Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SPO11 | 23626 | SPO11 meiotic protein covalently bound to DSB | 20 | CT35, SPATA43, TOPVIA |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24204606 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 30 Stage : - | GISTIC analysis,CNV, LOH and UPD Analysis. | Unknown | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008] |
| Chromosome | 20 |
| Location | 20q13.31 |
| Start | 55904831 |
| End | 55919049 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 14219 |
| OMIM ID | 605114 |
| HGNC ID | HGNC:11250 |
| Unigene ID | Hs.159737 |
| Ensembl ID | ENSG00000054796 |
| PharmGKB ID | PA36080 |
Protein Information
| Protein ID | NP_036576.1 |
|---|---|
| Protein Name | SPO11 meiotic protein covalently bound to DSB |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 396 |
| Uniprot ID | Q9HAW7 |
| Ensembl Protein ID | ENSP00000362525 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00223 | 218-380 | TOPRIM_TopoIIB_SPO |
| cl00718 | 218-380 | TOPRIM superfamily |
| pfam04406 | 104-171 | TP6A_N |
| cl04502 | 104-171 | TP6A_N superfamily |
| pfam03533 | Feb-44 | SPO11_like |
| cl04139 | Feb-44 | SPO11_like superfamily |
| cd00188 | 218-293 | TOPRIM |
| COG1697 | 43-391 | Spo11 |
| PRK04342 | 42-396 | PRK04342 |
| PLN00060 | 106-396 | PLN00060 |
Ontology Information
| HPRD ID | 7073 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Transferase activity (GO:0016740) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.