Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FOSB | 2354 | FBJ murine osteosarcoma viral oncogene homolog B | 19 | G0S3, GOSB, GOS3, AP-1, MGC42291, DKFZp686C0818 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19557575 | 2009 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 22 colorectal samples of the same GEO dataset Stage : - | GRNInfer tool and DAVID based on linear programming and a decomposition procedure with integrated Kappa statistics and fuzzy heuristic clustering. | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | basic leucine zipper proteins |
| Description | The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Chromosome | 19 |
| Location | 19q13.3 |
| Start | 45971253 |
| End | 45978437 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7185 |
| OMIM ID | 164772 |
| HGNC ID | HGNC:3797 |
| Unigene ID | Hs.590958 |
| Ensembl ID | - |
| PharmGKB ID | PA28213 |
mRNA Information
| mRNA ID | NM_006732.2 |
|---|---|
| Exon | join(1..718,2635..2955,3200..3307,4557..7185) | mRNA Sequence | Download Select all |
| Length | 3776 |
Protein Information
| Protein ID | NP_006723.2 |
|---|---|
| Protein Name | FBJ murine osteosarcoma viral oncogene homolog B |
| Molecular Wt. (Da) | 35797 |
| Protein Sequence | Download Select all |
| Length | 338 |
| Uniprot ID | P49788 |
| Ensembl Protein ID | ENSP00000237696 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3727 | JUND | 1304 | NP_005345.3 | in vitro | 10942775 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alcoholism | hsa05034 |
| Amphetamine addiction | hsa05031 |
| Cocaine addiction | hsa05030 |
| Osteoclast differentiation | hsa04380 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14721 | 165-218 | bZIP_Fos |
| cl21462 | 165-218 | bZIP superfamily |
| cd14699 | 165-215 | bZIP_Fos_like |
| cd14722 | 165-218 | bZIP_ATF3 |
| cd14686 | 165-212 | bZIP |
| cd14687 | 165-212 | bZIP_ATF2 |
| cd14692 | 165-212 | bZIP_ATF4 |
| smart00338 | 161-215 | BRLZ |
| pfam00170 | 165-211 | bZIP_1 |
Ontology Information
| HPRD ID | 5479 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.