Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SLC7A11 | 23657 | Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 | 4 | xCT; CCBR1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22930170 | 2012 | Cell line : KM12C, KM12SM, HT 29 Source : ATCC Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | Gene differentially expressed and analysed bye by Microarray. KM12C, KM12SM (SM), HT-29 cell line were used for this study. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Solute carriers |
| Description | This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011] |
| Chromosome | 4 |
| Location | 4q28-q32 |
| Start | 138164094 |
| End | 138312660 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 148567 |
| OMIM ID | 607933 |
| HGNC ID | HGNC:11059 |
| Unigene ID | Hs.390594 |
| Ensembl ID | ENSG00000151012 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_014331.3 |
|---|---|
| Exon | join(70312..70868,76210..76336,80279..80394,89337..89462, 93296..93395,98032..98076,127417..127540,129356..129459, 130268..130364,131871..132020,133267..133444, 140644..148567) | mRNA Sequence | Download Select all |
| Length | 9648 |
CDS Information
| Location | join(30873..30922,70600..70868,76210..76336,80279..80394, 89337..89462,93296..93395,98032..98076,127417..127540, 129356..129459,130268..130364,131871..132020, 133267..133444,140644..140705) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_055146.1 |
|---|---|
| Protein Name | Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 |
| Molecular Wt. (Da) | 55292 |
| Protein Sequence | Download Select all |
| Length | 501 |
| Uniprot ID | P07148 |
| Ensembl Protein ID | ENSP00000295834 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 26;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 570 | BAAT | 8376 | NP_001692.1 | in vitro | 12763038 |
| 6520 | SLC3A2 | 1148 | NP_001012679.1 | in vivo | 1 223 516 411 406 110 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| TIGR00907 | 83-369 | 2A0304 |
| cl00456 | 83-369 | SLC5-6-like_sbd superfamily |
| TIGR00911 | 1-499 | 2A0308 |
| pfam13520 | 69-461 | AA_permease_2 |
| COG0531 | 74-483 | PotE |
| TIGR00909 | 74-467 | 2A0306 |
| TIGR00908 | 70-467 | 2A0305 |
| TIGR00906 | 85-413 | 2A0303 |
| pfam00324 | 73-475 | AA_permease |
| PRK11357 | 35-475 | frlA |
| COG1113 | 85-478 | AnsP |
| TIGR00905 | 70-466 | 2A0302 |
| TIGR04298 | 72-381 | his_histam_anti |
| TIGR04299 | 72-392 | antiport_PotE |
| PRK10644 | 70-382 | PRK10644 |
| PRK11021 | 79-372 | PRK11021 |
| TIGR03813 | 94-476 | put_Glu_GABA_T |
| COG0833 | 60-500 | LysP |
| PRK10655 | 72-437 | potE |
| PRK15049 | 82-400 | PRK15049 |
| TIGR00913 | 175-371 | 2A0310 |
| PRK15238 | 165-283 | PRK15238 |
| PRK10435 | 72-354 | cadB |
| PRK10238 | 107-443 | PRK10238 |
| TIGR03428 | 83-371 | ureacarb_perm |
| PRK10580 | 113-425 | proY |
| PRK11387 | 95-383 | PRK11387 |
| PRK10249 | 83-408 | PRK10249 |
| TIGR00910 | 258-424 | 2A0307_GadC |
Ontology Information
| HPRD ID | 1968 |
|---|---|
| Molecular Class | Membrane transport protein |
| Molecular Function | DNA repair protein (GO:0003685) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9UPY5 | DB00138 | L-Cystine | SmallMoleculeDrug |
| Q9UPY5 | DB00740 | Riluzole | SmallMoleculeDrug |
| Q9UPY5 | DB00795 | Sulfasalazine | SmallMoleculeDrug |
| Q9UPY5 | DB06151 | Acetylcysteine | SmallMoleculeDrug |
| Q9UPY5 | DB01098 | Rosuvastatin | SmallMoleculeDrug |
| Q9UPY5 | DB08834 | Tauroursodeoxycholic acid | SmallMoleculeDrug |