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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PES1 | 23481 | pescadillo ribosomal biogenesis factor 1 | 22 | PES |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22860098 | 2012 | Cell line : HCT116, SW480, RKO, AGS Source : American type culture collection (ATCC). Peking University Cancer Hospital & Institute. . Sample Type : CRC tumor and normal tissues No. of Sample : 265 Stage : - | Chromatin immunoprecipitation and EMSA, immunohistochemistry | Up-regulation | - | Oncogenic role of PES1 in colon cancer and elucidates the molecular mechanism directing PES1 expression.Out of 265 colon cancer tissues, 89 (33.6%) showed positive PES1 expression, which was significantly higher than in non-cancerous tissues (P<0.001). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011] |
| Chromosome | 22 |
| Location | 22q12.1 |
| Start | 30972612 |
| End | 31003000 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 30389 |
| OMIM ID | 605819 |
| HGNC ID | HGNC:8848 |
| Unigene ID | Hs.517543 |
| Ensembl ID | ENSG00000100029 |
| PharmGKB ID | PA33190 |
Protein Information
| Protein ID | NP_001230154.1 |
|---|---|
| Protein Name | pescadillo ribosomal biogenesis factor 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 588 |
| Uniprot ID | P35900 |
| Ensembl Protein ID | ENSP00000167588 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 548;- |
| S | Phosphorylation | 457 |
| S | Phosphorylation | 488 |
| K | Acetylation | 98 |
| S | Phosphorylation | 13 |
| T | Phosphorylation | 15 |
| S | Phosphorylation | 578 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00027 | 329-402 | BRCT |
| cl00038 | 329-402 | BRCT superfamily |
| pfam06732 | 6-287 | Pescadillo_N |
| cl05998 | 6-287 | Pescadillo_N superfamily |
| smart00292 | 325-402 | BRCT |
| pfam00533 | 322-402 | BRCT |
| pfam04979 | 252-343 | IPP-2 |
| cl04871 | 252-343 | IPP-2 superfamily |
| COG5163 | 6-584 | NOP7 |
| PTZ00121 | 438-585 | PTZ00121 |
| PTZ00121 | 490-585 | PTZ00121 |
| COG3064 | 491-585 | TolA |
Ontology Information
| HPRD ID | 9913 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.