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• Evidence
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Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
23985256	2013	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : TNM Stage III,IV	Tissue microarray and immunohistochemistry	Up-regulation	-	Both univariate and multivariate analyses showed that VEGFR-3, HER-2, and TIMP-1 were significant predictors of lymph node metastasis. VEGFR-3, HER2 and TIMP-1 are independent factors for lymph node metastasis in stage T1 and T2 colorectal cancers.

Gene Details

Chromosome 5 - NC_000005.10 (180601506..180650271, complement)
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Gene Type	protein coding
Gene Family	Immunoglobulin superfamily / I-set domain containing, "Immunoglobulin superfamily / Immunoglobulin-like domain containing"
Description	This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA.
Chromosome	5
Location	5q34-q35
Start	180601506
End	180650271
Strand	-
Gene Sequence	>gi|568815593:c180650271-180601506 Homo sapiens chromosome 5, GRCh38.p2 Primary Assembly TGTCCCGCTCACGGGTGCGGCTTCCGTCGACACTGTCCGTCGACACTGTGCAGGTAAACACTGCTGAACG GGTTTTGTTTTTGCTTTTTTTTTTTTTTTTTTGGCTCCCAGACTGGAGTGCAGTGGCGCGATCTCGGCTC ACTGCAACCTCCTTCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCCCCCCGAGAAGCTGGGATTACAG GCGCGCACAACCAAGCTCGGCGTATTATTTTATTTATTTGCTTGTTTATTTTTGAGACTGGGTCTCCCTA TGTTACGCCGGCTGGTGCCACTATTTTCAAAGATGTAACATACTATTTTTACAAGGATTGCTTTCTTGTT TAGTCTAGATTTTACCGATGGAAAGAAAGGACGGAAAAGAGCGCGTGCCGCATTTTGCTCCCCTTTGCCC ACCAGGCTCCATCACCTCCGGAGCGCATCGCGAGACCGTCTGCGTTACCCGCGTCCCCGCGCCCGGAGCC GCCCAGGAGGGGGCCCGGACCCTGTGGTGCGGAGCGCGCACTGCTCGGGTGCACCGGACGCCCCGCGGCG GGCTGGGAGGGACGGGGGGAGGGGGGCGCGGGGAGCGGCCTGAATCCCGGGCCCGCCTCCGGCCCCCGCC CCGCCCCGCCCCGCCCCAGGCCAGCCGGCGCCCGCGCGGACACTTTCAGCCCCGAGCCGCGGCCGCTCGG GTCGGACCCACGCGCAGCGGCCGGAGATGCAGCGGGGCGCCGCGCTGTGCCTGCGACTGTGGCTCTGCCT GGGACTCCTGGACGGTGAGCGCGGCGAACGGGCCACCCGCCCGAGCGTGGGGCTGGCCGGGGAGGGGGTA CCGCGCACCTGGGGCGGGCGCTGAGACCGCTCCGCCGGGTACGGGCGGGGGACACGGTGGCCCTGGTGCG CGGACGCCTGAGGGGAGCACGGCGCTTGGGGCGCGGGACCTCGGGATGAGGAAGGGGCGGGCGGGGACCG CAGCCGGGTCAGGGCCAGGGCGGCCGGGCCGCGCCTCGGCGCAGGGGTAGCTCTCCCGGCCCCTGAATCC GCGTCTCCGTCGGTGGCTCCGCGTCCTCGGAGCCGGGCCCTGCCGGGCTGCGCGCTGAGCCCGGATCCTT CGCGCCCTTACTCGCTTCCCCGCGGGGTCCCCGCGCCGCGCCGTCCCGACCCACGCGCGCCGGAGATCCA TCCCGGCCGGGCCCCGGACTTGGGTGCGCACTTCCCGACGCCCAGCGCCTCCGCTCGCGGTCGGTCCCCC AGAGGGCGCTCGAGGCGGGCTTCCCCCTCCCCGTGGCCGGCGACGGCGGGGACAGGGGCCGGGGACCACC GCGCGCCCGAGGCGGACGGGTGCAGGTGCACGCTGGCACTTGAGACGAATCTTGAGGAGGCGAATCGCGG GCTGTCAGCGCCGCAGAAGGGGCGGAAGGCCAGGGGTCCCCGGATTTGAGGGGACAGGGGCCTCGAAGGC CAGCTGAGGAGCAGAGGCCCCCGCGGGAGGGTCCCCTGCACAGGAGAGGCGGGGTTCGGTTTGTGTTGGG ATGTGGCTCTGGCGGGGAGAGACGCAGACCTGAAGCGGAGGCGGAGGGGTTGGAAAGAGGGACTGTGGGG GATGAGCGGGCGGCAGAGGGAGTGGATGGAGATGTCAGGGAGGAAGCTGAGAAGATGAGCTGGGAGTCCC CACGGAGCTGGTGTCCCTGGAAATCAAAGGGTGTAAGGGCGGGGTCAGGGGTTCCAGTGTCTGAAGCCCT GAAGTCAGCGACGGGGACCTCAACATTTCTGCACGCCATAGGAATTAAATACTGGCTTTACATGCTTGTA ATTCTCACAGGGAGTGTCAGACCCATTTTACACATGGAGAAGCTTAGACCAAGGACATGTGTCACTTCCC CAAGGTCCCCAGGAGGCCCAAAGTAAGCCTGACAAAGCCTGCCTTTGCTCACCACCTGTATGTCCACTGG CTGAAGGGCAGAGGACAGGAGAGGGGGCAGGTCTGGCTCAACCAGGGGAGGAGGGAGGAGAACATCTATC TGGGCCTCCGAGTCGGGCAGGCCAGATCAGGGCGCTGCCCTTGGCCCTCCTGGACCCAGCCCAGGACCAG GCTCCCACAGGTGCTCAGGATGTATTTGTCGAGTGGCTGGTAGACCTTGGTTGGACTGCAGGGCTGTAGA ATGGGAGACGCTTATCCTGGAGGAGACATGGGACAGGCACCTGGGCGCAGTGTCTGAGCTGGGCTGAGTA GCTGGAGAGGAAGAGAGAGACCCGGGAGGGGAACCCTGGAGGAGGGGCCCAGAGGGCAAGGGGGCTTCCA GGGATCCAGGGAACATTCTGCAGGTATAAGGAGAACCAGGAGAGGCCAGTGTCCTGGTGCTCCCGGGTGG AGCACAGAGGGACGTGGGGTGAAGGGTGAGGAAGCTATTCCCTGCAGTAAGTAGTGACTCTTAGTGACCC AGTTATGAAGAGGAGAGAGGGCATTAGTTGGGCGCCCCATGGAGAGGGGTGTCCTGGGCTGGACCTGGGT TTGGCTGGTGGGGAGATGGCAATGAAGACAGAGGTCATCCCTCCGTGAGCCCTGCACCTTGCTGTACCCC CTGCTAGGCTGAAGACCCCGGGAGCCCCCAGCTTGATGGGGGATGCCATGGCGGAAGCACAAGCCCTCAG CTGCAGTCGGGTGTCAGGGCAGCTGGTCCGGTGGGAGCTGCAGTCGGGTGTCAGGGCAGCTGGTCCGGTG GGAGCAGGCCAGAAGCCTGAGCATCCTGAAGCTGACCCCTTAAAAGTGTGCTATTGATCATAGAACCAGA CTCTTGTCCTGCCTCTGCCGTAAAGTCCTTTCTGTGTGACCTGGGCCCCCTCCTTTCCCCTCCCTGCACC TCAGTTTCCCCAAGCATAGCCATGGCACAAGCATAGCCATGGCACAAGCATAGCCATGGCACAAGCTGGC AAGCCCCGAGGTTGTGTGGGTTGTGTGTGCTTGGGCTGGACTCCAAGACCCAGATGCCTGCTGCAGTTCC ACAGTCTTGCCCCAGTGGAGAGGGTAGGTCACAGATGTCTCTTGGGGCTTAGTCTAGAGAGAGGCCATTG GCACCTCTGCACTGTGGCTACCAGCTCAGGGACATGCAGGAGCAGGGTCTGCTGGGCATCTGGAGTGGCC TGGTCTCAGGACGTTTGCCCTTGCTGTGACCTGGGTCACAAAGGCCCAGATGTGGACAGATGTGTGGCCC AGGGATGCAAGTCACTGCAGGCAGGATGTGGGGATCAGGCCCACTTTACTTGGGCCTGGGGACCTTCTGC TCCAGCTCAGGGCTCTGAGGACTCGAATGCAGGTGCTGTTCCCTCATCCACCAGGCCTATGGCACAGAGC CAGTGTGGCTGAAGGAGTCCTGAGCCCTCCCAGAGCATAGGGCCCACATGGCTGGGCCCAGACAGGGTAC GAGGTGTGATGTGTGGTCTGTCTGGCGAATTCTTCACTGTAACCCCCAGCAGTGGCACCCCGACCCAGGG AAGGAGCCTGCAGTTCTATGCAAGACCCCAGCATAGTGCCTGTTCGGGGTGGCCCAGGGAGGACTTGGAC CTGGCCCCATCGCACAGGGGTTTCCTGTGCCTTGCAGGGACACAGACATGCCATCAGACGTGTATTGCCC AGGGATGAAAGTGTTCAGGGGCCCTGGTGAGGCCCAGCTGGTGGCTGTAAGCTGCACAGGAAGGCAGTGT CACTTCCAGCTAAGGGCTTCCTGGTGGGGTCTGCAGAACTCCAGGACAGGGAATTCCAAGCAGAGCAAAG AACCCCATGAAGCCCCAGAGACAGGCAAGTCCAGATGGTGAATGTGGCCAAGTGGGTGGTCCGGTGAGGC TGGAGTCTGGGAGGAGTGGATGGGAGGTAGGGGAAACGAGGCTGGAGATGCGGCAGTGCCAGCAGCAAGG AGGCTGGTGTCCAGGGGAGACAGGAACTGCAAGTGGATAACCCAGGGGATAAACTGGGGTGGAGGCAGGT AGCAGCTGGGGATGGTGGGGACAGAGGAAGTCCCAGGTCTCTGGCTTCAAGGATAATTTATCAAAGGGAG ACCCTGGGAGAGGAGCAGGACCTTGGGTGGAGGTAGGCAATGGGATTTCCTCGGAGACCTCAGCTGATGC ACCCGGCCAGATAAGGAGGGAGGAAAGTTGGGAGCACTTGAGTATGATGGGACAGAGGGGAATGGGGGAA CCAGGGAAATTAAGCGAATCAGCTGCAAGGGGAGGTGCTTCTCTGTGTCTGGCTTACTCCCCTCCTGCTG CCGTATTTTCCTCCACAGGGCAGTTTTCTCTCCACCAAGGCCTAGCCTGTGCCCCACGTCCCTCTGAGAT GCCCCTCGGAGTTGGGGGTGGGCAGGGAGAGGGGTCTGGAGAGCCTCTCACACCCCCTAGACTCTGAGCA AGATTCAGTCAGTGTGTCCAGCTGGAGCCAGGGATTCCTGAGTTTCGATCCTTTTCAGACACTGGCTTCC TCTGGAATCTGGGTTTTCCGGTCACACTGAGGAGACAGGTCTGGGAGCAGGAAGATGCGGGCATTCATTC CCGGAGGAGGAGCAGGGCGCCAGCCCTGGCCGGGCTGGACGGGGTAACAGCAGGCACACCCCCGGCCCTG TCTGAGGCCCGCACCACCCTAGCCCACGGCCAGGCCTGGGTAGATCCAGGTGGTGAGTAGGGGAGGCCCG CCACGTGGCCGGCGAGGTCAGCAGGGGTTCATGGGAAAGGACTTGTCGGCCACAGGAGAGGACATCCTGC CTGCATTTCCCTCTTCCTGCGGCAGGAGCTGGTGGCCCCGATTTAGCAGCACTGGGGGGCCACCTCTGCG CCAGCTGGGTTGTCTGATAACGCCGCTCGTCCTGCCGGCCAGCAAGCAGAGCCTTGACCCCACGGAAGCC GGGGAAACTGCCTGGCATAGCTGGCTGCCCCACGGCGGCCGTGTGCTGGGAGCTTAGCATCTGCTCAGGC CCCCTCCTCCTGGTCTCCACCCCCACGGGGCACTCAGGCAGCCCACGCTCCCCGCAGGTCCAGCCCTTCT CAACCTCATCACCACTCCCTGTTTCCAGCATCTTCCAGAAATTTGTCTCCATTCTGCCCCAAAGGGACTG CTGTAAATGAGCCTTCAGGGCCCCCCCCAACTCACCCACAAGATAAGCACCAGCTTCTTGGGCTCGTGGT ACCGGCCCTTCCTGCTGGAGTCCCAGGCCATCCCTAGCCCCGCGTCCACCCAGCCTCCACCCACTGCACA CACCAGCCCCAGCACCATGGCCTTTCGCCCACCCTGGACGTGCCCTTTGGGAGACTGCTGGGAACTCCGG GCAGACGGTGCTGCTCCAAGCGGAAGGGGCCTTCCGGGGCAGGTGATGGCTTCGTTCCCGCTCACAGTGT GCCTCAGACTTTCAGGTGGGTTTAGGGGAAGCCCCCATCATCACCCAACTCAACACACTGTCCTCGAAGC TACTCTAAATTCTACCAAATGGAGATTGATTTGTTTTAAGCAGCAAGCGTGCACCGGCACATGCACACAG ATGTGGCGTGTCCGGCAGTGGGCCACACCTCCGTGTGAAATGGTTTCTCAGATTGCTTCACAGCAGGGCA CGTACAGGTTTTAACCTCGTCACGCAGACCTTATTATGCTTATTTTGGAGATTAGGAAATTCAGGCCACA AGGGTGAAACGGCTCTCTAGATAATAGATGGCTCATTTCAGGGGGTTAATAGGTGTCTGACATCTGGTTC CAAATAGCATGGGGGCCAAGCGGGAAAGAAGGGGCAGGCACACAGGCCACTGTCCACATTCCCCAGGGAA TGCCCTAGAGGGCTGGCCAGGTGGACTCTTCAATTTCTAACCACCTCATGGCCATTTTTACTTTGCTGTC CCAGAGACCTTTACAAAGCAGCATGTTGCAGACATTTCCCCCAGGTCCACCACACGCCCGGCGTGCCCCT CCGTGCACAGCCTCTCCACCCTCCCGGTACCCTGTGCCCTCTTTCCGCTCACGCCTACACCTGCCCACAC ATACTATGGCTTCTTTTGGTCCCTTGGATCCTCAAAACCAGCCATGGGTAAATTGCTGGCTAAGTCCAAT CCTGGGAATATGCCACGACGAAAAGACACACAGAAGCCCTTGTCTTGAACTAAAGAACCGTTAAGAGCGG GTCATGGTGGCTCACGCCTGTAATCCCAGCACTTCGGGAGGCCAAGGCGGGCGGATCACAAGGTTAAGAG TTTGAGAGCCTGGCCAACACGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGCGTGCGGTGG CAGGCGTCTGTAATCCCAACTACTCGGGAGGCTGAGGCAGGAGAACTGTTTGAAACTGGGAGGCGGAGGT TACGGTGAGCCGAGACCGTGCCACTGCACTACAGCCTGGGCAACAGGGCGAGACTCCACTTCAAAAAAAA AAAAAACCTGTTAAAAGTGGTAATGAGCCGGCCGCTCCACAGAGCTATGGAAAAGTGCAGGAGTCCTGGG TGGGGAGCCTCGGTGTGAGACGCTGGGGAAGCAGCACAGCAGCTCAGACGTCAGAGGTGGGGAGGGGCTG TTCCAGATCTAGGGCACGTGGAGGTCTGGAGCCGCACCGGGTGGGTGGCAAGGAGGCCAAGGAGGCACCA GATTCTGTCCATAAGCAGCAAAGGGGCAGGGGATGGTTTTAGGCAGGAGAGGGACTTGTGTTCTAGAAAG ATCATCTGACCCCTGAGCAAGGACTGGGCCAGTGGGAGACACTGGTATTGCCACCCGGGGGGAGAGCCAT TGAGGCTGGCCAGCAGCGGGGAGGGGAGGAGGGAAAGTGGAGGGACAGCACGCCTGCAATGCCCGGGAGG GGTTCTGCGGCCAGAAAGCATCCACGCCAAGCTGCTGTCAGGATGGTGAGGAGAGGTGGGGGCAGGGGCC TGGCACTCTCAGCCACCCCACCCACAGTGCCCTCCTCTTGGGCCCGCTCCTACTCAGTCTGCAAAGCCCA TTTCAGCTCAGAATGGAGGCACTTGGTGACCGATTGGCTGTGGGGGATGAGCGGGGTCAGGAATGTCTGG TGGGTGAGCATCACCTGGACAGCCAACCTAGTGGGAGGGAGAGCAGGGTTTCCCACGCTGATGGAAGAGA TGATTACATTTTGTAAAATGCAGAAATGCAAATTATACAGACATCTGTAGAATGAATAGTAGCTTCCCTT AATCCTGTCTTCCCAAGACAATATCTTAACGGTCATGTGTTTTGGAATGCGTTAACCTCTGTGTGCTAGC TTTCTATCTGTACAGTGGCAATACGGAGGCAACCGCAGGGGTGTGAAGGCATGTGGAATGCACACATGCG TAGGGCTGTGCTTCACATGGACAGTGCTCGGTGCACGCTTGCTGCTGTTGCAGCAGGAGGTCTTGGGAAA GGAGAATTTGGAGAATTTGCCATCGGTGTATGGATGCTGTTTATCATTACTGTGTGGGTGCCTCCTTCTC CACATTCTCTCCAGCGCTGGGAATTCTCATTCTTTGTGGTACTTGCTCCTCTGGCGGGTGCACAGTTGTG AGCTCCGTGCTTCCAGTCATCCTACCCAGTGTTGGATGTGGGCTGGGCTCGAGGTCTGGGGTCCTCCAGG ACTGGAGCCCAGGAGAGCTGTCAGGGAGGGTGAGAGCACAGAGTGGGGTTGAAGCCCCCCGGTGTGCCAC CATCGAGAGAGAGAGTACATCCAGCGAGCAGGACAGGGCCCGAGGCCGGCTGGGGACCTGGGCCTGCTTC CACGGCCTCATCACCTTTACCATGCTCCATCTGCTCCATCTACTTGAGGGCCCAAAGTCACCGGCACTCT GGCCTGTGTGCCCGCCTCCTGGGCCAGCAAGCTCCTAATCAGTCTACAATGCCCCTTTCAGCTCACATGA ATCCTCTCCCACCAGCGAGGCCCCCATGCTCTGACGACAACACAGGGTCACAGTGATACAGCAGCTGTAG CAAACCAAGCATTCAGGAGGCAGGTGAGAGCAGAGGGATCCGTGTGCATGAGCCAGAGACAGCTTATTCT TTTTTTTTTTTTTTTCACACAGAGTCTCACTCTGTCGCCCAAGCTGGAGTGCAGTGGCGCGATCTCGGCC CACTGCAAGCTCTGCCTCTCAGGTTCACGCCATTCTCCTGCCTCAGCCTCTCGAGTAGCTGGGACTGCAG GCGCCCGCCACCACACTGGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGA TGGTCTCAATCTCTTGACCTCCTGATCCGCCCACCTTGGCCTCCCAAAGTGCTGTGATTACAGGCGTGAG CCACTGTGCCCAGCCGACAGTTTATTCTTAACCATGTTGTTTGTGGTCTGTAGTTCCCAGTCATCCTAGG GCCAATCCACATCTCACAAGTGGGAAGACTGGGGCTTGGAGAGAGGAAGTGATTTGCCCAAGACCATACA GCAAAGAGCGGCAGTGCGGGGTGCCCAGCCGGGCATGCGGGCTCAGCTCTCTCAGACCTGCAGGATGTGC AGTGAGGACCGACAGCCCCTTAAGCTCTGAAGGCACAGGGGCTGCTGGCCAGGTTAGCAGGGGCCACCAG ACAGGACGCTCCTGCTGCCTCCCCCCAGGTCCCTGCAGAGGCCTGGCCCCAGGAGTGAAGAGAGGGTGCA GGTGACCCCCTCTGCCCAACCCCAGCTCAGCCAGCAGCTCCGTTGCTCCCCGCCAGCTCCCTCCAGTCTG CAGCCTGGCTTCTGGCTGCCTTTGTCCTCCTGGGCTCAGCTGCCCAGAAAGTGTGTGTCCAGCTGGCAGG CCTGCCACACAGTCCCCGTCTTCCCAAGCACCCCAGGGAGAGGGAGAAGTAGGGCCAGGCCCAGGGTGGC CACCGCAGGGCCATGCTCTCTGCCAATGTGGAGGGGCCCCAAGCTGATGGATAATCCCAGTGCCATCCCT GTGCCGGCTGTGTTGGGCCTGGGGACAGAGCCATGGGCTGATGACACCCCGGCCCAGGAGCCGCTTGATG ACTCGGACCCTCCACGTGCTGTGGGTCAAGGCCAGAGTGGGGATGACATGCTCAGCTGGGGGCAGCAGTT TGCCGGGCACAGAGGACGAGGGAGGACAGAGGACACAGCCCAACCGGGCAGGGAGGAGCCTGCTGGAGAG CAGGGGCCTGGGAGGCTGGTGCTCAGGGTGATGGTTGAGAGAGATGGCAAGGCGAGGGCAGGGCTGCGAG GATGCAGCTAGTTCTACCCTCAATCTCTCATGCCGGCCCCTTCACCTCTGCACCAGGACCTGGACCCAGC CATGCCCTGTGGACTCAGCCATCATTCGGAGAGCAGCTCCCAGAAACCAGCTAAGGCCAGCGCTCACCCA CACTGCCCCGTAGAGAGGGCCGGGACCCTGTCCCACCAGGGTATGGCACAGCCAGCCCATCTCAGTCCCA TCCTGGTGGGCCCAGAGAGGATTTGATGAGAAAATATGGGTTCTGTACAGAACAAGGGACGCAGGACACG CAGGTGTGGAGCCGAGGGAGGGGCCGACTCCCACATCATGGGAGGAAAGCAAGGCTGGCTCTCCCAGCAG CTCTCACTGGGCTGGGCTGGGTTTTCCCTCCGTTTTCAGGAAAGAAGCTTTTGAAAAAAACGGCATCATT AGCTTAAAGGGCTTTGCCCTCAGCCAACTAGGGCATGAAGCCAGATGGAGGCCAGGCCCCAAGGAGGGGT GTGGTGGAGGCCACTGGGGCACAGGGCCCAGGCAGCCATGTGCCTCCTACGTGGGCCTTCCTGCCTGCAG GGGTCTCTGAGGCTTCATGCTAGGGGCTAGGAGGAAGGCCGGGCTGGGGTCTGGCCTGAGCCTCTGCCCC CGGCCTTTGGAGGGGAGCCTGGTCCTGGGGCAGGGACCGACCTGGACTCAGCCAGACTGGGCTCCCACGT GGCCACCTGCTGCTGTGAGGCCTGGCGCCTCAGTTTCCTCACTCGCTGACCTGGCTGTTGAGCCCTCCCT CCCAGGCTGCTGTGAGGATCAAATGAGGCAGTCGCAGCCGGCCGGCTGCCCCCCACCTCGCTCGCTGCTA GTGCCTAACCCATGGGACGTTCCCCCACCCTGCCTGGCCCTCATGGAGGGGTGCCAGCACTGCCCAGGGG AGGTGCAGGACCCTCCTGTGCTGCTCCCACGCCCGCCACGCCTGTGGCTGACGCCAAGGCCCCGTGGCCC GAGGACGGAGGGTGTCCTGGGGCTGCTGACAGTACAGAGAAGAGGAGGTATGCATTCTGGCCTTTCTGAC CTCCACCCGGTGCCTGCCCCAACCACGCTGCTGCAGGCTTGGGAGCCAGGGCTTTGCGGGGCCTCAGGGA AGGAAGAAGCCAGTTCCCGGGCCAGGAACAGGAAGGCAGGGGGAGCGCAGCAGAGGCCAGGATGACAGTG CTTCCTGCTGCGGGAAGGGAAGGACAGCAGAGACAGACAACAGCCAGGCAGGAAGGATGCGCCTTCTTCA GGGCTGCAGGTGGGGGCTGGGCAGTCACAGAGCCTCTGGACGTGGCAGGCTGCAGGCCTGAATCTGCCCA GGGAGCCCATCCTATAAAACAGGAAGCATCTTTTCCAGTGGAACAACAGGGTCTGACAAGAGTCTCTGAG GTTTCAGAGGTCTGTTGAGCCATCCATCCATCTACTTTCCATCCATCCAACCATCTAACCATCCACCCAT CCATGCTTCACCCATATGCCCACCTTTCCACCATCCATTCATCCTTCCATCCAGCCATTCGTTCATCCTT CCATCTGCCCGTCCATCCATCCTTCTGTTCAATCTACCCATCCATGCATCCTTCCATCTGTTGATCCATC TTTTTATCCACTCATCCATCCGTCCATCCATCCATCCATCCACCCATCCACTCATCTACCTGTCCATCCA TCCATTCATCTGTCTGTCCATCCATCCACCCATCCATCCTTCTACTCACCCACCCATCCACTCCTCCACC CACCCATGCATCCATCCATCCATTCATCCATCCATCCATCCGTCCACCCATCCACTCATCTACCTGTCCA TCCATCCATTCATCTGTCTGTCCATCCATCCACCCATCCATCCTTCTACTCACCCACCCATCCACTCCTC CACCCACCCATGCATCCATCCATCCATTCATCCATCCATCCATGCGTCCACCTATCCACCTACCTACCCA TCCATCCATCTACCCTTGCACCCATCTACCCACCTACCCACCCACCCACCCATCCATCCATACTTCTTCC ATCCCTCCATTTTTTTCATTCAACGAGTGTTCACTGAGACTTTACTCTGTGCCAGGTGCTGTGGGAAGCA TGGGGTGGGGTAAGAAAGAGCTGTCTTGGTCCTTACCCCATTGAAACTTACTGCCTATTGGAGGACATGG ACAGATATAACTTAAACAAACAAACACATAAATAAATAATTCCAAGTTGGGACAGGAAAGATGCCGTAAG CAGCCAGGAGGCTAGGATGGAGCCATTTTGTAGGGGTGAGGAGGCCGTGTCTAAGCTGAGTCCTTAGCGT GAGAAGTCAGCCTGGGGGCACAGAACAATCTGGAGGCAACAGTGGCTGGAGGACGTGAATGTGAAGGGGA TGAACCACGAGGGTGTGGAGACAGGGACAGGGACCAGGAGTTTGGATTTTCTTGGGAGTGCAGGGGAATC CAGTGCACCGGCGAGATTGAAGCACAAGTGTGATCAGGCCTGTGCTTTTTAAAGTGTCACTCACTGCAGG GAGCGGGGCCCAGAGGCAGGCCTGGAGGACGACAAGAGCGGGCCCCAGAAGCCACTTTGGGGTGCGTGCA GCTGTGCTGGCCCCAGTGAGAGAGCAGGGGCGGGCCCTAAGGTGCATCCAGCCTGACAGGCTTCAGTGGT CTGGCCAACGGATGGGCTGGGAGAGGATCTGGGGAGAGGGAGCTATCGAGGGAGGAGCCTTTGGTGGGGC TGGAGGGGGTGCACGTCTGCAGTTTAGCATCGGAAACGTAGACTGCGGGTTGTCTGTGGGGTGTCCCAAG TCCAGTGGGCAGCTGGATGCTTAAAACTGAAGTTGCAAACAGTAGTCCTGGCTGGAGCTAGAGACCTGGG AGGTGTCTGGACTCCAGAGAGACGGCGGTGGCCAGCACTGTGTGTTGGGCAGAGGGGAGCTGGGGAGAGG TAGGTCACAGATGCTGCCCAGGGGAGAGCATGCGCGGCTCCCTATCCTGTGTGCCCACTAGGTCTGCAGC CTGGAGGTCATAAGAGCCCCGCCCAGTGGCTCTGTGAAGTGAAGGAGCTGCACTCCATTGGTGGATGAGG GGAGACTAGCAGAGGGGACAGTGAACAGCTGTGGCCATGAAGGGGGATAGGAAAAGGGGCAGTGGCTGGA AGAGAGTGTGGAACCAAGTAATTATTTTGTTTTGTTTTTAAGATGGGAGATGGGCCAGGCATGGTGGCCC ACACCTGTAATCCCAGCACTTTGAGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACTAG CCTGACCAACATGGAGAAGCCCCGTCTACTAAAGATACAAAATTAGCTGGGCGTGATGGCGCATGCCTGT AATCCCAGCTACCCAGGAGGTTGAGGCAGGAGAATCACTTGAACCCGGAAGGTGGACGTTGCAGTGAGCC GAGATCACGCCACTGCACTGCAGCCTGGGCGACGAGCTAAACTCCATCTCAAAACAAACAAACAAACAAA AACGATGGGAGATGATTGCATAGCAAAGACTGGTGATTAGAAGAGAAATCCGTGGTGGGGGGACCCTGGG CACGATGGAGGGCCTGGTTTGCAGGCAGGAGGCATGTCAGAGGATTTCTGAGGCCCTGGCTGGCAGTGTG GGTTTTGGGATGTAGGAAGATGGGGAGTTTTTCTTTTTTCTTTTCTTTTTTTTTTTTTTTTCCTGAGACG GAGTCTCGCTCTGTCCCAGGCTGGAGTGTAGTGGCACGATCTCAGCTCACTGCAACCTCTGCCTCCCAGG TTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCACCACCGTGCCCGGCTA ACTTTTGTATTTTTAGTAGAGATGGGGTTCACCATGTTGGCCAGGATGGTCCGCCCGCCTCAGCCTCCCA AAGTGCTGGGATTACAGGCATGAGCCACTGTGCCCAGCCAGTGGGGTGTTTCTGTCTCATGATTTCGCCC TGTCGATGCTGAGAGTGAGAGGGGAGGAGCACCCTGAACTGTGTGCACCCAGGAAAATGGGGGGGAGGAG CTCCTGTGGGGGCCTTGTGCTGCCAGTGTTGTGCTGTTTGGAATGCATGCTGTCTCAGGGTTGGGATGCA GGACAAGAGGGGAGGGAGCATGCAGAGAGGCGGCTGCGGACCCCACGCACCAGGACGGGGCAGCACCGGG AGGGCACCAAGGGGTGGGGAGGAAGCAGTGGGGGCTTTGATGAGGCTGAAGGATGTGGATCAAGAACAGG GGAAGCAGGGAGAGAGACGTAGAAGACAGGTGTTCCGGGATGGCGCGGTCTCTGGTGATGACCAGGTCCA GGATGCGCCCACAGAACTGAGTGATTCAGGAGGAGAAGATGTGAGGGCCGTGCAGGGGGGATCTCAGAGG CCAGGGTGCTGGTGAGTCAGCCCTGTGGATGGTGAAGTCATGGAGAAGGGCAGGAGCTGGGGTGGGGGGG ATGGTGAGCCAGGAGCTACGGTCAGCAGAGAATGAGGGGAAGTGACGGGGGGGTGCAGCTGATGACAGCT TTAATGGGGAAGAGGGCGGTGCCGCCAAAGAGCAGGACCCTCAGAGGGACTGCTGTAGGGAGGGCAGGTG GCTGCGAGGAGTTCAGGCATGTGGGGTGGAGGGCAGTAACCGCCCAGGGCCAGTGCCGTGGCCAGAAAGC CAGGCTTCACATAAGGCAGGAAGGGACATTCGGAGTGGACAGTGAGGTCTACAGCAAAGTTTGCCGATCA CACAGGGCACAGTGGAAGGTTGGTAAAGGCAGAGGGGTCACTGGAATAAGTTATGGTATGTCATGAAAAA GGAGACATGTCATGAAAAAGCTTGCGTGGATGGGCAAAAGGGTTGGCAAGCGCGATGGATGGTCCTGCTC AGCAGTGATGCAGGTGCTTCCTTTGGTGGCACGGTGCCTTCAGGAGGAAGCTCCTACAGACTCCTCTCCC CATCCACCCTTCACCCATCCACTTACCTTTCACCTGTCCACCCACTCTTCCACCCATCCATCCATTCATC CTTCCACCCACCCATTCATCCATCCACCCACCCACCCATCCACCCATACTTCCATCCGTCCATCCATCCA TCCACCCACCCACCCACCCATCCACCCATACTCCCATCCATCCATCCACCCACCCATCCACCCATACTTC CATCCATGCATCCATCCACCCACCCACCCACCCATCCACCCATACTTCCATCCATGCATCCATCCATCCA CCCACCCACCCACCCATCCATCCATCCACCCATCCATCCATCCATCCATCCATCCATCCATCCATCCACC CATCCATCCATCCATCCATCCATACATCCATCCATCCATCCATCCATCCATCCATCCATCCATCCATCCA TCCATCCATCCATCCATCCATCCATCCATCCATCCATCCATCCATCCATCCATCCATCCATCCATCCATC CATCCATCCATCCATCCATCCATCCATCCATCCATCCATCCATCCATCCATCACCCTCCCATCCACCCAC ACTTCCATCCCACCACCCACCCACCCATCCACCCATACTTCCATCCATCCATCCACCCACCCTCCCATCC ACCCATACTTCCATCCATCCATCCATCCACCCACCCTCCCATCCACCCATACTTCCATCCATCCATCCAT CCACCCACCCTCCCATCCACCCATACTTCCATCCATCCATGCATCCATCCACCCATCCACCCATACTTCC ATCCATCCATCCACCCACCCACCCATCCACCCATACTTCCATCCATCCATCCACCCACCCACCCATCCAC CCATACTTCCATCCATCCATCCACCCACCCACCCATCCACCCATACTTCCATCCATCCATCCACCCACCC TTCCATCCATCCATGCATCCATCCACCCACCCCTCCACCCATACTTCCATCCATCCATCCATCCACCCAC CCTCCCACCCATACTTCCATCCATCCATCCACCCACCCACCCACCCATCCACCCATCCACCCATACTTCC GTCCATCCATGCATCCATCCTCTCAGCCACCCACCCACCCACCCATCCACCCATACTTCCCTCCATGCAT CCATCCACCCACCCACCCACCCATCCACCCATACTTCCATCCATCCATGCATCCATCCACCCACCCACCC ACCCATCCACCCATACTTCCATCCATCCATGCATCCATCCTCCCACCCACCCACCCACCCATCCACCCAT CTGTCTGTCCACTCATCCGTCCATTTATTCATCTGGCGATTCATCATTCATCCATCCCGTTTCCATCCAT CATCCATCTGACCATTCTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTCGCCCAGGCTGGA GTGCAGTGGTGCGATCTCCACTCACTGCAAGCTCCGCCTCCCGGCTTCACGCCATTCTCCCGCCTCAGCC TCCCAAGTTAGCTGGGCGCCCGCCACCATGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACGGGATTTC ACCGTGTTAGCCAGGATGGTCTCAATCTCCTGACCTTGTGACCCACCCGCCTCAGCCTCCCAAAGTGCTG GGATGACAGGCGTGAGCCACCACGCCTGGCCCATCCATCCTTTCTTATATCCACCCGTTGAATCTCCTTT GCACATCTCTGTCTTGGGCTTAGGAAGATGAATAAAATTGAGCCTCTGTTCAGATGTGATCATAAAACCA CAGTTCAGTCTGGTTGTGTTCTAGCAGAAGCTCGAAGAGGAGGAGGCTGATGCTGCCTGAGTGATGAGGG CGTCTGAACTAGACCCTAAAGAGGGAGGCCCTCGGGAGGGAAAGAAGGAAGGAGGGATGTCCCAGGAAAA AGGACAAGTGTTCAAGACAGGAAAACAACAGGCACTTTGGGAGGATGGGAGGAGGAGGTCCATGCCTCCT AGGAGAGGAAGCTGGAGAGAGGCAGTGGCTGGAGGGCAGAGGCCCAGCCCACCTTGCTTTATCTTGGGAA CAGAGGGGAGCCATCAGAGGAAGCTGGGCTGACAGCTGCCGCACGGTGGAGCTGGAAGGTGTCTGCTGGA TGTGCACTCCTGAGAAGGGGGCCACCAGCTCAACACTCCAGACCTCAGTAGGGGTGGCGGGATGTTCTCT CTCCTGCAGTCATGGGGCTGGGCAGGTGGACACTGGCCTCGAGCCTGGTCTCCTGACCTCCCGCTAGGTC CACTGGGAAGGTAGAGTCTATTCATCCGGACGGGTCTAGCCCCATGCTCATCATCCCTCCTCTGTAGCTC TGAGGACAGACCACCACCCACTCCGGTGCCCACATACATGCCCAGCTGTCTTCCTGGCATGGACTTACTT TCCACTACCTGGAAAAAAAATCCCCCTCCTTCAAAGCCCAGCTCAGAGGGATTCCTTCTTAGCCCCTCAC CACCTGAGGGGAGCCACCTCACTGCAGGGATCCCCCAGCCCCTGGCCCAGACTCCTCTCATGGCAGCCCC AGGGGTGCAAGCTACGGGCTGCCAGTGCCCAGGCCCCGCTGTGGTGCATGTGAGGGCTTGGCACCCCCAA GGGGAAGGGGCTGCAGAGCCCACAACCCCCTTCCACCTCGGGGCCCCAAGGGAGGGCTGGCAAAGCAAAG ACTCGGTGGTAGTCACAGCAGCAGACAGGCGAGGCGCTGCCTTCTGAGGGTGGCTGGAGGGCCTCAGTGT CCCAGTCTGTACAGTGGGTCTGGATGTGTGGTTTAAGGCCCTTCCTGCTCTGGACCCGTAGTGAAGTGGT GCCTGGAAGGGTTTGGCCAGGAGAGAGGGATAGAAGAAGGGAGAGGCCAGAGATCATTGACCGGTGACCA CATTGCCCGTGTGAGGCCGAAATGAGATCTTGGTGTGCAGCAGGTGCCGTCCTGGTGCTGCGTCCCAGGG TGGCTTGGGGTCAAGGATTCCCTGGGCTCCACCCCACCCCCGTTAGCTTCAGGGCGGGACCCTGGGGCCT CAGGGAGCTAGACTACTGCTGCCTCAAACCCCAAGGGACGTGTTGGACGGGAGGGGCCTGGGGGCAGAAG AGTGGGCTGTGCCCCCAGGAGGACAGGGACCTGGGGGAGGGACAGGACGCAGCCCTGGGCCTCTGGCCAT GCAGCCCTCCCTTCCTGTTGTCTCAGGATGGCCCCGGCAGGATGCATCTGCCAGAGTTCCAGACCCAGAC CTCCCCTGGGGCCTGCTCCCACCCACACCGGGATCCCACCACATACACACTCATGTGTGAACACACGCCA GCATGTCCGAGATACACAAACATGCATGCATGTTTGCACATACGCAGGAAGCCACACACACCACTCAGAC ATAGGCACACACAGACTCACACACCCAGGCCTACAGTTACAGATGCACATGGAGGCACGCGTGTGCACAC ACACACACACACACACACACACACACACACACCACCTCACGGGGAGGAGGGTGTGGGGGCAGCAGGGCTG AGTCCTGCAGGACAGAAGGCCCAGCCCGGCCAGCCTACAGTCTCTGGCTGATGGTGGGTTTCAGCCAGAT GAGGCGGGTTTATTTGTATGTCTGAGGAAGAGCCCTGTGAGAAGACCTGGGGGTGTCTAGGGAGGCCTGG GCAGGGAGAGCCCGGAGGAGGCTGGGGCAGCCAGCAGGGTCTGTGAGGGTGCGAGAAGCTGAGGAGCGAA AGGACACCTGTGAGGTGACACCACGTGGCCTGGGAAGGGGCGAGGCCCCTGGCAGAGAGCAGGCAGGAGG GGGCGAGGCCCCTGGCAGAGAGCAGGCAGGAGGGGGCGAGGCCTGCGTGGTTCGGGGAGGACCTGGGATG TGCGGACCCTCTGGGAAGCAGCGGGTGTAGGGCTGCAGTTCAGGAGGGAGGGCCTCAGGCAGCAGCACTG CAGGGGCCGTGATGTGGAGGTGACACACTCCAGCGCCCCTCCCCCGCTCCTTCATGCCAGCCGCTCAGCT CACCGGGGTCAGAGGTTGGGGTTAGGTCCAGGGCCGGTGTGTAGCTGAGGATGGGGGCTGTGGGGCAAGG CAGGGTGCGCCTGTGGGAGAGGTTCGTGGCTGTCTTGGCGCCTGGGAGCTGGTGCTGCTCACGGCGCACA TGGTGAGGCCAGGCCACGCGGTGCTGGCTGAGAACCTGAGCTGCTCCGGCCCTGCAGGGGTCTGCGCTTG CGATGCAGAATGCCCAGCCATGCCCCATCAACGTCGTGCCAAGTCACAGCCCAGCACCACGCTGACCCTG TCTCCCACCCCAGGCCTGGTGAGTGGCTACTCCATGACCCCCCCGACCTTGAACATCACGGAGGAGTCAC ACGTCATCGACACCGGTGACAGCCTGTCCATCTCCTGCAGGTACTGGGTCCCTCTCCCACTGGCAGGCCA GAGAGGCTGCACAAGCCCAAGGCAGGAGGTGGTGGCTGTGGGCCCAGATGGCAGCCCCCTCCCAGGGCAG AGTCAGGGCAGAGTGGCCTCGGGGCCGTGTGGTCTCCCAGGCTGTGGGTGACTTCGGTCCTCCCCAGCCT CAACCACACACCCCCATCAGCATTTCTTTTTTTTTTTCTGAGATGGAGTCTCACTCTGTCACCCAGGCTG GAGTGCAGTGGTGCGATCTCGGCTCACTGCAAGCTCTGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAG CCTCCCAAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCGGCTAATTTTTTGTATTTGTAGTAGAGA CGGGGTTTCACCGTGTTAAGCAGGATGGTCTTGATCTCCTGACCTCGTAACCCACCCACCTCAGCCTCCC AAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCCAGCCCACCCCATCAGCATTTCATATGGGGCCTCA TCACCCTGCACCCCACTCCTGACACCTCACACTGACCCCAGGCCACCTCCCAGGTCATCTGCATCCACTC CCAGCCACCCTGGGAGCACCCACTGGGGCCCCAGAGATGGGTACCTCCCCACCTTCCCAGCTGTGATCCA AGGCCTGTGCTTGGCCACAGGCCAGCCCCGGGAGCCTGGTAGAGGCCCGGGGGTCGGGGAGTGCCCTGCC CTGGGCACGGTCTGTAGTGTGCGCCCAAACCCTGGGCAGTTCCATGCTCTGGGTAAGACAAACCTGGTGA GGCTCGGCCTGAGGGAGGCTTCTCAGGGACAGTCCCCATGGGCTGCCCTGGGGCCCACCTGACCACTCCT GTCCTCTGCCAGGGGACAGCACCCCCTCGAGTGGGCTTGGCCAGGAGCTCAGGAGGCGCCAGCCACCGGA GACAAGGACAGCGAGGACACGGGGGTGGTGCGAGACTGCGAGGGCACAGACGCCAGGCCCTACTGCAAGG TGTTGCTGCTGCACGAGGTACATGCCAACGACACAGGCAGCTACGTCTGCTACTACAAGTACATCAAGGC ACGCATCGAGGGCACCACGGCCGCCAGCTCCTACGTGTTCGTGAGAGGTGAGACTTGGAGGCGGGCCAGG CTGGAGCAGGGTCCCGGGCAGCTGGGGCCCACACCGCCCCCAGCCTGTGGACCCTGGGCTGGCAGGAGGA GAGAACGGGGCCCTACCTGCTCCAGCGGGTGGCTGGTTCAGGACCAGCACCACCCAGCCCCGTGGAGCCC TCCCCCAGCCTGGCCGCCACGTCCCTTCCCCAACAGCTTGCTCCCTCTCCATAGACTTTGAGCAGCCATT CATCAACAAGCCTGACACGCTCTTGGTCAACAGGAAGGACGCCATGTGGGTGCCCTGTCTGGTGTCCATC CCCGGCCTCAATGTCACGCTGCGCTCGGTACGGCCCCACCCCAACCCCAGCATCCGACCCTCCCATCCCA CCCCTGGGAAAGGCGGCCGCCTGTCTGGCCAGGAGCAAGGGGCAGCTGGGCAATGATGGTGGCCTTGTCC CTCCAGCAAAGCTCGGTGCTGTGGCCAGACGGGCAGGAGGTGGTGTGGGATGACCGGCGGGGCATGCTCG TGTCCACGCCACTGCTGCACGATGCCCTGTACCTGCAGTGCGAGACCACCTGGGGAGACCAGGACTTCCT TTCCAACCCCTTCCTGGTGCACATCACAGGTAACAGGGCTGTGCCCCGTTCCCAGTAACGGGGCTGTCAC TGCCTCACTGGCCTCAGTGGGTGTCGTCCTGTGAGGGCGTGGGAGTCACTGTGTGCGTGTCAACAGGCAA CGAGCTCTATGACATCCAGCTGTTGCCCAGGAAGTCGCTGGAGCTGCTGGTAGGGGAGAAGCTGGTCCTG AACTGCACCGTGTGGGCTGAGTTTAACTCAGGTGTCACCTTTGACTGGGACTACCCAGGGAAGCAGGTGA GGTCAGCAGCGCTGCCAGGCTGTCCTGTCCCCAGGAGTCCCTGTGACTGTACAGCACACACTGGGCCTCC GCGTGGAGGATGTGTGGGCCCAGGCCTGCCCCAGGGGCCCCGGTCTGAGTGGCAAGTGTTCCACCCAAAG AAAACTCAGGGCCTGGGTCCAGGGCTTCCGGAGCCACCGCTGGCTGGGCTGGGAGGTGTGCCTTCGGTGG GGTAGCTGTGCAGGAGCCCGCCTGCTGACGCGGGGCTTCCCTGGGTGCGGGCAGGCAGAGCGGGGTAAGT GGGTGCCCGAGCGACGCTCCCAGCAGACCCACACAGAACTCTCCAGCATCCTGACCATCCACAACGTCAG CCAGCACGACCTGGGCTCGTATGTGTGCAAGGCCAACAACGGCATCCAGCGATTTCGGGAGAGCACCGAG GTCATTGTGCATGGTATGGCCTGGGAAACCAGGGTCCTTGTGCCCTGTGGGCCTGGGCCCAGAGCTCACG GTGCCCTTGAGCACTCAGGAGTCCAGCCAGAGGGAAGGGAGGGCCACGAGCAGAGGAGCTGCCCAGCTCC TGCACCGGGCGGCATGGCCAGCCCCAGTCTGCGGATGTCCGGCTGCCGGGGCTGCAGGGGCCGTGGGGGG AGTCCCTGGTCAGTCCACGACGGGTCAGTCCTGGATTTACAGTGACTTCTCCTGTCCGGCAGAAAATCCC TTCATCAGCGTCGAGTGGCTCAAAGGACCCATCCTGGAGGCCACGGCAGGAGACGAGCTGGTGAAGCTGC CCGTGAAGCTGGCAGCGTACCCCCCGCCCGAGTTCCAGTGGTAACAGCCCTGGCTCCCCACCGACCCCGC CGATACCCTTCCAAGTCCAGGGGCAAAACAGACCATAGGGGAAGACGGGCAGCGTCCTCCCCGTCAGGAC CTGCACACGGAGACCAGGCATGGCGGGGGCCTCTCTCAGGAGACCCCCCAAGGAACCCGCCCATAATGTG ATATTTCAGATGGAAGGTCTGTCTGTTCCTGCCACACTGTGAAAGGTTTCAGTACCAGCCTTCTGTTACA TGTGGGTGTGGTGGGCACAGCGAGGGGCTTTTCCTAACTGCCTCCTGACCGCTGGGCCCCTCTCTGCCCT GCAGAATCTCCAGGGCCTGCCCTGCAGCAATGGCTTAGCGTTCCCTATGCCTCCTTTTGCGAGGCTGCCT CTCCCAGGACCCTTCTGTCCAGAAATTTGGAGATGCCACAGGGAATTGACAGATTGCCTGGGCTGGGCCT GTGCTGCACGGCAGCGAGCGAGAGAGCTTCCAGGAGGCCGACAAGCTGCTGGAGTCCCCGCAGATCCCCG ATCTGCAAGCGTGTGCTGCGGCCCAGAGAAGGGAGGCCTCAGGGGTGGCCCTGTCTCCGCTGGCTACTCC CTGCAGGCTCTGGGGGGGCATGGCACCCCTCACAAACACGTCCTCAGGCCGTCTGAGTCATCCACATGGC TCACCCACAGTCAGTCACACTTTGAGTCCCCATTGCATAGACGAGGAAGCAGAGGCTAGGAAAGGGTATT CCTAACTGATCGCCAATTCCCCAGGAGGGGTCTCTGCACTGAGCTAGCCCAAGAGCCTCCTTCTCTTCAG CCTGGGCACCTCCCTCCTGGCAGGGCAACTTTTCCTGGAGCTGGGCAAGCAGAGGCCCAGGGTTTCCTCA GCCAGGGCCCCTTGCACTGGCTGGGGGCTCGTCTCTCCTGGGATGGAAGGCCCAGGGTGTCCTGGCCCTG AGCCCAGTGTGACCCTCCCACTGAGGACACAGACTTCGGTGTCCATCCAAGGCACCTGGTCAGTGCCAAG GCCCTTGGGGCAGAGTCCTGAGGGCACTGGCAGATCCTGGAGCCTCACTCACGGGTACAGCTCCTGGAGA CCCCTGGGCCCTGTCCCCTGCCCTCCAAGGCCACCATTACTGAGCCTGCTCTGGGCAGGTGGCAGCTCTG TTGCGTCCAGGGTCTACCCAGTCCTCAGGCAGCTGCCTCTCAGAACAGCTTTCCACTGGCTCACTCCTGC CACATCTGGCTCTCTTCCTATGGCAGCCACCCACCCTTCCTGTGGTGCCCACCCTTCCTATGGCACCAGC ACATGACGATGGCGAGCACTGACTGGGTGGACGGTCTAGCAAACACACAGATGGGCTGGTCCTTGGCTTC CGAAGCACCCGCAGTGTGTCCAGCACGCTGCTGTCACTGTCCGGGTTAAACCTCACGACAGCTGCAAGGT GCATGTCATCTCCATTGAGGCAATGAAGGAGTCTCAGATCCAGCAAGTGGCAGACTCAGGACCAGAGCCA TGCAGACAGCACCACCTCAGTTCCGCCCCTGCCCTGCCCTGCCTCACTCTGCGACCCCAGGCCAGGCACT CCCCCCGGGCCCCTGCTGTGATGTCCAAGTTGAGAATGGGCCCCTGCCTCCCCTTCTCTGTTGGTCTCTG CCCGAGGGCTGTGCCTCTCCCAGGACACAGTGGTGTATCTCTGGCCTGCCACACCCAGCACCAGGGGCAG GCACCTGTCCAAAGGAGGAGCATCTCCATACAGAGTCCAGGCCACAGAGACAGGTGCCTGCAGGGGCCCC AGCACACCCTCTGGGGCTGAGGCATCTGCTTCCTCACGTGTGCAGCAGACATGTAGGCATCTGGGCGCAA CTCTGCAGGAGGCAGCACTGCCCTCGTGGGGCTCCCAGCCCAGGGGGACGATGGGCAAACAGACACAGCA AGGCAGGGGCAGGCCACAGCATAGGACAGTCAGGAAGGCTGCACGCCCCCACCCAAATGAAGGAGGCAGG GAACCCTGCAGATTCCTGGCTACAGAAATGAGTGTCCCAGCGAGGCAGGCAGTGAGAGCCAGGCCTGGGG GCGGGGTGTGGGCAGCAAGAAGCCCACATGTCTGCAGGGGCCACGCACATGTCAAGGAGCTAGACTGTGC TCGCAGGGACTGCACCTCCACTCCTTCAGGTGTCTAAGAAAGAGGACGGGGTCTCCAGGCCGTGCCCAGC TGGGTGGAGGAACCAGGTGTGTGGGACCCTCCTGGGCTGGGCTGGGCAAGCCTGGCTGAAGAAGGCTGTC TGCAGCCACAGGCAGGGAGAGAAGGCGGCTGCCCCAGCAGTGACATGGTCATCTCACTACTTGTGGAGAG TTCAGAGGCTTTGGGGCAAGGCAGGAGGTGCTACTGCAGACCTCAGTGACCAATGCCCGAGCCGGCCGCC TGACACGGTTGTCACACCTGGCAGATACGGCCTGGAGACCATCTCCAGGGACTTAGACCATCCCCTCGCA GACCAGTGTTCCCCGTCCTACCCTGCACTCCTGCCAGCCCCTCCCTCCTCCCAACTGTATTTGGGGTGGG GGTGCCAGCATGAGGTTGGGGCTGTGGTGGGATCTGTATGGGCCCTGACCTCCCTTCCCTGGCCAGGTAC AAGGATGGAAAGGCACTGTCCGGGCGCCACAGTCCACATGCCCTGGTGCTCAAGGAGGTGACAGAGGCCA GCACAGGCACCTACACCCTCGCCCTGTGGAACTCCGCTGCTGGCCTGAGGCGCAACATCAGCCTGGAGCT GGTGGTGAATGGTAGGTCAGGGACGGGAGAGCGCACGGGTGGGCGGCCTGGCATTGGAGGCCAGCTGACC GGCCATCTGTGTGCCCACAGTGCCCCCCCAGATACATGAGAAGGAGGCCTCCTCCCCCAGCATCTACTCG CGTCACAGCCGCCAGGCCCTCACCTGCACGGCCTACGGGGTGCCCCTGCCTCTCAGCATCCAGTGGCACT GGCGGCCCTGGACACCCTGCAAGATGTTTGCCCAGCGTAGTCTGTGAGTACAGCTCCAGCCTCAGGTCCC CTGCACAGCCACAGCCCCCAGCCTCAGCCATGAGGAACCTCCTTTACAGCACCCCTCACTGCCCAGGTCT TCCCTGTACCCCTTCTCAGGGCCCTGCTCTGAACTTGAACCCTACCTTCAGCTATAGCCAATCCCTGGCC TCACCTCGCCTGAGTGAGGCTCAGAGCCTCCCTTGCACCCATCCTCCATCAGCTGGCCAAGCTGGACACA GGATGGGTCTGGCCCCTGCCCACCTCCCTCAAGAGCGAAGACCTCTGGACACGTAATTGCATCATCTGGA GGGAGAAGGAAGCACATGTCTCTGAGCACCCAGCAGGACACCTCCAGCGGGGTGGGGACCTGGGGGGGTG TCACCTGAGCCCCTGGGATGGTTGCACTGAGCCCCACGGCACACCATGTGTGCTCATGGGCCTCAGCTCA TCTGTGCACCACTCACATCCCCTTAGAGACAGGGAAATAGGGTCAGAGAAGGGAGGCGGCTTTCCCAGGG GCACAGCTGTAAGCAACAGGACCCAGCCACCTGCTGAGCCGTGCTCCCCTCCACTGAGCGGGATGCCAGC AGGACATTTAGACAAGCAGGGGGTGAGAGGAGGACGCCCAGGTGGGCAGGGCTTGAAGGCACTAGGGAGC CAGTGAAGGGTGTTGAGAAGTGGAGACATGGCTCAGGTTTGCCTTTTAGCAAGAGATTCCTAGTATCAAA CTGGGGCGGGATGGGAGCTGGGAACCTACATGGGAGATGAGGGTAGCCCCACTGGCTGTGGCTCTGGTGT GGTCAGTGGGGGAGGCTCAGTAGGGGTGGCATGAGCCGGCCCCAGATGTCCAAGGTTCATAGGTATTCTT CTAGATCGTGCGGCATGCAGCTCACTGCCAGCACCTCCAAATGTCCTTCCTTCTGGGTGTGCCACCTGTA TGCTCTGTGCCAAGTGATGGAGCCCTTCGGGGGGTCCCTGCTCGGCTCCTCCACAGGGGCAGATATGAGC CTCCCTTGGGGCCCTGAGACTACCCCCCCAATCCTGGCAGGAGGCCAAGCTTGCTGGGGATGCACACCCT GCCCAGAGGGAGGCCGCAGCTCCTAAAGCAGGAGAGAGGGAGAGGCTGGGCAGAGATGCCTCCGGGGGCA GCATGGGACTGTGCTGGGCCTGCAGCCATGTGGGCAGATCCCAGGTGGCCTCTGCAGGAAGGGGCACAGA GAAGCGGGACAGAGTGCACATGTGCCTGAGGGACAGTGGGCACAGGAAGCTGGTGTTGGCAGCCTGTGTA GGATGGGTTGCCGGGTCCTGAGCCTGAAGGGTGGGAGACAGAGCTCCAGAAACAGGCCGGGCTCGGTGGC TCACGCCTGTAATCCCAGCGCTTTGGGAGGCCAAGGCAGACCAATCACCTGAGGTCAGGAGTTCGAGACC AGCTGACCAACATGGAGAAACCCCGACTCTACTGAAAATACAAAAAAAATAGCCAGGCGTGGTGGCACAT GCCTATAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTTTCGG TGAGCTGAGATTGTGCCATTGCAGTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCAAAAAAAAAAAA AAAACACCAAAGTCCCCTTCCCATCTCCCTCACCCAGGCCCGAGGGCCAGCCTCGCCCACGACCCCATAT GAGAAGGTGACTGGATATGACAAGGGCTTGACCCCGCCCCCCATGTGGGCCCTTCCTGCCTGTATCCCTG ACCTGCCCTTGCCTCTTCTGGTCCTGGCAGCCGGCGGCGGCAGCAGCAAGACCTCATGCCACAGTGCCGT GACTGGAGGGCGGTGACCACGCAGGATGCCGTGAACCCCATCGAGAGCCTGGACACCTGGACCGAGTTTG TGGAGGGAAAGAATAAGGTACAGGCCAGCCGCGCTGCTGAGTGCCCAGGGAGAAGGAGAAGGGAGGAGAG AGAGGCCATTACTGCCATGTGGTTTCCACCTGGCTTCCAGAGTGCTGGGCAGAGCAGCCGAGAGCGGGTG ACCTTCCTGCAGTCTGTAGGCCTCGGCCACCCTGCCTGCAGAAAGGTCAGAGGGCCAGTCTCCGGCTTTG TGATGGAGGGCGGACCTCTGGCGGCTTCCCAGACAAGGAAGCTGACATGCAAGGCCACCTGGCCAGGCCA TGAGCCCCTGAGGCCCACAGGCCCCAGGACCAGGAGGGGACAGGGCTGGAGGCTGACCAGGTCTGCACAG AGGGCTGCTGAGCCGCTGGCGCAGCCTGGGGGCAACGCCGAGAAGGGGGTACTGAACAAAGGCACCTACT TCCTCCAGTCACTTCCTGTTTTCCTACACACCTCCAGAGCCTCTTCCTGTTCCAGTCCTGGACAGGAAGT GCCCAGCTGGGGGTGGGGTGGGGGTGGGGGTCTTTGGATGGTAGGCAGGGCCTGTGGCCCTCTCTCCTCC CCTGTGTCTCAGGCTTCCTACTCCCTGAGGCCTCAGTCCTTCTGGGAGCCATCCCCACCCCTCTCAATAA CCCTGGGCCTCGGGATTGCTGCTGAGGACAGTTCTGGGCTGAGGAGGCCATCTCACGAGGATCTCAGCAA GCAGCGACTGGATTGGGCCTGACCCCATCCAGAAGTGACTGGCTTTTGCTGTGACCCAGGCTGAATTCTC ACCCTGGCTTGCACTGACGCTGGTGCCCCCTCAACATAGCCACGGCCAGAGGTCTCTCTGGTCCTGCCAA AGGCTGCCCTCTGACGTCACTGCAGCCTAGGCCAGCAGTCCATACACTGTCCCTTGACTTTTCTGGGCAG CTACCTCTCTCTGCTGCCCAGGGGCCTTCTCTCCTCTGCCTCACTATCCCTGGTCCTGTGAGTTTTGGTC TTCTCCAGCCCAAAGCCTCAGTTTCCCCCATGATTGGGGGGGGTGGTGCACAGCGACCTCCTTGCAGAAA GACAGGGCCCAGGTTGGGAGAACTTGGGCAGGAAATGGATCCTTGTGCCTGTGCTCTCCCAGACTGTGAG CAAGCTGGTGATCCAGAATGCCAACGTGTCTGCCATGTACAAGTGTGTGGTCTCCAACAAGGTGGGCCAG GATGAGCGGCTCATCTACTTCTATGTGACCAGTGAGTGACCAGACCAGGGCGGGGAGGCCTGGGTACAGG GTCAGGAGGGGGCAGGTTTGGGCTCATTGAGTTTCTGGGGTCTTTGGGACACCCAGGAGAGAGATCCAAG GCCTACCGGTTGTAGACAGGAAAAATAGATTTAAGGGTCACCAGCATAGGGCCTGGGTGCTGGCGCACTG GGATGGAATGGCATCCTCTGTCCCCAACCCTGGGGCTCCTCCCTCAAGGATGCCCTTGGCTCACTGCAGC TCCTCCTAGCTATACCCACTCCCACCCTCCCCTTCCCAAGCCCTGAGACCTTGTGACTCGTGTGAATTTT GCTCTGGGGAGAAGCTCTGTGGTTTACTCAGATTTTCAAATGTGGTAGTGACCTCAGGAGAGCGGAGCCC AGGAGCAGACGTCACTGGGTCCCAGAATGTAGATCAGGGCACCAGCAGAGAGATGTAGATCAGGGCACCA GCAGAGAGATGGAGCCCAAAAGAACACCCGGGGGCTGGGGGGCCACAGGAGCCTGACCAGAAGTGACCAG AGAGACAAGAGGAAGTGGGCGCACGGCACTGGGAAAAGCCAGGGAACACGTTATTTCAGGCTGAGCATGG GGTGGGGCATGGCAAGCTTCAAGAGAGAATGAGGACTCAAGTCCCACTGAGGGTGACAAGGAACTCCTGA TGACCTGGGCTTTTGGTGGGGCGGGGGGCAAGCAGTCCAGCTGGGGCCCCTCCAGGAGAGAGGGAGGGAG GGAGGCAGGAGGAGACCCCGGGGCGGCAGGTGGATGGGGGAGCAAACTCCCAGGGCAGTGCCACAGGGCT TCTTCCTCCCTCCACAGCCATCCCCGACGGCTTCACCATCGAATCCAAGCCATCCGAGGAGCTACTAGAG GGCCAGCCGGTGCTCCTGAGCTGCCAAGCCGACAGCTACAAGTACGAGCATCTGCGCTGGTACCGCCTCA ACCTGTCCACGCTGCACGATGCGCACGGGAACCCGCTTCTGCTCGACTGCAAGAACGTGCATCTGTTCGC CACCCCTCTGGCCGCCAGCCTGGAGGAGGTGGCACCTGGGGCGCGCCACGCCACGCTCAGCCTGAGTATC CCCCGCGTCGCGCCCGAGCACGAGGGCCACTATGTGTGCGAAGTGCAAGACCGGCGCAGCCATGACAAGC ACTGCCACAAGAAGTACCTGTCGGTGCAGGGTGAGGCTGGCCGCGGGGAGGGCGGGGACGCGCTCTCTTC TAGCAGTAGCTGCCTCTGCCTTTGCCCCGGCGTGGCTCGCCCCTGGGAGGTCTATTCACAGCCCTGGCCT GCAGGAGCTACCCCTCCTGACTATCCGCCGCCCCCTGCGGAGGCGCGCCGCGCTCCTGCCCGGCGCACAA CCCCTAAGTCCAGCTTCCAGGGATCCTTTTCTACCTCTGCTCCCAGCCCAAAGAGGGTCCTCCTGCTAAG TGCAGCTCCACTTAGCTCCCTCTCGACCCCTGCCCCCAGCCCTGGAAGCCCCTCGGCTCACGCAGAACTT GACCGACCTCCTGGTGAACGTGAGCGACTCGCTGGAGATGCAGTGCTTGGTGGCCGGAGCGCACGCGCCC AGCATCGTGTGGTACAAAGACGAGAGGCTGCTGGAGGAAAAGTCTGGTAGGGAGGGTGGCCCTGGCGAAG GGCAGGTCCGGAGGCCCGCGAGGCCGACGATCCCAAACCCAGGTGGACCCGCACCTCCACCCCACCCCCT GCAGGAGTCGACTTGGCGGACTCCAACCAGAAGCTGAGCATCCAGCGCGTGCGCGAGGAGGATGCGGGAC GCTATCTGTGCAGCGTGTGCAACGCCAAGGGCTGCGTCAACTCCTCCGCCAGCGTGGCCGTGGAAGGTCT GGCCTCAGGCTGCACCCCTCAACTCCCTTCCCGTCCCCAGTTAACGCTTTCTTGTGGCCACCTTGGGCAA GTCGTGGCCACCAGAAGGGGTGCTGCCTGCAGGTGCACGCTCTTACACACACACACACACACGCCGGCCC CTTTCTGCCCACGCAGGCTCCGAGGATAAGGGCAGCATGGAGATCGTGATCCTTGTCGGTACCGGCGTCA TCGCTGTCTTCTTCTGGGTCCTCCTCCTCCTCATCTTCTGTAACATGAGGAGGGTGAGTGTCCCTCCCCG CTCCTGATGGAGTCTCTCTCAGGCCTTCCCCACCCTGGCCGCCCCTAAGATAAAGAATAAGGTGCCCGCC CTAGTTCACCTGGCAGCCTTGTTTCCTGGGAAGCCTCCCTGCCCTTCACGCTGGGCTCCAACCCCGCAGA GGTTGTCTGTCTTTTTTTCTGTCCCCTCCTTGACTGAGAACCCCGCAGGAAGTGCCATCTGTCCTGGGCA AAGTTCTGCCCAAGCCACAGTGGTATGGCCAAATCAGTGAGCTGCCCCACTCCTCCCTGTCCCCTCCCCG CAGCCGGCCCACGCAGACATCAAGACGGGCTACCTGTCCATCATCATGGACCCCGGGGAGGTGCCTCTGG AGGAGCAATGCGAATACCTGTCCTACGATGCCAGCCAGTGGGAATTCCCCCGAGAGCGGCTGCACCTGGG TGAGGCCAGCACCAGCCTGCCCAACCCACACCTCCTGCCCGACCCACCTGCTGCAGGCCGGAGTGCCTGA ATCCCTCCATTTTCAAAACTTGCACCAGGAAGTTCCGCCTGGCCTGACCTGTCCCTGTGGGCGTGGGTAC CTAGAACCTCAGCCAGGGTCCCCAGTTCCCAGGCTCCCTGAGGTCACCTGCTGCCACCCTGAGCAGGGTG TATCTGTCACACCTACCCGGGAGGATGCGCGGCCTCCTGTCCACCTCTCCTTGTCTTCCCGCTGTGGCTC CCCACGCTCCTCCTGCTGCCAGGCCTGTCCTCCTGGACCTCTGCACGGGGCTCCCCCGCCGCCCACCTGT CTCCACGCTCACCCCGTACAGCTCACCTGCAACTGGCCCCCTGCCCCGACAGGGAGAGTGCTCGGCTACG GCGCCTTCGGGAAGGTGGTGGAAGCCTCCGCTTTCGGCATCCACAAGGGCAGCAGCTGTGACACCGTGGC CGTGAAAATGCTGAAAGGTGTGGGGTCAGCGGGCGGAAGGGGCAGCCTAGCTGGTGAGGAGCAGCAGCTC GGGGTGGGCCGGTGGGACGGCAACTCGGGAAGGGAGACTGAGGCTGGAAGCCAGTCTCATCCGAGATTCT ACAGGGAGGCTGCGGGCTTCAGAGCCGAGGGACCACCCGAACCCCCTCTGCCTCAGTGGGGCCGGCAGGA TGTCCTGGGGGCCCTTAGTAACCCTCCCCCTCCCAAAAGCGCCGGGTGGCGGGGAACGGGGACCTGCCAG GGTCGGGGCCGGTGTGAGGCCCGTGTCCCCTCCAGAGGGCGCCACGGCCAGCGAGCACCGCGCGCTGATG TCGGAGCTCAAGATCCTCATTCACATCGGCAACCACCTCAACGTGGTCAACCTCCTCGGGGCGTGCACCA AGCCGCAGGGTACGGAGCGGGCGGCCCGCTGGGACGGCGAGACCCCGGGCGCGGGGCGCCGCGGGCGGGA GGGGGCGCGGGTGCAAACGCGGAGCGCGCCCGCAGCGCGCCCCGGGTTCCGAACGCACGGCCGCCGCCCG GTCCCGCCGCAGGCCCCCTCATGGTGATCGTGGAGTTCTGCAAGTACGGCAACCTCTCCAACTTCCTGCG CGCCAAGCGGGACGCCTTCAGCCCCTGCGCGGTGAGCGGGCGGCCTGCGGGGCGCCGCGGGCGGCGGGGG AATGGAGGCGCCTCTGCGGCGGACGACTGGGCGCCCTCGAGCCAGCTTCGTGCATCCGCAGGAGAAGTCT CCCGAGCAGCGCGGACGCTTCCGCGCCATGGTGGAGCTCGCCAGGCTGGATCGGAGGCGGCCGGGGAGCA GCGACAGGGTCCTCTTCGCGCGGTTCTCGAAGACCGAGGGCGGAGCGAGGCGGGCTTCTCCAGACCAAGA AGGTGAGAGCCTGGCCTCTTCCCTTTTCCTAGTGCCTGACGGGCCCGGTTATATCCCGTGATCAGGCACC CCAGCCTGGGGTCCTCAGCGGGGGCTTTCATGGGAGAGTGTGGAATGGGCTCTGCCTTAGGAAGGGAAGA CACCTCGGGGACAATTTTCACACAGATGTTTTACGATTGACTGGGTCATCAGAGGCTGAATAGGAAATTG CCCTGCAGACAAGGCAGGCAGTGGAGGGCCAAGCAGCAGGTGCCCGGCCCCCACAGAGCAACAGTATTTA CTGCTCTGGGAGTAGGACGTGGGTGTCCCAGAGGCTGAGGGGCAGGAGAGGGTCCTCTGGAGTAGGACGT GGGTGTCCCAGAGGCTGAGGAGCAGGAGAGGGTGCTCTGGAGTAGGATGTGGGTGTCCCAGAGGCTGAGG GGCAGGAGAGGGTGCTCTGGGAGTAGGACGTGGGTGTCCCAGAGGCTGAGGGGCAGGAGAGGGTGCTCTG GAGTAGGACGTGGGTGTCCCAGAGGCTGAGGGGCAGGAGAGGGTGCTCTGGGAGTAGGACGTGGGTGTCC CAGAGGCTGAGGGGCAGGAGAGGGTGCTCTGGAATAGGATGTGGGTGTCCCAGAGGCTGAGGGGCAGGAG AGGGTGCTCTGGAATAGGATGTGGGTGTCCCAGAGGCTGAGGGGCAGGAGAGGGTGCTCTGGGAGTAGGA CGTGGGTGTCCCAGAGGCTGAGGGGCAGGAGAGGGTGCTCTGGAGTAGGATGTGGGTGTCCCAGAGGCTG AGTGGCAGGAGAGGGTACTCTGGAATAGGATGTGGGTGTCCCAGAGGCTGAGGGGCAGGAGAGGGTGCTC TGGGAGTAGGACGTGGGTGTCCCAGAGGCTGAGTGGCAGGAGAGGGTGCTCTGGAATAGGACGTGGGTGT CCCAGAGGTTGAGGGGCAGGAGAGGGTGCTCTGGGAGTAGGACGTGGGTGTCCCAGAGGCTGAGGGGCAG GAGAGGGTGCTCTGGAATAGGACGTGGGTGTACCAGAGGCTGAGGGGCAGGAGAGGGTGCTCTGGAGTAG GACGTGGGTGTCCCAGAGGCTGAGGGGCAGGAGAGGGTGCTCTGGAGTAGGACGTGGGTGTCCCAGAGGC TGAGGGGCAGGAGAGGGTGCTCTGGAATAGGACGTGGGTGTCCCAGAGGCTGAGGGGCAGGAGAGGGTGC TCTGGAGTAGGACGTGGGTGTCCCAGAGGCTGAGGGGCAGGAGAGGGTGCTCTGGAGTAGGACGTGGGTG TCCCAGAGGCTGAGGGGCAGGAGAGGGTGCTCTGGAGTAGGACGTGGGTGTCCCAGAGGCTGAGGGGCAG GAGAGGGTGCTCTGGAGTAGGATGTGGGTGTCCCAGAGGCTGAGGGGCAGGAGAGGGTGCTCTGGAGTAG GACGTGGGTGTCCCAGAGTCTGAGGGGCAGGAGAGGGTGCTCTGGAGTAGGACGTGGGTGTCCCAGAGTC TGAGGGGCAGGAGAGGGTGCTCTGGAGTAGGACGTGTGTGTCCCAGAGGCTGAGGGGCAGGAGAGGGTGC TCTGGAGTAGGACGTGGGTGTCCCAGAGGCTGAGGGGCAGGAGAGGGTGCTCTGGAGTAGGATGTGGGTG TCCCAGAGGCTGAGGGGCAGGAGAGGGTGCTCTGGAGTAGGATGTGGGTGTCCCAGAGTCTGAGGGGCAG GAGAGGGGCTGACATGCTTGTTAGCTGTTCCCTGGGGCTGGGTAGATGGAGGCCGCGGAGGAGGCGCCTC CTGAGCCCACCTGGCTCCACTGTGTAGCTGAGGACCTGTGGCTGAGCCCGCTGACCATGGAAGATCTTGT CTGCTACAGCTTCCAGGTGGCCAGAGGGATGGAGTTCCTGGCTTCCCGAAAGGTGAGCTTCCCCCGAAGG CCCTTCAGACGGGAAAAGGGTGCATCCCCACCAGTCGCCAAGAAGTGCTTGGTACTGGCCTCACCCTGCA ATGGCTCTGTGGTCCATCAGTGTCTCTCCCACTTTGCAGAGGAGGAAACTCTGCCCAAAGCATGGAGTTG ACCTCCCAAGGTCTCTTGGCTGGTCAGCAGCAGAGTCTGTTTGACTCCACAACTTTCTCTGCTGTCCCCA CAATTCCACAAGCTCTCTCCATGATGAGTCCTGGAGATGGATGGGAATCCTTCCCCAAAGGAGCACAGTT CAGGCAGGGCATCCCCATGGTCCCCACTGCTTGGGCACCCTGGAGTTTCGGGTGTGGGTATTACCCCAGG GGCCTGCACTGACAGCCCCCCTGCCGCCTCCCCGCACCCCAGTGCATCCACAGAGACCTGGCTGCTCGGA ACATTCTGCTGTCGGAAAGCGACGTGGTGAAGATCTGTGACTTTGGCCTTGCCCGGGACATCTACAAAGA CCCCGACTACGTCCGCAAGGGCAGTGTGAGTGCAGGCCATTGAGGAGAGGGAACGTGGGGCGGAACAGGT GAAGGGGTGGGACCACAGACTGCCTGTCCAGGAGAGGGAGGGCTGGCACAGGGTGAGGTGAGCTCCTTGG TTGGCCAGCCATGTGCCCAGCTGCTGGTGGACCTCCTGCCCCCAGGGGACCCTACTGACCACCCCCCACC TTAGGCATCTTGGGGCAAGGAAGTGGAGAAGGGAGGTGACCGGCAGGCCCAGTGCTCCGAAAGGAAGTGG AGAAGGGAGGTGACCGGCAGGCCCAGTGCTCCGAAAGGAAGTGGAGAAGGGAGGTGACCGGCAGGCCCAG TGCTCCGAAAGGAAGTGGAGAAGGGAGGTGACCGGCAGGCCCAGTGCTCCGAAAGGAAGTGGAGAAGGGA GGTGACCGGCGGGGCCCAGTGCTCCGAAAGGAAGTGGAGAAGGGAGGTGACCGGCGGGGCCCAGTGCTCC GAAAGGAAGTGGAGAAGGGAGGTGACCGGCAGGCCCAGTGCTCCGAAAGGAAGTGGAGAAGGGAGGTGAC CGGCAGGCCCAGTGCTCCGAAAGGAAGTGGAGAAGGGAGGTGACCGGCGGGGCCCAGTGCTCCGAAAGGA AGTGGAGAAGGGAGGTGACCGGCGGGCCCAGTGCTCCGAAAGGAAGTGGATTTCGGAAGTGGAGAAGGGA GGTGACCGGCAGGCCCAGTGCTCCGAAAGGAAGTGGAGAAGGGAGGTGACCGGCGGGCCCAGTGCTCCGA AAGGAAGTGGAGAAGGGAGGTGACCAGCGGGACCCAGTGCTCCGAAAGGAAGTGGAGAAGGGAGGTGACC GGCGGGCCCAGTGCTCCGAAAGGAAGTGGAGAAGGGAGGTGACCGGCGGGGCCCCAGTGCTCCGAAAGAC AGTGGATTTCGGAAGTGGAGAAGGGAGGTGACCGGCGGGCCCAGTGCTCCGAAAGGAAGTGGAGAAGGGA GGTGACCAGCGGGACCCAGTGCTCCGAAAGGAAGTGGATTTCGGAAGTGGAGAAGGGAGGTGACCAGCGG GGCCCAGTGCTCCGAAAGGAAGTGGAGAAGGGAGGTGACCGGCGGGGCCCAGTGCTCCGAAAGGAAGTGG ATTTCGGAAGTGGAGATGGGAGTTGACCAGCGGGGCCCAGTGCTCCAAAAGGAAGTGGAGAAGGGAGGTG ACCAGCGGGGCCCAGTGCTCCGAAAGGAAGTGGAGAAGGGAGGTGACCAGCGGGGCCGCAGTGCTCCGAT TGGAGCTTGTTCTGATTGGAGCTTGTCTTTGCCCCGCGCCTTGCTCCGTGCGGTGGGTCCTGACTCCCAG GGCCTGCCCTATGGAGCCTGAGAGTGCAAAGCATTCTGTGGTGTCTGTCCTGGAGATGGACCCGCTTGGT GCAGTATGTGGAACTCAGGAGGCGGAGTGTCTTGTGAATGGAGCTCAGGCAGGGCAGCAGGTGCCTGGAT GAGCCTCCAAGGCGGGTCAGGGTTCCGCGCCTGGGGGAGAAAGGGTGTCAGAGGGGGAGGAGCAGGATGG GCCCAGGGCCTGGTCTTGATGAGCCATCCAGCCCAGCATGGCCGCTGGTTGGAGGGAAGTGTCAGGTTGT CTGCAGTTACAAAAACCTCCCTTATGCCGTAAGCTGGGAAGAGAGGGGAGTGGGGGTGCTGGGGTGGAGG TAGAGGCCAGTCCAGAAGGGCCCTGGCCCTCAGGGCTCCCAGGTAGAGACCATGAGAGGGAGAGAGACAG CCGGCGGCGGAGATGCCTCAGGAGCCCAGGAGGAGGGTGTCAGGAGTGATGGCCCGGCTTCCAGGGTGGG GACAGTGAGTGGACAGAGCGTGCTTGTCAGGGGAGATGGTGAGAGTGTGCAGGGGTGCGTTTCATCAGGA GGCTGCGCTGGAGGTCTAGGGCTGGAGGAAGGTGTACAGTCTACCCCGATACCCCTCCCCTGAGAGCTGG GAGGGAGAGGGGCCCAGACAGACCCAGGAGAACAGCAGCAGGGAGATACCTTCAACCCAGGCAGAGGACC CTGTTAGGGGGTGCCAGAGCATCTGGCCTCAGCCCTCTCTTCCCATCCACCACGGGACACGCTTCCCTCC GTCTCCCCATCCACCGCAGGACACGCTTCCCTCCGTCTCCCCATCCACCACGGGACACGCTTCCCTCCGT CTCCCCATCCACCACGGGACAAGCTTCCCTCTGTCTCCCCAGGCCCGGCTGCCCCTGAAGTGGATGGCCC CTGAAAGCATCTTCGACAAGGTGTACACCACGCAGAGTGACGTGTGGTCCTTTGGGGTGCTTCTCTGGGA GATCTTCTCTCTGGGTGAGTGCAGGATGGGGTGCCGGTGGGGAGAGGAGGCGAGGTCACTGGCGGCAGGT TACATGACCGCCCCTGCTGGAGTAAGGGACTGGGCACCTGGAGGTGTGTGCCAGGTCGTTCTGAAGCAGG TGGTTTGTGGGCCACCAAGGGCCCCCCACCTCTCCCCAGCCTGGCCCAGCCTCCGAGAGGACTTTGCCTC CAACGTGGGCCACCCTCTGTGGGGTGCACATTGAAGCCTGAGCCAGGACTGAGCCTTTTCACATGGCAGC CCCAGAGGGAGCTCAGTGCCCAGTCAGCAGACGTGCCTACTCCAAGAGCTCCAAGAGCTCCATGTGGGAA CTCAGGCCCCGCTGCGAGCATGATGAAGTCTCCAGGCCAGGGTAGGGCAGTGAACTTGAAAAAGTTAAAA TGTCACCAAGTGGCAACTGATCCACGCTACTGCGGAAACTAAAGGAGCAGGAAGAGTGTAGGAGGCGTGG GAGCTCGGGTAAGCCAGAGGGGCCCAAGGAGGGAGTTCAGCAGTCCAGGACGGGGAGCAGCAGGGGTTGG GAGGAGCAGCAGGGGTTGGGGGGAGCAGCAGGGGTTGGGGGGAGCAGCAGGAGAAGCAGCGAGAAGCAAG AGAGGCTTTGTTGAAACTGCCTGCAGGCGGCTCCCCCGCCGCTGATGATCCAGTAACCATGATGTCTACC GTGTCGCCAGTGGGTGGATGCTCTTGGCACCCCTAGCAAGCAGGCGGCACAGTCCTCTTTTAACCAAATG AACTAGAGCTGGGGAGGGCAGCGACTTGCCCACAGGTCCCAGGTAGAGCACAGTCGGGTGAGCCATCTCC ACCCCACCACGGATGGGGAAAGGGACAGGACGGGGTGACTTGATGGGGAAGGGACAGGATGGGGTGACTT GGGGGGCTGGGCTGAGCCGCAGGAGGCTTGCTCCCCACCCACCTCCCCTTCCTGTTGTCAGGGGCCTCCC CGTACCCTGGGGTGCAGATCAATGAGGAGTTCTGCCAGCGGCTGAGAGACGGCACAAGGATGAGGGCCCC GGAGCTGGCCACTCCCGCCATGTGAGCCTCCCCATGGCCCTGCAGGTTTTGGGGACAGCAAGCGTCGGGG GCGTGGGGGTTGTGTCCATGAGAAGGTGGCATCAGGGAAGCCAGGGCCAGTAGGACAGGCCTGGGCACCA CCCTCAAGATACACGGGTAGTCTGTAGCACAGCTGCACCAGGAGGACACCAGGAGGGAAGGCCGGGCGCT GTCGGAACAGAGCCGAGTGTTCAGGGAAAGCATCACCAGGAGGGGACGCTGGGCTAACACTTGAAGGAGG AACGAGGGTAGCTGGACAAGAGTGGGAGACGTGTCAGGAGGAGGGCAGAGTGGGTGAGAGGGCCCAGGAA GGCTGGGGCACTGAAGGTCCTGGGACGGGGGTGGGGTGCATGCAGTCCAGCAGCCCACGTGATCCTGCAG ACGCCGCATCATGCTGAACTGCTGGTCCGGAGACCCCAAGGCGAGACCTGCATTCTCGGAGCTGGTGGAG ATCCTGGGGGACCTGCTCCAGGGCAGGGGCCTGCAAGTGAGCCCCTTCCCCACCCTGTTCTACTATGGCC TTTGGCCCCTGCCCTGGGTCCCTGGCCCGAGCTGCCCCTCCAAGCCCATCTAGGCTCTGCCCACCTCTCA GCTGCTAGGCTAGGGTGGTGGGGTCCTGGGCCCCTATCCACACCTCGTCCCCACACCCTTGCATCTTTCT GTTGAGTACACACCCGCTGCACAGCTCCACTGCCTGCTCCAGGTGCTGTGTGGATAGTCAGAGCCTGTCC CTGCGCGAGGGGAATCCTAGGCTGGTCCCCCCCGGCCTGTGAGGCAGCCCCATCTCCCTGGCATCGTCAT GATGTATTCCTTCACCTGGTGCCAGTTCTGTCCCCCACTCCACTGAACACACGGACCCTTGACCTGTGTG TGCTGACATCTCTCCCTCCCCACGTGGTGCTCCTCCAGGGTGGGGGATGGAGCCGGCTTGTGACCCAGCT CAAGGTGGGGCCTGGAGCAAGAAGCAGGGGGTGGCCTGTTGCCCAGGCCTTAGGGACTGGGATGGGTGCT GCGGGTCTAGTTCCATCCAAAGAAGAAGGTAGGGAGTGCTGGCCCCAGTTCCTGAGGCTGCCAGCTCAGC TAGGGACTGGAGGAGGGATGATCCGGCTGAGCCCCAGCCTGCCCCACCTGCCTCATCCATAAATGTACCT GGAAGGGCTGTTGGGAGAACTTAGCGAGGCTGGCACAGCCAGCATTCTGCTACCTTGACCCCTTATCTGT CTTGATGGCTGAGATGTGCTGGTTTCTGGCATGAGCTCGTTTCCTCTGTGGAGCACTCACGTGCCCGCAT GGTCTGTTAGGGCCCTATCTCAGGGGTCAGGAGCCCAAGCAGTCCCGAGGGCAGAGCGAGGGCTGAGGGC AGGGCGAGGGCGGGGGCGAGAGCTGAGTGCGGGGGCGAGGGCTGAGGGCGGGGGTGAGGGCTGAGGGCGG GGGTGAGGGCTGAGGGTGGGGGCGAGGGCTGAGGGCAGTGGCTGGTGGTTTCTGGCCTGGCTGCCTCTCC TGTTCCCGCCAGGAGGAAGAGGAGGTCTGCATGGCCCCGCGCAGCTCTCAGAGCTCAGAAGAGGGCAGCT TCTCGCAGGTGTCCACCATGGCCCTACACATCGCCCAGGCTGACGCTGAGGACAGCCCGCCAAGCCTGCA GCGCCACAGCCTGGCCGCCAGGTCAGCTGTCCTGCAGGTCCAGGAGTAGGGTGGGAGAAAGCCATGTGGA CAAGGTGCATTTTATCCCTCTGCGTCATCGGGGAAAAGCAAATCATGCGACGTCAGAGGCCAGTGTGCAC AAACTCAGAGCACAGAGTGGCTTTAAATGACCCACTGCAGGGTCCTTCCACGGCCGTGTGGCCTGGCTGC GTGCTTGTTTTTGAGTCCTGTCCACCCACCAGTGTCCCCTCACCCCAACATCAAGGGTACTTTTTATTTA TTTATTTATTTTTTTGAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCT CACCGCAAGCTCCGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAG GCACCCGCCACCACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGG ATGGTCTCGATCTCCTGACCTCGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGA GCCACTGCGCCCGGCAAGCGTACTTTTTCTCCCGGAGAGGTGGAGTGGACTGTGTTTGGGCCAAGATTCC TCCCAGGAATCTCTGATTATCTAAATCACTGATTAGTCTGGGGGTGAGTCCCCAAGAGTCCCTGGGAGCA GGGAAGGACTCCAACTATGAGGCGTGGGCAGGAGGAGAACGTAACCTAATTCCCGGAACTCTGCCCAGGC TCTCTTATCCCTGGCATTTCACACTCAGGATGGCTGTGCTGGCCCCATTCACAGCAGTGTTGCTGAGATG CAGGCTCTGCGTCCTGTCCCTCTGCCCTAGCATACGGCAGGGCTAGGCCTGGGGGACAACAACAGTTAGC TGGATTCTGCCAGGCTCCTTCCACAAACCCCTCAACGTGTGCCTTAGTGCACCCACGTACGGGCAGGGCA GTCGGCGGCTTGCAGCCCCAGGGCTGCCTGGCTGGCCCAGGGTAGCCCATCCCCGGGAGGAGCTCCATGC CACACGGGGCTGGATGCCCCCTCACTTCCCATCACAGAGCTCAGCAGTGGACTCGGGAGGAAACACAGCC CAGGGTGCTGCTGGGGCTGTGGGGTAGACATCTGAGGCCAGGCACACGGAGGAGCCCCTGCCAGCACTCA GGCCCAGGCCCATCCATACTCCTGCCCCAGGCGGGGGGTCCTTTCCAGGAGAAGAGGGGGCACAGGGACA GTGGAGAGAAGTTCGAGGAGGGTTGCTGCAGCGCGTTCCTCAGCACCTTCTGATTTCTCCCCACAGGTAT TACAACTGGGTGTCCTTTCCCGGGTGCCTGGCCAGAGGGGCTGAGACCCGTGGTTCCTCCAGGATGAAGA CATTTGAGGAATTCCCCATGACCCCAACGACCTACAAAGGCTCTGTGGTACTTCACATGAAGGGTGGGGG CTGCGCTCTCGGCTCAGGGCTGGGGCCGCCTCAGGGGAGGCAGCGTCAGGAATTCGTAAGGCAAATGGCA GAACCCAACGACTGTCCTTTGAAAGTGCAAGTCCAGGGTGAGCCTTGGGCACATTTGGGCCCTCCTGCGA TGCCACGACTCACAGCTGCTTTCTGTCCTATGCCCTCGTCACCCCCACACGAGGCCTCCCCTCCTCAGCA GCGCAGAAACCCCAGTGGAAGGACGGCTCCTCCTCGGTGGCAGGTTCGGGGGTCCCGGGCCTGGTCAGTG AGCGCTGGGCAGAGGGGCCCCATGGGAGCCCTTGGCCAGACCACAGGGACCTGGGTTCCTGCCTCCAGGG CCACTTGGAGATGTTGGGGGACTCTGAAAAGATCGCAGTTTCCCTCCCGTGTAATTCAAAATAAAAACCA CACCAAGCCACAGTCGAAGGATAACAAAGCCCCCCAAACCGGGAGGCAGCCTCACATGGATCGTTTTTTG AACTACGAGCTGCCAGGTTGTGAGGCCTCTCCCTGCTTCTCCCACGGCTCCTGCTCTTCACACACTGAGC ATATGCTTGGCCACCGTGGAGGTCCCCAAGTATGAGGCGTCCACGGGCCACACACAGCCCCCCTGACCTC AGTGTCTCCCTCCGTGGCAGGGGCATGTGACCCTCACCCTGGGATGGAATGGACGCCTTGTTTCTGGCTC AGCTTCCCAGGGACAGGTGTTAGGTCAGCCGCGCTGCAGGACCATGCCGCACTTTCCTGGCTGGGGGTGG CTGCCCTGCAGGAGGGCCTCAGGCGGGACCCACAGCCTGGCTTGTCCTCTCCACACAGGACAACCAGACA GACAGTGGGATGGTGCTGGCCTCGGAGGAGTTTGAGCAGATAGAGAGCAGGCATAGACAAGAAAGCGGCT TCAGGTAAGGGCTTCGTGAGCCTCCTGCACTGCAGGTATCGATGTTGCCCTCCCCTGGAGGAGGGAGGCT GGGGTCTGGGTGTGCCCAGCCCTCTTCCCGGAACCTTTCGTGGCTCCCTATGGCCTTTTCGCGCGTTCAA GGTGAGCTGCCTGAGACCCCTCCTGACCTACAGCACCGCGGGAGCCCCTCCCTGTCACATGCTGGCCACG TGGGCGCTGGTCCCGACACCTCCCTGTCATCTGACAGAGCTCAGATGCTGTGTCTTTCTGACACCACACG TAACCCACCATGCCCAGGGCACACACACTCTCCTCCAGGTTGGGGAGGCCACCCCAGCCCCAGAACCCCG GAACTTCACCCAGTGGCTCCAGAAGCCGGGTAGATACTGTAATCTGAACTGGCTGGTGTAGGGTCCGGCC CTGTGGGGCTTAGCGGGTGTTCTCCCCGTGTGTGGAGATAAGAGATCGTAAGAAAGAAAGACACAAGACA GAGATAAAGAGAAAACAGCTGGGCCTGGGGGACCCCTACCATCAAGACGTGGAGACCGGTAGTGGCCCCG AATGGCTGAGCACGCTGATATTTATTGCATGCAAGACAAGGGGGCAGGGTCAGGAGGGTGAGTCGTTCAA GTGATTGATAAGGTGAAGCAAGTCACATGATCATGGGACGGGGCCCTTCCCTCTTAGGTAGCTGAAGCAG AGAGAGAGAAGGCAGCATACGTCAGCATTTTCTTCTCTGCACTTATAAGAAAGATCAAAGACTTTAAGAC TTTCGCTATTTCTTCTACTGCTATCTACTACAAACTTCAAAGAGGAACCAGGAGGACAAGAGGAGCATGA AAGTGGACAAGGAGTGTGACCACTGAAGCACCACAGGGAGGGGTTAGGCCTCCGGATGACTGCGGGCAGG CCTGGATAATATCCAGCCTCCCACAAGAAGCTGGTGGAGCAGAGTGTTCCCTGACTCCTCCAAGGAAAGG GAGACGCCCTTTCATGGTCTGCTGAGTAACAGGTGCCTTCCCAGACACTGGCGTTACTGCTTGACCAAAG AGCCCTCAAGCGGCCCTTATGCCAGCGTGACAGAGGGCTCACCTCTTGCCTTCTAGGTCACTTCTCACAA TGTCCCTTCAGCACCTGACCCTGTGCCCACCAGTTATTCCTTGGTAATATGAGTAATACATCAAAGAGTA GTATTAAAAGCTAATTAATCATGTTTATACTAATGACTGATAATGTCCATGATCATCTCTCTATCTAATT TGTATTATGACTATTCTTATTCTATTTTCTTTATTTTATATATATATATGTATGTATGTATTTTTTTTTT TTTGAGACAGTCTCGCTCTGTCTCCCAGGCTAGAGTGCAGTGGTGCGATCTCTGCTCGCTGCAACCTCCG CCTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTTCCGAGTAGCTGGGACTACAGGCACCCGCCACCAC GCCCGGCTAATTGTTTTGTATTTTTTTTAGTAGAGACCGGGTTTCGCCATGTTAGCCAGGATGGTCTCGA TCTCCTGACCTCGTGATCCGCCCGCCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCCTGAGCCACCGCG CCCGGCCACTGTTTTCTTTATTATACTGAAACAGTTTGTGCCTTCAGTCTCTTGCCTCAGCACCTGGGTG ATCCTTCGCCCACAGGCTGGGATGTATTTTGGCAACAGAGAAATACCCACATATCCCAGATAGAAAGTGA ACTCCATTTGCCCAACATGACAGCCAGGGGAAAAACAGTTTTGGCCATTTTGAATGTTGAAACTTTTAAG GGTATAGATTTAAACAAAGACTTCAGTGTCTGCTTAAAAGATTCATTTTATTTTTATTTTTATTTTTATT TTTTGAGACAGAGTCTCACTCCGTCACCCAGGCTAGAGTGCAGTGGTGCGATCTCGGCTCACCGCAACCT CCACCTCCCGGGTTCACGTGATTATCCTGCCTCAGCCTCTTGAGTAGCTGGGATTATAGGCGTGTGCCAC CACGCCCAGCTAAGTTTGTTTGTTTGTTTTTTTTTTTTTTTTTTTTTTAGTAGAGACGGGGTTTCGCCAC GTTGGCCAGGCTGGTCTTGAACTCCTGGCCTCAAGTGATCTGCCCTCAGCCTCCCAGGGTGCTGGGATTA CAGGTATGAGCCACCACGCCCAGCTCATCAGGTGACTCCTGTTAGTACCTGGTTTTGGAAAATCAATGGT GGTCACATTTACGGAAATAGCTTTGGGCTAATTTTTCGTCACCAAACAGCATTTCGACATTCAAAAAACA AGGTAATTAAGTAAAAGGTGTCACAGAGAATGATCGCCACGTAAATTCAAACCTCTACACACCTTCGAGA AACAGCACAGCTCCTTGAGATCAAAGAAGGCCGCTCAGCCCAGGCCTGTGGCTCAGCTAGGAGACAGACT CCGTGGAAACGTGAGTTGGGGACTCAACGCCAGGACCCGCACGGCTGAGCCTGCACCATGGTGGGAGAGT CAGATAGGGCCGTCCCGTGAGAGGAGAGTGTGACGAGGTCCTTGGGGATGTGGCAACACAGACCCAGGGG TGACGGAGGAGATGGGGCTGCGAGGAGAGCTCCCTTGCCAAGCCCGAGGCACTGGGCAGCCATCTTGCTT CTGAAAGGGCGGCGAGCCAGAAGGGAGTGCAGCCCCTTGGATGCTTGGTGGTAGAGGAAGAAGAAAGTTC CAGAAGACATGGGTCCTAAGGAAGCAAGATAGTATCCAGAAGTCAGAAGAAGACACATGATGGATTTGTT CATTTGAGAAACTGCACCACCCTGTATCGGCAGCAGAGGGCACTGTTCTTTGTCCTCTGTCGACAATGAG CCAAGAAAAGGTGCCACAGGTCTCTGGCGGGTGCATCCGCTTGGCATACAGAATGCTGTGCAAACAGGTG CAAGGAGAGAATGTGCCTTGGTGGGGTGTGGGGAGAAGAAGGAGGAATCTATCTGCCTAGTCCTTCGCTG TCTCCTGTTAACCACTGGTCGGCACTCGCCCCATGGGGGTTCACCTCCTCACTCCTGGGTTACATCATCC AGCCCCTTCAGTACCCACTTAGGATGCCAGAGCCCGTACCTATAGATGTGGCTTTTCACCTGCATCTGTG GGTGGAAGGAGATCAGGAAACTGGGCTTGTGGTCACTCAGCATGGCTGCGTGCAGCCAGTGGAGGGCCTA GCTCTTCTGGGTAAGAGACTAGCTGGCCCCTGGTGGCAGGATGATACGGGACGTGTATGAGCCTTCAGAA GGAAGAATGTGCTCAAAGGAACTTGAGATGCCAAAGATATGGGTTTGAGGTGGCACTTTTAAGTGAAGAA ATGTAGGATGCCACCAAAATCCCTAGTCCCATCCACAGGAGAAGTGGCTATTTCTGGTGTAGGAAATCCT AACATGAATAATCCTGAACCCCCAAAAAAGCACCCTCCATACAAAGTTATAGGAATAAGACAGTATTAGA GTTAAAACTTCCCGGTAGACAATTGTTCAAAAGAAACAGGAAAACGAGCAAAATGCTCCAACATGAATTA AACATATAAGGAAACAAGCAGTGGCTTGTTTTGTTGAATCTGAAATTCAAAATTTCAGGATAGAAATGGA CGGACAATGTGATGATACAACTGACAGCAGACTAAATTCAGGAAAGAAATCGAAATAAAAGATAGATTCG GCCAGGCAGTAGCTCTCACCTGTAATCACAGCACACTGGGAGGCTGAGGCAGGAGGATCACTTGAGGCCC GGAGTTCAAGACCAACCTGGGCAACAGAATGAGACGCTGTCTCTACAAATAGTAATTTTAAAAATTAGCT GGGTGTGGTGGCCCATGCCTGTGGTAGCAGCCGCTCAGCAGGCTGAGGTGGGAGAGTTGCTTGAGCCCAG AAGGTCGAGGATGCAGTGAGCCATGATCGTGCCACTGCACTCCAGGCTGGGCAACACAGCAAGCCCCCAT TTTGGGGGAAAAAAACCCGATAAATCTTTTCTAAAACCAGGGCACCACAGGGACAATATGTATGAGCAGA CTGATAGTGCCAGACACAGAGGATGGACGTGAAAAGAGGAAAACAAAACTGAAAAGAGGCAAAAGGATCA GAAAGTGACAGGAATAGAAAAGAGACAATATATATAAAATTGGGAGTCCCAGAGGAAGAAAATGCAAACA GTAAAAGAACTAATATTTTAAACTTACAGTCAAGAGTTTTCAGTAGCACCATGCAAAGCACCAAACAAGA AGTCAACATCTTCAAAAAATGCAAAGAAAGTGAGCGCTTGAGGATGGTGCATGATAGGGCAGGCAGAGAG GAGGGCAGGGGCAGAAACCACCCCCTAGGTCAAGGCGAGAGGCCTGGATTTGCTTCGTGGAGTGACGGGA AGCCGTTGGAGGGCGTGTCAGGAGGAGAATGACATAGTGTAACTTGAAGGACCTCTCTGAAGGGTGGACC ACCAGGAGGCCAGGGTGGAAGCACACAGCAGTCCGCGGGAGGATGTCACAGAGCCGGCAAGGACACAGCT GGCTCCGCAGGAGGGCCAGGAATGGAGATGCACGGATGTGTCCTGGAGTTAGAATGGACAGGACTTCTGG ATGGATTGGCTTTGAAGAGTGAGGGGAAGGAGGAAGCAAGGAGAACCCCAGGGTGCTTGGCTTGAGCGGC TGAGGGGACGGTGGTGCCGTTCACTGAGATGGGCAAGACAGAGTGAGAACTGGGTTGGGGGATGAAGTTG GACATTCTTCACAGTCTCGGGTCCAGGCTAGGTAGGGACAGAGCTCCAGTGAGTGCTGGATCAGATCGAT CCGCTTTGCTGTTTGAGTCGAGTCTGTGTGTGTTTTCTGAAGTCTGAACGCATGCCATGCTCCACTGTGT CCTTGGTGGTTCCCATCAGACCCTGACAGGGCTCCAGTCCCTCCTTGTTTTTTGTTAGTTTGTTTTTGAG ACAGGGTCTCACTTTGTCACCCAGGCTGGAGTGCAGCGGCACGATCTTGGCTCACTGAAACCTCCACCTC CTGGGCTCAAGCAATTTTTTTTTTTTTTAAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGG TGCGATCTCAGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTA GCTGGGACTACAGGCGCCCGCCACCACGCCCGGCTAATGTTTTGTATTTTTAGTAGAGACGGGGTTTCAC CGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGTCTCCCAGCAAAGTGCT GGGATTACAGGCATGAGCCACCGCACCCGGCCTCAAGCAATTGTTTCACTTAGCTGGGACCGCAGGCGTG CACCACCATGCCTGGCTAATTTTTGTATTTTTTGTAGAGACGGGGTTTCCCCATGTTGCCTGGGCTGGAC TCTAACTCCTGGCCTGAAGCCATCCGCCTGCCTAGGCCTCCCAAGTACTGGGATTACCAGTATGCACCAC CCGCCACCCAGCCTTCTTCTCTTACTAACACCACCTTCCCTGTCTTGGCAGCTGTAAAGGACCTGGCCAG AATGTGGCTGTGACCAGGGCACACCCTGACTCCCAAGGGAGGCGGCGGCGGCCTGAGCGGGGGGCCCGAG GAGGCCAGGTGTTTTACAACAGCGAGTATGGGGAGCTGTCGGAGCCAAGCGAGGAGGACCACTGCTCCCC GTCTGCCCGCGTGACTTTCTTCACAGACAACAGCTACTAAGCAGCATCGGACAAGACCCCCAGCACTTGG GGGTTCAGGCCCGGCAGGGCGGGCAGAGGGCTGGAGGCCCAGGCTGGGAACTCATCTGGTTGAACTCTGG TGGCACAGGAGTGTCCTCTTCCCTCTCTGCAGACTTCCCAGCTAGGAAGAGCAGGACTCCAGGCCCAAGG CTCCCGGAATTCCGTCACCACGACTGGCCAGGGCCACGCTCCAGCTGCCCCGGCCCCTCCCCCTGAGATT CAGATGTCATTTAGTTCAGCATCCGCAGGTGCTGGTCCCGGGGCCAGCACTTCCATGGGAATGTCTCTTT GGCGACCTCCTTTCATCACACTGGGTGGTGGCCTGGTCCCTGTTTTCCCACGAGGAATCTGTGGGTCTGG GAGTCACACAGTGTTGGAGGTTAAGGCATACGAGAGCAGAGGTCTCCCAAACGCCCTTTCCTCCTCAGGC ACACAGCTACTCTCCCCACGAGGGCTGGCTGGCCTCACCCACCCCTGCACAGTTGAAGGGAGGGGCTGTG TTTCCATCTCAAAGAAGGCATTTGCAGGGTCCTCTTCTGGGCCTGACCAAACAGCCAACTAGCCCCTGGG GTGGCCACCAGTATGACAGTATTATACGCTGGCAACACAGAGGCAGCCCGCACACCTGCGCCTGGGTGTT GAGAGCCATCCTGCAAGTCTTTTTCAACAGAACTTCACAGACTGTTAGAGCTGCTGAGAAGAATTTGCTT TCCGAATTCAGCCTGGAAGGCGCCCAGGGACAGCTGTACTGAGTCTAGATGACTCTGACCCCCGCCCCAG GTCAAGGCCAGCAGAGCAGTCAGTGCCTCTGGAGAAGGCCCTTGCTCTCCCACCTGGCCCAGACTCCGAG GAGCCTGGGTCTGGAGCTGCCGGTCTGGTTCTTCCCTTTAGAGCCCGGATCTGCCACCTGCGGCCCCTCC CAAGCCGTGAACCAGCTCATGAGAGATGAACACTGTGGGATCCACTCAGGAAGGCTCGGGGCTGGCACAA AGGACCACCCAGCATTGCCCTGTGCCACCCAGCACTCAGTGGACATTCTGGGGACCTGCCTTCAGCCTTT TCCTGCCCTGTGCCTGACATCAGCACCCTGGCTGGTCAGAATGCCGCCCTCCCAGAGGAGCAGCCGAGAG ATCCCCTGAAGGCTGGAGGCATTCTGCTCAGGACCCCTATCCCAGCTCACAGTGCCCAACCATCTCACCA GGAGAAAGAGCCACATCCCCACGTTAGGACCACGGAGACTGACCACCACCCTGACCCCCCAAACCCACGC ACCAGACGCTTGCAGGACAGGCGCCGCGCAGCGGGCAGGGGCTTGCCCGGCCGACCCTCCCCTCCCCACC TCCCCCACTGCGCGTTACTCCAGGATATGCCGAGTGCACGTATAAGGTCATCTTCGTCGTCCCCGTGGAC CTCCCCCTTCCTCTGCACGTCGTCCAACGTGGGACTGGCGTGTCAGGCTTCCCTGGGAGGATCTGGAGGT TGTTCTCTGCAGAGAACCAGCCTGGCTCCTGGCGCGCACCTCTGCTCCCTTCTCCTCACTACCCACCCAC GCATGTACCGGGAAAAAAACTACTATGCCCTTCTAGACCATGTTCTGAGAAAAGATCGAAAATATTTAAC AAGAGATAATAATAAATCTGATGCCGGTCTTTGTGTGTGTTGCGGA    Download   Select all
Length	48766
OMIM ID	136352
HGNC ID	HGNC:3767
Unigene ID	Hs.646917
Ensembl ID	ENSG00000037280
PharmGKB ID	-

mRNA Information

mRNA ID	XM_011534483.1
Exon	join(1..53,18494..18590,19473..19717,19917..20047, 20167..20329,20437..20576,20845..21013,21273..21390, 24007..24161,24241..24403,26211..26337,27433..27541, 28368..28730,29020..29166,29265..29396,29557..29663, 29964..30099,30503..30607,30906..31019,31163..31251, 31352..31502,33278..33372,33783..33905,36093..36204, 37162..37261,37661..37766,38793..38941,40247..40367, 41219..41304,46882..48766)
mRNA Sequence	>2324 AGGCCAGCCGGCGCCCGCGCGGACACTTTCAGCCCCGAGCCGCGGCCGCTCGGGTCGGACCCAC GCGCAGCGGCCGGAGATGCAGCGGGGCGCCGCGCTGTGCCTGCGACTGTGGCTCTGCCTGGGAC TCCTGGACGGCCTGGTGAGTGGCTACTCCATGACCCCCCCGACCTTGAACATCACGGAGGAGTC ACACGTCATCGACACCGGTGACAGCCTGTCCATCTCCTGCAGGGGACAGCACCCCCTCGAGTGG GCTTGGCCAGGAGCTCAGGAGGCGCCAGCCACCGGAGACAAGGACAGCGAGGACACGGGGGTGG TGCGAGACTGCGAGGGCACAGACGCCAGGCCCTACTGCAAGGTGTTGCTGCTGCACGAGGTACA TGCCAACGACACAGGCAGCTACGTCTGCTACTACAAGTACATCAAGGCACGCATCGAGGGCACC ACGGCCGCCAGCTCCTACGTGTTCGTGAGAGACTTTGAGCAGCCATTCATCAACAAGCCTGACA CGCTCTTGGTCAACAGGAAGGACGCCATGTGGGTGCCCTGTCTGGTGTCCATCCCCGGCCTCAA TGTCACGCTGCGCTCGCAAAGCTCGGTGCTGTGGCCAGACGGGCAGGAGGTGGTGTGGGATGAC CGGCGGGGCATGCTCGTGTCCACGCCACTGCTGCACGATGCCCTGTACCTGCAGTGCGAGACCA CCTGGGGAGACCAGGACTTCCTTTCCAACCCCTTCCTGGTGCACATCACAGGCAACGAGCTCTA TGACATCCAGCTGTTGCCCAGGAAGTCGCTGGAGCTGCTGGTAGGGGAGAAGCTGGTCCTGAAC TGCACCGTGTGGGCTGAGTTTAACTCAGGTGTCACCTTTGACTGGGACTACCCAGGGAAGCAGG CAGAGCGGGGTAAGTGGGTGCCCGAGCGACGCTCCCAGCAGACCCACACAGAACTCTCCAGCAT CCTGACCATCCACAACGTCAGCCAGCACGACCTGGGCTCGTATGTGTGCAAGGCCAACAACGGC ATCCAGCGATTTCGGGAGAGCACCGAGGTCATTGTGCATGAAAATCCCTTCATCAGCGTCGAGT GGCTCAAAGGACCCATCCTGGAGGCCACGGCAGGAGACGAGCTGGTGAAGCTGCCCGTGAAGCT GGCAGCGTACCCCCCGCCCGAGTTCCAGTGGTACAAGGATGGAAAGGCACTGTCCGGGCGCCAC AGTCCACATGCCCTGGTGCTCAAGGAGGTGACAGAGGCCAGCACAGGCACCTACACCCTCGCCC TGTGGAACTCCGCTGCTGGCCTGAGGCGCAACATCAGCCTGGAGCTGGTGGTGAATGTGCCCCC CCAGATACATGAGAAGGAGGCCTCCTCCCCCAGCATCTACTCGCGTCACAGCCGCCAGGCCCTC ACCTGCACGGCCTACGGGGTGCCCCTGCCTCTCAGCATCCAGTGGCACTGGCGGCCCTGGACAC CCTGCAAGATGTTTGCCCAGCGTAGTCTCCGGCGGCGGCAGCAGCAAGACCTCATGCCACAGTG CCGTGACTGGAGGGCGGTGACCACGCAGGATGCCGTGAACCCCATCGAGAGCCTGGACACCTGG ACCGAGTTTGTGGAGGGAAAGAATAAGACTGTGAGCAAGCTGGTGATCCAGAATGCCAACGTGT CTGCCATGTACAAGTGTGTGGTCTCCAACAAGGTGGGCCAGGATGAGCGGCTCATCTACTTCTA TGTGACCACCATCCCCGACGGCTTCACCATCGAATCCAAGCCATCCGAGGAGCTACTAGAGGGC CAGCCGGTGCTCCTGAGCTGCCAAGCCGACAGCTACAAGTACGAGCATCTGCGCTGGTACCGCC TCAACCTGTCCACGCTGCACGATGCGCACGGGAACCCGCTTCTGCTCGACTGCAAGAACGTGCA TCTGTTCGCCACCCCTCTGGCCGCCAGCCTGGAGGAGGTGGCACCTGGGGCGCGCCACGCCACG CTCAGCCTGAGTATCCCCCGCGTCGCGCCCGAGCACGAGGGCCACTATGTGTGCGAAGTGCAAG ACCGGCGCAGCCATGACAAGCACTGCCACAAGAAGTACCTGTCGGTGCAGGCCCTGGAAGCCCC TCGGCTCACGCAGAACTTGACCGACCTCCTGGTGAACGTGAGCGACTCGCTGGAGATGCAGTGC TTGGTGGCCGGAGCGCACGCGCCCAGCATCGTGTGGTACAAAGACGAGAGGCTGCTGGAGGAAA AGTCTGGAGTCGACTTGGCGGACTCCAACCAGAAGCTGAGCATCCAGCGCGTGCGCGAGGAGGA TGCGGGACGCTATCTGTGCAGCGTGTGCAACGCCAAGGGCTGCGTCAACTCCTCCGCCAGCGTG GCCGTGGAAGGCTCCGAGGATAAGGGCAGCATGGAGATCGTGATCCTTGTCGGTACCGGCGTCA TCGCTGTCTTCTTCTGGGTCCTCCTCCTCCTCATCTTCTGTAACATGAGGAGGCCGGCCCACGC AGACATCAAGACGGGCTACCTGTCCATCATCATGGACCCCGGGGAGGTGCCTCTGGAGGAGCAA TGCGAATACCTGTCCTACGATGCCAGCCAGTGGGAATTCCCCCGAGAGCGGCTGCACCTGGGGA GAGTGCTCGGCTACGGCGCCTTCGGGAAGGTGGTGGAAGCCTCCGCTTTCGGCATCCACAAGGG CAGCAGCTGTGACACCGTGGCCGTGAAAATGCTGAAAGAGGGCGCCACGGCCAGCGAGCACCGC GCGCTGATGTCGGAGCTCAAGATCCTCATTCACATCGGCAACCACCTCAACGTGGTCAACCTCC TCGGGGCGTGCACCAAGCCGCAGGGCCCCCTCATGGTGATCGTGGAGTTCTGCAAGTACGGCAA CCTCTCCAACTTCCTGCGCGCCAAGCGGGACGCCTTCAGCCCCTGCGCGGAGAAGTCTCCCGAG CAGCGCGGACGCTTCCGCGCCATGGTGGAGCTCGCCAGGCTGGATCGGAGGCGGCCGGGGAGCA GCGACAGGGTCCTCTTCGCGCGGTTCTCGAAGACCGAGGGCGGAGCGAGGCGGGCTTCTCCAGA CCAAGAAGCTGAGGACCTGTGGCTGAGCCCGCTGACCATGGAAGATCTTGTCTGCTACAGCTTC CAGGTGGCCAGAGGGATGGAGTTCCTGGCTTCCCGAAAGTGCATCCACAGAGACCTGGCTGCTC GGAACATTCTGCTGTCGGAAAGCGACGTGGTGAAGATCTGTGACTTTGGCCTTGCCCGGGACAT CTACAAAGACCCCGACTACGTCCGCAAGGGCAGTGCCCGGCTGCCCCTGAAGTGGATGGCCCCT GAAAGCATCTTCGACAAGGTGTACACCACGCAGAGTGACGTGTGGTCCTTTGGGGTGCTTCTCT GGGAGATCTTCTCTCTGGGGGCCTCCCCGTACCCTGGGGTGCAGATCAATGAGGAGTTCTGCCA GCGGCTGAGAGACGGCACAAGGATGAGGGCCCCGGAGCTGGCCACTCCCGCCATACGCCGCATC ATGCTGAACTGCTGGTCCGGAGACCCCAAGGCGAGACCTGCATTCTCGGAGCTGGTGGAGATCC TGGGGGACCTGCTCCAGGGCAGGGGCCTGCAAGAGGAAGAGGAGGTCTGCATGGCCCCGCGCAG CTCTCAGAGCTCAGAAGAGGGCAGCTTCTCGCAGGTGTCCACCATGGCCCTACACATCGCCCAG GCTGACGCTGAGGACAGCCCGCCAAGCCTGCAGCGCCACAGCCTGGCCGCCAGGTATTACAACT GGGTGTCCTTTCCCGGGTGCCTGGCCAGAGGGGCTGAGACCCGTGGTTCCTCCAGGATGAAGAC ATTTGAGGAATTCCCCATGACCCCAACGACCTACAAAGGCTCTGTGGACAACCAGACAGACAGT GGGATGGTGCTGGCCTCGGAGGAGTTTGAGCAGATAGAGAGCAGGCATAGACAAGAAAGCGGCT TCAGGTAGCTGAAGCAGAGAGAGAGAAGGCAGCATACGTCAGCATTTTCTTCTCTGCACTTATA AGAAAGATCAAAGACTTTAAGACTTTCGCTATTTCTTCTACTGCTATCTACTACAAACTTCAAA GAGGAACCAGGAGGACAAGAGGAGCATGAAAGTGGACAAGGAGTGTGACCACTGAAGCACCACA GGGAGGGGTTAGGCCTCCGGATGACTGCGGGCAGGCCTGGATAATATCCAGCCTCCCACAAGAA GCTGGTGGAGCAGAGTGTTCCCTGACTCCTCCAAGGAAAGGGAGACGCCCTTTCATGGTCTGCT GAGTAACAGGTGCCTTCCCAGACACTGGCGTTACTGCTTGACCAAAGAGCCCTCAAGCGGCCCT TATGCCAGCGTGACAGAGGGCTCACCTCTTGCCTTCTAGGTCACTTCTCACAATGTCCCTTCAG CACCTGACCCTGTGCCCACCAGTTATTCCTTGGTAATATGAGTAATACATCAAAGAGTAGTATT AAAAGCTAATTAATCATGTTTATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA    Download   Select all
Length	4534

CDS Information

   

Location	join(727..784,18494..18590,19473..19717,19935..20047, 20167..20329,20437..20576,20845..21013,21273..21390, 24007..24161,24241..24403,26211..26337,27433..27541, 28368..28730,29020..29166,29265..29396,29557..29663, 29964..30099,30503..30607,30906..31019,31163..31251, 31352..31502,33278..33372,33783..33905,36093..36204, 37162..37261,37661..37766,38793..38941,40247..40367,
CDS Sequence	>lcl|NM_002020.4_cds_NP_002011.2_1 [gene=FLT4] [protein=vascular endothelial growth factor receptor 3 isoform 2 precursor] [protein_id=NP_002011.2] [location=80..3976] ATGCAGCGGGGCGCCGCGCTGTGCCTGCGACTGTGGCTCTGCCTGGGACTCCTGGACGGCCTGGTGAGTG GCTACTCCATGACCCCCCCGACCTTGAACATCACGGAGGAGTCACACGTCATCGACACCGGTGACAGCCT GTCCATCTCCTGCAGGGGACAGCACCCCCTCGAGTGGGCTTGGCCAGGAGCTCAGGAGGCGCCAGCCACC GGAGACAAGGACAGCGAGGACACGGGGGTGGTGCGAGACTGCGAGGGCACAGACGCCAGGCCCTACTGCA AGGTGTTGCTGCTGCACGAGGTACATGCCAACGACACAGGCAGCTACGTCTGCTACTACAAGTACATCAA GGCACGCATCGAGGGCACCACGGCCGCCAGCTCCTACGTGTTCGTGAGAGACTTTGAGCAGCCATTCATC AACAAGCCTGACACGCTCTTGGTCAACAGGAAGGACGCCATGTGGGTGCCCTGTCTGGTGTCCATCCCCG GCCTCAATGTCACGCTGCGCTCGCAAAGCTCGGTGCTGTGGCCAGACGGGCAGGAGGTGGTGTGGGATGA CCGGCGGGGCATGCTCGTGTCCACGCCACTGCTGCACGATGCCCTGTACCTGCAGTGCGAGACCACCTGG GGAGACCAGGACTTCCTTTCCAACCCCTTCCTGGTGCACATCACAGGCAACGAGCTCTATGACATCCAGC TGTTGCCCAGGAAGTCGCTGGAGCTGCTGGTAGGGGAGAAGCTGGTCCTGAACTGCACCGTGTGGGCTGA GTTTAACTCAGGTGTCACCTTTGACTGGGACTACCCAGGGAAGCAGGCAGAGCGGGGTAAGTGGGTGCCC GAGCGACGCTCCCAGCAGACCCACACAGAACTCTCCAGCATCCTGACCATCCACAACGTCAGCCAGCACG ACCTGGGCTCGTATGTGTGCAAGGCCAACAACGGCATCCAGCGATTTCGGGAGAGCACCGAGGTCATTGT GCATGAAAATCCCTTCATCAGCGTCGAGTGGCTCAAAGGACCCATCCTGGAGGCCACGGCAGGAGACGAG CTGGTGAAGCTGCCCGTGAAGCTGGCAGCGTACCCCCCGCCCGAGTTCCAGTGGTACAAGGATGGAAAGG CACTGTCCGGGCGCCACAGTCCACATGCCCTGGTGCTCAAGGAGGTGACAGAGGCCAGCACAGGCACCTA CACCCTCGCCCTGTGGAACTCCGCTGCTGGCCTGAGGCGCAACATCAGCCTGGAGCTGGTGGTGAATGTG CCCCCCCAGATACATGAGAAGGAGGCCTCCTCCCCCAGCATCTACTCGCGTCACAGCCGCCAGGCCCTCA CCTGCACGGCCTACGGGGTGCCCCTGCCTCTCAGCATCCAGTGGCACTGGCGGCCCTGGACACCCTGCAA GATGTTTGCCCAGCGTAGTCTCCGGCGGCGGCAGCAGCAAGACCTCATGCCACAGTGCCGTGACTGGAGG GCGGTGACCACGCAGGATGCCGTGAACCCCATCGAGAGCCTGGACACCTGGACCGAGTTTGTGGAGGGAA AGAATAAGACTGTGAGCAAGCTGGTGATCCAGAATGCCAACGTGTCTGCCATGTACAAGTGTGTGGTCTC CAACAAGGTGGGCCAGGATGAGCGGCTCATCTACTTCTATGTGACCACCATCCCCGACGGCTTCACCATC GAATCCAAGCCATCCGAGGAGCTACTAGAGGGCCAGCCGGTGCTCCTGAGCTGCCAAGCCGACAGCTACA AGTACGAGCATCTGCGCTGGTACCGCCTCAACCTGTCCACGCTGCACGATGCGCACGGGAACCCGCTTCT GCTCGACTGCAAGAACGTGCATCTGTTCGCCACCCCTCTGGCCGCCAGCCTGGAGGAGGTGGCACCTGGG GCGCGCCACGCCACGCTCAGCCTGAGTATCCCCCGCGTCGCGCCCGAGCACGAGGGCCACTATGTGTGCG AAGTGCAAGACCGGCGCAGCCATGACAAGCACTGCCACAAGAAGTACCTGTCGGTGCAGGCCCTGGAAGC CCCTCGGCTCACGCAGAACTTGACCGACCTCCTGGTGAACGTGAGCGACTCGCTGGAGATGCAGTGCTTG GTGGCCGGAGCGCACGCGCCCAGCATCGTGTGGTACAAAGACGAGAGGCTGCTGGAGGAAAAGTCTGGAG TCGACTTGGCGGACTCCAACCAGAAGCTGAGCATCCAGCGCGTGCGCGAGGAGGATGCGGGACGCTATCT GTGCAGCGTGTGCAACGCCAAGGGCTGCGTCAACTCCTCCGCCAGCGTGGCCGTGGAAGGCTCCGAGGAT AAGGGCAGCATGGAGATCGTGATCCTTGTCGGTACCGGCGTCATCGCTGTCTTCTTCTGGGTCCTCCTCC TCCTCATCTTCTGTAACATGAGGAGGCCGGCCCACGCAGACATCAAGACGGGCTACCTGTCCATCATCAT GGACCCCGGGGAGGTGCCTCTGGAGGAGCAATGCGAATACCTGTCCTACGATGCCAGCCAGTGGGAATTC CCCCGAGAGCGGCTGCACCTGGGGAGAGTGCTCGGCTACGGCGCCTTCGGGAAGGTGGTGGAAGCCTCCG CTTTCGGCATCCACAAGGGCAGCAGCTGTGACACCGTGGCCGTGAAAATGCTGAAAGAGGGCGCCACGGC CAGCGAGCACCGCGCGCTGATGTCGGAGCTCAAGATCCTCATTCACATCGGCAACCACCTCAACGTGGTC AACCTCCTCGGGGCGTGCACCAAGCCGCAGGGCCCCCTCATGGTGATCGTGGAGTTCTGCAAGTACGGCA ACCTCTCCAACTTCCTGCGCGCCAAGCGGGACGCCTTCAGCCCCTGCGCGGAGAAGTCTCCCGAGCAGCG CGGACGCTTCCGCGCCATGGTGGAGCTCGCCAGGCTGGATCGGAGGCGGCCGGGGAGCAGCGACAGGGTC CTCTTCGCGCGGTTCTCGAAGACCGAGGGCGGAGCGAGGCGGGCTTCTCCAGACCAAGAAGCTGAGGACC TGTGGCTGAGCCCGCTGACCATGGAAGATCTTGTCTGCTACAGCTTCCAGGTGGCCAGAGGGATGGAGTT CCTGGCTTCCCGAAAGTGCATCCACAGAGACCTGGCTGCTCGGAACATTCTGCTGTCGGAAAGCGACGTG GTGAAGATCTGTGACTTTGGCCTTGCCCGGGACATCTACAAAGACCCCGACTACGTCCGCAAGGGCAGTG CCCGGCTGCCCCTGAAGTGGATGGCCCCTGAAAGCATCTTCGACAAGGTGTACACCACGCAGAGTGACGT GTGGTCCTTTGGGGTGCTTCTCTGGGAGATCTTCTCTCTGGGGGCCTCCCCGTACCCTGGGGTGCAGATC AATGAGGAGTTCTGCCAGCGGCTGAGAGACGGCACAAGGATGAGGGCCCCGGAGCTGGCCACTCCCGCCA TACGCCGCATCATGCTGAACTGCTGGTCCGGAGACCCCAAGGCGAGACCTGCATTCTCGGAGCTGGTGGA GATCCTGGGGGACCTGCTCCAGGGCAGGGGCCTGCAAGAGGAAGAGGAGGTCTGCATGGCCCCGCGCAGC TCTCAGAGCTCAGAAGAGGGCAGCTTCTCGCAGGTGTCCACCATGGCCCTACACATCGCCCAGGCTGACG CTGAGGACAGCCCGCCAAGCCTGCAGCGCCACAGCCTGGCCGCCAGGTATTACAACTGGGTGTCCTTTCC CGGGTGCCTGGCCAGAGGGGCTGAGACCCGTGGTTCCTCCAGGATGAAGACATTTGAGGAATTCCCCATG ACCCCAACGACCTACAAAGGCTCTGTGGACAACCAGACAGACAGTGGGATGGTGCTGGCCTCGGAGGAGT TTGAGCAGATAGAGAGCAGGCATAGACAAGAAAGCGGCTTCAGGTAG    Download   Select all
CCDS ID	CCDS4457.1

Protein Information

      

Protein ID	NP_002011.2
Protein Name	fms-related tyrosine kinase 4
Molecular Wt. (Da)	143058
Protein Sequence	>2324 MQRGAALCLRLWLCLGLLDGLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGA QEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASS YVFVRDFEQPFINKPDTLLVNRKDAMWVPCLVSIPGLNVTLRSQSSVLWPDGQEVVWDDRRGML VSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRKSLELLVGEKLVLNCTVWA EFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQHDLGSYVCKANNGIQRFR ESTEVIVHENPFISVEWLKGPILEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRHSPHAL VLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNVPPQIHEKEASSPSIYSRHSRQALTCTAY GVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVE GKNKTVSKLVIQNANVSAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLL SCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFATPLAASLEEVAPGARHATLSLSI PRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMQCLVAGA HAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGS EDKGSMEIVILVGTGVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLS YDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSE LKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRF RAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARG MEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKGSARLPLKWMAPESIFD KVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCW SGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFSQVSTMALHIAQADAED SPPSLQRHSLAARYYNWVSFPGCLARGAETRGSSRMKTFEEFPMTPTTYKGSVDNQTDSGMVLA SEEFEQIESRHRQESGFR    Download   Select all
Length	1298
Uniprot ID	P16403
Ensembl Protein ID	ENSP00000339566

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
Y	Phosphorylation	1230
Y	Phosphorylation	1231
Y	Phosphorylation	1265
Y	Phosphorylation	1333
Y	Phosphorylation	1337
Y	Phosphorylation	1363
Y	Phosphorylation	1230
Y	Phosphorylation	1231
Y	Phosphorylation	1265
T	Phosphorylation	517
Y	Phosphorylation	532
T	Phosphorylation	517
Y	Phosphorylation	532

Enzyme Information

   

EC	2.7.10.1
Name	receptor protein-tyrosine kinase AATK AATYK AATYK2 AATYK3 ACH ALK anaplastic lymphoma kinase ARK ATP:protein-tyrosine O-phosphotransferase (ambiguous) AXL Bek Bfgfr BRT Bsk C-FMS CAK CCK4 CD115 CD135 CDw135 Cek1 Cek10 Cek11 Cek2 Cek3 Cek5 Cek6 Cek7 CFD1 CKIT CSF1R DAlk DDR1 DDR2 Dek DKFZp434C1418 Drosophila Eph kinase DRT DTK Ebk ECK EDDR1 Eek EGFR Ehk2 Ehk3 Elk EPH EPHA1 EPHA2 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EphB5 ephrin-B3 receptor tyrosine kinase EPHT EPHT2 EPHT3 EPHX ERBB ERBB1 ERBB2 ERBB3 ERBB4 ERK Eyk FGFR1 FGFR2 FGFR3 FGFR4 FLG FLK1 FLK2 FLT1 FLT2 FLT3 FLT4 FMS Fv2 HBGFR HEK11 HEK2 HEK3 HEK5 HEK6 HEP HER2 HER3 HER4 HGFR HSCR1 HTK IGF1R INSR INSRR insulin receptor protein-tyrosine kinase IR IRR JTK12 JTK13 JTK14 JWS K-SAM KDR KGFR KIA0641 KIAA1079 KIAA1459 Kil Kin15 Kin16 KIT KLG LTK MCF3 Mdk1 Mdk2 Mdk5 MEhk1 MEN2A/B Mep MER MERTK MET Mlk1 Mlk2 Mrk MST1R MTC1 MUSK Myk1 N-SAM NEP NET Neu neurite outgrowth regulating kinase NGL NOK nork novel oncogene with kinase-domain Nsk2 NTRK1 NTRK2 NTRK3 NTRK4 NTRKR1 NTRKR2 NTRKR3 Nuk NYK PCL PDGFR PDGFRA PDGFRB PHB6 protein-tyrosine kinase (ambiguous) protein tyrosine kinase (ambiguous) PTK PTK3 PTK7 receptor protein tyrosine kinase RET RON ROR1 ROR2 ROS1 RSE RTK RYK SEA Sek2 Sek3 Sek4 Sfr SKY STK STK1 TEK TIE TIE1 TIE2 TIF TKT TRK TRKA TRKB TRKC TRKE TYK1 TYRO10 Tyro11 TYRO3 Tyro5 Tyro6 TYRO7 UFO VEGFR1 VEGFR2 VEGFR3 Vik YK1 Yrk
Class	Transferases; Transferring phosphorus-containing groups; Protein-tyrosine kinases
Sysname	ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
Substrate	ATP [CPD:C00002]; [protein]-L-tyrosine
Product	ADP [CPD:C00008]; [protein]-L-tyrosine phosphate
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING)      View   

                                                                                                                        

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
2885	GRB2	150	NP_002077.1	in vitro;in vivo	7   970   715   767   545   180   000   000   000   000
3678	ITGA5	627	NP_002196.2	in vitro	15389531
3688	ITGB1	628	NP_391987.1	in vivo	11553610
3791	KDR	1867	NP_002244.1	in vitro	15474514
5747	PTK2	2859	NP_005598.3	in vitro;in vivo	16452200
5781	PTPN11	1470	NP_002825.3	in vivo	15102829
53358	SHC3	12005	NP_058544.3	in vitro	9345034
55729	ATF7IP	9811	NP_060649.3	yeast 2-hybrid	15231748

Pathway Information

                              

Pathway Name	Pathway ID
Cytokine-cytokine receptor interaction	hsa04060
Focal adhesion	hsa04510
PI3K-Akt signaling pathway	hsa04151
Rap1 signaling pathway	hsa04015
Ras signaling pathway	hsa04014

Structure Information

PDB ID	4BSJ
Resolution	2.5
Method	X-RAY DIFFRACTION
Chains	A
Molecule	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 3
Model	View

Domain Information

ID	Location	Description
cd05102	837-1176	PTKc_VEGFR3
cl21453	837-1176	PKc_like superfamily
cd05862	245-329	Ig1_VEGFR
cl11960	245-329	Ig superfamily
cd05863	352-418	Ig2_VEGFR-3
cl11960	352-418	Ig superfamily
cd00096	695-762	Ig
cl11960	695-762	Ig superfamily
cd00096	574-658	Ig
cl11960	574-658	Ig superfamily
cd05054	837-1172	PTKc_VEGFR
cd05103	837-1174	PTKc_VEGFR2
cd14207	837-1172	PTKc_VEGFR1
cd05055	815-1173	PTKc_PDGFR
cd05106	815-1173	PTKc_CSF-1R
cd05104	815-1169	PTKc_Kit
cd05105	811-1175	PTKc_PDGFR_alpha
cd00192	849-1169	PTKc
cd05053	837-1173	PTKc_FGFR
cd05107	811-1173	PTKc_PDGFR_beta
cd05099	831-1173	PTKc_FGFR4
cd05101	823-1173	PTKc_FGFR2
cd05098	837-1180	PTKc_FGFR1
cd05045	844-1173	PTKc_RET
cd05100	837-1173	PTKc_FGFR3
cd05032	838-1171	PTKc_InsR_like
cd05036	839-1170	PTKc_ALK_LTK
cd05050	839-1169	PTKc_Musk
cd05044	849-1171	PTKc_c-ros
cd05049	839-1169	PTKc_Trk
cd05039	838-1169	PTKc_Csk_like
cd05048	839-1165	PTKc_Ror
cd05061	838-1174	PTKc_InsR
cd05047	850-1174	PTKc_Tie
cd05041	851-1169	PTKc_Fes_like
cd05089	843-1176	PTKc_Tie1
cd05046	840-1171	PTK_CCK4
cd05034	849-1169	PTKc_Src_like
cd05035	845-1173	PTKc_TAM
cd05056	838-1174	PTKc_FAK
cd05058	849-1166	PTKc_Met_Ron
cd13999	851-1169	STKc_MAP3K-like
cd05059	845-1170	PTKc_Tec_like
cd05051	839-1165	PTKc_DDR
cd05052	838-1165	PTKc_Abl
cd05068	837-1165	PTKc_Frk_like
cd05082	838-1172	PTKc_Csk
cd05074	841-1169	PTKc_Tyro3
cd05083	838-1169	PTKc_Chk
cd05148	838-1170	PTKc_Srm_Brk
cd05060	851-1174	PTKc_Syk_like
cd05057	839-1167	PTKc_EGFR_like
cd14204	842-1175	PTKc_Mer
cd05085	848-1165	PTKc_Fer
cd05075	844-1174	PTKc_Axl
cd05088	833-1176	PTKc_Tie2
cd05038	840-1169	PTKc_Jak_rpt2
cd05084	848-1170	PTKc_Fes
cd05062	838-1171	PTKc_IGF-1R
cd05033	849-1169	PTKc_EphR
cd05043	842-1171	PTK_Ryk
cd05067	837-1173	PTKc_Lck_Blk
cd05092	851-1165	PTKc_TrkA
cd05097	839-1169	PTKc_DDR_like
cd05112	851-1169	PTKc_Itk
cd05072	838-1172	PTKc_Lyn
cd05073	833-1172	PTKc_Hck
cd05091	851-1165	PTKc_Ror2
cd05114	849-1174	PTKc_Tec_Rlk
cd05113	842-1166	PTKc_Btk_Bmx
cd05063	849-1173	PTKc_EphR_A2
cd05095	839-1169	PTKc_DDR2
cd05040	851-1171	PTKc_Ack_like
cd05066	844-1173	PTKc_EphR_A
cd05096	839-1165	PTKc_DDR1
cd00180	851-1169	PKc
cd05093	842-1172	PTKc_TrkB
cd05090	839-1165	PTKc_Ror1
cd05109	849-1167	PTKc_HER2
cd05108	849-1166	PTKc_EGFR
cd05094	842-1169	PTKc_TrkC
cd05065	850-1173	PTKc_EphR_B
cd05111	840-1165	PTK_HER3
cd14203	851-1171	PTKc_Src_Fyn_like
cd05742	245-328	Ig1_VEGFR_like
cd05069	838-1171	PTKc_Yes
cd05081	843-1165	PTKc_Jak3_rpt2
cd05070	838-1171	PTKc_Fyn
cd05071	838-1171	PTKc_Src
cd05116	851-1163	PTKc_Syk
cd05115	842-1162	PTKc_Zap-70
cd14205	840-1165	PTKc_Jak2_rpt2
cd05110	849-1165	PTKc_HER4
cd14058	851-1174	STKc_TAK1
cd06606	844-1167	STKc_MAPKKK
cd14061	850-1169	STKc_MLK
cd14206	851-1165	PTKc_Aatyk3
cd05064	839-1173	PTKc_EphR_A10
cd05087	851-1165	PTKc_Aatyk1
cd05042	851-1165	PTKc_Aatyk
cd05080	840-1169	PTKc_Tyk2_rpt2
cd05079	840-1167	PTKc_Jak1_rpt2
cd14059	851-1166	STKc_MAP3K12_13
cd04976	352-418	Ig2_VEGFR
cd14146	850-1169	STKc_MLK4
cd06627	844-1165	STKc_Cdc7_like
cd14066	851-1172	STKc_IRAK
cd14148	1014-1172	STKc_MLK2
cd14062	851-1169	STKc_Raf
cd14145	845-1169	STKc_MLK1
cd05122	847-1165	PKc_STE
cd14147	1014-1172	STKc_MLK3
cd13978	851-1164	STKc_RIP
cd14151	838-1166	STKc_B-Raf
cd14000	850-1171	STKc_LRRK
cd13979	843-1169	STKc_Mos
cd14060	1009-1169	STKc_MLTK
cd14065	851-1169	PKc_LIMK_like
cd14014	847-1161	STKc_PknB_like
cd05086	851-1169	PTKc_Aatyk2
cd05118	849-1109	STKc_CMGC
cd14007	846-1167	STKc_Aurora
cd05117	846-1104	STKc_CAMK
cd14063	845-1169	PK_KSR
cd06623	845-1116	PKc_MAPKK_plant_like
cd06632	848-1167	STKc_MEKK1_plant
cd07829	851-1101	STKc_CDK_like
cd14150	851-1174	STKc_A-Raf
cd06614	1020-1167	STKc_PAK
cd14003	847-1160	STKc_AMPK-like
cd14002	843-1115	STKc_STK36
cd14008	1008-1124	STKc_LKB1_CaMKK
cd14009	851-1106	STKc_ATG1_ULK_like
cd06628	1020-1166	STKc_Byr2_like
cd14155	1008-1176	PKc_TESK
cd05123	851-1159	STKc_AGC
cd07833	850-1117	STKc_CDKL
cd13992	1021-1169	PK_GC
cd06648	1009-1167	STKc_PAK_II
cd08530	1008-1165	STKc_CNK2-like
cd14156	1008-1172	PKc_LIMK_like_unk
cd14221	1015-1173	STKc_LIMK1
cd06608	841-1102	STKc_myosinIII_N_like
cd05037	1020-1170	PTK_Jak_rpt1
cd14121	851-1164	STKc_ULK3
cd08215	849-1165	STKc_Nek
cd07846	1017-1167	STKc_CDKL2_3
cd07838	851-1110	STKc_CDK4_6_like
cd07832	847-1129	STKc_CCRK
cd14149	838-1174	STKc_C-Raf
cd14064	1018-1172	PKc_TNNI3K
cd05570	849-1117	STKc_PKC
cd07830	847-1110	STKc_MAK_like
cd06611	851-1107	STKc_SLK_like
cd14027	1020-1167	STKc_RIP1
cd14011	1019-1168	PK_SCY1_like
cd14069	846-1166	STKc_Chk1
cd06629	1012-1167	STKc_Bck1_like
cd14154	851-1165	STKc_LIMK
cd06605	1018-1167	PKc_MAPKK
cd06621	1018-1116	PKc_Pek1_like
cd07845	1007-1108	STKc_CDK10
cd13975	1009-1174	PKc_Dusty
cd14202	837-1165	STKc_ULK1
cd05589	850-1117	STKc_PKN
cd14120	851-1164	STKc_ULK1_2-like
cd06631	848-1165	STKc_YSK4
cd13997	851-1166	PKc_Wee1_like
cd08225	844-1126	STKc_Nek5
cd06609	1020-1165	STKc_MST3_like
cd14158	848-1172	STKc_IRAK4
cd14047	1020-1169	STKc_EIF2AK2_PKR
cd06622	1018-1167	PKc_PBS2_like
cd06619	1021-1167	PKc_MKK5
cd08217	1029-1167	STKc_Nek2
cd07834	1008-1108	STKc_MAPK
cd06617	1018-1167	PKc_MKK3_6
cd06917	1025-1165	STKc_NAK1_like
cd06647	1020-1167	STKc_PAK_I
cd06654	1023-1167	STKc_PAK1
cd08228	1017-1168	STKc_Nek6
cd14025	1020-1173	STKc_RIP4_like
cd06655	1023-1167	STKc_PAK2
cd07849	1013-1117	STKc_ERK1_2_like
cd08529	1007-1165	STKc_FA2-like
cd14068	850-1169	STKc_LRRK2
cd14010	1021-1109	STKc_ULK4
cd06644	817-1167	STKc_STK10
cd06610	1020-1167	STKc_OSR1_SPAK
cd14111	1012-1115	STKc_SPEG_rpt2
cd07866	1009-1108	STKc_BUR1
cd06612	850-1167	STKc_MST1_2
cd14080	846-1160	STKc_TSSK-like
cd06659	1015-1198	STKc_PAK6
cd05619	1017-1159	STKc_nPKC_theta
cd06642	1020-1167	STKc_STK25
cd05592	1017-1165	STKc_nPKC_theta_like
cd06640	1020-1167	STKc_MST4
cd07840	1016-1117	STKc_CDK9_like
cd14222	851-1165	STKc_LIMK2
cd14106	1020-1167	STKc_DRAK
cd07862	999-1108	STKc_CDK6
cd06641	1008-1167	STKc_MST3
cd14152	844-1172	STKc_KSR1
cd05582	849-1142	STKc_RSK_N
cd06656	1023-1167	STKc_PAK3
cd14664	851-1171	STK_BAK1_like
cd07841	1009-1106	STKc_CDK7
cd07847	1019-1117	STKc_CDKL1_4
cd06618	1034-1167	PKc_MKK7
cd06636	834-1114	STKc_MAP4K4_6_N
cd14105	1009-1159	STKc_DAPK
cd08222	1020-1168	STKc_Nek11
cd14099	1016-1167	STKc_PLK
cd14048	1020-1167	STKc_EIF2AK3_PERK
cd14187	1017-1166	STKc_PLK1
cd08221	1012-1167	STKc_Nek9
cd13996	849-1108	STKc_EIF2AK
cd05864	352-418	Ig2_VEGFR-2
cd07843	1008-1109	STKc_CDC2L1
cd14052	851-1175	PTKc_Wee1_fungi
cd06638	841-1167	STKc_myosinIIIA_N
cd05580	847-1107	STKc_PKA_like
cd08229	1017-1160	STKc_Nek7
cd06630	1014-1165	STKc_MEKK1
cd14006	1009-1164	STKc_MLCK-like
cd14201	838-1115	STKc_ULK2
cd05620	1017-1159	STKc_nPKC_delta
cd14209	849-1150	STKc_PKA
cd14001	999-1169	PKc_TOPK
cd13993	844-1104	STKc_Pat1_like
cd07863	1010-1108	STKc_CDK4
cd07856	1008-1125	STKc_Sty1_Hog1
cd05578	1021-1149	STKc_Yank1
cd07871	1009-1124	STKc_PCTAIRE3
cd05577	1009-1164	STKc_GRK
cd06613	1006-1106	STKc_MAP4K3_like
cd06643	851-1107	STKc_SLK
cd13985	849-1107	STKc_GAK_like
cd06616	1032-1167	PKc_MKK4
cd14137	1017-1101	STKc_GSK3
cd07873	1009-1124	STKc_PCTAIRE1
cd05572	1017-1107	STKc_cGK
cd08528	1031-1171	STKc_Nek10
cd14199	1006-1115	STKc_CaMKK2
cd07851	834-1117	STKc_p38
cd07859	1009-1117	STKc_TDY_MAPK
cd05630	1015-1183	STKc_GRK6
cd05611	1012-1115	STKc_Rim15_like
cd13987	1020-1171	STKc_SBK1
cd05078	1020-1169	PTK_Jak2_rpt1
cd07855	1008-1188	STKc_ERK5
cd05616	1015-1124	STKc_cPKC_beta
cd07854	1008-1117	STKc_MAPK4_6
cd14189	1017-1167	STKc_PLK3
cd07839	1017-1123	STKc_CDK5
cd14119	1016-1125	STKc_LKB1
cd14076	847-1166	STKc_Kin4
cd08220	1012-1165	STKc_Nek8
cd06620	1008-1166	PKc_Byr1_like
cd08223	847-1110	STKc_Nek4
cd14188	1009-1167	STKc_PLK2
cd06607	1008-1102	STKc_TAO
cd14070	847-1164	STKc_HUNK
cd07872	1009-1124	STKc_PCTAIRE2
cd14097	846-1117	STKc_STK33
cd07853	1008-1109	STKc_NLK
cd07858	1007-1117	STKc_TEY_MAPK
cd05077	1020-1166	PTK_Jak1_rpt1
cd07848	1017-1117	STKc_CDKL5
cd06637	841-1114	STKc_TNIK
cd05587	1015-1124	STKc_cPKC
cd07844	1009-1123	STKc_PCTAIRE_like
cd05581	848-1118	STKc_PDK1
cd05590	849-1130	STKc_nPKC_eta
cd05608	1017-1164	STKc_GRK1
cd05605	1009-1115	STKc_GRK4_like
cd07852	1019-1117	STKc_MAPK15-like
cd14090	848-1117	STKc_Mnk
cd14042	1011-1165	PK_GC-A_B
cd14043	1023-1165	PK_GC-2D
cd13994	1009-1108	STKc_HAL4_like
cd13995	989-1167	STKc_MAP3K8
cd06625	1016-1109	STKc_MEKK3_like
cd07857	844-1114	STKc_MPK1
cd06658	1015-1167	STKc_PAK5
cd14084	842-1115	STKc_Chk2
cd07878	838-1117	STKc_p38beta
cd05579	1017-1115	STKc_MAST_like
cd08224	1017-1168	STKc_Nek6_7
cd05595	1017-1159	STKc_PKB_beta
cd14077	1017-1105	STKc_Kin1_2
cd08218	1012-1167	STKc_Nek1
cd14056	1035-1160	STKc_TGFbR_I
cd05631	1015-1159	STKc_GRK4
cd14194	1009-1159	STKc_DAPK1
cd13989	1021-1142	STKc_IKK
cd07831	1017-1110	STKc_MOK
cd06639	841-1167	STKc_myosinIIIB_N
cd14118	1013-1167	STKc_CAMKK
cd14190	1007-1117	STKc_MLCK2
cd14153	1020-1172	PK_KSR2
cd14164	847-1161	STKc_TSSK6-like
cd07860	1017-1117	STKc_CDK2_3
cd07864	1012-1126	STKc_CDK12
cd06633	1008-1174	STKc_TAO3
cd14057	1015-1169	PK_ILK
cd07877	1019-1129	STKc_p38alpha
cd14200	1007-1115	STKc_CaMKK1
cd14071	1020-1137	STKc_SIK
cd14079	847-1105	STKc_AMPK_alpha
cd14197	1020-1124	STKc_DRAK1
cd14116	837-1167	STKc_Aurora-A
cd14045	1016-1169	PK_GC_unk
cd14004	1003-1167	STKc_PASK
cd14033	1005-1167	STKc_WNK4
cd14067	1018-1171	STKc_LRRK1
cd14186	1008-1115	STKc_PLK4
cd13983	1020-1167	STKc_WNK
cd06657	1015-1167	STKc_PAK4
cd14049	1020-1167	STKc_EIF2AK1_HRI
cd05585	1017-1159	STKc_YPK1_like
cd14054	1005-1159	STKc_BMPR2_AMHR2
cd06650	1018-1167	PKc_MEK1
cd14195	1009-1167	STKc_DAPK3
cd13998	1009-1159	STKc_TGFbR-like
cd05632	1012-1159	STKc_GRK5
cd14663	844-1167	STKc_SnRK3
cd14162	1020-1105	STKc_TSSK4-like
cd06615	1018-1116	PKc_MEK
cd05615	1015-1124	STKc_cPKC_alpha
cd05861	245-329	Ig1_PDGFR-alphabeta
cd14175	1019-1131	STKc_RSK1_C
cd14103	1009-1117	STKc_MLCK
cd07870	1017-1118	STKc_PFTAIRE2
cd14081	1008-1115	STKc_BRSK1_2
cd14208	1001-1166	PTK_Jak3_rpt1
cd07836	1017-1129	STKc_Pho85
cd14198	1020-1161	STKc_DRAK2
cd05076	1020-1169	PTK_Tyk2_rpt1
cd14223	1013-1183	STKc_GRK2
cd14161	1020-1117	STKc_NUAK2
cd14093	1020-1115	STKc_PhKG
cd14178	1021-1115	STKc_RSK3_C
cd08219	1012-1166	STKc_Nek3
cd14177	1019-1115	STKc_RSK4_C
cd06626	1017-1167	STKc_MEKK4
cd05612	1017-1115	STKc_PRKX_like
cd14039	1021-1106	STKc_IKK_alpha
cd14104	1009-1130	STKc_Titin
cd07861	1017-1107	STKc_CDK1_euk
cd13968	851-1057	PKc_like
cd06653	847-1166	STKc_MEKK3_like_u1
cd14173	985-1117	STKc_Mnk2
cd14094	1012-1117	STKc_CASK
cd14110	1017-1167	STKc_obscurin_rpt2
cd05613	1009-1159	STKc_MSK1_N
cd14044	1019-1169	PK_GC-C
cd07869	1012-1128	STKc_PFTAIRE1
cd14107	1007-1164	STKc_obscurin_rpt1
cd07835	1017-1106	STKc_CDK1_CdkB_like
cd14196	1009-1148	STKc_DAPK2
cd14192	1009-1117	STKc_MLCK3
cd05856	691-765	Ig2_FGFRL1-like
cd14108	998-1117	STKc_SPEG_rpt1
cd07865	851-1123	STKc_CDK9
cd14012	1017-1165	PK_eIF2AK_GCN2_rpt1
cd14109	1010-1122	PK_Unc-89_rpt1
cd14050	1023-1165	PKc_Myt1
cd06649	1018-1116	PKc_MEK2
cd06635	1008-1167	STKc_TAO1
cd06634	1008-1107	STKc_TAO2
cd05583	1017-1115	STKc_MSK_N
cd05607	1009-1115	STKc_GRK7
cd05586	1017-1115	STKc_Sck1_like
cd14113	1009-1125	STKc_Trio_C
cd14159	1008-1172	STKc_IRAK1
cd14191	1009-1122	STKc_MLCK1
cd14036	844-1105	STKc_GAK
cd06624	1017-1167	STKc_ASK
cd14092	1020-1131	STKc_MSK_C
cd14193	1009-1122	STKc_MLCK4
cd14098	1020-1164	STKc_Rad53_Cds1
cd14135	1016-1109	STKc_PRP4
cd07880	1012-1109	STKc_p38gamma
cd14176	1019-1115	STKc_RSK2_C
cd05594	1017-1159	STKc_PKB_alpha
cd14174	1021-1117	STKc_Mnk1
cd05606	1017-1115	STKc_beta_ARK
cd14055	1007-1159	STKc_TGFbR2_like
cd14136	1020-1106	STKc_SRPK
cd07842	1019-1110	STKc_CDK8_like
cd05614	1012-1115	STKc_MSK2_N
cd14665	1012-1165	STKc_SnRK2-3
cd05609	1008-1130	STKc_MAST
cd14179	1034-1115	STKc_MSK1_C
cd07702	353-418	Ig2_VEGFR-1
cd14133	1020-1117	PKc_DYRK_like
cd14046	850-1167	STKc_EIF2AK4_GCN2_rpt2
cd06652	1017-1109	STKc_MEKK2
cd14037	1034-1107	STKc_NAK_like
cd14087	978-1115	STKc_PSKH1
cd14082	1020-1123	STKc_PKD
cd14072	1020-1122	STKc_MARK
cd05593	1017-1115	STKc_PKB_gamma
cd14073	1020-1117	STKc_NUAK
cd14038	1021-1115	STKc_IKK_beta
cd05604	1017-1164	STKc_SGK3
cd13991	1012-1099	STKc_NIK
cd05599	1034-1106	STKc_NDR_like
cd05729	691-765	Ig2_FGFR_like
cd13977	1020-1105	STKc_PDIK1L
cd14053	1021-1109	STKc_ACVR2
cd14026	1019-1162	STKc_RIP2
cd14131	1034-1165	PKc_Mps1
cd14167	1019-1115	STKc_CaMKI_alpha
cd06651	1017-1166	STKc_MEKK3
cd14165	1016-1137	STKc_TSSK1_2-like
cd05573	1033-1115	STKc_ROCK_NDR_like
cd07850	1019-1117	STKc_JNK
cd07879	1012-1130	STKc_p38delta
cd05591	849-1115	STKc_nPKC_epsilon
cd14143	1008-1159	STKc_TGFbR1_ACVR1b_ACVR1c
cd14114	1009-1117	STKc_Twitchin_like
cd13990	1019-1165	STKc_TLK
cd14078	1020-1105	STKc_MELK
cd05633	1017-1148	STKc_GRK3
cd14086	1030-1115	STKc_CaMKII
cd14091	851-1116	STKc_RSK_C
cd14132	1009-1108	STKc_CK2_alpha
cd14180	1027-1119	STKc_MSK2_C
cd05617	1017-1159	STKc_aPKC_zeta
cd14095	1010-1123	STKc_DCKL
cd14229	1006-1119	STKc_HIPK3
cd14662	1012-1115	STKc_SnRK2
cd14213	1008-1116	PKc_CLK1_4
cd05584	1011-1117	STKc_p70S6K
cd07875	1019-1117	STKc_JNK1
cd14183	1019-1123	STKc_DCKL1
cd14112	1020-1123	STKc_Unc-89_rpt2
cd14144	1035-1159	STKc_BMPR1
cd14117	1020-1124	STKc_Aurora-B_like
cd13988	851-1123	STKc_TBK1
cd14075	1020-1105	STKc_NIM1
cd14185	1023-1123	STKc_DCKL3
cd14184	1010-1115	STKc_DCKL2
cd06646	1008-1110	STKc_MAP4K5
cd14142	1035-1107	STKc_ACVR1_ALK1
cd05622	1017-1115	STKc_ROCK1
cd05728	682-765	Ig4_Contactin-2-like
cd14138	1005-1167	PTKc_Wee1a
pfam13895	689-760	Ig_2
cd07876	1019-1107	STKc_JNK2
cd14210	1020-1117	PKc_DYRK
cd05610	1017-1115	STKc_MASTL
cd05618	1017-1159	STKc_aPKC_iota
cd14212	1020-1117	PKc_YAK1
cd04975	332-420	Ig4_SCFR_like
cd13982	996-1115	STKc_IRE1
cd05603	1017-1115	STKc_SGK2
cd14005	1019-1167	STKc_PIM
cd14220	1035-1159	STKc_BMPR1a
cd05602	1017-1115	STKc_SGK1
cd06645	1008-1110	STKc_MAP4K3
cd07874	1019-1107	STKc_JNK3
cd14170	985-1166	STKc_MAPKAPK2
pfam13895	340-418	Ig_2
cd05588	1017-1115	STKc_aPKC
cd05571	1017-1107	STKc_PKB
cd05731	695-766	Ig3_L1-CAM_like
cd14089	1020-1105	STKc_MAPKAPK
cd05859	332-420	Ig4_PDGFR-alpha
cd14020	1021-1109	STKc_KIS
cd14225	1017-1117	PKc_DYRK4
cd00096	248-324	Ig
cd14101	1016-1166	STKc_PIM2
cd05575	1017-1106	STKc_SGK
cd05725	696-765	Ig3_Robo
cd07837	1008-1174	STKc_CdkB_plant
cd14074	1012-1115	STKc_SNRK
cd14219	1035-1159	STKc_BMPR1b
cd13986	1023-1174	STKc_16
cd14172	985-1166	STKc_MAPKAPK3
cd14166	1020-1142	STKc_CaMKI_gamma
cd08216	1012-1165	PK_STRAD
cd00096	352-413	Ig
cd04975	681-765	Ig4_SCFR_like
pfam07714	845-1169	Pkinase_Tyr
smart00408	693-755	IGc2
smart00410	238-327	IG_like
smart00410	343-415	IG_like
smart00408	570-658	IGc2
smart00221	845-1169	STYKc
smart00219	845-1169	TyrKc
smart00220	846-1167	S_TKc
pfam00069	845-1167	Pkinase
COG0515	846-1160	SPS1
PTZ00283	1020-1166	PTZ00283
PTZ00267	1019-1167	PTZ00267
pfam07679	678-765	I-set
PHA03209	1008-1116	PHA03209
smart00410	686-765	IG_like
smart00409	686-765	IG
PTZ00024	1009-1117	PTZ00024
PTZ00263	834-1115	PTZ00263
PTZ00036	1008-1116	PTZ00036
PLN00034	1018-1189	PLN00034
smart00409	238-327	IG
PTZ00426	843-1115	PTZ00426
PRK13184	1020-1176	pknD
PLN00009	1017-1109	PLN00009
PHA02988	1035-1169	PHA02988
smart00409	343-415	IG
PHA03207	1007-1121	PHA03207
pfam07679	238-327	I-set
smart00408	352-398	IGc2
PHA03212	1013-1107	PHA03212
smart00409	564-657	IG
smart00410	564-657	IG_like
TIGR03903	956-1106	TOMM_kin_cyc
pfam07679	343-398	I-set

Ontology Information

   

HPRD ID	7045
Molecular Class	Receptor tyrosine kinase
Molecular Function	Transferase activity (GO:0016740)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report   

Drug Information

Uniprot ID	DrugBank ID	Name	Type
P35916	DB00398	Sorafenib	SmallMoleculeDrug
P35916	DB01268	Sunitinib	SmallMoleculeDrug
P35916	DB06589	Pazopanib	SmallMoleculeDrug
P35916	DB06626	Axitinib	SmallMoleculeDrug
P35916	DB08896	Regorafenib	SmallMoleculeDrug
P35916	DB09078	Lenvatinib	SmallMoleculeDrug
P35916	DB09079	Nintedanib	SmallMoleculeDrug

External Links

                                 

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO