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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ANKRD12 23253 ankyrin repeat domain 12  18KIAA0874, FLJ20053, GAC-1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23718802   2013Cell line : -

Source : Second Affiliated Hospital of Zhejiang University.

Sample Type : CRC tumor and normal tissue

No. of Sample : CRC tumor 68 and adjacent normal mucosa 51

Stage : -

 real time RT-PCRDown-regulation-ANKRD12 mRNA were down regulated in CRC tumor tissues and low ANKRD12 expression was correlated with liver metastasis and poor survival of CRC patients.


Gene Details



NC_000018.9 (9136751..9285983)

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Gene Type protein coding
Gene Family Ankyrin repeat domain containing
Description This gene encodes a member of the ankyrin repeats-containing cofactor family. These proteins may inhibit the transcriptional activity of nuclear receptors through the recruitment of histone deacetylases. The encoded protein interacts with p160 coactivators and also represses transcription mediated by the coactivator alteration/deficiency in activation 3 (ADA3). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]  
Chromosome 18
Location 18p11.22
Start 9136751  
End 9285983  
Strand +  
Gene Sequence

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Length 149233  
OMIM ID 610616   
HGNC ID HGNC:29135   
Unigene ID Hs.464585   
Ensembl ID ENSG00000101745   
PharmGKB ID PA134899860   

mRNA Information


mRNA ID ?NM_001083625.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS11843.1



Protein Information


      
Protein IDNP_001077094.1
Protein Nameankyrin repeat domain 12
Molecular Wt. (Da)0
Protein Sequence

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Length 2062  
Uniprot IDQ9Y574
Ensembl Protein ID ENSP00000321388  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation149
SPhosphorylation126
KAcetylation39
KAcetylation39
SPhosphorylation861
SPhosphorylation838

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00204179-291  ANK
cl02529179-291  ANK superfamily
cd00204178-271  ANK
pfam00023185-215  Ank
pfam00023218-245  Ank
pfam00023250-282  Ank
smart00248218-245  ANK
smart00248250-277  ANK
smart00248184-213  ANK
pfam13606218-246  Ank_3
pfam13606185-213  Ank_3
pfam12796189-281  Ank_2
pfam12796187-247  Ank_2
PHA03095178-290  PHA03095
PHA02874177-291  PHA02874
COG0666177-276  ANKYR
PHA03100120-276  PHA03100
pfam12796222-291  Ank_2
PHA02876147-276  PHA02876
PTZ00322116-284  PTZ00322
PHA02878146-291  PHA02878
PHA02874178-291  PHA02874
PHA02878178-274  PHA02878
PTZ00121720-1165  PTZ00121
PHA02875186-273  PHA02875
PHA03095178-287  PHA03095
PHA03095197-276  PHA03095
COG0666174-250  ANKYR
COG0666170-291  ANKYR
pfam13637187-238  Ank_4
PTZ00121734-1068  PTZ00121
pfam13637218-271  Ank_4
PHA02878197-291  PHA02878
PHA03100177-246  PHA03100
pfam13857172-225  Ank_5
PTZ00121369-1004  PTZ00121
pfam02463316-1012  SMC_N
PHA02876118-275  PHA02876
PHA02875187-276  PHA02875
pfam12796177-215  Ank_2
PLN03192189-252  PLN03192
PLN03192184-285  PLN03192
PTZ00108708-1007  PTZ00108
PHA02859178-284  PHA02859
PHA03095143-272  PHA03095
pfam13857237-291  Ank_5
PTZ00121666-1064  PTZ00121
PHA02875183-291  PHA02875
PTZ00322234-291  PTZ00322
PRK03918698-1007  PRK03918
PHA03100187-276  PHA03100
PHA02874201-288  PHA02874
PHA02876165-276  PHA02876
COG1196721-1035  Smc
pfam02463674-983  SMC_N
COG0419700-996  SbcC
PLN03192192-270  PLN03192
pfam13857204-256  Ank_5
PHA02798198-284  PHA02798
TIGR02169717-986  SMC_prok_A
TIGR02168719-983  SMC_prok_B
PRK00409703-835  PRK00409
pfam10243883-1058  MIP-T3
PHA02875185-277  PHA02875
PHA02874178-291  PHA02874
COG1340720-970  COG1340
COG0610703-979  COG0610
PTZ00108713-1063  PTZ00108
pfam13637178-205  Ank_4
PRK03918714-967  PRK03918
PHA02874189-274  PHA02874


Ontology Information


   
HPRD ID17637
Molecular ClassUnclassified
Molecular FunctionProtein serine/threonine kinase activity (GO:0004674)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO