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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| KRT23 | 25984 | keratin 23 (histone deacetylase inducible) | 17 | K23, DKFZP434G032, HAIK1, CK23, MGC26158 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24039993 | 2013 | Cell line : - Source : ATCC Sample Type : CRC tumor and normal tissues No. of Sample : - Stage : - | Whole Genome Methylation Analysis, bisulfite sequencing,Expression profiling of shRNA mediated stable KRT23 knockdown. | Up-regulation/ hypomethylated | - | Knockdown of KRT23 rendered colon cancer cells more sensitive to irradiation and reduced proliferation of the KRT23 depleted cells compared to irradiated control cells. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | -, "Intermediate filaments type I, keratins (acidic)" |
| Description | The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| Chromosome | 17 |
| Location | 17q21.2 |
| Start | 39078948 |
| End | 39093895 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 14948 |
| OMIM ID | 606194 |
| HGNC ID | HGNC:6438 |
| Unigene ID | Hs.9029 |
| Ensembl ID | ENSG00000108244 |
| PharmGKB ID | PA134914537 |
Protein Information
| Protein ID | NP_001269362.1 |
|---|---|
| Protein Name | keratin 23 (histone deacetylase inducible) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 422 |
| Uniprot ID | Q7Z2X4 |
| Ensembl Protein ID | ENSP00000283937 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00038 | 71-378 | Filament |
| COG1196 | 159-376 | Smc |
| COG1196 | 88-417 | Smc |
| COG1196 | 169-369 | Smc |
| COG1269 | 79-263 | NtpI |
| TIGR02168 | 169-387 | SMC_prok_B |
| pfam05483 | 115-407 | SCP-1 |
| TIGR02168 | 73-353 | SMC_prok_B |
| COG1196 | 121-401 | Smc |
| COG4251 | 331-419 | COG4251 |
| PRK03918 | 141-390 | PRK03918 |
| pfam05557 | 162-407 | MAD |
| TIGR02169 | 71-401 | SMC_prok_A |
| pfam05483 | 162-376 | SCP-1 |
| TIGR02168 | 86-376 | SMC_prok_B |
Ontology Information
| HPRD ID | 11434 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.