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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GATA1 | 2623 | GATA binding protein 1 (globin transcription factor 1) | X | ERYF1, NFE1, GATA-1, NF-E1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25230694 | 2015 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | real time RT-PCR | Down-regulation | - | GATA1 and GATA2 expression alterations are associated with poor survival and adverse clinicopathology in prostate and colorectal cancer.GATA1 and GATA2 expression levels were significantly decreased in tumor tissues compared with normal tissues |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GATA zinc finger domain containing |
| Description | This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008] |
| Chromosome | X |
| Location | Xp11.23 |
| Start | 48644982 |
| End | 48652718 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7737 |
| OMIM ID | 305371 |
| HGNC ID | HGNC:4170 |
| Unigene ID | Hs.765 |
| Ensembl ID | ENSG00000102145 |
| PharmGKB ID | PA28584 |
mRNA Information
| mRNA ID | XM_011543897.1 |
|---|---|
| Exon | join(1..86,4532..4770,5285..5662,5764..5909,6613..6738, 7219..7752) | mRNA Sequence | Download Select all |
| Length | 1509 |
Protein Information
| Protein ID | XP_011542199.1 |
|---|---|
| Protein Name | GATA binding protein 1 (globin transcription factor 1) |
| Molecular Wt. (Da) | 43276 |
| Protein Sequence | Download Select all |
| Length | 418 |
| Uniprot ID | O14924 |
| Ensembl Protein ID | ENSP00000338509 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 310 |
| S | Phosphorylation | 26 |
| S | Phosphorylation | 72 |
| S | Phosphorylation | 142 |
| S | Phosphorylation | 187 |
| S | Phosphorylation | 116 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 836 | CASP3 | 2799 | NP_004337.2 | in vitro | 17167422 |
| 2313 | FLI1 | 1901 | NP_002008.2 | in vitro;in vivo;yeast 2-hybrid | 12724402 |
| 4005 | LMO2 | 1586 | NP_005565.2 | in vitro;in vivo;yeast 2-hybrid | 75 681 779 209 374 |
| 5595 | MAPK3 | 3479 | NP_002737.2 | in vitro | 15967790 |
| 6688 | SPI1 | 1305 | NP_001074016.1 | in vitro;in vivo | 10364157 |
| 23462 | HEY1 | 4260 | NP_001035798.1 | in vitro;in vivo | 15314183 |
| 161882 | ZFPM1 | 11800 | NP_722520.2 | in vitro;in vivo;yeast 2-hybrid | 923 030 711 675 338 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00202 | 203-247 | ZnF_GATA |
| cl00158 | 203-247 | ZnF_GATA superfamily |
| cd00202 | 268-308 | ZnF_GATA |
| cl00158 | 268-308 | ZnF_GATA superfamily |
| pfam00320 | 204-238 | GATA |
| pfam00320 | 266-292 | GATA |
| smart00401 | 202-247 | ZnF_GATA |
| COG5641 | 154-313 | GAT1 |
| smart00401 | 266-302 | ZnF_GATA |
| COG5641 | 204-320 | GAT1 |
Ontology Information
| HPRD ID | 3945 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | GTPase activator activity (GO:0005096) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.