Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PIK3R5 | 23533 | phosphoinositide-3-kinase, regulatory subunit 5 | 17 | P101-PI3K, p101 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26222778 | 2015 | Cell line : - Source : Databases Sample Type : - No. of Sample : - Stage : - | Microarray | Up-regulation | - | Kras, araf, pik3r5, ralgds and akt3 via our novel
designed parameters illustrating high statistical significance. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011] |
| Chromosome | 17 |
| Location | 17p13.1 |
| Start | 8782233 |
| End | 8869029 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 86797 |
| OMIM ID | 611317 |
| HGNC ID | HGNC:30035 |
| Unigene ID | Hs.278901 |
| Ensembl ID | ENSG00000141506 |
| PharmGKB ID | PA134890823 |
Protein Information
| Protein ID | NP_001136105.1 |
|---|---|
| Protein Name | phosphoinositide-3-kinase, regulatory subunit 5 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 880 |
| Uniprot ID | Q8WYQ5 |
| Ensembl Protein ID | ENSP00000263209 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5294 | PIK3CG | 3135 | NP_002640.2 | in vivo | 1 250 799 510 488 140 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Acute myeloid leukemia | hsa05221 |
| Adrenergic signaling in cardiomyocytes | hsa04261 |
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Aldosterone-regulated sodium reabsorption | hsa04960 |
| Amoebiasis | hsa05146 |
| AMPK signaling pathway | hsa04152 |
| Apoptosis | hsa04210 |
| B cell receptor signaling pathway | hsa04662 |
| Bacterial invasion of epithelial cells | hsa05100 |
| cAMP signaling pathway | hsa04024 |
| Carbohydrate digestion and absorption | hsa04973 |
| Central carbon metabolism in cancer | hsa05230 |
| cGMP-PKG signaling pathway | hsa04022 |
| Chagas disease (American trypanosomiasis) | hsa05142 |
| Chemokine signaling pathway | hsa04062 |
| Choline metabolism in cancer | hsa05231 |
| Cholinergic synapse | hsa04725 |
| Chronic myeloid leukemia | hsa05220 |
| Colorectal cancer | hsa05210 |
| Endometrial cancer | hsa05213 |
| Epstein-Barr virus infection | hsa05169 |
| ErbB signaling pathway | hsa04012 |
| Estrogen signaling pathway | hsa04915 |
| Fc epsilon RI signaling pathway | hsa04664 |
| Fc gamma R-mediated phagocytosis | hsa04666 |
| Focal adhesion | hsa04510 |
| FoxO signaling pathway | hsa04068 |
| Glioma | hsa05214 |
| Hepatitis B | hsa05161 |
| Hepatitis C | hsa05160 |
| HIF-1 signaling pathway | hsa04066 |
| HTLV-I infection | hsa05166 |
| Inflammatory mediator regulation of TRP channels | hsa04750 |
| Influenza A | hsa05164 |
| Insulin resistance | hsa04931 |
| Insulin signaling pathway | hsa04910 |
| Jak-STAT signaling pathway | hsa04630 |
| Leukocyte transendothelial migration | hsa04670 |
| Longevity regulating pathway - mammal | hsa04211 |
| Longevity regulating pathway - multiple species | hsa04213 |
| Measles | hsa05162 |
| Melanoma | hsa05218 |
| mTOR signaling pathway | hsa04150 |
| Natural killer cell mediated cytotoxicity | hsa04650 |
| Neurotrophin signaling pathway | hsa04722 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 |
| Non-small cell lung cancer | hsa05223 |
| Osteoclast differentiation | hsa04380 |
| Oxytocin signaling pathway | hsa04921 |
| Pancreatic cancer | hsa05212 |
| Pathways in cancer | hsa05200 |
| Phosphatidylinositol signaling system | hsa04070 |
| Phospholipase D signaling pathway | hsa04072 |
| PI3K-Akt signaling pathway | hsa04151 |
| Platelet activation | hsa04611 |
| Progesterone-mediated oocyte maturation | hsa04914 |
| Prolactin signaling pathway | hsa04917 |
| Prostate cancer | hsa05215 |
| Proteoglycans in cancer | hsa05205 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Regulation of actin cytoskeleton | hsa04810 |
| Regulation of lipolysis in adipocytes | hsa04923 |
| Renal cell carcinoma | hsa05211 |
| Signaling pathways regulating pluripotency of stem cells | hsa04550 |
| Small cell lung cancer | hsa05222 |
| Sphingolipid signaling pathway | hsa04071 |
| T cell receptor signaling pathway | hsa04660 |
| Thyroid hormone signaling pathway | hsa04919 |
| TNF signaling pathway | hsa04668 |
| Toll-like receptor signaling pathway | hsa04620 |
| Toxoplasmosis | hsa05145 |
| Type II diabetes mellitus | hsa04930 |
| VEGF signaling pathway | hsa04370 |
| Viral carcinogenesis | hsa05203 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam10486 | 6-880 | PI3K_1B_p101 |
| cl11126 | 6-880 | PI3K_1B_p101 superfamily |
Ontology Information
| HPRD ID | 6321 |
|---|---|
| Molecular Class | Enzyme regulator |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Regulation of cell proliferation (GO:0042127); Apoptosis (GO:0006915) |
Drug Information
No matching records could be found.