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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22678777 | 2013 | Cell line : - Source : Utah, the Northern California Kaiser Permanente Medical Care Program (KPMCP), and the Twin Cities Metropolitan area of Minnesota (colon cancer study only) Sample Type : Population-based case control studies No. of Sample : CRC case 1,574 and controls 1,970 and rectal cancer cases 791 and controls 999 Stage : - | Genotyping | Polymorhpism | - | The ALOX15 rs11568131 (10,339 C > T) wild type in combination with a high inflammation score (low EPA intake, high AA intake, no regular NSAID use, high BMI, smoking) was associated with increased colon cancer risk. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Arachidonate lipoxygenases |
| Description | - |
| Chromosome | 17 |
| Location | 17p13.3 |
| Start | 4534214 |
| End | 4545583 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 11370 |
| OMIM ID | 152392 |
| HGNC ID | HGNC:433 |
| Unigene ID | Hs.73809 |
| Ensembl ID | ENSG00000161905 |
| PharmGKB ID | PA48 |
mRNA Information
| mRNA ID | NM_001140.3 |
|---|---|
| Exon | join(1..149,2035..2236,2534..2615,2694..2816,2982..3085, 3289..3449,4408..4551,5698..5907,8166..8252,8351..8520, 8684..8805,9385..9485,9610..9777,9887..10747) | mRNA Sequence | Download Select all |
| Length | 2707 |
Protein Information
| Protein ID | NP_001131.3 |
|---|---|
| Protein Name | arachidonate 15-lipoxygenase |
| Molecular Wt. (Da) | 74674 |
| Protein Sequence | Download Select all |
| Length | 662 |
| Uniprot ID | Q07820 |
| Ensembl Protein ID | ENSP00000309973 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Arachidonic acid metabolism | hsa00590 |
| Linoleic acid metabolism | hsa00591 |
| Metabolic pathways | hsa01100 |
| Serotonergic synapse | hsa04726 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01753 | 2-111 | PLAT_LOX |
| cl00011 | 2-111 | PLAT superfamily |
| pfam00305 | 137-654 | Lipoxygenase |
| cl09510 | 137-654 | Lipoxygenase superfamily |
| smart00308 | 4-103 | LH2 |
| pfam01477 | 4-104 | PLAT |
| cd00113 | 2-103 | PLAT |
| cd01756 | 4-118 | PLAT_repeat |
| PLN02305 | 160-662 | PLN02305 |
| PLN02264 | 213-662 | PLN02264 |
| PLN02337 | 219-654 | PLN02337 |
Ontology Information
| HPRD ID | 303 |
|---|---|
| Molecular Class | Enzyme: Oxygenase |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.