Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SOSTDC1 | 25928 | sclerostin domain containing 1 | 7 | DKFZp564D206, USAG1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23443137 | 2013 | Cell line : KM12C, KM12SM Source : Fidler laboratory (MD Anderson Cancer Center, Houston, TX) and Serum sample from Hospital Puerta de Hierro (Madrid, Spain), Hospital de Salamanca (Salamanca, Spain), and the Hospital of Cabuees (Gijn, Spain). Sample Type : Serum sample No. of Sample : Sixty serum samples from CRC patients 40, A-D Duke's stages and healthy control reference sera 20 Stage : Duke stage A-D. | SDS-PAGE and In-gel Digestion,Mass Spectrometry, Protein Identification, and SILAC Quantification,Western Blotting , | Up-regulation | - | Silencing or blocking experiments with SOSTDC1, CTSS, EFNA3, CD137L/TNFSF9, ZG16B, and Midkine caused a significant decrease in migration and invasion of highly metastatic cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008] |
| Chromosome | 7 |
| Location | 7p21.2 |
| Start | 16501106 |
| End | 16505562 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 4457 |
| OMIM ID | 609675 |
| HGNC ID | HGNC:21748 |
| Unigene ID | Hs.648106 |
| Ensembl ID | ENSG00000171243 |
| PharmGKB ID | PA134937603 |
Protein Information
| Protein ID | NP_056279.1 |
|---|---|
| Protein Name | sclerostin domain containing 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 206 |
| Uniprot ID | Q68DV7 |
| Ensembl Protein ID | ENSP00000385328 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 650 | BMP2 | 206 | NP_001191.1 | in vitro;in vivo | 1 502 024 414 623 230 |
| 652 | BMP4 | 207 | NP_001193.2 | in vivo | 15020244 |
| 654 | BMP6 | 211 | NP_001709.1 | in vitro | 14623234 |
| 655 | BMP7 | 212 | NP_001710.1 | in vitro;in vivo | 1 502 024 414 623 230 |
| 991 | CDC20 | 4686 | NP_001246.2 | in vitro;in vivo;yeast 2-hybrid | 15280373 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam05463 | 6-206 | Sclerostin |
| cl21545 | 6-206 | GHB_like superfamily |
| smart00041 | 133-165 | CT |
Ontology Information
| HPRD ID | 5934 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.