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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25202404 | 2014 | Cell line : - Source : Li Huili Hospital (Ningbo, China). Sample Type : CRC tumor and normal tissue No. of Sample : 56 CRC and 40 normal tissue Stage : - | Methylation-specific PCR ,Sodium bisulfite conversion | Methylation | - | Methylation of the SFRP2, GATA4/5, NDRG4 and VIM promoters in fecal DNA is associated with the presence of colorectal tumors. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GATA zinc finger domain containing |
| Description | This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] |
| Chromosome | 8 |
| Location | 8p23.1-p22 |
| Start | 11534433 |
| End | 11617510 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 83078 |
| OMIM ID | 600576 |
| HGNC ID | HGNC:4173 |
| Unigene ID | Hs.243987 |
| Ensembl ID | ENSG00000136574 |
| PharmGKB ID | PA28587 |
mRNA Information
| mRNA ID | XM_005272386.1 |
|---|---|
| Exon | join(1..140,23585..23855,30933..32005,71993..72162, 73188..73313,78123..78210,80012..80160,81370..83078) | mRNA Sequence | Download Select all |
| Length | 3726 |
Protein Information
| Protein ID | XP_005272443.1 |
|---|---|
| Protein Name | GATA binding protein 4 |
| Molecular Wt. (Da) | 44534 |
| Protein Sequence | Download Select all |
| Length | 443 |
| Uniprot ID | P61221 |
| Ensembl Protein ID | ENSP00000296577 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 406 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1397 | CRIP2 | 3113 | NP_001303.1 | in vitro;in vivo | 12530967 |
| 1482 | NKX2-5 | 2787 | NP_004378.1 | in vitro;in vivo | 931 202 710 948 187 |
| 2033 | EP300 | 4078 | NP_001420.2 | in vivo | 11481322 |
| 2353 | FOS | 1275 | NP_005243.1 | in vitro | 9207128 |
| 2516 | NR5A1 | 1702 | NP_004950.2 | in vitro;in vivo | 10446911 |
| 3720 | JARID2 | 3355 | NP_004964.2 | in vitro;in vivo | 15542826 |
| 4208 | MEF2C | 2809 | NP_002388.2 | in vitro;in vivo | 10790371 |
| 5469 | MED1 | 5055 | NP_004765.2 | in vitro | 11724781 |
| 5595 | MAPK3 | 3479 | NP_002737.2 | in vitro | 11585926 |
| 6722 | SRF | 2788 | NP_003122.1 | in vitro;in vivo | 1 100 365 111 158 290 |
| 6910 | TBX5 | 3372 | NP_000183.2 | in vitro;in vivo | 12845333 |
| 9464 | HAND2 | 3872 | NP_068808.1 | in vitro;in vivo | 11994297 |
| 23414 | ZFPM2 | 4737 | NP_036214.2 | in vitro;in vivo;yeast 2-hybrid | 992 767 511 297 508 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| cGMP-PKG signaling pathway | hsa04022 |
| Thyroid hormone signaling pathway | hsa04919 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00202 | 270-321 | ZnF_GATA |
| cl00158 | 270-321 | ZnF_GATA superfamily |
| cd00202 | 216-266 | ZnF_GATA |
| cl00158 | 216-266 | ZnF_GATA superfamily |
| pfam00320 | 271-305 | GATA |
| pfam00320 | 217-249 | GATA |
| pfam05349 | 1-208 | GATA-N |
| smart00401 | 268-315 | ZnF_GATA |
| smart00401 | 212-257 | ZnF_GATA |
| COG5641 | 192-324 | GAT1 |
| COG5641 | 219-335 | GAT1 |
| COG5641 | 267-341 | GAT1 |
Ontology Information
| HPRD ID | 3890 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.