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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
FOS 2353 FBJ murine osteosarcoma viral oncogene homolog  14c-fos, AP-1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26209639   2015Cell line : LS180

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

Western Blotting, Real-time RT-PCR, ELISA, Cell Proliferation Assay, Transwell Migration Assay.Phosphorylation-IL1R2 acts with c-Fos to enhance the transcription of IL-6 and VEGF-A, which promotes angiogenesis in CRC.

22076613   2012Cell line : LoVo

Source : -

Sample Type : -

No. of Sample : -

Stage : -

QRT-PCR, Western blot, luciferase assay, and chromatin immunoprecipitation (ChIP).Up-regulation-TF/FVIIa/MAPK/c-Fos/MMP-7 axis plays an important role in modulating the invasion of colon cancer cells.

21344377   2012Cell line : Colo205, DLD 1, H3347, SW620, HCT116, HT29

Source : Veterans General Hospital (Taipei, Taiwan)

Sample Type : -

No. of Sample : -

Stage : -

Proliferation analysis,Gene expression analysis, Molecular cloning, Chromatin immunoprecipitation (ChIP), ChIP-seq analysisUnknown- c-Fos has oncogenic activity and is frequently overexpressed in tumour cells.


Gene Details



NC_000014.8 (75745477..75748937)

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Gene Type protein coding
Gene Family basic leucine zipper proteins
Description The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]  
Chromosome 14
Location 14q24.3
Start 75745477  
End 75748937  
Strand +  
Gene Sequence

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Length 3461  
OMIM ID 164810   
HGNC ID HGNC:3796   
Unigene ID Hs.25647   
Ensembl ID -   
PharmGKB ID PA28212   

mRNA Information


mRNA ID NM_005252.3
Exon join(1..346,1100..1351,1783..1890,2006..3457)  
mRNA Sequence

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Length 2158  



CDS Information


   
Location206..1348
CDS Sequence

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CCDS ID CCDS9841.1



Protein Information


      
Protein IDNP_005243.1
Protein NameFBJ murine osteosarcoma viral oncogene homolog
Molecular Wt. (Da)40564
Protein Sequence

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Length 380  
Uniprot IDP10826
Ensembl Protein ID ENSP00000332296  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation232
TPhosphorylation325
TPhosphorylation331
SPhosphorylation374
SPhosphorylation362
SPhosphorylation362
TPhosphorylation114

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                                                                                
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
602BCL3179NP_005169.2in vitro;in vivo10497212   
861RUNX11043NP_001745.2in vivo11641401   
1054CEBPG738NP_001797.1in vitro7665092   
1386ATF2443NP_001871.2in vitro;in vivo182   810   716   511   568   
1457CSNK2A1277NP_001886.1in vitro9685505   
1459CSNK2A2279NP_001887.1in vitro9685505   
1649DDIT3529NP_004074.2in vitro;in vivo10523647   
2113ETS11260NP_001137292.1in vitro8557686   
3726JUNB1303NP_002220.1 in vivo;in vitro;in vitro14   066   551   076   476   000   000   000   
4000LMNA1035CAA27173.1in vitro;in vivo;yeast 2-hybrid16452503   
4088SMAD34380NP_005893.1in vitro;in vivo;yeast 2-hybrid9732876   
4286MITF1138NP_937802.1in vivo9918847   
4790NFKB11238NP_003989.2in vivo9468519   
5970RELA1241NP_068810.3in vivo;yeast 2-hybrid10488148   
6772STAT12777NP_009330.1in vivo12788789   
6927HNF1A800NP_000536.5in vitro;in vivo11134330   


Pathway Information


                                                                                                                                                      
Pathway Name Pathway ID
Amphetamine addiction hsa05031
B cell receptor signaling pathway hsa04662
cAMP signaling pathway hsa04024
Chagas disease (American trypanosomiasis) hsa05142
Choline metabolism in cancer hsa05231
Cholinergic synapse hsa04725
Circadian entrainment hsa04713
Colorectal cancer hsa05210
Dopaminergic synapse hsa04728
Estrogen signaling pathway hsa04915
Hepatitis B hsa05161
Herpes simplex infection hsa05168
HTLV-I infection hsa05166
Leishmaniasis hsa05140
MAPK signaling pathway hsa04010
Osteoclast differentiation hsa04380
Oxytocin signaling pathway hsa04921
Pathways in cancer hsa05200
Pertussis hsa05133
Prolactin signaling pathway hsa04917
Rheumatoid arthritis hsa05323
Salmonella infection hsa05132
T cell receptor signaling pathway hsa04660
TNF signaling pathway hsa04668
Toll-like receptor signaling pathway hsa04620


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd14721147-200  bZIP_Fos
cl21462147-200  bZIP superfamily
cd14699147-197  bZIP_Fos_like
cd14722147-200  bZIP_ATF3
smart00338143-199  BRLZ
cd14686147-189  bZIP
cd14687147-198  bZIP_ATF2
cd14692147-200  bZIP_ATF4
cd14698123-193  bZIP_CNC
cd14691147-194  bZIP_XBP1
pfam07716147-189  bZIP_2
cd14720123-194  bZIP_NFE2-like
pfam00170147-193  bZIP_1
cd14695147-193  bZIP_HLF
cd14705147-193  bZIP_Zip1
cd14701147-189  bZIP_BATF
cd14812147-184  bZIP_u3
pfam12325161-194  TMF_TATA_bd
cl22438161-194  TMF_TATA_bd superfamily
cd12193147-191  bZIP_GCN4
pfam03131147-193  bZIP_Maf
cd14809147-191  bZIP_AUREO-like
pfam12325147-194  TMF_TATA_bd
cd14717147-201  bZIP_Maf_small
cd14719147-194  bZIP_BACH
COG1579147-194  COG1579


Ontology Information


   
HPRD ID5477
Molecular ClassTranscription factor
Molecular FunctionSignal transducer activity (GO:0004871)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P01100DB00852PseudoephedrineSmallMoleculeDrug
P01100DB08813NadroparinSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO