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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
FN1 2335 fibronectin 1  2MSF, CIG, LETS, GFND2, FINC 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24919860   2014Cell line : -

Source : -

Sample Type : CRC Tumor

No. of Sample : 146

Stage : -

Microarray Polymorhpism-GG genotype at SNP rs6707530 showed significantly higher FN1 expression than did 23 tumors with GT/TT genotypes (p<0.05).

25914544   2015Cell line : -

Source : Gene Expression Omnibus (GEO),National Center for Biotechnology Information (NCBI).

Sample Type : -

No. of Sample : -

Stage : -

Data preprocessing and analysis of DEGs,Functional and pathway enrichment analysis,PPI network construction,Module analysis of the PPI network.Up-regulation-DEGs, such as FOS, FN1, PPP1CC, and CYP2B6, may be used as potential targets for CRC diagnosis and treatment.


Gene Details



NC_000002.11 (216225177..216300890, complement)

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Gene Type protein coding
Gene Family Fibronectin type III domain containing, "Endogenous ligands"
Description This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]  
Chromosome 2
Location 2q34
Start 216225177  
End 216300890  
Strand -  
Gene Sequence

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Length 75714  
OMIM ID 135600   
HGNC ID HGNC:3778   
Unigene ID Hs.203717   
Ensembl ID ENSG00000115414   
PharmGKB ID PA28194   

mRNA Information


mRNA ID NM_212474.2
Exon join(100..513,1344..1472,2707..2844,4204..4335,5316..5453, 7830..7988,10883..11074,11843..12022,12642..12818, 13925..14077,15367..15495,16783..16926,21210..21331, 26054..26234,26429..26605,27742..27870,27971..28060, 28847..29041,29658..29930,31513..31779,36817..36911, 38320..38488,38945..39031,41449..41640,44354..44536, 47867..47956,49210..49479,51192..51308,51984..52148, 52685..52840,53843..53956,56851..57038,57906..57993, 59494..59670,60450..60539,60775..60954,62757..62846, 64153..64259,65736..65874,68141..68305,70538..70663, 71183..71289,74089..74199,74542..75714)  
mRNA Sequence

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Length 7930  



CDS Information


   
Location 267..6797
CDS Sequence

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CCDS ID CCDS2399.1



Protein Information


      
Protein IDNP_997639.1
Protein Namefibronectin 1
Molecular Wt. (Da)237162
Protein Sequence

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Length 2176  
Uniprot IDP10276
Ensembl Protein ID ENSP00000254066  



Post-translational Modification Information (Source : HPRD)


Residue Type site
QTransglutamination1443
QTransglutamination1980
QTransglutamination34
NGlycosylation528
QTransglutamination63
QTransglutamination34
NGlycosylation528
QTransglutamination63
QTransglutamination1534
QTransglutamination2071
QTransglutamination34
NGlycosylation528
QTransglutamination63
QTransglutamination1534
QTransglutamination2071
QTransglutamination34
NGlycosylation528
QTransglutamination63
QTransglutamination1443
QTransglutamination1980
QTransglutamination34
NGlycosylation528
QTransglutamination63
QTransglutamination1443
QTransglutamination1890
QTransglutamination34
NGlycosylation528
QTransglutamination63
QTransglutamination1443
QTransglutamination1890
QTransglutamination34
NGlycosylation528
QTransglutamination63
SPhosphorylation909;-
SPhosphorylation909;-
SPhosphorylation909;-
SPhosphorylation909;-
SPhosphorylation909;-
SPhosphorylation909;-
SPhosphorylation2353;-
SPhosphorylation2475;-
SPhosphorylation2419;-
SPhosphorylation2328;-
SPhosphorylation2294;-
SPhosphorylation2174;-
NGlycosylation542
NGlycosylation542
NGlycosylation542
NGlycosylation542
NGlycosylation542
NGlycosylation542
NGlycosylation542
NGlycosylation1007
NGlycosylation1007
NGlycosylation1007
NGlycosylation1007
NGlycosylation1007
NGlycosylation1007
SPhosphorylation2318
SPhosphorylation2440
SPhosphorylation2384
SPhosphorylation2293
SPhosphorylation2259
SPhosphorylation2139
SPhosphorylation2310
SPhosphorylation2432
SPhosphorylation2376
SPhosphorylation2285
SPhosphorylation2251
SPhosphorylation2131
SPhosphorylation904
SPhosphorylation904
SPhosphorylation904
SPhosphorylation904
SPhosphorylation904
SPhosphorylation904

Enzyme Information


No matching records could be found.

PPi Information


No STRING Network could be found.

                                                                                                                                                                                                                                                                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
325APCS101NP_001630.1in vivo12100475   
356FASLG610NP_000630.1in vitro;in vivo11276204   
712C1QA393NP_057075.1in vitro6981115   
1277COL1A1362NP_000079.2in vivo8468356   
1278COL1A2363NP_000080.2in vivo8468356   
1280COL2A1361NP_001835.3in vivo39   975   522   229   073   
1282COL4A1359NP_001836.2in vivo3997552   
1284COL4A2355NP_001837.2in vivo3997552   
1285COL4A3354NP_000082.2in vivo3997552   
1286COL4A4360NP_000083.3in vivo3997552   
1294COL7A1358NP_000085.1in vitro91   694   087   963   647   
1305COL13A1383NP_005194.3in vitro11956183   
1401CRP422NP_000558.2in vitro6693419   
1509CTSD291NP_001900.1in vivo3988746   
1634DCN501NP_001911.1in vitro1468447   
2162F13A1604NP_000120.2in vitro8905624   
3082HGF799NP_000592.3in vitro15717924   
3488IGFBP5901NP_000590.1in vitro;in vivo;yeast 2-hybrid14645245   
4089SMAD42995NP_005350.1yeast 2-hybrid15231748   
4093SMAD94484BAA21128.1yeast 2-hybrid15231748   
4318MMP9387NP_004985.2in vitro11134254   
6498SKIL1319NP_005405.2yeast 2-hybrid15231748   
9507ADAMTS44853NP_005090.3in vitro;yeast 2-hybrid15161923   
10272FSTL35632NP_005851.1in vitro;yeast 2-hybrid16336961   
10468FST641NP_037541.1in vitro16336961   
55660PRPF40A10995NP_060362.3yeast 2-hybrid15231748   


Pathway Information


                                                            
Pathway Name Pathway ID
AGE-RAGE signaling pathway in diabetic complications hsa04933
Amoebiasis hsa05146
Bacterial invasion of epithelial cells hsa05100
ECM-receptor interaction hsa04512
Focal adhesion hsa04510
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151
Proteoglycans in cancer hsa05205
Regulation of actin cytoskeleton hsa04810
Small cell lung cancer hsa05222


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00062354-401  FN2
cl09951354-401  FN2 superfamily
cd00062414-461  FN2
cl09951414-461  FN2 superfamily
cd000631904-1984  FN3
cl215221904-1984  FN3 superfamily
cd000631449-1531  FN3
cl215221449-1531  FN3 superfamily
cd00063811-899  FN3
cl21522811-899  FN3 superfamily
cd000631543-1630  FN3
cl215221543-1630  FN3 superfamily
cd000631268-1349  FN3
cl215221268-1349  FN3 superfamily
cd000631359-1438  FN3
cl215221359-1438  FN3 superfamily
cd00061559-602  FN1
cl00063559-602  FN1 superfamily
cd00063998-1084  FN3
cl21522998-1084  FN3 superfamily
cd000612294-2333  FN1
cl000632294-2333  FN1 superfamily
cd0006195-136  FN1
cl0006395-136  FN1 superfamily
cd00063910-995  FN3
cl21522910-995  FN3 superfamily
cd000612204-2248  FN1
cl000632204-2248  FN1 superfamily
cd000631723-1810  FN3
cl215221723-1810  FN3 superfamily
cd00061184-227  FN1
cl00063184-227  FN1 superfamily
cd0006152-89  FN1
cl0006352-89  FN1 superfamily
cd00061468-508  FN1
cl00063468-508  FN1 superfamily
cd000631633-1713  FN3
cl215221633-1713  FN3 superfamily
cd000631175-1264  FN3
cl215221175-1264  FN3 superfamily
cd000612250-2291  FN1
cl000632250-2291  FN1 superfamily
cd00061229-273  FN1
cl00063229-273  FN1 superfamily
cd000631815-1895  FN3
cl215221815-1895  FN3 superfamily
cd00061139-181  FN1
cl00063139-181  FN1 superfamily
cd00061516-558  FN1
cl00063516-558  FN1 superfamily
cd00063727-809  FN3
cl21522727-809  FN3 superfamily
cd00061307-345  FN1
cl00063307-345  FN1 superfamily
cd00063628-678  FN3
cl21522628-678  FN3 superfamily
cd000631096-1161  FN3
cl215221096-1161  FN3 superfamily
smart00059353-401  FN2
smart00059413-461  FN2
pfam00040360-401  fn2
pfam000411449-1530  fn3
pfam00040420-461  fn2
pfam000411268-1349  fn3
pfam000411543-1623  fn3
pfam000411904-1984  fn3
pfam000411359-1438  fn3
pfam000411723-1803  fn3
pfam00039561-599  fn1
smart00058186-230  FN1
pfam00041812-883  fn3
smart00058561-604  FN1
smart000582206-2250  FN1
smart000582251-2292  FN1
smart00058470-508  FN1
smart00058231-275  FN1
pfam00041908-988  fn3
pfam000411815-1894  fn3
smart000601268-1347  FN3
smart00058518-560  FN1
pfam0003997-135  fn1
pfam00041998-1076  fn3
smart000601451-1527  FN3
pfam00039186-225  fn1
smart000601904-1982  FN3
pfam00041727-798  fn3
smart0005897-140  FN1
pfam000392206-2245  fn1
smart00058141-184  FN1
pfam00039471-508  fn1
pfam00039231-270  fn1
smart00060811-889  FN3
pfam000411175-1258  fn3
pfam00041619-688  fn3
smart000601543-1621  FN3
smart000601359-1437  FN3
smart000582295-2335  FN1
pfam00039141-179  fn1
pfam000411633-1713  fn3
pfam000392251-2288  fn1
pfam000392295-2330  fn1
smart00060998-1075  FN3
smart0005852-92  FN1
pfam0003952-87  fn1
smart000601723-1794  FN3
pfam00039523-555  fn1
smart00060908-986  FN3
smart000601175-1256  FN3
smart000601815-1889  FN3
pfam000411092-1154  fn3
pfam00039311-341  fn1
smart00060727-791  FN3
smart000601635-1711  FN3
smart00060616-688  FN3
pfam000412120-2178  fn3
cl215222120-2178  FN3 superfamily
smart00058308-347  FN1
smart000601096-1161  FN3


Ontology Information


   
HPRD ID7183
Molecular ClassExtracellular matrix protein
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P02751DB08888OcriplasminBiotechDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO