Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| HEY1 | 23462 | hes-related family bHLH transcription factor with YRPW motif 1 | 8 | HESR-1, CHF2, HESR1, HRT-1, CHF-2, HERP2, BHLHb31 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23900217 | 2013 | Cell line : - Source : Sir Charles Gairdner Hospital (SCGH), Western Australia. Sample Type : CRC tumor No. of Sample : 1056 consenting CRC patients Stage : - | Immunohistochemistry,tissue microarray | Up-regulation | - | HEY1 overexpression correlates with poorer outcome in CRC. |
| 24265293 | 2014 | Cell line : HT29, HCT116, SW480, SW620, DLD1,FHC Source : ATCC Sample Type : - No. of Sample : - Stage : - | Spheroid assay,Luciferase assay, real time RT-PCR,Western blotting,ELISA | Up-regulation | - | Increased accumulation of the cleaved/active form of Notch-1 receptor (Notch intracellular domain) and increased expression of Notch responsive genes HEY1, HES1. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Basic helix-loop-helix proteins |
| Description | This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| Chromosome | 8 |
| Location | 8q21 |
| Start | 80676245 |
| End | 80680098 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 3854 |
| OMIM ID | 602953 |
| HGNC ID | HGNC:4880 |
| Unigene ID | Hs.234434 |
| Ensembl ID | - |
| PharmGKB ID | PA29258 |
Protein Information
| Protein ID | NP_001035798.1 |
|---|---|
| Protein Name | hes-related family bHLH transcription factor with YRPW motif 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 304 |
| Uniprot ID | Q9NR96 |
| Ensembl Protein ID | ENSP00000353874 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 25 |
| S | Phosphorylation | 45 |
| S | Phosphorylation | 25 |
| S | Phosphorylation | 45 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4654 | MYOD1 | 1166 | NP_002469.2 | in vitro;in vivo | 11279181 |
| 55294 | FBXW7 | 5888 | NP_361014.1 | in vivo | 11585921 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00083 | 50-107 | HLH |
| cl00081 | 50-107 | HLH superfamily |
| pfam00010 | 50-105 | HLH |
| smart00353 | 56-104 | HLH |
| smart00511 | 120-166 | ORANGE |
| cl02638 | 120-166 | Hairy_orange superfamily |
| pfam07527 | 121-165 | Hairy_orange |
| PLN03217 | 49-105 | PLN03217 |
| cl14736 | 49-105 | PLN03217 superfamily |
Ontology Information
| HPRD ID | 12193 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.