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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25230694 | 2015 | Cell line : - Source : Peking University cancer Hospital and Institute. Sample Type : CRC tumor and normal tissue No. of Sample : 307 CRC and 178 adjescent normal tissue Stage : TNM Stage I-IV | real time RT-PCR | Down-regulation | - | GATA1 and GATA2 expression alterations are associated with poor survival and adverse clinicopathology in prostate and colorectal cancer.GATA1 and GATA2 expression levels were significantly decreased in tumor tissues compared with normal tissues |
| 26287967 | 2015 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Sanger sequencing,immunohistochemistry,Kaplan-Meier survival analysis and Cox proportional hazard regression | Polymorhpism | - | GATA2 SNP rs2335052 is an independent predictor for prognosis of CRC patients. |
| 23423786 | 2013 | Cell line : - Source : Department of Pathology at Peking University Cancer Hospital & Institute. Sample Type : CRC tumor No. of Sample : 180 Stage : TNM Stage I-IV | Multivariate analysis, immunohistochemistry | Up-regulation | - | Multivariate analysis showed GATA2 expression to be an independent prognostic factor for patients with colorectal cancer.The expression of GATA2 was found to be significantly higher in colorectal cancer tissues than in matched adjacent noncancerous tissues |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GATA zinc finger domain containing |
| Description | This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] |
| Chromosome | 3 |
| Location | 3q21 |
| Start | 128198265 |
| End | 128212030 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 13766 |
| OMIM ID | 137295 |
| HGNC ID | HGNC:4171 |
| Unigene ID | Hs.367725 |
| Ensembl ID | ENSG00000179348 |
| PharmGKB ID | PA28585 |
mRNA Information
| mRNA ID | NM_032638.4 |
|---|---|
| Exon | join(1..289,6112..6385,6820..7461,9183..9328,11244..11369, 11870..13766) | mRNA Sequence | Download Select all |
| Length | 3383 |
Protein Information
| Protein ID | NP_116027.2 |
|---|---|
| Protein Name | GATA binding protein 2 |
| Molecular Wt. (Da) | 50369 |
| Protein Sequence | Download Select all |
| Length | 480 |
| Uniprot ID | O15492 |
| Ensembl Protein ID | ENSP00000356529 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 401 |
| S | Phosphorylation | 182 |
| S | Phosphorylation | 73 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1050 | CEBPA | 296 | NP_004355.2 | in vitro | 1563207 |
| 3087 | HHEX | 6829 | NP_002720.1 | in vitro | 15016828 |
| 3725 | JUN | 1302 | NP_002219.1 | in vitro | 11278891 |
| 5371 | PML | 23 | NP_150241.2 | in vitro;in vivo;yeast 2-hybrid | 10938104 |
| 5594 | MAPK1 | 1496 | NP_002736.3 | in vitro | 7876160 |
| 5914 | RARA | 6769 | NP_000955.1 | in vitro;in vivo;yeast 2-hybrid | 15254248 |
| 6256 | RXRA | 1577 | NP_002948.1 | in vivo | 15254248 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00202 | 349-398 | ZnF_GATA |
| cl00158 | 349-398 | ZnF_GATA superfamily |
| cd00202 | 294-344 | ZnF_GATA |
| cl00158 | 294-344 | ZnF_GATA superfamily |
| pfam00320 | 349-383 | GATA |
| pfam00320 | 295-329 | GATA |
| smart00401 | 344-393 | ZnF_GATA |
| smart00401 | 290-338 | ZnF_GATA |
| COG5641 | 297-398 | GAT1 |
| COG5641 | 349-398 | GAT1 |
| COG5641 | 295-373 | GAT1 |
Ontology Information
| HPRD ID | 3132 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.