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General Information
- Evidence
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25785061 | 2015 | Cell line : - Source : Liaocheng People�s Hospital Sample Type : CRC tumor and normal tissue No. of Sample : 50 CRC and 20 normal tissues Stage : - | Immunohistochemistry,Real Time RT- PCR | Up-regulation | - | SIRT1 have a dual character in colorectal cancer, and Phospho-SIRT1 may determine the role of SIRT1 in colorectal cancer formation. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008] |
| Chromosome | 10 |
| Location | 10q21 |
| Start | 69644427 |
| End | 69678147 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 33721 |
| OMIM ID | 604479 |
| HGNC ID | HGNC:14929 |
| Unigene ID | Hs.369779 |
| Ensembl ID | ENSG00000096717 |
| PharmGKB ID | PA37935 |
Protein Information
| Protein ID | NP_001135970.1 |
|---|---|
| Protein Name | sirtuin 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 747 |
| Uniprot ID | Q7Z3B4 |
| Ensembl Protein ID | ENSP00000264883 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 27 |
| S | Phosphorylation | 47 |
| S | Phosphorylation | 26;- |
| S | Phosphorylation | 569 |
| T | Phosphorylation | 719 |
| S | Phosphorylation | 14 |
| S | Phosphorylation | 16 |
| S | Phosphorylation | 525 |
| T | Phosphorylation | 530 |
| S | Phosphorylation | 535 |
| S | Phosphorylation | 538 |
| S | Phosphorylation | 539 |
| T | Phosphorylation | 554 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2033 | EP300 | 4078 | NP_001420.2 | in vitro;in vivo | 15632193 |
| 3009 | HIST1H1B | 821 | NP_005313.1 | in vitro | 15469825 |
| 3280 | HES1 | 770 | NP_005515.1 | in vivo | 12535671 |
| 5970 | RELA | 1241 | NP_068810.3 | in vivo | 15152190 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vitro;in vivo | 11672523 |
| 7376 | NR1H2 | 2660 | NP_009052.3 | in vivo | 17936707 |
| 10062 | NR1H3 | 7211 | NP_005684.2 | in vivo | 17936707 |
| 23493 | HEY2 | 5243 | NP_036391.1 | in vitro;in vivo | 12535671 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Amphetamine addiction | hsa05031 |
| AMPK signaling pathway | hsa04152 |
| FoxO signaling pathway | hsa04068 |
| Glucagon signaling pathway | hsa04922 |
| Longevity regulating pathway - mammal | hsa04211 |
| Longevity regulating pathway - multiple species | hsa04213 |
| MicroRNAs in cancer | hsa05206 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01408 | 254-489 | SIRT1 |
| cl00195 | 254-489 | SIR2 superfamily |
| cd01407 | 254-481 | SIR2-fam |
| pfam02146 | 261-447 | SIR2 |
| COG0846 | 243-489 | SIR2 |
| cd00296 | 254-481 | SIR2 |
| cd01413 | 250-470 | SIR2_Af2 |
| PTZ00410 | 254-467 | PTZ00410 |
| PRK00481 | 241-495 | PRK00481 |
| PRK14138 | 243-452 | PRK14138 |
| cd01411 | 246-479 | SIR2H |
| cd01412 | 254-482 | SIRT5_Af1_CobB |
| cd01410 | 254-471 | SIRT7 |
| cd01409 | 247-445 | SIRT4 |
| PTZ00409 | 233-452 | PTZ00409 |
| PRK05333 | 255-445 | PRK05333 |
| PTZ00408 | 253-452 | PTZ00408 |
| cd01406 | 254-350 | SIR2-like |
| COG0028 | 431-536 | IlvB |
Ontology Information
| HPRD ID | 5685 |
|---|---|
| Molecular Class | Enzyme: Deacetylase |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.