Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| JMJD6 | 23210 | jumonji domain containing 6 | 17 | PTDSR1, KIAA0585 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24667498 | 2014 | Cell line : HCT116 Source : Peking University Health Science Center. Sample Type : - No. of Sample : - Stage : - | Immunopurification, Silver Staining, and Mass Spectrometry,In-Gel Digestion,GST Pull-Down Assay,Co-Immunoprecipitation and Western Blotting,real time RT-PCR, Flow Cytometry,Chromatinimmunoprecepetation | Up-regulation | - | JMJD6 as a potential biomarker for colon cancer aggressiveness and a potential target for colon cancer intervention.JMJD6 antagonizes p53 acetylation, promotes the association of p53 with its negative regulator MDMX, and represses transcriptional activity of p53. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 17 |
| Location | 17q25 |
| Start | 74708914 |
| End | 74722881 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 13968 |
| OMIM ID | 604914 |
| HGNC ID | HGNC:19355 |
| Unigene ID | Hs.514505 |
| Ensembl ID | ENSG00000070495 |
| PharmGKB ID | PA162392513 |
Protein Information
| Protein ID | NP_001074930.1 |
|---|---|
| Protein Name | jumonji domain containing 6 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 403 |
| Uniprot ID | Q9UGJ0 |
| Ensembl Protein ID | ENSP00000287878 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 135 |
| S | Phosphorylation | 135 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam02373 | 174-288 | JmjC |
| cl22893 | 174-288 | JmjC superfamily |
| pfam13621 | 57-294 | Cupin_8 |
| smart00558 | 145-203 | JmjC |
Ontology Information
| HPRD ID | 10942 |
|---|---|
| Molecular Class | Integral membrane protein |
| Molecular Function | Structural constituent of cytoskeleton (GO:0005200) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.