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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26086877 | 2015 | Cell line : SW480, HCT116, and HT29 Source : - Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry,proliferation, migration and invasion assay, real-time RT-PCR ,Western blotting,Transfection | Down-regulation | - | SIRT4 has a tumour-suppressive function and may serve as a novel therapeutic target in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008] |
| Chromosome | 12 |
| Location | 12q24.31 |
| Start | 120730002 |
| End | 120751045 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 21044 |
| OMIM ID | 604482 |
| HGNC ID | HGNC:14932 |
| Unigene ID | Hs.50861 |
| Ensembl ID | ENSG00000089163 |
| PharmGKB ID | PA37937 |
Protein Information
| Protein ID | NP_036372.1 |
|---|---|
| Protein Name | sirtuin 4 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 314 |
| Uniprot ID | Q96T23 |
| Ensembl Protein ID | ENSP00000311513 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 255 |
| S | Phosphorylation | 261 |
| S | Phosphorylation | 262 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01409 | 47-308 | SIRT4 |
| cl00195 | 47-308 | SIR2 superfamily |
| PRK05333 | 40-308 | PRK05333 |
| cd01407 | 55-303 | SIR2-fam |
| cd00296 | 55-295 | SIR2 |
| PRK00481 | 42-309 | PRK00481 |
| COG0846 | 43-311 | SIR2 |
| cd01413 | 51-303 | SIR2_Af2 |
| pfam02146 | 62-267 | SIR2 |
| cd01412 | 55-309 | SIRT5_Af1_CobB |
| cd01410 | 55-303 | SIRT7 |
| PRK14138 | 44-301 | PRK14138 |
| cd01411 | 47-266 | SIR2H |
| cd01408 | 55-266 | SIRT1 |
| PTZ00409 | 45-290 | PTZ00409 |
| PTZ00410 | 47-266 | PTZ00410 |
| PTZ00408 | 55-278 | PTZ00408 |
Ontology Information
| HPRD ID | 6352 |
|---|---|
| Molecular Class | Enzyme: Deacetylase |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.