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General Information
- Evidence
- Gene
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25294915 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 195 CRC tissue and 45 normal controls Stage : - | Immunohistochemistry and ELISA | Up-regulation | - | Serum ANGPTL2 is a novel diagnostic and recurrence-predictive biomarker in patients with CRC. High serum ANGPTL2 was significantly associated with advanced T stage, lymph node and liver metastasis, early relapse and poor prognosis in CRCs. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Fibrinogen C domain containing |
| Description | Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. |
| Chromosome | 9 |
| Location | 9q34 |
| Start | 127087349 |
| End | 127122797 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 35449 |
| OMIM ID | 605001 |
| HGNC ID | HGNC:490 |
| Unigene ID | Hs.653262 |
| Ensembl ID | ENSG00000136859 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_012098.2 |
|---|---|
| Exon | join(33..483,14018..14883,28872..29065,30858..31128, 33660..35449) | mRNA Sequence | Download Select all |
| Length | 3572 |
CDS Information
| Location | join(14067..14883,28872..29065,30858..31128,33660..33859) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS6868.1 |
Protein Information
| Protein ID | NP_036230.1 |
|---|---|
| Protein Name | angiopoietin-like 2 |
| Molecular Wt. (Da) | 54803 |
| Protein Sequence | Download Select all |
| Length | 493 |
| Uniprot ID | P51787 |
| Ensembl Protein ID | ENSP00000155840 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00087 | 273-487 | FReD |
| cl00085 | 273-487 | FReD superfamily |
| smart00186 | 276-487 | FBG |
| pfam00147 | 276-487 | Fibrinogen_C |
Ontology Information
| HPRD ID | 5388 |
|---|---|
| Molecular Class | Secreted polypeptide |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.