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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25576648 | 2015 | Cell line : - Source : RNA-sequencing data (ID: SRP009386) from cancerous, paracancerous non-tumor and distant normal tissue from one Chinese patient with stage III colorectal cancer were downloaded from Sequence Read Archive Sample Type : - No. of Sample : - Stage : - | FastQC,sequence alignment using TopHat v1.3.3. Cufflinks, NOISeq, DAVID, TRANSFA, SAMTools and VCFTools,TopHat-fusion | Up-regulation | - | Dysregulated transcription factors including SOX4, BCL6, CEBPB and MSX2 were enriched in the unique biological process. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Solute carriers |
| Description | This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA can give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015] |
| Chromosome | 11 |
| Location | 11p11.2 |
| Start | 47638858 |
| End | 47664206 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 25349 |
| OMIM ID | 613221 |
| HGNC ID | HGNC:17587 |
| Unigene ID | Hs.269944 |
| Ensembl ID | ENSG00000109919 |
| PharmGKB ID | PA134951260 |
Protein Information
| Protein ID | NP_055157.1 |
|---|---|
| Protein Name | mitochondrial carrier 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 303 |
| Uniprot ID | P22309 |
| Ensembl Protein ID | ENSP00000304845 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 6 |
| Y | Phosphorylation | 23 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00153 | 128-192 | Mito_carr |
| cl02813 | 128-192 | Mito_carr superfamily |
Ontology Information
| HPRD ID | 16138 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.