCTACAT GAATTACCTTATAAATCACATGATGTGGCACGGGAAGATGATGAAATTATGACAGGGGCTATGAAATAAG ACAAGGGAACCTCTCCATGGCGAATTGCTGAGGCAGCTGGTGTCAGGCCTAAGTGGATCTCATACATCTG AGAGTCAGTGAAGGAACAAGTGTGGTGGCTCACACTTGTAGTCCCAGCACTTTGGGAGGCTGAGGTGGGT GGATCACTGGAGCCCAGGAGTTTGAGACCAGCCTGCTTAACATAGGGAAACCCCACCTCTACAAAAAATA CAAAAATTAGGCATGACGGTGCATGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGGATCCCTT GAGGCCGGAAGGGGGAGGTTGCAGTGAGCTGAGATCACACCACTGCACTCCAGCTTGGGTGACAGAGCCA GACCCTTGGGTGACAGAGCCAGAAGGAACGTTTGGGAATGGAATCATCGTGTTGGTCGATCTGCAGATGT TAGTGATTGTGAGCGTTAGTTTTGCACCCATTGTGGGTTCTCACCCCACTTGGAAAACTGGTGGCTGTGC CCCATTTCATGGGTGAGGAGACTGAGGCTGGAAGAAGTCCAGGCCTGTGTCTGTCCTGTAGCTATCGACC AGGCTCTCAGACTCCAGAAACAAACCTCAGTAGGAATCAGAAGTGTTGGCCGGGCGCGGTCTGCCTGTAG CTATCGAGCAGGCTGTCAGACTCCAGAACCAAACCTCAGTAGAAATCAGAAGTGTCGGCCGGTTGCGGTG GCTCATGCCTGTAATCCCAGCACTTTCGGAAGCTGATGTGGGCGGATCATCTGAGATGAGGAGTTCGAGA CCAGCCTGACCAACATGGGAGAAACCCATCTCTACTAAAAATACAAAATTAGCCAGGCGTGGTGGCACAC ACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAAACCGGGAGGCGGAGGTTGCAG TGAGCCGAGATCGTGCCATTGCACTCCAGCCTGGGTGACGAGCAAAACTCCATCTCAAAAAAAAAAAAAG AAAGAAATTAGAAGTGTTAATTCCAAAAAAGTTATCTTCCTCCATTATAAAGTAAGATCTGGAAGGTCAG GGAGGTCTTTGTACCGTTCTGATGCCTCAGTCCATGGCTCCTCATTGTGTCTTCCTCTTCAGCTGGAGCT GCGAGGGTGTCCAGGAGGGGTGAGTTCTGCTCGGAGGGCCTGCCGAGGGCATTCCTTCCTGTCCTCCAGC ATGAGAGGGACAGTGTGGGGCCCCTAGAGTACAGGGAAGACCTCCTCATAACTGAAGAGATGCGAGTCTG AGAGTCTTTATTGGCTCTTTTGTAGGAATCGCTGCAGGTCTCTTTGGTCCTTGGAGCCAGCCCGTGAGGC CGGGGGCAGGCTCTTGCTCTCTAAATGCAGTCACTCTTGGAGGAAAGGACGTTATGTTGGATTCAGTGTT AGTAAAGAGACTCATGTTTGGTTGGGTCTCTGTTGACCTTGTACTCTGTGCTGCACCTCTGCTTACAGAA TACCTCCCATCCATGCCGGTTCGTGACTGCTCACCCGTTTCAGTGATCTGAGAAGGCTGGCCCTGAAAGA GTGGTTACTGCTCCCGTGCAGTTTAGAGCTTTTCCTGCACCTTGACTTGTCCGTTTCACAGTGAGGACAC CAAGTCACAAGAAGGTCACTAGCCTGTAAGGTTGCGTGACTGCTCAGTGGTGGGCTCAGACTTCTGACTC CACAGCTGGCGCTCCAGCTGTCAGGAACGTGCTCCAGGTGTGACGTGTGGACACTCCCCACTTGCAGCGT CCTCCACAGTACCGAGAGGAGGGTGCAGTGTGGTGGGAGAAGCAAGGGATCATGTTTTCAGAGTGTCCGC CACTAGCCCTAGGGGAATGTATGACTCGCTCCCAACAGAGGGCAGGATTCTCGGGGAGGGCCGGAGTGCG TTTCTCTGGACGGAGGAGCAGAGCAGCTTGGGGCACGGTGTGGGAGCCCTCCTTAGGGACCTCATGGGTC ACGTTCGCCGTGGCTGCGCCACTCCTGTTCACTGCCAAGCACCGTGATTGCTCCTTGGATTTGCTCCCCT GGGGTTTCCTGGTCTCCTTGATGGTTTATACAGTGAGCAATCTGAGGCCACACACCTGTAATTTTCACAG TTATAGCTGGAGGTGTGGTGGTGTATTTGAACTTAATGGAACACCTCTTATTCCCTTCACTCTGAAGTTG GCTTCCTTGCCTATAAAGTTTGGTGATAAACCTAAGAAATACACCTGCTGTGCATTTTACTGCGTCCGTG ATGAAAATCCCTCAACTTCACAGCCGCTCAGGCCTCGTGACCCTGCTTTCAGAGGGAGCCTTTTTCCTTT TCTTCCTTATCTATACTTCTCTCATTCCTTTACCATTTATATTTTTAATATGGGAAACTAGACATCCTAG AAGTTTCTCAGCTTCCAGATTCTGTTACTGCAGACTGTTACTGATTCAACAATATGGTCCTTTTCCTGAT GACATACGCCACATTCTTCTGAAGTACAGATGGTCTCCAAACTACCATGGTTTGACTTACAATTTTTTGA CTTTACGATAGTGTGAAAGCAGTATGCATTCTATGGAAACCATACTTGACGTTTTGAATTTTGATCTTTT TCTGGGCTAGCAGTATGCCTCCAGATACTCTCGAGATGCCAGATAGCTCCTCGTCAGCCACATCATGAGA AGGGGGAATGACCCCTGCTCTACAGGGCACTGTGTTGCCAGCTGAGTTTGCCCAACTGTAGGCTAATGTA AGTGTTCTGAGCACATTTAAGGCAGGCTAGGCTAAGCTATGATGTTAGGTAGATTACGTGTATTCAATGC TTTTTTTTTTTTTTTTTTTGAGACAGAGTTTCACTCTCCCACCTGGGCTGGAATGCAGTGGCGCGATCTC AGGTCACTGCAGCCTCCGCCTCCTGGGTTTAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATT ACAGGCACCTGCCACCATGCCCGAGTAACTTTTTGTGTTTTTAATAGAGATGGGATTTCACCATGTTGAC CAGGCTGGTCTCCAACTCCTGACCTCAGGTGATCCACCCGCCTTGGCCTCCCCAAGTGCTGGGATTACAG GCATGAGCCCCTGTGCCTGGCCTCAGTGCATTTTTGACCTAAGTATTTTCAATTTACAATGGGTTTATTG GACATAATCCCATCCTAATTAAGGAACATCTGTAGTCTACAAAGAGATACTTGCCAGTGTTCATTTAGCT CTGCTGTACTTTAAATAAAAGATATGTGTATCTTTAGTTCAAAGCTGGTGCCTTGGAACGGTGTCAAACA TGAGAAGAATGTTCCAACAGCAAGATGGAATCATTGTCTTGCAGTGTTGAAATTAGACCGGTGGTGGCCA GGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGAGGATCATGAGGTCAGGAG ATTGAGACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAAAAATACAAAAAATTAGCCAGGC GTGGTGGCGGGCGCTTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGCATGAGCCGGGAGGC AGAGCTTGCAGTGAGCCGAGATCGCGCTACTGCACTCCAGCCTGGTGGGCGACAGAGTGAGACTCCGTCT CAAAAAAAAAAAAAAAAAAAAAGAAAAGAAATTAGACCGGTGGTGTTTTCATCCTTTTTCCTTGAGAATA AGTTTTCTGGATTTTAGTCTATATATTGAATAAAGCCTACAGGTCAAAGAATAGTAGGGACTTCTGAAGA TTCAGGAGTGGCTTTAGAGAGGTAGCAGGGACATCATGATGTTTTTCAGCTCTTTAAAAAGATAGGAGTG GGCCGGATGCTGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACTTGAGG TCAGGAGATCGAGACCAGCCTGGCTAACACAGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCG GGCATGGTGGCAGATGTCTGTAATCCCAGCTACTCGGGAGGATGAGGCAGGAGAATTTCTTGAACCCGGA AGGTGGAGGTTGCAGGGAGCCAAGATCATGCCACTGCACTTCAGCCTGGGCAACAGAGTGAGACTCCATC ACAAAAGAATAAAAAAAAGGCATGGACCTTAATTCATCCTAATTCAGTTTTTGTAATCATGTGCAGAAAC AAGTAACATATATATAAAAAGGCAGGAGAGAATGTAAACTTGGACTTTATTTATTCACAGTCACCAAGCA GTTTGGTTGATAATGTCTCTGAAAGCATGGACAAGTGAAATATGTAAGAGCAGAGCTCTTGGGGGCCAGG TGCAGTGGCTCATGCCTGTAATCCCAGCCTTCGGGAGGCTAAGGCAGGTGGATTGCTTGAGCCTAGGAGT TTGAGACCAGCTTGACAACATGATTAGACCTCATCTCTACAAAAAATACAAGAATTAGCTGGGTGTGGTG GCACATGCCTGTAGTCTCAGCTGCTCAGGAGGCTGAGACCGGAGAATTGATTGAGCCTGGGAGTTTGAGG CTGCAGTAAGCTGTGATTACACCACTGTACTCCAGCCTGGGTGACAAAATGAGTCCCGGTCTCAAAAAAA AAAAAGAAAAAAAAACAGGAGCAGAGCTCTTGGACAAAGCCCTGCTGTGGAAAGCTTGCTTCATCTGGCT GCAGCCGCTCCACAACGCCCGTCATCTTGCTCAGGAAGCCACAGCACTACTCTAGGAAAGGGGCAGAGAG GGGCCTGGGTCTCCCACAGCTGAGAATCCTTTAAACAGTGCCTGTAGGGCCCTCTATTGTGGATTTGGTA GTTCTGCCTGCACCGAGGGAGATGCTTGCAGGTGCTTCTGAACCCTGTGTTTGGGAATTAGCTGCGCATA CAATTAAGGCTTTTGGGTATAGTAAAATTTGTGTGCCTTTGACCCTGTGGTTCTGAGTCCTCGATGTTAA TGACAGAGCGGACATTGCAGCCCTTCTGTCTGCCAGCCAGCACCTCATTGGAAGTGTTTCATTGAAACGT CACACCCATATGCTGAGGCTGTCCTGTTGTTATCCCATTTTATGGATGAGGGAACATTCACACTTAGAAG TTAAGTGAGTGGCCCAGGAAACTACAGTTTACCAGTACCCAAGCTGGGCTTTAAATTCTGACTGCCCCCT GCCTCCCCAAGGGGATTGTGCACAGCACAGAAGTTCACACACGATGCTTTTTAGTATCAGCTTAGGTGGA GATCTGTGTTTATGTAGAATGCTGAGGAAACCACAGGCATAGTATGATTTCACGTACGAACCTGTGCATA AAGACTTCTGGAAAGAGTCATTGCTGGGCAACGAGGCTTCACGTGATTTGTGTATTTTTGTAGTCTTCAG AATTTTTTATGATTAGCATATGTCATTCTTATTGAAGTGTGGGGTTGTTATCAAAAAGTAAATTTAGATG TGGGAGAAATTCATATGTGATTGATTTTCAAAAGATTGCTGTAAAGTTGCTGGTGAAGGATGAGTGATCA GACACCATCAGAGCTGGAGAGGCAGCAGATGGGAATTGTGTGTTCCCAGTTCCCTGAAGAGCAGCTGGAG AGAGATGCCTCTGGTGCCGCCCCAGAATACGCAATGGGCATCTCGCCACATGGGTGTTTGGGCTGGTGCA TTGCTGCTGGCTGGCGCCTTCTTTTCAGGAACATTGTGGGACATGGGTATCCTCAGCCACAGTTCTGTGG ACAGGAAGACCCTGGGCCTCTCTAGTTTCTTTCTTTCTTTTTTTTCTTTTTCTTTTCTTTTTCTTTTTTT TTTTTTTTTGAGATGGAGTTTCACTCTTGTCACCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCACTG CAACCTCCACCTTCTGGGTTCAAGTGATTCTCTTGGCTCAGTCTCCCTAGTAGCTGGGATTACAGGCGCC CGCCACCACGCCTGGCTAATTGTTGTACTTTTAGTAGAGACGGAGTTTCACCATGTTGACCAGGCTGGTC TCAAACTCCTGGCCTCAGGTGATCTGCCCACCTCGGCCTCCCAGAGTGCTGGGATCACAGGCATGAGCCA CTGTGCCTGGCCTAGTTTCTTAATTGAAGTAAAACAGAGTAAGATGGCATGCAGGGCTAATCATTAGCCC AGCAGGTAAGCACCATGGCTCTGCAGCCAGCTGCCTCCTTAGAAAGTGGGGTGTTGCCCCATGGAAGTGG TGGCATGCTCTTCTGGTAGCATTGTTGAAATGAAAACAGGTTCAGTCCTTGATCACTAGGCTTTTTGTAC CCGGGTACCTCTGGGGACTTGGCAGAGAGTTTGATCTCTCAGTGTCCAGGGGTTAACTTTCTACCTGAGA GTAGCACCCCATGCTTCTCCAGCACCTGCTCCTAACCAGGAAATTGGGGTAGACCAGAACCCCAGTCTTC CCAGCAGCTCAGTGTTTCTTGCCCCGGAGCATCTGCCTTCATCACAGTGACTCTGAACACGCTGCCATGG TGACATCTGGTAAACCTTAGGATGGCCATGGAAAACGACTCTTTGCCCTGTTTCTTCTTGGCTTCCCTTG CGTACAAGGATGAAGGAGGTGGTTTAACTTTATTTTTGTCCTTTACTTTTTAAGTCTAAAGTAAGTGCTT GAATCGGGTGGGTTTTCATTTTTTTGCTTTCTCACCCCTCAGGTTGGCCCCTAACTTGGCCTCTCACCCT CGTGTCAGCTGTTAGACACTGACTCAGTGGCTCAGAATATGAAAGGCTCAGGAAGTAGCATGCTGGCCCC ACCTCCCTGTCCCCATACCTTAGCAGAGCAGCTGCCCAGCAGGGCCTCCTTCTCTTTCCTAAGAGTTTAC TCCATCCATGGTGGGTGTCTTGGTAGGCCCGAGATACGAGAGGGAGTGCTGCTGTTACAAGAATTTACAG TTGTTCTCTTCAGCACAGAAATGCTGTAAATGGCCTCTTTCGATACTAGTTTATGAAATTATAAGTGTCT GATGATTGTGCATCTTTGGTTTCAACAGCTACTCTGACCTACGACACTCTCCGGTTTGCTGAGTTTGAAG ATTTTCCTGAGACCTCAGAGCCCGTTTGGATACTGGGTAGAAAATACAGCATTTTCACAGGTATCGGCCA TGCTGGAGCCCACCCTGGTCTGACCGCTTGGCCTGCAGAAGCATTTTGTGATCACTGTTCTCTGCTAACT CTGCCATAACTTGTGACTTGCAAACTTAAGGCGTTGTGTGTGTGTGTTTTTTTTCTTTTAAACAACCTCT AGAAAAGGACGAGATCTTGTCTGATGTGGCATCTAGACTTTGGTTTACATACAGGAAAAACTTTCCAGCC ATTGGTAAGTACTCTGTTTTATTACAACGCGGGACAAAATATGTTTTTAGGAAGGAGGAAAACTTACGCT TGTAGATTTGACTTCAATATGCCACTGACTTCATTTGAATCTTCACAGCAATCCTGCTTAACTGAATTGG CCGAGGCCTCACGTGTAGTAGTGGCAAAGCTAGAATCCACGGCGCCTGACTCTAGGCTAGTGTGTTTTCA ACTGCAAATCCCAGCTTATTACTGGAGCTGGAAATCAGTATCATGAGTTATGACCAACGTTGTTTTAAAT GTAGGACAGAATGTCATAGAAAGCGGTGTGTGTCCGCCACGGGCACGCAGCATGGCGCTTCAGGGATCTT CGTTTTCGTTTGCATGTTTGAGTGTGTGTTCTGGGTCACAGCTGTACAATGTGTTTCTTACTTAGGTCCA GAATGTTTGGAAGCCATTCTCTGTAGCCCTCATCTTTTTTAGTATTTTCCACACTTAACCTGTGGGGAGA TTTGAAGGGCCAGGTGAATGTGACATGTTTTTATGTAACACTAAGGTGCATTCTGTTAAAAGCCATTCAT CATTGTTGTATACCCTGGAGCTGGAAGGAGATGGGGACTGGTTCTCAGCCTTGCCTCTCACCGGCGGAGA ACTGAGGCCGGAGGTGAGGGCCGGGCTGGCGTCATGCTTCCTCAGTGCCAGGTCAGGGTTTGGTCCCTCT TCTAGGGGTGGTTTCATTCTTTATCCTGAAGTGAGGTGGAAGTCAAATAGCCACAACGGCTGGACATTGG AGAACACTGACGCGTAGGGACATACGACAGTGTCTCCTTAGGTTGATATTTAATGATACACCTTGTGAGA TGTACCCTGGGAATATTGATATGTAATGATATATTTTAATGACATACCTTGTCAGATGTGCCCTGGGAAT AGTTGCTCATTCCACAGTTTCCGCTTGTTTCGCAGCTGCGCTGAACCTGCTCTCTTGGCCGCCTTGGATG CAGGTTTGTCCCCAGCCTCCATCTCCTTCACAGCTACCCTGCCGCGTGCTGGGAAGGAGAACAGGACTGG AGCGAAGCCTTTCTGGTTTGGCAGAGGCCTTGTGGAGGAGGTAGAGGCTGGGGATGAGCCTGCACATGAA GCAGCCCTGTCGCAGTTCTGAAGGGCAGTGTGCTGTGTTTCCTTCTTAGCCCCACGGAGATAATTTTTTA AAATTATTACTTTCATTTTTTTAATAGATGGGGTTTCGCTATGTTGCCCAGGCTGGACTTGAACTCCTGG GCTCAAGCAGTTCTCCCTCCTCAGCCTCCTGAGTGTCTGGGACTACAGGTGCACACCACCACGCCTGGCT CTGAGATACGTTTTTATCAGCAGTAGAGCGATCAGCAGTGGAGCGAGGGTGACCATGGGCACTGCTGATT GGGTTGTTGGTGGGTGACGGCCACCACTACCCCAAGACACAGGGTTTATTGTCCGTGCCAGTGCATGGAG AAGCTGCCGGAAGCCCAGAGGTGGGCACAGGGCGAACCTTGTGGTCTGACCCCTGAATCTCTGCTTCTCA CCCTGGTGTGCAGCCACCTAGCAGCCTCTTGTCTGCTGCACAGGTGGCCCTCTCTGTTGTCACAGCTGTG CAGTGGCCTTCCACTGGACCCCTGCTATGGGCTGGCAGTGTTTCCCACGTGCCTGTCACATGCCGCGCAG TTCCATGGTGCATGTTGTCCATCTTTCTGGGCCCCAGGGAGTGGCCGTGAGGGCAGGGCCCAGGCACCTG TGCTGGAAGGGCTGAGTTGCTGCCCTTGCGGCCCTTCCTGTGCTCTCAGCAGCACTGGATGTCATCAAGC GTTTGAATTTCTGCCTTTCTGATAATTGGAAAATGCGTTGTTTTGTTTAACTTTGCATTTTCTGGATGAC TTACGGGGGTCAGTGTCTTCATATGTTTGTCAGACATTCCTTTTGCTCCGTGACTGACTTGTTCATGTGT TTTGCCCATTTTGAGGAGGTTGTCGGGACATTTCACTCTCCAGTAAATGTGGCCCTTGGCGTTACTGAGT CCTAAGAGGTGTGTGTTGCCCCAGGTGGAGCTGATGGAGGAGGGAGTCGGTGCCTGTGGTGTGGGACTGA CCGGCTGCCTCCTGCCAGTGGGCTTGTGGCCTGTGGGGCCATCTGGCCATGAGCACTTCTCTCTCTGTCT GCCACGACAGGGGGGACAGGCCCCACCTCGGACACAGGCTGGGGCTGCATGCTGCGGTGTGGACAGATGA TCTTTGCCCAAGCCCTGGTGTGCCGGCACCTAGGCCGAGGTGAGTCACAGCCCTGGGGAGGGCGCATGGC CACGGTGTTCTCAGGAAGCAAAGGGGACTGTGGGGTCAGGGCTCTTTAGAGCAGACCACAGGTAAAACAG TAAGTAGAACTTGGGGGTTTCTTGAGTAATGAGCCACTTGTTTTTCTTGATTTAAAAAACTGACTTTAAA GAATGCTAATAAATCCGCATGGGCAACATGGCGAGACCCCGTCTCACAAAAAATACAAAAATTAGCCAGG CGTGGTGGCTCCTGCCTGTAGTCCCAGCTACTTCGGAGACTGATGTGGAGAATTGCTAGAACCCAGGAGA TGGAGGCTGCAGTGAGCTGAGATCGCACCACTGCGCTCCAGCCTCTGCAACAGAGTTAGACCCTATCTGA AAAAAAAAAAAAAAAAAAAAGAAGAAGAAGAATGCTAATAAATGTTTTAAATTACTGAAACTGTTTTCTG TACAGATTTGTTTTGATAACTTGGCGTATATGTATTTGAAATCCTGGAGAACATGGGTTTTTACTTTTAA AAGATTCTGGGCTGGGTGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGATGCCGAGGCGGGTGGGT CACGAGGTCAGGAGATCAAGACCATCCTGGCCAGCATGGTGAAACCCCATCTCTACTAAAAACACAAAAA TTAGCTAGGCTTGGTGACATGTGCCTGTAGTCCCAGCTACTCGGGAGGCTGAAGCAGGAGAATCGCTTGA ACCCGGGAGGTGGAGGTTGCAGTGAGCCGAGATCACGCCATTGCACTCCATCCTGGGTGAGAGAGCGAGA CTCTGTTTAAAAAAAAAAAAAAAAAAAAAAAGATTCTGAAAAAGGTTTGGATGCCATCTGTATCTTTAGT GTGAAAGTGAAAACTTGTTTCTCATATTTATGGTAGAGCTGACCTGTAATTTTTTTTCCAATAGATTGGA GGTGGACACAAAGGAAGAGGCAGCCAGACAGCTACTTCAGCGTCCTCAACGCATTCATCGACAGGAAGGA CAGTTACTACTCCATTCACCAGATAGGTGGGAGGCTGCAGAATGTGCCAGGCCCCACCCGGGCTGTCTGG AGAGGGTGGAGTGGTCGGTTTCCCCTCAGAGCTTTTCTGGTGTCGTGGGATGTGGAGCAGGAGGCTGTAA ACCTGTAAACACTGACCTCTGACCATCTGTGCGCTGCTGTCACATCACCCCCGTGTCATCCCACATCACC CCCGTCCCACCCAGGCCCAGACCCTGGGCCTTGCCCTTCCTGCTGTCCATGCGGCTTGCAGTGCCTGGTG CTCGGCACAGTCTGGGGAAATTGGCCTCGCCCCATCAGTGAATCTGAATGCTCAGATTGAAGTGGAGTGA GTAAAGAAGAGTTGGCCTTTCTTGCAAGCAAGGCCGGCTTTTGAGCACTGTGTTTTCACTTATAGAAGGA AGTGGTCCCTTCATTTCCCCTCCTTTTCTAAGTTCATAGTGAAGGACAGTCCCTGAGACCTTGTTTGCCC CCTCATGCCTCCCCCGATCTTGTTGGGGCATCCTTCCGTCTGGAGGCTGGGTCGGGTGCTGTCCAGGCCT TCCTGTGACGTGTCTCCTGGCACCACGTGCCACCAGAGGTCAGGGCTGGGGGCGGGTGTGTGTTGCTAAT GTGTATCTGTTCCCTGCAGCGCAAATGGGAGTTGGCGAAGGCAAGTCCATAGGCCAGTGGTACGGGCCCA ACACTGTCGCCCAGGTCCTGAAGTATGTACTGCGCTTCCACTGCTGAGCATGGGGCAGCAGGGATGTTCC CTGGGGGTTAAATTCTCCTTGAGTCTTCATGGCTACAGGAAATAAGGGGTCTCTAATTATTTACTTCATG GCCCTCAGAAGGTTTCTCAGCGATGACTGTGTTGAGGTCTTGTGAATAGGAATTTATGTTTTCTAACAAA ATGAACACCGTAGTCCACATCCTGGCTGGCACATTGGACCCTTGTTCTTTGCTGCATGGATCCACCTGTA ATGGTGGCTTCTGATGGGGTGGGCAGCTGAAGCTAGTCTGCAGCCATCTGTGCGGGTGCCGGGCCCTTCC ACCTCTGCAGGCTTGTTGGAGGCTGCCCTCCGCGGGCCTTGCCACCTGCCTTTCTCACTCTACCCGGAGA CTCCCTGTAGCCTCGCTCACCTTCCCATACACCTCAGCGTCTGAAAGTGTGCTCTGCACCTGCTCCGCAC CGCTTCCTTTCGCACCTCACTCAGCCCCATTGCGTGCCCGCCCCCCAGATTCCTCTGAGATGACCTTCCC TGCAGTTCCAGAAACTTGCCTGTGGTTTCAGCTTCGTGTCCACTCTTCACTCCTCTTGACCCATCCAGGG TCATTTGGTCTGATTCCATGTGTCCTGGCATCCCAGCATTTTTGGGGAGGCTCTGGCCAGATCCCCCAGG ACTTGTCCCCTCAGGGTCTCCTCCCCACTGGTCTGAGGGCCAGCGTCTCCCCAGCCTGTCTTCAGCCACG GCCCCCTTGAAGCCTCTCCTTCTGCATCTGCCTGTTCTGTATCCCACTCAAGGCCCTCAGGCATCCCACG TTCCACATTCCTGAAATGGCCCTGTCTCCCCTCACCCACAGCCTGCTCCTCAGCATGGCAGTCACTGTCT CCACCCAGCTTTTCTGTCAGGTTCCCTGGGGTCCTGCACAAGTCCGTCTCTGCCACATCCCACGTCACCC GCGTCCCACGTCACCCCCGTCCCACATCCCCAGCCTGCTGCTCCCTCTGTCTCCAGGGCCCGCCCTGTGT TTGGCGTGGCACCTGCTCAGTCCCTACTGCATGCCCTTCAGAGTCCTCTGTCCAGCAGCTCCCCAGCCCC CACCACACCCTTCCACTCACACTTCTCTTGCTGCTGCCTGGAGTGGCCCCACCAAGTCAGCGCTGTTTCT CTGGAAGCACCAGGCCACTCGCCATGCTCGCTGTTTCTCCTGGTCCCCTGCCTGCTCCCCACCAGCCCCC GCCCCTGTTGCTGGATGATCCTCCCCAACCTGCAAGTGCTGTGGCACTCAGGCACATGGACGGCTTCCAG GGCTGATTTGTCCCTGGACTCCAAGCTCAGGTCCAGCTGCTTATTCTGCATTTCCACCTGGGTATCTGTG TGCATGGTGACCTGACAGCCAGAGCCCGTGCTGGCCCCAGCCTGCTTCTCCTACAGTGGTCCTTCAGGTG CTCAAACCAAAATCTGGGATTGTTCTAGACCCCTCTTTTTGAGACGGAGTCTCGCTCTGTCGCCAGGCTG GAGTGTAGTGGCATGATCTCTGCTCAGAATCCCAAGTGATTCTCCTGCCTCAGCCTCCCGAAGTGCTGGG ATTACAGGCGTGAGCCACCGTGCCTGGCCAGGACTCCTCTCTTTTTTCTTTTTTTTTGAGACAGTCTAGC TCAGTAGCCTGGGCTGGAGTGCAGTGGTGCAATCTTGGGCTCACTGCTTCCTCCACCTCCTGGGTCCCGG TTCAAGCAGTTCTCCTGCCTCAGCCTCCCCAGTACCTGGAATTACAGGCACCCGCCACCATGCCCAGCTA ATTTTTTCAATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCG TGATCCACCTGCCTTCGCCTCCCAGAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCAGGACTC CTCTCTTTCTTTTTTTTTTTTTTATTTTTTTTCCGAGACAGAGTCTAGCTCTGTAGTCCAGGCTGGAGTG CAGTGGTGCAATCTTGGGCTCACTGCTACCTCCGCCTCCCGGGTCCCAGTTCAAGCAATTCTCCTGCCTT AGCCTCTTCAGTAGCTGGGATTATAGGCACATGCCACCATGCCCAACTAATTTTTGTATTTTTAGTGGAG ACAAGGTTTCACCATGTTAGCCAGGCTGGTCTTGAACTCCTGACCTCGTGATCCACCTGCCTCATCCTCC CAAAGTGCTGGGATTACAGGCATGAGCCACCGCTCCTGGCCAATTCCTCTTTATTTCAGTGGGCCCATTC AAAATATCAATTCCTCTTTCTTTCAGTGGGCCCATTCAAAATATGTCCAGACTCTGACCAGTGTTCATCC TTTCACTCCCTGTGCTGGTCCCAGCCCCATCTTCTTCTTTCTTGTTGATCTTCCTTCTCTCTTTGTCATC CTAGAGTCTCTTTAGCAAATAACAGCAGAGCCATCTGCATAAAACATATTGGCCACTGCTCTGCCTTGAA CCGCCCTGGCTCTTCACTGCTGACTCAGGCGGGGCTCTACCCGACCTCCCTGGCATGACACGTTGTGCTC CTGGGACACACCAGCCTCAGGGCCTTTGCATGTGTGGTGCCTGGCACTTGGACCCTGTTCCCCCGACACC TGCCTGGGTTGCGCCCCATGTCTGCCCAGGTACCCTTTGGCACCAAGGTCTTCCCTGTGGCTACGTTAGT AGTGCCACTCCCCGTTCCTGCGTTACTGTTCTCTGCAGTGTTGACCACCGGCCCACGTGGCTGCTGCTTC CTTGTTTGCCCTCCGCCAGGTCAGCTTTGCCAGTGCTGCTGTGTCCCTTGTGTGTGGGTGCGTCTTCGGC ACTGCATCTGGGCTAGAGGTGGGAGGAGGAAGGTGGTGTGGGAGTGGGGCGGGGAAGCAGGCTGTCCTCC CATCTTCAGCACTGCAGCTGGGCTGGAGATGGGAGGAGGAAGGTGGTGGGGCAGGGGGGCAGTGGGGGGC AGGCTGTCCTCCCAGTGTCCCCCCTGGGCTTGTGCATTGGGAGGGGCTCTGTGTGGTCACCCCAGTCCCC TGCTCCACCCCCACCCAGCTCCCCTCCACAGGTCTTGCATTCTGTCCCCGGGAGCACCAGGTCTTTGCTG CCTCAGGGCCTTTTCTATTGTTTTACCTTTTGTTGAGGTCCTCTGACCCCACCTCCGCCAGACCTGAGAT GAGATCAGAGTCGTGTTAGACTTTTGGCTGCAGAATCTGCCCTTCCCTCAGAAGGGGAAATCCAAGGCCA TGGTTCCTCCTCACTGGCGTGCACAGTCGTGCTTCCCACTAAGCTGCAGATTTCTCTATAAGGACTCAGA TTCCTTGGTTGTCAGCTCAGCGTGTTTGGTGGAGGGGAGAGCAGAGCAGAGCGTGAAGGTGCTGGGAGGC CTGCCTCAAAGTTGGCAAAACCCACAGCGTCTCAGAGCTGCGTTCATGTTCTAGTTCCTGCCTCTGTGCC AGTGAGACCAGAAAACCAGGCCACTCAAAAGCCTCTTGCGTGTGCTCTCTATGAATGGAGGCTGGGGCAA GGGCAGGACCCCTGGGCCTCAGGCGAGAAGAAGCAGATTTACCCTCAGCTTTCTTCCTGTCTGTGGCATT GGCTGTGCCCCGGATTTTAGGAGCCTTGGCCCTTCTCATCCGAGAAGCACCTCTAACGCGAACCCTCCTT CGCGCAGCTATAGCTGCAAAGATGAACCGTCTTTGAATTGTACAAAAGCTTATGGTCATTCTCCTACTCT CTGTAGGAAGCTTGCTGTCTTCGATACGTGGAGCTCCTTGGCGGTCCACATTGCAATGGACAACACTGTT GTGATGGAGGAAATCAGTAAGTGGCTCAGAGTTTCCATGGACAAGAAAGTTGAAATCACGGGCAACATAC ACACTTCCTCGCCTGAGTCCCCACGGGAGCCTCGGCGAGTGTTGTCAGTCGCCCCATGCCGTGCAGGTGC TCCGTGGGGCCTGTGCGCCAAGCCAGATGCACGGTGGCCTCGCTCTCCTATCCCGGCGGTCATACCAAGA GAGGAGAGCCCAGGCTGTCTGGAGGCCGCGACTTGGTATCTCACGTCGTGTTTTGTGTCTTGGTTACAAA TCGTTTATGAAGGCCCTGCTGTGCTTAGGCGCCCTCGTGTGGGAATTCTGGTGAAGTTATTTTGCGTGCC TTGATGTGCGACAGAGAGATGTAGCAACCATCTCTAGCTGCACCATCTCGAGCAAAGGCACGTCGTGAAG GCAGAGCTCTTTTCAGCTTTCTGGAAGAAAGGTCTGCTGCAACCCTGAAGGAACCTGGGCGTGGCAACAT TTACATCTAGGAGGAAAACTGTGGCTCAGTTTTAACAAATGGGCTCATTGAGTGAGTTCCAAATTCATGT TTCACCTTCCATGATGTAGCCAAGCTGAGAACTCTTAAAAATGCCTCATTGCCTTTTTCACTCAGGGCCA CCTTTTTCCCAAGGAACTTCTCAAAACTCCCTCAATTCCAATTTTATTGAAGTTCTACATGTAGGCTATT GCCTTGAATCCAATTTTCCATAAGAAAGAGCTCATTTAGGCCGGGCGCGGTGGCTCATGCCTGTAATCCC AGCACCTTGGGAGGCCGAGGTGGGTGGATCATGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTG AAACCCCGTCTCTACTAAAAATACAGAAACTAGCTGGGCATGGTGGCACGCGCCTATAGTCCCAGCTACT CGGGAGGCTGAGGCAGAAGAATCGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCTTGATCACGCCAC TGCACTCCAGCCTGGCCACAGAGCGAGAATCCGTCCCCCGCCCCCCAAAAAAAAGACCTCATTCAGAGCC ACAGCCGTAACTGCGCACAGATTCACAGTGGGAGTGGGTCCTGCCCTGTGACTGTGGGTGTGCCAGGTCA CCACACAGGTGTGTGCTGGGTCACAGACACGCCCCTTCCCTGCCTCTCCATTCTGTTTCTTCATCGTCTG GCCATCCTCGGGGGCATTGTGACACAGCGGAGGGAGTGAGGCAGGACTTTATAAGGGAGAGTGAGGCTGG CTTCTGCAGCATTGAGAGCTTTGCCACAGCAGGCTCTCCTTCCAGGATTCTGTTCCTCAGAGACTTGAAC TTGGGATCATAACCAAAGGGTGTTTGTTTCTTCCATCTGCCTTTTTCCTCCATTCTGTTTCTTGAAATTT TTATAAAACATTGGAAACACAGGAAGAGTACAAAGAAAGAGAAAAATTATTGATTTTACCACTCAGAAAT AACTCATATGAGCATTTTGACATTCTTACTCTCAGTATTTCTCCTGTGCTTTTCAAAAACTTACATAGTT TCCTAAGTATTTTCTCCTGGCCATGAGTGACAGCATTGTAATTATTAACTGGCTACACAATATACTATTA TACCTTAGTTCCCTGTTCACTGCCCCATCCTCCCTCCCGTGTTTGGGGAAATCACTTACCCCCTCGTTCC GCACGCGTGCTCAGGATCTCACCAAGTCACACCTCAGTCCCTGGCCTCGGATTAGGGAGGCTGTTGCTGG GTGCAGTGGCCAGGAAGGCGCAAGGGTCAGGGCTTCCTAGAACCTCCGTCCCTCTGGGTGCAGGTAGCAC TGGTGGGAGTGTTGGGGGCAGCTTGTCTGTGTGGACTCCAGCTCCGTCCCTTCGGGAGTCTCAGGGCTGC CCAAAGCAGTGCTGCTGAAACGTGGCTTGTCAGAGTGAGAGTGGAGTCAGGTCCTGGAAGAGCTTGAATC TGCATTTCCCAGCCCCTGGGGATGGTGGCTCCCGGGAGGATGTGGAGGCTGCCTGGTCTGACTGGCTTCG TCTCACTGCGTCAGCTGCCTGAAAGGACACTGTTCCTCACAGGAGCATGTGGAAGGTGCCTGATGCCCCC ATTTAGGAAGAAAGGCATCCACATCCAGCCAGCAAAGGCACTGGCATTGATGCACAAGGCTTGGGTTTCT GGGTTCCTGAGTGTGGCGTGGTGTTGTGAGGAGGACATCGGGGTCGTTCTGAATGACCCCTACCAAAAGC CCCAGGAGGGAGTAGTGGGGGGAGGGCAGGAAGCAGGCTGCTTTTTTCAGTCGTGCTGCTAAGAGTGCGC AAGGGAGGACGTCTGAGGAAGAAGTCCGCAAAGCCGAAGCTAGAGAAACAGACGTGTCCTTGGCTAAGCA AGGACTTTTCTTCTAGTTTCTCGGAACTGCTTGTGGAAGGAGCAGTTAGATAGGAGAAGACTGATGCCAT TCAGAAATTCCACTAAAGCTTCTTCCTGCAGCGAAAGAGCTGCCTGACGGTGTTCCCACTCAGATTTTAG GTGAAGCCTGTGGGGTAAGGGGAGACCTTACTGCCTACAGTGTCCCCATCCACCAACCCATCCCCCCCGC AACTCATCCTTCTGTCCACCCCCAGTCAAAGGCCAGCCAGGACATCCTTAGCATGCTCTTCTTGTCCTTA ACGTTGATGGGCTTAGACCTTTCTAACGACAGTAGACAGAATGTCACTGAATGTAGGGAGGAAATACAGA TTGGAAAACGTGTCAGTCTGGCAGTGAGGACAAATGACTCCAATGAAAGAAAAGTAAATACCAGAGCAAG CACAGTCAGAAACAGAGTGGGGAGGAGAATCACAATAGCTGGAACTCAACTCTCTGAGAGGCAGTGCAGC CAAATAGAGGCAGCTGAGAGCAGAGTATGTGGATTAGAACTTTTCGGGAGAGTTGGCCACTGAAGGAGTA GGAGAAAATTCCCCTGAGTTGGTGAGAGTTGAGTCTTTAGAGCTAAAGACCCCCAAATTTTTTTATCAGA AGTACTTAAACATACATGTTCCTGATAATATTTCCAAATTGCAGAAGTAAAGGGAAACTTCTCTAAACAT CCAAATAATAGTATCACTACTAAGCTGCTTTGAAGAAAGGCAGTCTCAACTGGCCTGGGCATCTCATCTT TGTGCCATACCAAATGCTACTGGAAAATGTTTAGAATTCTGAGAAAAGACCTGGCTTCATGAGGTGAGAG TAGGTATGTGTACTGTGTAGTTGTCATTGATAGAGAAATATAAATTTTAAATGTGTTCAAAATATAAAGA GAACACGAGAAAATTTCAGGTGGTGGCAGGAATAGGCAAAAGCCCGTTGCACCCTGTTGACAGCAGGGTG TTTGTGACGTGGTAGGTCACACACTCAGTGCTGGGCTCTGGAGGCACAGAAGCAACCGGCCCAGCTACGC ATCAGCCCTTGAGCCGATTCATGTGTTCGATCATATTCCTGAGACAGTAGGGTCTGTGCAGGTAACAAAG CACCAGTCAGCAGGAAACTCACCACCGGGAAGCCTTTCTATCAAAACATAACTTCAAAATCAGTAAAGTG GGCCGGGCATGGTGGCTCACGCCTATAATCCCAACTTCAAAATCAATAAAGCGGGCCGGGCGCGGTGGCT CACGCCTATAATCCCAACTTCAAAACCAATAAAGTGGGCCGGGCGCGGTGGCTCACGCCTATAATCCCAA CTTCAAAATCAATAAAGCGGGCCGGGCATGGTGGCTCACGCCTATAATCCCAACTTCAAAACCAATAAAG CGGGCCGGGCGCGGTGGCTCACGCCTATAATCCCAGCACTTCGGGAGGCCAAGGTGGGTAGATCACATGA GGTCAGGAGTTAAAGACCAGCCTGGTCAACATCGTAAAACCCCATGTCTACTAAAAAAAAAGTTAGCTGG GCATGGTGGCACGCCCTCGTAATCCCAGCTGCTCGGGAAGCTGAGGCACGAGAATTGCTTGAACCTGGGA GGCAGAGGCTACAGTGAGCTGAGATCATGCCACTGCACTCCAGCCTGTGTGACACAGTAAGACTGTGTCT CAAAAAACCAAAACAACAAAAAATAATAAAAATATATAGAAAACAGAATAATTAACAGATTAGCTATGGA AAGATCAAAGCTACAGGGGACCCAGATAACACAACAGGCAGAGTTTAGTAGATACGTGTCAAACCCTAGA TTGTGACAGCAGAGTGTGCCTGGGAATTTCTATGAAACTAATGCGGAATAAAATGAAAAAAGGACAAAAC CCTGCTGCCTGGAAATGTGAAACCTCAAAAAAGTCAAGTGTAGAGACCGTAACTATGTATCTGAACCTGA TGTGTACAGAACTCAGAAGAAAACCTGTGTATCTTCAGTACTAGTATATGGGTTCTTTACAAAGTGAAAA TTAATGAAATAAGCATACAACTCAAGAATTCGGAAAAAGCAAAATTAACTGAAGAAACCAAAGAATAATA TTAAAGACAAATACAGAAATTAATGATTTAAAGGAAGAAATGTATTAGGCCAGGTGTAGTGGCTCATGTT TGTAATCCCAGCACTTTGTGAGGCTGAGGCAGGAGGATTGCTTAAAGCCAGGAATTCAAGACCAGCCTGG GCAACATAGCCAGACGTCTATTTTTTTTTTTTTTTTGGAACAGTTCTGCTCTGTCGCCAGGCTGGAGTGC AGTGGTGGCACGATCTTGGCTCACTGCAATTTCCGCTGCCCAGGTTCAAGTGATTCCCCTGCCTCAGCCT CCTGAGTAGCTGAGACTACAGGTGCATGCCACCACGCCTGGCTAATTTTTTGTATTTTAGTGGAGATGGG GTTTCACCATATTTCACCATGTTGGCCAGGATGGTCTTGATCTCCTGACCTCATGATCTGCCCACCTTGG CCTCCCAGAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCTGGACCTCATTCTATAAAATATTTTAAAA ATAAATTTTAAAATTAAATTTATTAGAACTAACACATACTAGAACTGGCTCTTTGAAGCAATAACATATA TGTTTTAAAAAAATCAAAGTTAAAATCCCTCCCTTGGCTAAGCACTGTGGCTCCCGCCTGTAATCCTAGC ACTTTGGGAGGTGGAGGCAGGCAGATTGCTTGAGTCCAGGAGTTTGAGACCAGCCGCCTAGGTAACATGG TAAAACCTCATCTCTACAAAAAAACAAAACAAAAAAACTAGCCGGACATGGGGGCATGTACCTGTAGTCC CACCTACTCGGGAGTCTGAGGTGGGAGGATCCCATGAGCCTGGGAGGTTGAGGCTGCAGTGAGACATGAT TGCACCACTTCACTCCAGCCTGGGTGACACAGTAAGACCCTGTCTCAAAAACCAAACAGAAACCCAAACA ACTCCCTTAAGGCTGGGCGTGGTAGCTCCTACCCATAATCGCACCTCTCAGGGAGGCTGAGTTGGAGGAT TGCTTGAGACCAACCTGGACAACTCCCTCTCTATAAGAAATAGAAAAATGAGGCCAGGCACATGGCTCAT GTCTGTAATCTCAGCACTTCGGGAGGCTGAGGTGAGCAGATCACTTGAGGTCAGGAGTTCGAGACCAGCC CGGCCAATGTGGCAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGACACACACCTG TAATCCCAGCTACTGGGGAGGCTGAGGCAGGAGAATTGCTTGAGCCCAGAAGGCGGAGGTTGCAGTGAAC CGAGATTATGCCACTGCACTCCAGCCTGGACAACAGAGAATCGGCTTCAAAAAAGAAAAGTCAGGGGGCA CAGTGGCCCACACCTGTTGTTCCAGCTACTCGGGAGGCTGAGGCGGGAGGATTGCTTAAGTGCAGGTGTT TGAGGCTGCAGTGAGCTGTGGTTGCACCACTGCACTGCAGCCTGGGTGACAGAGTGAGACCCCGTCTCTA AAAGAAATTTAAAAAGTTCTGTCTCAGAATCCTTGTTTTCCAGCTGTCTGTTTTGAGAAATTTGAGTCCT ACAAAAAAGTTCAGTGAGTCATGGCCACAAACCCTCCACCTAGATCCACCAATTGTGTTTTGACACGCTT GGTTTTTATGAGCAAGCCTCCTACGAATGAGAGTGTTCCTGAGAGCCACACAGCCTCATCACCACAAAAG AGGTGACGCCACGACTCACCAGGGTCCGTCTTGGCCCCTTGCTGTCCAGGGAACAACCCGTGCCGCTGAT TTGTGTTCCTGGTTGAGGGTCCGGTGCTGTGTGTATATAGTTGTGATGTCTTTCTAGTCTTTAATTGAGA AGGTTCTGCCTCTTTGTTGTGGTTGTTGCTGCTTTGTGGCATTTTTGACGAGTTCAGGTCAGCTGACCAT CCCACACGCTGGATTTGTCTGCTTCCTCACAGTTGGGCTTGGGTTGAGCCTGTGGCTGAGAGTAGCCTCT GGGTGGCAGTGTCCTCTGCTCTCCCATCCGGGGCCTGCAGTGGGACACTATGTCAGATCCCCGGAGATGG TGTCTTTTTTCCTTTGTAATTAATGAATAATCCAGTGGTGACACTGAGCATGTCCTGGTGAGCTGTGTGA CTCCTGCCTGATAATGGTGGTTTTTCTAGCCTGTCCTTTCCTTTCACGTTTATTGGTTGGCGTTCTGAGA AGAGCCGCCTTTTCTCCCATCACTTAGTGTGCAGTGTGCTACCTGTCACCTGTCTGTCACCTGTCAGTCA CTGTCACCTGTCACTGTCACTGTCACCTGTCACTGTCCATCTTTTTGATGCTTGACGGTTCCACCTTTGG CCGGTGGCCACCTCAGTCTGGTGGTGTCTTTTGCCGTGTTCTGGCGTTTTTCGTTTATGTTTTGAGCCCT CCCTTATGTTCTGGGTTAAGCAGATGCTGCAGGCACCTCTGAACATTCCCTGCCTGGCCCTGGAATCAGC CTGGCTCCTCTGAGTGGGGAGTGGTGTTGAGAAACCTCGATCTAGACGCCGGGCATGCTCCATGCTCCCG GAGTGTCTTCTCCCATCACCGCACCCTCCGGTTGATGTGTCCTCCGGACCATTGACTCACGGGTGTGTGT AGGCAGAAGGGGTGGAAGCGAGGAAAGGCGTTGCTGAGGAGGCCCGGAGGGAGCGGGTTCTGGCTGTGCT GGCACTAGCCAGGCTGGCAGGCTGCGTGGGTACTTCTGTGATTTTCCTCTCAAGTGCACGTGGCTTTTTC TTGCACTGTTTCGTGTGTGTGCTTTATTTCACAATAAAACTCTTGAATTAAGTATGCATAGAAACTATTT CTTTTTTCTCTGGGTGGCAAGATTATGAAAAAATTTTCTTACGCTTTTCTATATTTTCCAAGTTTGAATT TCACTGTAAGCACCTGGCTTTGTACCGCCCTTTTTCTGTTACACAGTCATCATTTGCTTGCTTGTTGTGG GAGCACTTTTGCACAGGTCTGCTTGGTTAGTGAAAGCATGTCTCCCTTTCTAGGAAGGTTGTGCAGGACC AGCGTTCCCTGTGCAGGCGCCACTGCGTTTCCTGCAGATTCCGACCGGCACTGCAACGGATTCCCTGCCG GAGCTGAGGTCACCAACAGGCCGTCGCCATGGAGACCCCTGGTACTTCTCATTCCCCTGCGCCTGGGGCT CACGGACATCAACGAGGCCTACGTGGAGACGCTGAAGGTGGGTCCTGCCGTGCGGCGCTTGCCCTGAGTC CCCGTCCCCTTCTCCCAGTTCTTAGTCACTTTCAGCGCATCGTCGTCACGTGGCCATTTGTGCAGCCGGC TCTCGGGGGAGGGGTAAACAACCCTGGTTTACACCGTTGCCCAAGGGGTGAGTGGGCGTGAGGCACGTCC ATCAGTAGGCACGTGCTGCTTTCGTTCTGCAAGTGTCAAGGCGAGTGTCGAGGATGAAAGCATGAGGCGC TTGCAGGGGGTCCTTGGAACCAGGTGCCACTCCTCGGCCTGACGGGGAGCCCCGCCCCCTCCCGGGTCTC CACTGTGCCCCAGGCATGCCCACCCCACTCCCCCACAGCCCTCTTGGCCTGAGGTCCCTTCGGAGGGTGG GTTGGCCTGTGAGGAAGGGACGTGTGGGCAGGGCCTGGGGATGGGCAGGGCTGTGTGAGGAGCTCCAGCC ACAGGCTCCCCCATGTCATGAAAGCAAAAGGGGGCGGGGAGCGGTGGCTCATGACTGTAATCCCAGCACT TTGGGAGGGCAAAGCGGGCAGATCACGAGGTCAGGAGTCTGAGACCAGCCTGGCCAACATGGTGAAACCC TGTCTCTACTAAAAATATAAAAATTAGCCGGGCATGGTGGTGCGCGCCTGTAGTCCCAGCTACACAGGAG GCTGAGGCAGGAGAATCTCTTGAACCCAGGAGGCGGAGCTTGCAGTGACCCGAGATCATGCCATTGCACT CCATCCTGGGTGACAGAGTGAGACTCCATCTCAAATAAAAAAAAAAAAAAAGCAAGCAGAAGGGAAAACC ATCCTTTCTTCAGGTAACTCAAATTTTAGACCAAGGAGTCACATTTGTATGGAACTGAAATGTGGCTTCC TGTTAAAATTATTCAGTTGTCTGAACTTGGCCCCTCCGTCCAGCCTTCTGCCCATCCTGTGGGGTCTCAG CTGCCCCCACACATAGGCCCCGTCTCCATCGCTTCTGCCCTGTCAGGTCAAAGCACTCAGCAGGGCCACC TCCCGCACCCCTGCTCACATCTCCTGCCAGGCCCCCTCACTCCCGGCCTCCCCAAAGCCCACCTCTGACA TGAAGCTTCCCTGAGCTGAGCCTGCAGATTGGGTTTCTTGTGCCTGTGGGATGTCCTGTGGTCTTTCCTG GACAGTAAGCTCTTTGGTACCATGTCCCCTCCTGTCCCCTCTTGTGTCACCCAGTTGGGCCTCAGCAGGC CCTTGGGCCCCCTATGGCAGTGGGTGGGGGGACCGTCTGCTCCCACCTGGGACCTGTGCTCAGTCCCCCG CCCCTCCACAGCACTGCTTCATGATGCCCCAGTCCCTGGGCGTCATCGGAGGGAAGCCCAACAGCGCCCA CTACTTCATCGGCTACGTTGGTGAGTCCAGGGTTCCCACCGTGTCCCTGTGGGCCTGGGCCTTTTAAGGG CATTCCATGAGCAGGTACCACACCCCAGGTGACCACTTGAGGCCACTGGTGGAAAAGCAGCATGCCCTGG GGTTCATTTTCAGCCTGGTCGCGGGCGGCCTCCTGTGTGCCCCTTTCCCTGATGGTCTGGTGCCCTCGGC TCCCTCCCCACCTCCTGCCCACTGCTTCTCAGTGTGATGTGGGTGCAGTGGGTCTGAAATGCGGCCTCCT CTGTCCCTTTCCTCTGCCGGCTCGGCCACCCACCTGCCCACCTGCCTCATCCTCCCAGGTGAGGAGCTCA TCTACCTGGACCCCCACACCACGCAGCCAGCCGTGGAGCCCACTGATGGCTGCTTCATCCCGGACGAGAG CTTCCACTGCCAGCACCCGCCGTGCCGCATGAGCATCGCGGAGCTTGACCCGTCCATCGCTGTGGTACGT GGCGGCCACCTGAGCACACAGGCATTTGGTGCTGAATGCTGTTTGGGAATGACGAGGAAAACTTTCGGAT TTTTGCGTTTTTTTTTTCAGCATGTTGGGATAAGTACTGTGTTCACGTGGTTGGGAATCTGAAGGGTATA AGAGCCGGAACTGTGTCCTTGCACCCTCACGTCCCTCCCCCAGGCACCACCTCCTGTGCAGCCTTCATGG CCTTCGAGTGGCCCAGAGAGCGTGTGTCTGGATGTGAGCGTGTGTGGGCGCGTGCTGAGTGTGCATGGAT GAGTGTGAGCCATGGTGAGTGTGTCCCCCTCACACCTACATTTAAACACACGGGCGGCCCCTCCACCCAC CCCTGCACCACCTTCGTCACACCCACATTTAAACACGGGCGGCCCCTCCACCCACCCACTCCTGCACCAC CTTTTGTTTTCCGGAGGCTCTGACTTGACCTCTCTGGGGGATTTCCTAAGAAGGAGCTTCCCTGTTTTTC CATTTTGATTACCTAGTTGTGATTTTTGGTGTGTGATTTATGCAGACCTGCCTGCCCTCAAATATATTTG ATGGGGAAAGAGGCCAAAAAACCCCCCTAGAAATCATGAATGACGGTGACATGCTCAGGGAAGCAGTTAA CCGAATCGGGGGCTCTGTTGTGGATGCTCCGCCCCATTTAGGAGGAAGAAGGCAGATCTGGGCCTGAAAT GGGACGGTCTCTGAGCTGTGGCGCAGCCCCAGAGTGCACACCACGCTCCATGCACCTCCTGGGCAGGGTG GCAGTAGTGGGGAACATGGGCTGGAGCTCTGTGGCTCACACTTTTTGTTTGTTTGTTTGTTTTTGAGACG GAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCGGCTCACTGCAAGCTCCGCCTCCCA GGTTCACGCCATTCTCCTGCCTCAGCCTCTGGATTAGCTGGGACTACAGGCACCCGCCACCACGCCTGGC TAATTTTCTGTATTTTTAATAGAGACGGGTTTTCACTGTGTTAGCCAGGATGGTCTTGATCTCCTGACCT CATGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGCGCAGCCTGGCG CACACTTCTTACCAGAACCTAGTCACGAATTCCTCGTCGAACTAGAATTAGGTATGTTTGTTACTGTAAA CGCAGCTTGGTGGCTTACAGTGATTGGCACTCTAACAGTCAGGTCAGGCTAGAGAGCCAGCCACCGCAGA CAGAGGAGTGGACGCGTGAACGTTGAGTTGAGACCAAAGGGGCCACCTGGTGGGATAACTGTCCTCACCC GTGAGGAGGAGGAATGTCCCCTGTCCCCGGGGGAGAGTGCTCCTACACCAGCGCCGAGGCGGCAGAATGG TGTCTTCAGGGGAAGAGAGTGCCCAGTTTGAGCTTCTCCCCCCATTTCGTTTCTTTTTGTGTTAACATCT GCGCATCTGGCAGCGTTGAGAATTCCTAGTGACTGTCATTACAGGCGGCAGCTTTAAGGATGTGATTGCC GGTGACCCTTGGCCGGTCCCCTGTCTCCTGGCTCCTCAGCAGGAGGCTCCCTGTGTCACGGTGTCCTTGG GCAGTTCTCGGTGGCCTTTGCCGCCAAGCTTCCAGGGAGCTGCTGGGCGAAGGCTGAGACCCAGCGGCCC TGCCTCACAGTCACAGAGAGAAGAGCTCCCCACTTGGCCCTAACTCATAACCTGCCCCAATCCCGGAACA CTCGGTGAGGTTTGAGAGATGCACACCACGTAACATCTCGTGGGCGAATCAAGGCACAGCAACGCAGTGG AGCCTGAGGGGAGCCGGGCACTGGTGCAGGGGACCATGCACAGGGCACCCTCGGAGCTCCGTTCCTGGCC ACAGGAGCCAAGGCAGGCTGGAATGTCCAGCACCTGCATGCTGGGGGCCTCTGCTGCGCCACTGGCAGTG GGAATGGAAGCCCCCACCTCTTAGCCGACTGCAGATGGGGGTGTCGTGTTCTGCTCATCGTCATTTCGTT TTAGGGGTTTTTCTGTAAGACTGAAGATGACTTCAATGATTGGTGCCAGCAAGTCAAAAAGGTTTGTAGC CGCCCCACACCCACAGCCGAGCTGAGCCACCCAGGGAGACAGGCAGTGGGGCGTGCAGGGGTCGAAGGCC TGCGTCCAGGTCTCAGGCAGCCTCACTGGGCCGTGGGGAGCTTTGTCCCGCCTGGCACAGCTATGTAGCT GAGCAGGGTGGGGCGTCCTGGATTGCCCATCTGGCAACACAGTTAACAACCCTGGGGACGGATGTTGCGT GTTGACTTTAGAATGGGATTTCCAGTGTCCTCATCCGTCTCCTGTTGAGATGGGGGTGGTGATGGGGTGC TGAGCTACGCCGGCCGAGTGCGTGTGGCCCACCCCCCTCTGCCGTGGTGGTCAGACTGTGCTGTGTGTTG ATCACCACACTGGGTTCTCGTGTAGCCTTTAGTGTGGAGCTGCCTCTGTTTTCTCATCAGTGAGATGGGA TGACAGGTTTGTCCGCTGGCTGTGGCCGGCTGGCCCCTTTCTCTTGGCCGCAGCAAGCACTGGGGTGAGG CTGCACCTAACGGCCATGTCTCACTAACAGCTGTCTCTGCTTGGAGGTGCCCTGCCCATGTTTGAGCTGG TGGAGCTGCAGCCTTCACATCTGGCCTGCCCCGACGTCCTGAACCTGTCCCTAGGTGAGAGCTGCCAAGT CCAGGTGGGGTCCCTCGGAGGTACGATCTGTGCCCTTGCTTCCCCAGTCCTGGCCCCCTTGGTTTTGACC ATTAAGGTGTGTGTGAGCCTGAGCCGTGAGCACTTGGCAGTGGTTCGCCTGTGAGACCAGGTATGGAGTG GAGCGTCCCCTCCTCCAAGCTTGCGCCCAGCAGCCCAGGACCCACCTCGTCTTCCCCACCAGCGCTGCCT GCCCGGGCGCTGTGGAGCTGGGCGTGCTACCATGGAGTCCTCAGGGGTCTGGAGCAGACAGAACATGCAG GCTCTGTGGTGACGCAGTCCTGGGTGGGGGACTGGTTCACTTGGGCACCACTGGCCATGGGTGGCGTAGA CCCCTCGGACCATGGCCAGCGTGCCGCAGGAGCCGGCCTGGGCTCGTGCAGTGAAGTGAGTGGCCGTGAG CGCGTCCTCCTCATCTCTGTCTCCCTGTGGGAAACTCTACAAACAAGGCAATGGCAATGGAACCACTCCT GATGACCACGAGGGTCAGACGCGGGACAGAGGCCCCTCAGGCCTGAGATTGTGCCGGCCGCCCCCTGCCC TCCTCACCCTGCCCTGCTCCTCTTCTCTGCTCCCTCCCCCCATATTCGCAGGTCTGCACAACCCCCGGAC CTGTTCACACCCGCATGGGGACAGCTGTCTGTGGGCTGCAGAGCAGGCACTGCTCAGTCTGCCCCACGCC AAGGGCCCTTGACTCACACCCAGGTGGCCCACCCAAGATGCCTGATGCGCTATGTCCTGTTCCTTCTAGA TTCTTCTGATGTAGAGCGACTGGAAAGATTCTTCGACTCAGAAGATGAAGACTTTGAAATCCTGTCCCTT TGAAAATCCTGGGGTCGGGGGTGGCACCTGTGAGAGCCTGGGGCTCCTGGTGCCGCTGCGTTTCATCCAT CCCGCCCGCTCGCCTGCCGAGGGCTGCGCCCCGTGCTGCCTCCCCCCAGAGGGCCACCCGCTGTGCTCGT GGACTGAGGCTGCGCTGCCCGGGAGGCCTTACTGCTTGGTGTCAGACTGCCCAGCTCAGAGTGCCCGTCA GGGCCTGTGCATCCGCACGCGGAGCCGTCTGTTAGGAGCTTCCAGAGTGTTCTCTCGACACTGCCAGCCC CGTGTTAGCACCTGGGCCTCAGTCCCACTTGCTCCCAGGCGCCGGTTCTGTGGTTGGTTTGGAATTAAAG TCCTGTTTGAAGTTGTCAGACACAGACATGAATTTCTGGGCGCTCCCTGAGTCAGAGTCTCAGAAGACCT GTGCAGGCTGGCGTGAGAGGAGCGGCAGCCACACTGCGGCCCCACGCCCAAGGACTGGGCTGCTCTCGAG GGGGGCGCGCCCACCGCTGTGTCCTCTCTGCCCAGCCTGGCTTACCAAGGGCTACCTCAGTGGGAGATGA GGTTGGAGGAACGAAGGCGAGGTTCCTCCTTGCTTTGGGGAGAAAAGTATTCAGGAAGTGGGTGTGTGGG AAACCTGAAGATGGCGTGCACAGGACACAGCGTGGGCGGCCTGGGCAGAAGGGCGGCTGGCTGTCCTGGA GCTGCTGCTGGAGCCTGCCCTCAGAGTGTCCCTTTCCAGTGCTGTGGCATTCTGTGGCAGCTTCCCCAGG TGTGGTGACGGGGGGGGGGCGGGGCCTCCACCTGTGACAGCCAGGCTTGAGGGTGGACGGCGTGCCTCTC CCAGGAGCCTTCCCCATGTCCTTGCCTTGCTGAGAATTGCCCTCCCATGCCGCTGAGGTGTTAGGTGGTT TAGGGCCAAAAGGGGAAAACCACTTGAGTCTTGTGGTGTGTGGTGGGCAGACACCACAGGGTGGCATCAC CTGGTGGCATTTCCAGAACCTCAGCCCCGATTCCAGCACCCACCACCGCCTGACCCTGTGTAACCTGCTG TCCCGGGTCCCAGAGTGCACTCTGCCCCGCTGCTCTGCTGCCTGTCCTGGGAAAGTATCTTTGCCCCACT AGGAAATGTAAACAGGAGGGCTTGGGGAGCGTGGGCACTTTTCTCATGAGCAGCTACTGCGGCGTTGGCA GGACTCGCTGCTGCTGCTGCTGCTTGTGTAGGTCGGGGAGCCAGAGATCCCCGAGGACGCGCGCCGGACA GTCGGCACTGACCGGCCCACCTGGTAGCAGAGGACACCCCCAGCCCCCCAAGCATTGAAGACATAGTGTA TTTCCTCGTATCCTTTCTCCCTTGGGTGTAGTTGGGGTGGGGAAGCAGGGAAGGCTGGTGCGATCTCCAT TCCTTGGGCTCCACGTCCGAGTTCATGGTGCGCCGCTGTGCTGGGAGCTGCAGTGGTAATGTGTGGGACA CCTTGACCAAAGGGGAGCTTTGTCTCGTGTGTTTTGAAAAAGGCTTAATGAAGAGAATGTTGTTCATTCT TAGTAGTATAGTTTGCAATTCTTAATGGCAAATAATAAGTTTCAGTAGAAAACAAA Download Select all
Length	36246
OMIM ID	611338
HGNC ID	HGNC:20790
Unigene ID	Hs.283610
Ensembl ID	ENSG00000168397
PharmGKB ID	-

mRNA Information

mRNA ID	NM_178326.2
Exon	join(1..113,13399..13500,13653..13724,15901..15999, 16935..17036,17660..17732,21497..21576,29034..29227, 30532..30610,30929..31074,33115..33171,33701..33814, 34580..36246)
mRNA Sequence	>23192 GCGCCGGCACACCTATTGGCCCCCGCGGCGTCCCGTCGCCGCGTCGCGTTGCTGGCCCGTCGGA GCGACGCCGCTCGGGTCAGTCGGCGGCCGGACTGGGAAGATGGACGCAGCTACTCTGACCTACG ACACTCTCCGGTTTGCTGAGTTTGAAGATTTTCCTGAGACCTCAGAGCCCGTTTGGATACTGGG TAGAAAATACAGCATTTTCACAGAAAAGGACGAGATCTTGTCTGATGTGGCATCTAGACTTTGG TTTACATACAGGAAAAACTTTCCAGCCATTGGGGGGACAGGCCCCACCTCGGACACAGGCTGGG GCTGCATGCTGCGGTGTGGACAGATGATCTTTGCCCAAGCCCTGGTGTGCCGGCACCTAGGCCG AGATTGGAGGTGGACACAAAGGAAGAGGCAGCCAGACAGCTACTTCAGCGTCCTCAACGCATTC ATCGACAGGAAGGACAGTTACTACTCCATTCACCAGATAGCGCAAATGGGAGTTGGCGAAGGCA AGTCCATAGGCCAGTGGTACGGGCCCAACACTGTCGCCCAGGTCCTGAAGAAGCTTGCTGTCTT CGATACGTGGAGCTCCTTGGCGGTCCACATTGCAATGGACAACACTGTTGTGATGGAGGAAATC AGAAGGTTGTGCAGGACCAGCGTTCCCTGTGCAGGCGCCACTGCGTTTCCTGCAGATTCCGACC GGCACTGCAACGGATTCCCTGCCGGAGCTGAGGTCACCAACAGGCCGTCGCCATGGAGACCCCT GGTACTTCTCATTCCCCTGCGCCTGGGGCTCACGGACATCAACGAGGCCTACGTGGAGACGCTG AAGCACTGCTTCATGATGCCCCAGTCCCTGGGCGTCATCGGAGGGAAGCCCAACAGCGCCCACT ACTTCATCGGCTACGTTGGTGAGGAGCTCATCTACCTGGACCCCCACACCACGCAGCCAGCCGT GGAGCCCACTGATGGCTGCTTCATCCCGGACGAGAGCTTCCACTGCCAGCACCCGCCGTGCCGC ATGAGCATCGCGGAGCTTGACCCGTCCATCGCTGTGGGGTTTTTCTGTAAGACTGAAGATGACT TCAATGATTGGTGCCAGCAAGTCAAAAAGCTGTCTCTGCTTGGAGGTGCCCTGCCCATGTTTGA GCTGGTGGAGCTGCAGCCTTCACATCTGGCCTGCCCCGACGTCCTGAACCTGTCCCTAGATTCT TCTGATGTAGAGCGACTGGAAAGATTCTTCGACTCAGAAGATGAAGACTTTGAAATCCTGTCCC TTTGAAAATCCTGGGGTCGGGGGTGGCACCTGTGAGAGCCTGGGGCTCCTGGTGCCGCTGCGTT TCATCCATCCCGCCCGCTCGCCTGCCGAGGGCTGCGCCCCGTGCTGCCTCCCCCCAGAGGGCCA CCCGCTGTGCTCGTGGACTGAGGCTGCGCTGCCCGGGAGGCCTTACTGCTTGGTGTCAGACTGC CCAGCTCAGAGTGCCCGTCAGGGCCTGTGCATCCGCACGCGGAGCCGTCTGTTAGGAGCTTCCA GAGTGTTCTCTCGACACTGCCAGCCCCGTGTTAGCACCTGGGCCTCAGTCCCACTTGCTCCCAG GCGCCGGTTCTGTGGTTGGTTTGGAATTAAAGTCCTGTTTGAAGTTGTCAGACACAGACATGAA TTTCTGGGCGCTCCCTGAGTCAGAGTCTCAGAAGACCTGTGCAGGCTGGCGTGAGAGGAGCGGC AGCCACACTGCGGCCCCACGCCCAAGGACTGGGCTGCTCTCGAGGGGGGCGCGCCCACCGCTGT GTCCTCTCTGCCCAGCCTGGCTTACCAAGGGCTACCTCAGTGGGAGATGAGGTTGGAGGAACGA AGGCGAGGTTCCTCCTTGCTTTGGGGAGAAAAGTATTCAGGAAGTGGGTGTGTGGGAAACCTGA AGATGGCGTGCACAGGACACAGCGTGGGCGGCCTGGGCAGAAGGGCGGCTGGCTGTCCTGGAGC TGCTGCTGGAGCCTGCCCTCAGAGTGTCCCTTTCCAGTGCTGTGGCATTCTGTGGCAGCTTCCC CAGGTGTGGTGACGGGGGGGGGGCGGGGCCTCCACCTGTGACAGCCAGGCTTGAGGGTGGACGG CGTGCCTCTCCCAGGAGCCTTCCCCATGTCCTTGCCTTGCTGAGAATTGCCCTCCCATGCCGCT GAGGTGTTAGGTGGTTTAGGGCCAAAAGGGGAAAACCACTTGAGTCTTGTGGTGTGTGGTGGGC AGACACCACAGGGTGGCATCACCTGGTGGCATTTCCAGAACCTCAGCCCCGATTCCAGCACCCA CCACCGCCTGACCCTGTGTAACCTGCTGTCCCGGGTCCCAGAGTGCACTCTGCCCCGCTGCTCT GCTGCCTGTCCTGGGAAAGTATCTTTGCCCCACTAGGAAATGTAAACAGGAGGGCTTGGGGAGC GTGGGCACTTTTCTCATGAGCAGCTACTGCGGCGTTGGCAGGACTCGCTGCTGCTGCTGCTGCT TGTGTAGGTCGGGGAGCCAGAGATCCCCGAGGACGCGCGCCGGACAGTCGGCACTGACCGGCCC ACCTGGTAGCAGAGGACACCCCCAGCCCCCCAAGCATTGAAGACATAGTGTATTTCCTCGTATC CTTTCTCCCTTGGGTGTAGTTGGGGTGGGGAAGCAGGGAAGGCTGGTGCGATCTCCATTCCTTG GGCTCCACGTCCGAGTTCATGGTGCGCCGCTGTGCTGGGAGCTGCAGTGGTAATGTGTGGGACA CCTTGACCAAAGGGGAGCTTTGTCTCGTGTGTTTTGAAAAAGGCTTAATGAAGAGAATGTTGTT CATTCTTAGTAGTATAGTTTGCAATTCTTAATGGCAAATAATAAGTTTCAGTAGAAAACAAAAA AAAAAAAAAAAA Download Select all
Length	2892

CDS Information

Location	join(104..113,13399..13500,13653..13724,15901..15999, 16935..17036,17660..17732,21497..21576,29034..29227, 30532..30610,30929..31074,33115..33171,33701..33830, 34580..34653)
CDS Sequence	>lcl\|NM_013325.4_cds_NP_037457.3_1 [gene=ATG4B] [protein=cysteine protease ATG4B isoform a] [protein_id=NP_037457.3] [location=104..1285] ATGGACGCAGCTACTCTGACCTACGACACTCTCCGGTTTGCTGAGTTTGAAGATTTTCCTGAGACCTCAG AGCCCGTTTGGATACTGGGTAGAAAATACAGCATTTTCACAGAAAAGGACGAGATCTTGTCTGATGTGGC ATCTAGACTTTGGTTTACATACAGGAAAAACTTTCCAGCCATTGGGGGGACAGGCCCCACCTCGGACACA GGCTGGGGCTGCATGCTGCGGTGTGGACAGATGATCTTTGCCCAAGCCCTGGTGTGCCGGCACCTAGGCC GAGATTGGAGGTGGACACAAAGGAAGAGGCAGCCAGACAGCTACTTCAGCGTCCTCAACGCATTCATCGA CAGGAAGGACAGTTACTACTCCATTCACCAGATAGCGCAAATGGGAGTTGGCGAAGGCAAGTCCATAGGC CAGTGGTACGGGCCCAACACTGTCGCCCAGGTCCTGAAGAAGCTTGCTGTCTTCGATACGTGGAGCTCCT TGGCGGTCCACATTGCAATGGACAACACTGTTGTGATGGAGGAAATCAGAAGGTTGTGCAGGACCAGCGT TCCCTGTGCAGGCGCCACTGCGTTTCCTGCAGATTCCGACCGGCACTGCAACGGATTCCCTGCCGGAGCT GAGGTCACCAACAGGCCGTCGCCATGGAGACCCCTGGTACTTCTCATTCCCCTGCGCCTGGGGCTCACGG ACATCAACGAGGCCTACGTGGAGACGCTGAAGCACTGCTTCATGATGCCCCAGTCCCTGGGCGTCATCGG AGGGAAGCCCAACAGCGCCCACTACTTCATCGGCTACGTTGGTGAGGAGCTCATCTACCTGGACCCCCAC ACCACGCAGCCAGCCGTGGAGCCCACTGATGGCTGCTTCATCCCGGACGAGAGCTTCCACTGCCAGCACC CGCCGTGCCGCATGAGCATCGCGGAGCTTGACCCGTCCATCGCTGTGGGGTTTTTCTGTAAGACTGAAGA TGACTTCAATGATTGGTGCCAGCAAGTCAAAAAGCTGTCTCTGCTTGGAGGTGCCCTGCCCATGTTTGAG CTGGTGGAGCTGCAGCCTTCACATCTGGCCTGCCCCGACGTCCTGAACCTGTCCCTAGATTCTTCTGATG TAGAGCGACTGGAAAGATTCTTCGACTCAGAAGATGAAGACTTTGAAATCCTGTCCCTTTGA Download Select all
CCDS ID	-

Protein Information

Protein ID	NP_037457.3
Protein Name	autophagy related 4B, cysteine peptidase
Molecular Wt. (Da)	44163
Protein Sequence	>23192 MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGT GPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQI AQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGA TAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVI GGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVG FFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSE DEDFEILSL Download Select all
Length	393
Uniprot ID	P17535
Ensembl Protein ID	ENSP00000252818

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	383;-
S	Phosphorylation	392;-

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
79686	C14orf139	16606	NP_078909.1	yeast 2-hybrid	16169070

Pathway Information

Pathway Name	Pathway ID
Regulation of autophagy	hsa04140

Structure Information

PDB ID	2CY7
Resolution	1.9
Method	X-RAY DIFFRACTION
Chains	A
Molecule	Cysteine protease APG4B
Model	View

Domain Information

ID	Location	Description
pfam03416	37-337	Peptidase_C54
cl04056	37-337	Peptidase_C54 superfamily

Ontology Information

HPRD ID	9004
Molecular Class	Cysteine protease
Molecular Function	Receptor regulator activity (GO:0030545)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO