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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ARHGAP8 23779 Rho GTPase activating protein 8  22FLJ20185, BPGAP1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
15225876   2004Cell line : A431, TE-8, Hep-G2, Panc-1, Saos-2 HL-60, MDA-MB-453, MCF- 7, SK-BR-3,T47-D,293T,NIH3T3

Source : -

Sample Type : -

No. of Sample : -

Stage : -

DNA sequencing,RT-PCR, real-time RT-PCR,Northern blot analysisUp-regulation-ARHGAP8 expression was up-regulated in the majority of primary�colorectal�tumors analyzed.


Gene Details



NC_000022.10 (45148438..45258664)

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Gene Type protein coding
Gene Family Rho GTPase activating proteins
Description This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]  
Chromosome 22
Location 22q13.3
Start 45148438  
End 45258664  
Strand +  
Gene Sequence

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Length 110227  
OMIM ID 609405   
HGNC ID HGNC:677   
Unigene ID Hs.102336   
Ensembl ID ENSG00000241484   
PharmGKB ID PA24961   

mRNA Information


mRNA ID ?NM_001017526.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS14060.2



Protein Information


      
Protein IDNP_001017526.1
Protein NameRho GTPase activating protein 8
Molecular Wt. (Da)0
Protein Sequence

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Length 464  
Uniprot IDO60656
Ensembl Protein ID ENSP00000346768  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation448
TPhosphorylation417

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
387RHOA1323NP_001655.1in vitro;in vivo12944407   
663BNIP24481NP_004321.2in vitro;in vivo12944407   
2017CTTN1268NP_005222.2in vitro;in vivo15064355   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0017012-188  SEC14
cl1578712-188  SEC14 superfamily
cd04404222-412  RhoGAP-p50rhoGAP
cl02570222-412  RhoGAP superfamily
cd00159241-407  RhoGAP
pfam00620241-389  RhoGAP
smart00324240-408  RhoGAP
cd04386222-412  RhoGAP_nadrin
cd04402224-412  RhoGAP_ARHGAP20
cd04393224-406  RhoGAP_FAM13A1a
cd04394224-416  RhoGAP-ARHGAP11A
cd04390239-412  RhoGAP_ARHGAP22_24_25
pfam1371622-197  CRAL_TRIO_2
cd04377224-378  RhoGAP_myosin_IX
cd04398224-412  RhoGAP_fRGD1
cd04403224-406  RhoGAP_ARHGAP27_15_12_9
cd04372240-412  RhoGAP_chimaerin
cd04395224-412  RhoGAP_ARHGAP21
cd04378224-395  RhoGAP_GMIP_PARG1
cd04381224-376  RhoGap_RalBP1
cd04376240-415  RhoGAP_ARHGAP6
cd04392253-415  RhoGAP_ARHGAP19
smart0051616-196  SEC14
cd04389224-382  RhoGAP_KIAA1688
cd04400224-414  RhoGAP_fBEM3
cd04383225-382  RhoGAP_srGAP
cd04407224-405  RhoGAP_myosin_IXB
cd04373224-385  RhoGAP_p190
cd04391224-415  RhoGAP_ARHGAP18
cd04406224-378  RhoGAP_myosin_IXA
cd04409234-407  RhoGAP_PARG1
cd04379224-386  RhoGAP_SYD1
cd04397224-416  RhoGAP_fLRG1
cd04396240-411  RhoGAP_fSAC7_BAG7
cd04387224-393  RhoGAP_Bcr
cd04382224-378  RhoGAP_MgcRacGAP
cd04408224-395  RhoGAP_GMIP
cd04380224-382  RhoGAP_OCRL1
cd04375224-396  RhoGAP_DLC1
cd04374251-406  RhoGAP_Graf
cd04384235-386  RhoGAP_CdGAP
cd04385240-378  RhoGAP_ARAP
cd04388238-418  RhoGAP_p85
pfam00650136-185  CRAL_TRIO


Ontology Information


   
HPRD ID6978
Molecular ClassGTPase activating protein
Molecular FunctionUbiquitin-specific protease activity (GO:0004843)
Biological ProcessApoptosis (GO:0006915)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO