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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
NEDD4L 23327 neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase  18KIAA0439, RSP5, NEDD4-2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24312311   2013Cell line : -

Source : VUMC 55 and MCC 195

Sample Type : CRC tumor and normal tissue

No. of Sample : 250

Stage : TNM Stage I-IV.

Western blotting, TOPFlash assay,NEDD4L knock-downDown-regulation-NEDD4L may play a tumor suppressive role in colorectal cancer, possibly through inhibition of canonical WNT signaling.


Gene Details



NC_000018.9 (55711580..56068772)

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Gene Type protein coding
Gene Family -
Description This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]  
Chromosome 18
Location 18q21.31
Start 55711580  
End 56068772  
Strand +  
Gene Sequence

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Length 357193  
OMIM ID 606384   
HGNC ID HGNC:7728   
Unigene ID Hs.185677   
Ensembl ID ENSG00000049759   
PharmGKB ID PA31534   

mRNA Information


mRNA ID ?NM_001144964.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS45872.1



Protein Information


      
Protein IDNP_001138436.1
Protein Nameneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Molecular Wt. (Da)0
Protein Sequence

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Length 975  
Uniprot IDQ9ULC5
Ensembl Protein ID ENSP00000346223  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation342
SPhosphorylation428
SPhosphorylation428;-
TPhosphorylation302
TPhosphorylation318
SPhosphorylation426
SPhosphorylation429
SPhosphorylation444
TPhosphorylation431
SPhosphorylation459
SPhosphorylation463
SPhosphorylation467
SPhosphorylation455
TPhosphorylation453

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
6337SCNN1A2575NP_001029.1in vitro;in vivo112   440   921   849   824   000   000   000   
6338SCNN1B2861NP_000327.2in vitro;in vivo112   440   921   849   824   000   000   000   
6340SCNN1G2862NP_001030.2in vitro;in vivo112   440   921   849   824   000   000   000   
7324UBE2E14225NP_003332.1in vitro8576257   
7332UBE2L34762NP_003338.1in vitro8576257   


Pathway Information


                  
Pathway Name Pathway ID
Aldosterone-regulated sodium reabsorption hsa04960
Endocytosis hsa04144
Ubiquitin mediated proteolysis hsa04120


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00078618-972  HECTc
cl00077618-972  HECTc superfamily
cd0403321-153  C2_NEDD4_NEDD4L
cl1460321-153  C2 superfamily
cd00201500-530  WW
cl00157500-530  WW superfamily
cd00201388-416  WW
cl00157388-416  WW superfamily
cd00201551-581  WW
cl00157551-581  WW superfamily
cd00201198-224  WW
cl00157198-224  WW superfamily
pfam00632670-972  HECT
cd0003022-127  C2
smart0023921-121  C2
pfam0016822-108  C2
cd0404022-121  C2D_Tricalbin-like
cd0402622-115  C2_PKC_alpha_gamma
cd0403821-112  C2_ArfGAP
cd0837721-150  C2C_MCTP_PRT
cd083865-122  C2A_Synaptotagmin-7
cd0400922-121  C2B_Munc13-like
cd083855-113  C2A_Synaptotagmin-1-5-6-9-10
cd0839121-113  C2A_C2C_Synaptotagmin_like
cd0402421-140  C2A_Synaptotagmin-like
cd0027520-115  C2_PLC_like
cd0404421-154  C2A_Tricalbin-like
cd0404222-121  C2A_MCTP_PRT
cd0402222-149  C2A_MCTP_PRT_plant
cd0403622-116  C2_cPLA2
cd0838721-115  C2A_Synaptotagmin-8
cd0402722-150  C2B_Munc13
cd0027622-118  C2B_Synaptotagmin
cd0404521-121  C2C_Tricalbin-like
cd0867613-118  C2A_Munc13-like
cd0404122-115  C2A_fungal
cd0838222-137  C2_Smurf-like
cd0867522-115  C2B_RasGAP
cd0405422-108  C2A_Rasal1_RasA4
cd0403116-114  C2A_RIM1alpha
cd0840521-108  C2B_Synaptotagmin-7
cd0402522-115  C2B_RasA1_RasA4
cd0837621-120  C2B_MCTP_PRT
cd0403522-132  C2A_Rabphilin_Doc2
cd0404727-115  C2B_Copine
cd0838420-108  C2B_Rabphilin_Doc2
cd0404619-111  C2_Calpain
cd0404827-117  C2A_Copine
cd085216-123  C2A_SLP
cd0840222-118  C2B_Synaptotagmin-1
smart00456386-416  WW
cd0837522-134  C2_Intersectin
cd0403721-107  C2E_Ferlin
smart00456499-530  WW
cd0405021-130  C2B_Synaptotagmin-like
cd0841022-108  C2B_Synaptotagmin-17
cd0867839-154  C2_C21orf25-like
cd0839022-113  C2A_Synaptotagmin-15-17
smart00456549-581  WW
cd0401022-150  C2B_RasA3
pfam00397387-416  WW
pfam00397499-528  WW
cd0840322-110  C2B_Synaptotagmin-3-5-6-9-10
cd0404324-106  C2_Munc13_fungal
cd0838818-125  C2A_Synaptotagmin-4-11
cd0839322-113  C2A_SLP-1_2
cd0838322-152  C2A_RasGAP
cd0402122-115  C2_E3_ubiquitin_ligase
pfam00397550-579  WW
pfam00397198-224  WW
cd0403222-113  C2_Perforin
cd0840162-151  C2A_RasA2_RasA3
cd0840422-107  C2B_Synaptotagmin-4
cd0401422-119  C2_PKC_epsilon
smart00456198-224  WW
cd0403022-115  C2C_KIAA1228
cd0402024-108  C2B_SLP_1-2-3-4
cd0404921-118  C2_putative_Elicitor-responsive_gene
cd0401123-111  C2B_Ferlin
cd0869134-151  C2_NEDL1-like
cd0405239-115  C2B_Tricalbin-like
cd0402941-124  C2A_SLP-4_5
cd0405121-148  C2_SRC2_like
cd0868516-105  C2_RGS-like
cd0868262-115  C2_Rab11-FIP_classI
cd0403963-122  C2_PSD
cd0868822-123  C2_KIAA0528-like
cd0837822-120  C2B_MCTP_PRT_plant
cd0868121-152  C2_fungal_Inn1p-like
cd0837326-115  C2A_Ferlin
cd0838142-115  C2B_PI3K_class_II
cd0401722-108  C2D_Ferlin
cd0837932-117  C2D_MCTP_PRT_plant
cd0401922-126  C2C_MCTP_PRT_plant
cd040285-122  C2B_RIM1alpha
cd0401821-106  C2C_Ferlin
cd0839463-116  C2A_Munc13
cd0839243-124  C2A_SLP-3
cd0869042-118  C2_Freud-1
smart00119642-971  HECTc
COG5021387-971  HUL4
COG503822-123  COG5038
COG503812-129  COG5038
COG503822-120  COG5038
PLN0222320-115  PLN02223
PLN029521-115  PLN02952
PHA03247319-502  PHA03247
PLN0222822-115  PLN02228
PLN0223020-115  PLN02230
PHA03247334-513  PHA03247


Ontology Information


   
HPRD ID5501
Molecular ClassUbiquitin proteasome system protein
Molecular FunctionOxidoreductase activity (GO:0016491)
Biological ProcessApoptosis (GO:0006915)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO