Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RICTOR | 253260 | Rapamycin-insensitive companion of mTOR | 5 | PIA; mAVO3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19934294 | 2009 | Cell line : HCT 116, KM 20, Caco 2, and SW 480 Source : ISUABXIS through Accurate Chemical & Scientific Corporation. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Immunohistochemistry, Cell lines, plasmid transfections, and lentiviral transductions | Up-regulation | - | Targeted inhibition of the mTORC2 protein, Rictor, leads to growth inhibition and induces apoptosis in both rapamycin-sensitive and rapamycin-resistant CRCs, suggesting that selective targeting of mTORC2 may represent a novel therapeutic strategy for treatment of CRC. |
| 20226010 | 2010 | Cell line : HT 29, LS 174T Source : - Sample Type : - No. of Sample : - Stage : - | Gene knock down, short hairpin RNA expression. | Up-regulation | - | Inhibition of mTORC2 reduces colon cancer cell proliferation in vitro and tumor xenograft formation in vivo. They also suggest that specifically targeting mTORC2 may provide a novel treatment strategy for colorectal cancer. Downregulation of rictor in HT29 and LS174T colon cancer cells significantly reduced cell proliferation and Knockdown of rictor also resulted in a G1 arrest. |
| 21430067 | 2011 | Cell line : HCT 116, SW 480, and KM 20 Source : ATCC Sample Type : - No. of Sample : - Stage : TNM Stage IV | Immunohistochemistry, real time RT-PCR, Wound-healing assay, Transwell migration assay | Up-regulation | - | Found that increased expression of mTOR, Raptor, and Rictor mRNA was with advanced stages of CRC. Rictor protein levels were also significantly elevated in primary CRCs (stage IV) and their matched distant metastases compared with normal colon. |
| 22285861 | 2012 | Cell line : SW 620, HT 29,HCT 116 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Cell culture and transfection, Western blotting, Immunoprecipitation and in vivo ubiquitination | Up-regulation | - | Authors indings identify rictor as an important component of FBXW7 E3 ligase complex participating in the regulation of c-Myc and cyclin E protein ubiquitination and degradation. |
| 22983984 | 2012 | Cell line : HT 29, CaR 1 Source : Kyushu University Hospital at Beppu and affiliated hospital, ATCC and the Japanese Collection of Research Bioresources. Sample Type : - No. of Sample : 280 Stage : - | Transfection, Cell proliferation and viability assays, luciferase reporter assay, Protein expression | Up-regulation | - | Among many genes consisting of the mTOR pathway, only high expression of Rictor was associated with poor prognosis of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008] |
| Chromosome | 5 |
| Location | 5p13.1 |
| Start | 38937920 |
| End | 39074419 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 136500 |
| OMIM ID | 609022 |
| HGNC ID | HGNC:28611 |
| Unigene ID | Hs.407926 |
| Ensembl ID | ENSG00000164327 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011514161.1 |
|---|---|
| Exon | complement(<130006..130219) | mRNA Sequence | Download Select all |
| Length | 9439 |
Protein Information
| Protein ID | NP_001272368.1 |
|---|---|
| Protein Name | Rapamycin-insensitive companion of mTOR |
| Molecular Wt. (Da) | 194881 |
| Protein Sequence | Download Select all |
| Length | 1732 |
| Uniprot ID | P14867 |
| Ensembl Protein ID | ENSP00000023897 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 21 |
| Y | Phosphorylation | 262 |
| S | Phosphorylation | 1219 |
| T | Phosphorylation | 1222 |
| S | Phosphorylation | 1282 |
| S | Phosphorylation | 1284 |
| S | Phosphorylation | 1344 |
| S | Phosphorylation | 1348 |
| S | Phosphorylation | 1385 |
| S | Phosphorylation | 1396 |
| Y | Phosphorylation | 1386 |
| S | Phosphorylation | 1388 |
| S | Phosphorylation | 1353 |
| K | Acetylation | 582 |
| S | Phosphorylation | 1591 |
| T | Phosphorylation | 1592 |
| S | Phosphorylation | 1235 |
| T | Phosphorylation | 1295 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| mTOR signaling pathway | hsa04150 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam14664 | 57-437 | RICTOR_N |
| cl20619 | 57-437 | RICTOR_N superfamily |
| pfam14666 | 523-742 | RICTOR_M |
| cl20621 | 523-742 | RICTOR_M superfamily |
| pfam14665 | 1084-1188 | RICTOR_phospho |
| cl20620 | 1084-1188 | RICTOR_phospho superfamily |
| pfam14663 | 743-857 | RasGEF_N_2 |
| cl02520 | 743-857 | REM superfamily |
| pfam14668 | 920-991 | RICTOR_V |
| cl20622 | 920-991 | RICTOR_V superfamily |
| pfam00618 | 765-844 | RasGEF_N |
Ontology Information
| HPRD ID | 713 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.