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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CHD5 26038 chromodomain helicase DNA binding protein 5  1- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19750230   2009Cell line : -

Source : Iranians and African Americans (AA) population

Sample Type : Population based case-control study

No. of Sample : 51 Iranians (a white population) and 51 African Americans

Stage : -

Methylation-specific PCR , chi-square analysisMethylation-A significantly higher methylation rate was found for GPNMB, ICAM5, and CHD5 genes in AA patients compared to Iranians. These genes might play a role in the high incidence and aggressiveness of CRC in the AA population.

24243398   2014Cell line : RKO, HTC116

Source : African American subjects

Sample Type : CRC tumor

No. of Sample : 24

Stage : -

Methylation-specific PCR , bisulfite sequencing, real time RT-PCRMethylation-CHD5 activity is regulated by DNA methylation and repressive histone modifications. CHD5 likely acts as a tumor-suppressor gene in early colorectal carcinogenesis.


Gene Details



NC_000001.10 (6161847..6240194, complement)

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Gene Type protein coding
Gene Family Zinc fingers, PHD-type
Description This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma. [provided by RefSeq, Feb 2012]  
Chromosome 1
Location 1p36.3
Start 6161847  
End 6240194  
Strand -  
Gene Sequence

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Length 78348  
OMIM ID 610771   
HGNC ID HGNC:16816   
Unigene ID Hs.522898   
Ensembl ID ENSG00000116254   
PharmGKB ID PA134969178   

mRNA Information


mRNA ID ?NM_015557.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS57.1



Protein Information


      
Protein IDNP_056372.1
Protein Namechromodomain helicase DNA binding protein 5
Molecular Wt. (Da)0
Protein Sequence

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Length 1954  
Uniprot IDQ8TC59
Ensembl Protein ID ENSP00000349208  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation610
SPhosphorylation1654
SPhosphorylation1658

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd000791019-1146  HELICc
cl214551019-1146  P-loop_NTPase superfamily
cd15531345-387  PHD1_CHD_II
cl22851345-387  PHD_SF superfamily
cd15532418-460  PHD2_CHD_II
cl22851418-460  PHD_SF superfamily
cd00046720-878  DEXDc
cl21455720-878  P-loop_NTPase superfamily
cd00024589-642  CHROMO
cl17459589-642  CHROMO superfamily
cd00024508-545  CHROMO
cl17459508-545  CHROMO superfamily
pfam080741731-1903  CHDCT2
cl069031731-1903  CHDCT2 superfamily
pfam064611390-1530  DUF1086
cl057881390-1530  DUF1086 superfamily
pfam08073146-200  CHDNT
cl06902146-200  CHDNT superfamily
pfam064651296-1359  DUF1087
cl057921296-1359  DUF1087 superfamily
smart004901054-1138  HELICc
pfam002711058-1138  Helicase_C
cd15533419-460  PHD1_PHF12
cd15523418-460  PHD_PHF21A
cd15532345-387  PHD2_CHD_II
cd15539419-460  PHD1_AIRE
cd15541418-460  PHD_TIF1_like
pfam00628418-462  PHD
cd15539345-387  PHD1_AIRE
cd15523345-387  PHD_PHF21A
cd15559419-460  PHD1_BPTF
cd15519419-460  PHD1_Lid2p_like
pfam00628345-387  PHD
cd15524345-387  PHD_PHF21B
cd15531418-460  PHD1_CHD_II
cd15535418-460  PHD1_Rco1
cd15524418-460  PHD_PHF21B
cd15515419-460  PHD1_KDM5A_like
cd15567418-460  PHD4_NSD
smart00249418-460  PHD
cd15519346-387  PHD1_Lid2p_like
cd15541345-387  PHD_TIF1_like
cd15605419-460  PHD1_Lid_like
cd15533345-387  PHD1_PHF12
cd15567345-387  PHD4_NSD
cd15604419-460  PHD1_KDM5C_5D
cd15625417-460  PHD_TIF1delta
cd15535345-387  PHD1_Rco1
smart00249345-387  PHD
cd15622418-460  PHD_TIF1alpha
cd15627419-460  PHD_BAZ1A
cd15568345-386  PHD5_NSD
cd15537345-387  PHD_BS69
cd15543419-460  PHD_RSF1
cd15628419-460  PHD_BAZ1B
cd15489345-387  PHD_SF
cd15658418-460  PHD4_NSD3
cd15489418-460  PHD_SF
cd15559345-387  PHD1_BPTF
cd15527419-460  PHD2_KAT6A_6B
cd15624418-460  PHD_TIF1gamma
cd15602419-460  PHD1_KDM5A
cd15627346-387  PHD_BAZ1A
cd15568418-459  PHD5_NSD
cd15545418-460  PHD_BAZ2A_like
cd15527346-387  PHD2_KAT6A_6B
cd15661345-385  PHD5_NSD3
cd15544419-460  PHD_BAZ1A_like
cd15525419-460  PHD_UHRF1_2
cd15538345-387  PHD_PRKCBP1
cd15603419-460  PHD1_KDM5B
cd15544346-387  PHD_BAZ1A_like
cd15617419-460  PHD_UHRF2
cd15622345-387  PHD_TIF1alpha
cd15536418-460  PHD_PHRF1
cd15628346-387  PHD_BAZ1B
cd15625342-387  PHD_TIF1delta
pfam00385594-642  Chromo
smart00298592-625  CHROMO
cd15545345-387  PHD_BAZ2A_like
cd15656418-460  PHD4_NSD1
cd15543345-387  PHD_RSF1
cd11725334-393  ADDz_Dnmt3
cd15624345-387  PHD_TIF1gamma
cd15538418-460  PHD_PRKCBP1
cd15513346-387  PHD5_KMT2C_like
cd15657418-460  PHD4_NSD2
cd15660345-385  PHD5_NSD2
cd15629346-387  PHD_BAZ2A
cd15513419-460  PHD5_KMT2C_like
cd15497419-460  PHD1_Snt2p_like
cd15623419-460  PHD_TIF1beta
cd15595419-460  PHD2_KMT2D
cd15616419-460  PHD_UHRF1
cd15629419-460  PHD_BAZ2A
cd15536345-387  PHD_PHRF1
cd15661418-458  PHD5_NSD3
cd15604346-387  PHD1_KDM5C_5D
cd15515346-387  PHD1_KDM5A_like
cd15594346-387  PHD2_KMT2C
cd15525346-387  PHD_UHRF1_2
cd15595346-387  PHD2_KMT2D
cd15617346-387  PHD_UHRF2
cd15623346-387  PHD_TIF1beta
cd15497345-387  PHD1_Snt2p_like
cd15499346-389  PHD1_MTF2_PHF19_like
cd15534418-459  PHD2_PHF12_Rco1
cd15530345-387  PHD2_d4
cd15510419-460  PHD2_KMT2C_like
cd15626346-387  PHD_SP110_140
cd15658345-387  PHD4_NSD3
cd15603346-387  PHD1_KDM5B
cd15605346-387  PHD1_Lid_like
cd15563346-387  PHD3_PHF14
cd15626419-460  PHD_SP110_140
cd15504345-387  PHD_PRHA_like
cd15602346-390  PHD1_KDM5A
cd15656345-387  PHD4_NSD1
cd15530419-460  PHD2_d4
cd15566418-459  PHD3_NSD
cd15562346-387  PHD2_PHF14
smart00298466-546  CHROMO
cd11726334-389  ADDz_ATRX
cd15510346-387  PHD2_KMT2C_like
cd15630418-460  PHD_BAZ2B
cd15504418-460  PHD_PRHA_like
cd15502418-460  PHD_Phf1p_Phf2p_like
cd15594419-460  PHD2_KMT2C
cd15630345-387  PHD_BAZ2B
cd15616346-387  PHD_UHRF1
cd15529419-460  PHD2_PHF10
cd15657345-387  PHD4_NSD2
cd15562418-460  PHD2_PHF14
cd15509346-387  PHD1_KMT2C_like
cd15659346-385  PHD5_NSD1
cd15529346-387  PHD2_PHF10
cd15502346-387  PHD_Phf1p_Phf2p_like
cd15660419-458  PHD5_NSD2
cd15534346-385  PHD2_PHF12_Rco1
cd15648346-387  PHD1_NSD1_2
cd15659419-458  PHD5_NSD1
cd15537418-460  PHD_BS69
cd15578346-388  PHD1_MTF2
cd15499419-462  PHD1_MTF2_PHF19_like
cd15572418-466  PHD_BRPF
cd15590418-460  PHD2_KMT2A
cd15648419-461  PHD1_NSD1_2
cd15507418-460  PHD2_KMT2A_like
cd15566345-386  PHD3_NSD
cd15591418-460  PHD2_KMT2B
cd15505345-387  PHD_ING
cd11726417-438  ADDz_ATRX
cd15585345-387  PHD_ING3
cd04718438-461  BAH_plant_2
cl02608438-461  BAH superfamily
cd15578419-460  PHD1_MTF2
cd15563419-460  PHD3_PHF14
cd04718365-390  BAH_plant_2
cl02608365-390  BAH superfamily
cd15492418-460  PHD_BRPF_JADE_like
cd15509418-460  PHD1_KMT2C_like
cd15522418-460  PHD_TAF3
cd15506419-460  PHD1_KMT2A_like
cd15676419-464  PHD_BRPF1
cd15522345-387  PHD_TAF3
cd15501419-460  PHD_Int12
cd15677419-460  PHD_BRPF2
cd11672334-387  ADDz
cd15685345-390  PHD_ING5
cd15585426-460  PHD_ING3
cd15678418-466  PHD_BRPF3
cd15677349-387  PHD_BRPF2
cd15586345-387  PHD_ING4_5
cd15584345-387  PHD_ING1_2
cd15507345-387  PHD2_KMT2A_like
cd15492346-387  PHD_BRPF_JADE_like
cd15573346-387  PHD_JADE
cd15679346-387  PHD_JADE1
pfam062731479-1664  eIF-4B
cl056601479-1664  eIF-4B superfamily
cd15680419-460  PHD_JADE2
cd15564419-461  PHD1_NSD
cd15590345-387  PHD2_KMT2A
cd15517346-387  PHD_TCF19_like
cd15505426-460  PHD_ING
cd15649419-460  PHD1_NSD3
cd09639728-887  Cas3_I
cd15681346-387  PHD_JADE3
cd11728334-387  ADDz_Dnmt3b
cd15573419-460  PHD_JADE
cd15679419-460  PHD_JADE1
cd15682345-390  PHD_ING1
pfam00176703-999  SNF2_N
PLN03142698-1214  PLN03142
COG0553685-1196  HepA
smart00487694-902  DEXDc
PRK04914840-947  PRK04914
COG5034334-390  TNG2
COG1111728-1202  MPH1
COG05131021-1138  SrmB
pfam11496993-1156  HDA2-3


Ontology Information


   
HPRD ID10964
Molecular ClassDNA binding protein
Molecular FunctionAcyltransferase activity (GO:0008415)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO