Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GAD2 | 2572 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) | 10 | GAD65 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22552777 | 2012 | Cell line : - Source : - Sample Type : Fresh frozen CRC tissues No. of Sample : 3 Stage : - | MIRA-based microarrays | Methylation | - | A set of novel hypermethylated genes including GAD2 in CRC, which may have potential to be used as biomarkers for the early diagnosis of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008] |
| Chromosome | 10 |
| Location | 10p13-p11. |
| Start | 26505236 |
| End | 26593491 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 88256 |
| OMIM ID | 138275 |
| HGNC ID | HGNC:4093 |
| Unigene ID | Hs.231829 |
| Ensembl ID | ENSG00000136750 |
| PharmGKB ID | PA28508 |
mRNA Information
| mRNA ID | NM_000818.2 |
|---|---|
| Exon | join(1..579,1304..1363,1536..1685,2737..2970,7581..7671, 8233..8345,13356..13471,29615..29694,52813..52867, 54334..54450,57330..57394,64703..64781,70039..70188, 76159..76266,76596..76685,84482..84689,87728..88256) | mRNA Sequence | Download Select all |
| Length | 2824 |
Protein Information
| Protein ID | NP_000809.1 |
|---|---|
| Protein Name | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) |
| Molecular Wt. (Da) | 65280 |
| Protein Sequence | Download Select all |
| Length | 585 |
| Uniprot ID | Q01201 |
| Ensembl Protein ID | ENSP00000221452 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| R | Proteolytic Cleavage | 69 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5581 | PRKCE | 1500 | NP_005391.1 | in vitro | 15147202 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alanine, aspartate and glutamate metabolism | hsa00250 |
| beta-Alanine metabolism | hsa00410 |
| Butanoate metabolism | hsa00650 |
| GABAergic synapse | hsa04727 |
| Metabolic pathways | hsa01100 |
| Taurine and hypotaurine metabolism | hsa00430 |
| Type I diabetes mellitus | hsa04940 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06450 | 178-581 | DOPA_deC_like |
| cl18945 | 178-581 | AAT_I superfamily |
| pfam00282 | 138-509 | Pyridoxal_deC |
| COG0076 | 113-585 | GadA |
| TIGR03799 | 237-579 | NOD_PanD_pyr |
| PLN02590 | 151-571 | PLN02590 |
| PLN02880 | 151-527 | PLN02880 |
| PRK13520 | 225-496 | PRK13520 |
| PRK02769 | 237-489 | PRK02769 |
| TIGR03812 | 237-496 | tyr_de_CO2_Arch |
| PLN03032 | 266-481 | PLN03032 |
| PLN02263 | 266-481 | PLN02263 |
| cd01494 | 309-410 | AAT_I |
| TIGR03811 | 282-429 | tyr_de_CO2_Ent |
| COG1104 | 277-366 | NifS |
| COG2008 | 274-366 | GLY1 |
| cd00615 | 339-424 | Orn_deC_like |
| TIGR03235 | 238-415 | DNA_S_dndA |
| cd06454 | 312-372 | KBL_like |
| COG0520 | 299-416 | CsdA |
| pfam00266 | 331-505 | Aminotran_5 |
| COG0156 | 267-372 | BioF |
| pfam01212 | 280-366 | Beta_elim_lyase |
| TIGR00191 | 272-341 | thrB |
Ontology Information
| HPRD ID | 1266 |
|---|---|
| Molecular Class | Enzyme: Decarboxylase |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.