Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GC | 2638 | Group-specific component (vitamin D binding protein) | 4 | DBP; GRD3; VDBG; VDBP; DBP/GC |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and Normal tissue No. of Sample : - Stage : - | Biochemical isolation to nano-LC-MS/MS analysis. | Up-regulation | - | This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue. CRC tissue was collected at the VU University Medical Center, Amsterdam, The Netherlands. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011] |
| Chromosome | 4 |
| Location | 4q12-q13 |
| Start | 71741693 |
| End | 71805520 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 63828 |
| OMIM ID | 139200 |
| HGNC ID | HGNC:4187 |
| Unigene ID | Hs.418497 |
| Ensembl ID | ENSG00000145321 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001204306.1 |
|---|---|
| Exon | join(1..179,21467..21560,36121..36190,37088..37220, 39878..40089,41585..41717,42019..42113,47350..47479, 48607..48809,50414..50543,51013..51110,52871..53003, 59316..59370,63651..63828) | mRNA Sequence | Download Select all |
| Length | 2024 |
CDS Information
| Location | join(1575..1595,21467..21560,36121..36190,37088..37220, 39878..40089,41585..41717,42019..42113,47350..47479, 48607..48809,50414..50543,51013..51110,52871..53003, 59316..59345) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS56332.1 |
Protein Information
| Protein ID | NP_000574.2 |
|---|---|
| Protein Name | Group-specific component (vitamin D binding protein) |
| Molecular Wt. (Da) | 51198 |
| Protein Sequence | Download Select all |
| Length | 474 |
| Uniprot ID | Q13873 |
| Ensembl Protein ID | ENSP00000363702 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 288 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 58 | ACTA1 | 30 | NP_001091.1 | in vitro | 12 119 014 120 482 400 000 000 |
| 59 | ACTA2 | 31 | NP_001604.1 | in vitro | 12119014 |
| 70 | ACTC1 | 15 | NP_005150.1 | in vitro | 1 245 243 912 554 930 |
| 718 | C3 | 400 | NP_000055.2 | in vitro | 2824652 |
| 10169 | SERF2 | 5447 | NP_005761.2 | yeast 2-hybrid | 16169070 |
| 55791 | C1orf103 | 17975 | NP_060842.3 | yeast 2-hybrid | 16169070 |
| 79577 | CDC73 | 9581 | NP_078805.3 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1J78 |
|---|---|
| Resolution | 2.31 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B |
| Molecule | vitamin D binding protein |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00015 | 26-206 | ALBUMIN |
| cl00031 | 26-206 | ALBUMIN superfamily |
| smart00103 | 19-201 | ALBUMIN |
| pfam00273 | 25-199 | Serum_albumin |
| smart00103 | 208-385 | ALBUMIN |
| cl00031 | 208-385 | ALBUMIN superfamily |
| pfam00273 | 216-385 | Serum_albumin |
| pfam09164 | 405-472 | VitD-bind_III |
| cl23591 | 405-472 | VitD-bind_III superfamily |
| cd00015 | 217-392 | ALBUMIN |
Ontology Information
| HPRD ID | 2880 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Receptor signaling protein serine/threonine kinase activity (GO:0004702) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P02774 | DB00169 | Cholecalciferol | SmallMoleculeDrug |
| P02774 | DB01436 | Alfacalcidol | SmallMoleculeDrug |