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General Information
- Evidence
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26046797 | 2015 | Cell line : - Source : University of Tokyo Hospital, Tokyo, Japan. Sample Type : CRC tumor and normal tissue No. of Sample : 212 Stage : TNM Stage I-IV | Meta analysis,Real-time PCR,cDNA sequencing | Up-regulation | - | RAD54B expression has potential to serve as a novel prognostic biomarker, particularly for distant recurrence in CRC patients. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008] |
| Chromosome | 8 |
| Location | 8q22.1 |
| Start | 95384188 |
| End | 95487343 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 103156 |
| OMIM ID | 604289 |
| HGNC ID | HGNC:17228 |
| Unigene ID | Hs.30561 |
| Ensembl ID | ENSG00000197275 |
| PharmGKB ID | - |
Protein Information
| Protein ID | |
|---|---|
| Protein Name | RAD54 homolog B (S. cerevisiae) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | Q6GPH4 |
| Ensembl Protein ID | ENSP00000341029 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5888 | RAD51 | 1557 | NP_597994.3 | in vivo | 10851248 |
| 7329 | UBE2I | 9045 | NP_003336.1 | yeast 2-hybrid | 16189514 |
| 8697 | CDC23 | 7221 | NP_004652.2 | yeast 2-hybrid | 16189514 |
| 26003 | GORASP2 | 8303 | NP_056345.3 | yeast 2-hybrid | 16189514 |
| 26150 | RIBC2 | 11493 | NP_056468.2 | yeast 2-hybrid | 16189514 |
| 51157 | ZNF580 | 18353 | NP_057286.1 | yeast 2-hybrid | 16189514 |
| 79090 | TRAPPC6A | 14503 | NP_077013.1 | yeast 2-hybrid | 16189514 |
| 80125 | CCDC33 | 9959 | NP_079331.3 | yeast 2-hybrid | 16189514 |
| 84708 | LNX1 | 17287 | NP_001119800.1 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Homologous recombination | hsa03440 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam13873 | Jun-85 | Myb_DNA-bind_5 |
| cl21498 | Jun-85 | SANT superfamily |
| cd00046 | 321-462 | DEXDc |
| cl21455 | 321-462 | P-loop_NTPase superfamily |
| cd00079 | 636-766 | HELICc |
| cl21455 | 636-766 | P-loop_NTPase superfamily |
| pfam00271 | 678-758 | Helicase_C |
| smart00490 | 675-758 | HELICc |
| pfam00176 | 299-598 | SNF2_N |
| COG0553 | 296-815 | HepA |
| PLN03142 | 296-812 | PLN03142 |
| smart00487 | 288-482 | DEXDc |
| COG1061 | 277-570 | SSL2 |
| pfam11496 | 553-785 | HDA2-3 |
| COG0553 | 286-835 | HepA |
| COG1111 | 329-785 | MPH1 |
| COG0513 | 634-760 | SrmB |
| COG4096 | 296-549 | HsdR |
| TIGR00603 | 277-466 | rad25 |
Ontology Information
| HPRD ID | 11042 |
|---|---|
| Molecular Class | ATPase |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.