Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| KLK5 | 25818 | kallikrein-related peptidase 5 | 19 | SCTE, KLK-L2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19367279 | 2009 | Cell line : - Source : Oncologic Hospital of Athens �Saint Savvas. Sample Type : CRC tumor and normal tissue No. of Sample : 122 Stage : - | Immunofluorometric ELISA measurement of kallikreins | Down-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Kallikreins |
| Description | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
| Chromosome | 19 |
| Location | 19q13.33 |
| Start | 51446559 |
| End | 51456344 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 9786 |
| OMIM ID | 605643 |
| HGNC ID | HGNC:6366 |
| Unigene ID | Hs.50915 |
| Ensembl ID | - |
| PharmGKB ID | PA30155 |
Protein Information
| Protein ID | NP_001070959.1 |
|---|---|
| Protein Name | kallikrein-related peptidase 5 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 293 |
| Uniprot ID | Q9BXN1 |
| Ensembl Protein ID | ENSP00000364694 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1828 | DSG1 | 515 | NP_001933.2 | in vitro | 15140227 |
| 5265 | SERPINA1 | 2463 | NP_000286.3 | in vitro | 12890555 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00190 | 67-288 | Tryp_SPc |
| cl21584 | 67-288 | Tryp_SPc superfamily |
| smart00020 | 66-285 | Tryp_SPc |
| pfam00089 | 67-285 | Trypsin |
| COG5640 | 61-285 | COG5640 |
Ontology Information
| HPRD ID | 12838 |
|---|---|
| Molecular Class | Serine protease |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.