Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PPP1R15A | 23645 | Protein phosphatase 1, regulatory (inhibitor) subunit 15A | 19 | GADD34 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22930170 | 2012 | Cell line : KM12C, KM12SM, HT 29 Source : ATCC Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | Gene differentially expressed and analysed bye by Microarray. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits |
| Description | This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008] |
| Chromosome | 19 |
| Location | 19q13.2 |
| Start | 48872392 |
| End | 48876062 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 3671 |
| OMIM ID | 611048 |
| HGNC ID | HGNC:14375 |
| Unigene ID | Hs.631593 |
| Ensembl ID | ENSG00000087074 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_014330.3 |
|---|---|
| Exon | join(1..260,834..2507,3223..3671) | mRNA Sequence | Download Select all |
| Length | 2399 |
CDS Information
| Location | join(843..2507,3223..3582) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS12738.1 |
Protein Information
| Protein ID | NP_055145.3 |
|---|---|
| Protein Name | Protein phosphatase 1, regulatory (inhibitor) subunit 15A |
| Molecular Wt. (Da) | 73347 |
| Protein Sequence | Download Select all |
| Length | 674 |
| Uniprot ID | P03951 |
| Ensembl Protein ID | ENSP00000264692 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 262 |
| S | Phosphorylation | 264 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 573 | BAG1 | 3292 | NP_004314.4 | in vitro;in vivo;yeast 2-hybrid | 12724406 |
| 1965 | EIF2S1 | 4881 | NP_004085.1 | in vitro;in vivo | 12556489 |
| 3303 | HSPA1A | 774 | NP_005336.3 | in vivo | 12724406 |
| 4067 | LYN | 1301 | NP_002341.1 | in vitro;in vivo;yeast 2-hybrid | 11517336 |
| 4297 | MLL | 1162 | NP_005924.2 | in vitro;in vivo;yeast 2-hybrid | 10490642 |
| 5499 | PPP1CA | 15942 | NP_001008709.1 | yeast 2-hybrid | 15231748 |
| 5502 | PPP1R1A | 17893 | NP_006732.3 | in vitro;in vivo;yeast 2-hybrid | 11564868 |
| 6598 | SMARCB1 | 3364 | NP_003064.2 | in vitro;in vivo | 1 049 064 212 016 200 |
| 11127 | KIF3A | 5250 | NP_008985.3 | in vitro;in vivo;yeast 2-hybrid | 10631107 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Protein processing in endoplasmic reticulum | hsa04141 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam10488 | 544-609 | PP1c_bdg |
| cl11128 | 544-609 | PP1c_bdg superfamily |
Ontology Information
| HPRD ID | 2689 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.