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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
MTOR 2475 mechanistic target of rapamycin (serine/threonine kinase)  1RAFT1, RAPT1, FLJ44809 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
26097572   2015Cell line : -

Source : Department of Pathology, Binzhou Medical University Hospital, China.

Sample Type : CRC Tumor and adjecent normal tissue

No. of Sample : 242

Stage : TNM Stage I-IV

Real time RT- PCR ,Western blotting,Immunohistochemistry,Up-regulation-The LC3 and mTOR genes must be simultaneously detected to evaluate progression and prognosis of CRC.

26261591   2015Cell line : -

Source : Institute of Pathology of the University Hospital of Basel),Institute of Pathology of the University Medical Center, Hamburg-Eppendorf.

Sample Type : Tissue microarrays

No. of Sample : 1800

Stage : -

ImmunohistochemistryUp-regulation-p-mTOR overexpression is abundant in CRC


Gene Details



NC_000001.10 (11166588..11322614, complement)

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Gene Type protein coding
Gene Family -
Description The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]  
Chromosome 1
Location 1p36
Start 11166588  
End 11322614  
Strand -  
Gene Sequence

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Length 156027  
OMIM ID 601231   
HGNC ID HGNC:3942   
Unigene ID Hs.338207   
Ensembl ID ENSG00000198793   
PharmGKB ID PA28360   

mRNA Information


mRNA ID NM_004958.3
Exon join(7..113,3135..3310,3965..4073,5393..5625,6366..6566, 8585..8719,14464..14739,14825..14933,19258..19444, 20877..21005,22011..22255,23941..24156,24510..24715, 28293..28415,29071..29160,30030..30122,31124..31258, 31504..31633,33640..33890,46324..46410,48992..49159, 49650..49762,50084..50246,51652..51744,53100..53246, 57855..57997,62855..63017,63155..63300,95041..95116, 105267..105406,112332..112432,115767..115882, 117513..117590,117803..117910,122900..123025, 123123..123254,128092..128207,129361..129478, 131781..132029,132720..132820,133607..133703, 134006..134104,134432..134554,134752..134934, 135414..135548,135762..135936,137925..138060, 140432..140579,141190..141312,145472..145554, 147090..14  
mRNA Sequence

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Length 8733  



CDS Information


   
Location 122..7771
CDS Sequence

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CCDS ID CCDS127.1



Protein Information


      
Protein IDNP_004949.1
Protein Namemechanistic target of rapamycin (serine/threonine kinase)
Molecular Wt. (Da)288762
Protein Sequence

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Length 2549  
Uniprot IDQ9UL19
Ensembl Protein ID ENSP00000255688  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation2481
TPhosphorylation2446
SPhosphorylation2448
SPhosphorylation2448
TPhosphorylation2446
SPhosphorylation2448
TPhosphorylation2446
SPhosphorylation1166;-
TPhosphorylation1162
TPhosphorylation1262
TPhosphorylation2474
SPhosphorylation2478
KAcetylation1218
SPhosphorylation1261
SPhosphorylation2454
SPhosphorylation2448
SPhosphorylation567
TPhosphorylation2444
SPhosphorylation1847
SPhosphorylation1849

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                     
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1978EIF4EBP13746NP_004086.1in vitro;in vivo11   438   723   940   546   800   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   000   
3667IRS1943NP_005535.1in vitro11287630   
5338PLD23857NP_002654.3in vitro16837165   
6009RHEB3188NP_005605.1in vitro;in vivo15   854   902   166   316   100   000   000   000   000   000   
6198RPS6KB110202NP_003152.1in vitro;in vivo119   143   781   127   923   000   000   000   
6199RPS6KB210203NP_003943.2in vitro11733037   
6774STAT326NP_644805.1in vitro15522880   
10971YWHAQ886NP_006817.1in vitro;in vivo10664457   
57521RPTOR6184NP_065812.1in vitro;in vivo121   509   251   635   468   000   000   000   000   000   000   000   000   000   000   000   
121268RHEBL115245NP_653194.1in vivo16098514   
253260RICTOR10682NP_689969.2in vitro;in vivo157   184   701   660   339   000   000   000   


Pathway Information


                                                                                                                                    
Pathway Name Pathway ID
Acute myeloid leukemia hsa05221
Adipocytokine signaling pathway hsa04920
AMPK signaling pathway hsa04152
Central carbon metabolism in cancer hsa05230
Choline metabolism in cancer hsa05231
ErbB signaling pathway hsa04012
Glioma hsa05214
HIF-1 signaling pathway hsa04066
Insulin resistance hsa04931
Insulin signaling pathway hsa04910
Jak-STAT signaling pathway hsa04630
Longevity regulating pathway - mammal hsa04211
Longevity regulating pathway - multiple species hsa04213
MicroRNAs in cancer hsa05206
mTOR signaling pathway hsa04150
Pathways in cancer hsa05200
Phospholipase D signaling pathway hsa04072
PI3K-Akt signaling pathway hsa04151
Prostate cancer hsa05215
Proteoglycans in cancer hsa05205
Thyroid hormone signaling pathway hsa04919
Type II diabetes mellitus hsa04930


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd051692153-2431  PIKKc_TOR
cl214532153-2431  PKc_like superfamily
cd051642153-2424  PIKKc
smart001462184-2433  PI3Kc
cd008922153-2430  PIKKc_ATR
pfam004542184-2430  PI3_PI4_kinase
cd051702153-2429  PIKKc_SMG1
cd001422153-2424  PI3Kc_like
cd051712153-2431  PIKKc_ATM
cd051722153-2430  PIKKc_DNA-PK
pfam11865854-1024  DUF3385
cl20434854-1024  DUF3385 superfamily
pfam087712015-2114  Rapamycin_bind
cl073982015-2114  Rapamycin_bind superfamily
cd008962145-2410  PI3Kc_III
cd051632153-2394  PIKK_TRRAP
cd008912146-2410  PI3Kc
cd008932184-2421  PI4Kc_III
pfam022602519-2549  FATC
cl035052519-2549  FATC superfamily
cd051652162-2380  PI3Kc_I
cd051662162-2380  PI3Kc_II
cd051742147-2410  PI3Kc_IA_delta
cd051682184-2419  PI4Kc_III_beta
cd051672187-2387  PI4Kc_III_alpha
cd051762164-2380  PI3Kc_C2_alpha
cd051732185-2410  PI3Kc_IA_beta
cd051752115-2381  PI3Kc_IA_alpha
cd051772146-2423  PI3Kc_C2_gamma
cd008952146-2359  PI3Kc_C2_beta
cd008942304-2380  PI3Kc_IB_gamma
pfam13513748-805  HEAT_EZ
cl22454748-805  ARM superfamily
COG5032363-2549  TEL1
pfam022591521-1908  FAT
pfam01602707-832  Adaptin_N


Ontology Information


   
HPRD ID745
Molecular ClassCell cycle control protein
Molecular FunctionGTPase activator activity (GO:0005096)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P42345DB00337PimecrolimusSmallMoleculeDrug
P42345DB00877SirolimusSmallMoleculeDrug
P42345DB01590EverolimusSmallMoleculeDrug
P42345DB06287TemsirolimusSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO